Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial SSU ribosomal protein, putative

Species:

Leishmania mexicana

UniProt:

E9B490_LEIMU

TriTrypDb:

LmxM.32.2510

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B490

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B490

PDB structure(s): 7ane_l

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0043631	RNA polyadenylation	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	483	487	PF00656	0.522
CLV_NRD_NRD_1	228	230	PF00675	0.444
CLV_NRD_NRD_1	33	35	PF00675	0.494
CLV_NRD_NRD_1	388	390	PF00675	0.750
CLV_NRD_NRD_1	435	437	PF00675	0.463
CLV_NRD_NRD_1	601	603	PF00675	0.351
CLV_NRD_NRD_1	641	643	PF00675	0.405
CLV_NRD_NRD_1	85	87	PF00675	0.393
CLV_PCSK_FUR_1	599	603	PF00082	0.346
CLV_PCSK_KEX2_1	228	230	PF00082	0.444
CLV_PCSK_KEX2_1	388	390	PF00082	0.750
CLV_PCSK_KEX2_1	411	413	PF00082	0.408
CLV_PCSK_KEX2_1	435	437	PF00082	0.463
CLV_PCSK_KEX2_1	601	603	PF00082	0.351
CLV_PCSK_KEX2_1	641	643	PF00082	0.387
CLV_PCSK_KEX2_1	85	87	PF00082	0.393
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.427
CLV_PCSK_PC7_1	637	643	PF00082	0.506
CLV_PCSK_SKI1_1	146	150	PF00082	0.311
CLV_PCSK_SKI1_1	151	155	PF00082	0.312
CLV_PCSK_SKI1_1	166	170	PF00082	0.215
CLV_PCSK_SKI1_1	485	489	PF00082	0.513
CLV_PCSK_SKI1_1	590	594	PF00082	0.476
CLV_PCSK_SKI1_1	617	621	PF00082	0.419
CLV_Separin_Metazoa	265	269	PF03568	0.562
DEG_APCC_DBOX_1	165	173	PF00400	0.280
DEG_Nend_Nbox_1	1	3	PF02207	0.446
DEG_ODPH_VHL_1	416	427	PF01847	0.529
DOC_CYCLIN_RxL_1	329	338	PF00134	0.353
DOC_MAPK_gen_1	119	128	PF00069	0.355
DOC_MAPK_gen_1	544	551	PF00069	0.347
DOC_MAPK_gen_1	601	610	PF00069	0.380
DOC_MAPK_gen_1	641	649	PF00069	0.363
DOC_MAPK_HePTP_8	105	117	PF00069	0.368
DOC_MAPK_MEF2A_6	108	117	PF00069	0.349
DOC_MAPK_MEF2A_6	544	551	PF00069	0.367
DOC_PP1_RVXF_1	330	337	PF00149	0.312
DOC_PP1_RVXF_1	506	512	PF00149	0.514
DOC_PP2B_LxvP_1	212	215	PF13499	0.427
DOC_PP2B_LxvP_1	415	418	PF13499	0.547
DOC_PP2B_PxIxI_1	112	118	PF00149	0.346
DOC_PP4_FxxP_1	255	258	PF00568	0.410
DOC_USP7_MATH_1	179	183	PF00917	0.591
DOC_USP7_MATH_1	196	200	PF00917	0.506
DOC_USP7_MATH_1	23	27	PF00917	0.494
DOC_USP7_MATH_1	248	252	PF00917	0.493
DOC_USP7_MATH_1	361	365	PF00917	0.568
DOC_USP7_MATH_1	370	374	PF00917	0.665
DOC_USP7_MATH_1	547	551	PF00917	0.469
DOC_USP7_MATH_1	569	573	PF00917	0.591
DOC_USP7_MATH_1	629	633	PF00917	0.476
DOC_USP7_MATH_1	673	677	PF00917	0.467
DOC_USP7_MATH_1	73	77	PF00917	0.543
DOC_USP7_MATH_2	179	185	PF00917	0.520
DOC_WW_Pin1_4	10	15	PF00397	0.367
DOC_WW_Pin1_4	362	367	PF00397	0.601
LIG_14-3-3_CanoR_1	157	162	PF00244	0.391
LIG_14-3-3_CanoR_1	310	316	PF00244	0.549
LIG_14-3-3_CanoR_1	360	366	PF00244	0.552
LIG_14-3-3_CanoR_1	490	494	PF00244	0.578
LIG_14-3-3_CanoR_1	570	577	PF00244	0.382
LIG_14-3-3_CanoR_1	641	649	PF00244	0.435
LIG_14-3-3_CanoR_1	72	78	PF00244	0.456
LIG_Actin_RPEL_3	115	134	PF02755	0.345
LIG_Actin_WH2_2	13	31	PF00022	0.552
LIG_APCC_ABBA_1	126	131	PF00400	0.386
LIG_APCC_ABBA_1	333	338	PF00400	0.297
LIG_APCC_ABBAyCdc20_2	332	338	PF00400	0.315
LIG_deltaCOP1_diTrp_1	135	144	PF00928	0.498
LIG_deltaCOP1_diTrp_1	471	475	PF00928	0.379
LIG_EH_1	345	349	PF12763	0.372
LIG_FHA_1	209	215	PF00498	0.477
LIG_FHA_2	496	502	PF00498	0.385
LIG_FHA_2	589	595	PF00498	0.311
LIG_GBD_Chelix_1	580	588	PF00786	0.459
LIG_LIR_Apic_2	252	258	PF02991	0.412
LIG_LIR_Apic_2	379	384	PF02991	0.620
LIG_LIR_Apic_2	471	477	PF02991	0.358
LIG_LIR_Gen_1	217	227	PF02991	0.451
LIG_LIR_Gen_1	345	356	PF02991	0.388
LIG_LIR_Gen_1	446	457	PF02991	0.451
LIG_LIR_Gen_1	470	480	PF02991	0.371
LIG_LIR_LC3C_4	578	582	PF02991	0.483
LIG_LIR_Nem_3	164	168	PF02991	0.400
LIG_LIR_Nem_3	18	24	PF02991	0.367
LIG_LIR_Nem_3	217	223	PF02991	0.345
LIG_LIR_Nem_3	313	318	PF02991	0.405
LIG_LIR_Nem_3	345	351	PF02991	0.399
LIG_LIR_Nem_3	38	44	PF02991	0.334
LIG_LIR_Nem_3	470	475	PF02991	0.399
LIG_LIR_Nem_3	644	649	PF02991	0.425
LIG_LYPXL_yS_3	315	318	PF13949	0.368
LIG_MAD2	652	660	PF02301	0.497
LIG_PCNA_PIPBox_1	264	273	PF02747	0.430
LIG_PCNA_PIPBox_1	99	108	PF02747	0.416
LIG_PCNA_yPIPBox_3	261	271	PF02747	0.523
LIG_PCNA_yPIPBox_3	323	334	PF02747	0.419
LIG_PCNA_yPIPBox_3	92	106	PF02747	0.428
LIG_SH2_CRK	150	154	PF00017	0.294
LIG_SH2_CRK	165	169	PF00017	0.327
LIG_SH2_CRK	381	385	PF00017	0.621
LIG_SH2_GRB2like	474	477	PF00017	0.339
LIG_SH2_NCK_1	499	503	PF00017	0.362
LIG_SH2_SRC	499	502	PF00017	0.374
LIG_SH2_STAT5	16	19	PF00017	0.349
LIG_SH2_STAT5	167	170	PF00017	0.368
LIG_SH2_STAT5	222	225	PF00017	0.285
LIG_SH2_STAT5	230	233	PF00017	0.302
LIG_SH2_STAT5	30	33	PF00017	0.411
LIG_SH2_STAT5	357	360	PF00017	0.560
LIG_SH2_STAT5	474	477	PF00017	0.342
LIG_SH2_STAT5	532	535	PF00017	0.391
LIG_SH2_STAT5	646	649	PF00017	0.433
LIG_SH3_3	107	113	PF00018	0.343
LIG_SH3_3	306	312	PF00018	0.540
LIG_SH3_3	346	352	PF00018	0.373
LIG_SH3_3	531	537	PF00018	0.393
LIG_SH3_3	552	558	PF00018	0.399
LIG_SH3_3	59	65	PF00018	0.506
LIG_SH3_3	625	631	PF00018	0.524
LIG_SUMO_SIM_par_1	101	107	PF11976	0.361
LIG_TRAF2_1	288	291	PF00917	0.486
LIG_TYR_ITIM	148	153	PF00017	0.293
MOD_CK1_1	182	188	PF00069	0.666
MOD_CK1_1	189	195	PF00069	0.669
MOD_CK1_1	199	205	PF00069	0.699
MOD_CK1_1	362	368	PF00069	0.543
MOD_CK1_1	403	409	PF00069	0.477
MOD_CK1_1	467	473	PF00069	0.453
MOD_CK1_1	489	495	PF00069	0.556
MOD_CK1_1	550	556	PF00069	0.396
MOD_CK1_1	562	568	PF00069	0.594
MOD_CK2_1	195	201	PF00069	0.776
MOD_CK2_1	370	376	PF00069	0.663
MOD_CK2_1	495	501	PF00069	0.455
MOD_CK2_1	588	594	PF00069	0.325
MOD_GlcNHglycan	181	184	PF01048	0.725
MOD_GlcNHglycan	201	204	PF01048	0.767
MOD_GlcNHglycan	283	287	PF01048	0.620
MOD_GlcNHglycan	300	303	PF01048	0.661
MOD_GlcNHglycan	361	364	PF01048	0.513
MOD_GlcNHglycan	455	458	PF01048	0.607
MOD_GlcNHglycan	466	469	PF01048	0.475
MOD_GlcNHglycan	517	520	PF01048	0.580
MOD_GlcNHglycan	643	646	PF01048	0.474
MOD_GlcNHglycan	655	659	PF01048	0.447
MOD_GSK3_1	157	164	PF00069	0.362
MOD_GSK3_1	182	189	PF00069	0.707
MOD_GSK3_1	195	202	PF00069	0.687
MOD_GSK3_1	298	305	PF00069	0.701
MOD_GSK3_1	528	535	PF00069	0.483
MOD_GSK3_1	654	661	PF00069	0.427
MOD_N-GLC_1	189	194	PF02516	0.610
MOD_N-GLC_1	199	204	PF02516	0.527
MOD_N-GLC_1	248	253	PF02516	0.452
MOD_NEK2_1	253	258	PF00069	0.400
MOD_NEK2_1	426	431	PF00069	0.442
MOD_NEK2_1	44	49	PF00069	0.596
MOD_NEK2_1	453	458	PF00069	0.469
MOD_NEK2_1	588	593	PF00069	0.306
MOD_NEK2_1	654	659	PF00069	0.400
MOD_NEK2_2	67	72	PF00069	0.565
MOD_PIKK_1	276	282	PF00454	0.619
MOD_PIKK_1	45	51	PF00454	0.596
MOD_PKA_1	641	647	PF00069	0.470
MOD_PKA_2	196	202	PF00069	0.597
MOD_PKA_2	298	304	PF00069	0.600
MOD_PKA_2	359	365	PF00069	0.590
MOD_PKA_2	453	459	PF00069	0.494
MOD_PKA_2	489	495	PF00069	0.452
MOD_PKA_2	569	575	PF00069	0.371
MOD_PKA_2	641	647	PF00069	0.402
MOD_PKA_2	73	79	PF00069	0.519
MOD_PKB_1	308	316	PF00069	0.475
MOD_Plk_1	189	195	PF00069	0.646
MOD_Plk_1	208	214	PF00069	0.622
MOD_Plk_1	470	476	PF00069	0.375
MOD_Plk_4	208	214	PF00069	0.583
MOD_Plk_4	403	409	PF00069	0.488
MOD_Plk_4	528	534	PF00069	0.462
MOD_Plk_4	547	553	PF00069	0.409
MOD_Plk_4	610	616	PF00069	0.351
MOD_ProDKin_1	10	16	PF00069	0.364
MOD_ProDKin_1	362	368	PF00069	0.614
MOD_SUMO_for_1	260	263	PF00179	0.487
MOD_SUMO_rev_2	32	37	PF00179	0.429
MOD_SUMO_rev_2	48	55	PF00179	0.565
TRG_DiLeu_BaEn_1	326	331	PF01217	0.410
TRG_DiLeu_BaEn_1	338	343	PF01217	0.418
TRG_DiLeu_BaEn_4	460	466	PF01217	0.610
TRG_DiLeu_BaEn_4	483	489	PF01217	0.404
TRG_ENDOCYTIC_2	150	153	PF00928	0.308
TRG_ENDOCYTIC_2	165	168	PF00928	0.444
TRG_ENDOCYTIC_2	220	223	PF00928	0.302
TRG_ENDOCYTIC_2	315	318	PF00928	0.368
TRG_ENDOCYTIC_2	646	649	PF00928	0.373
TRG_ER_diArg_1	227	229	PF00400	0.443
TRG_ER_diArg_1	308	311	PF00400	0.598
TRG_ER_diArg_1	434	436	PF00400	0.456
TRG_ER_diArg_1	599	602	PF00400	0.403
TRG_ER_diArg_1	641	643	PF00400	0.406
TRG_ER_diArg_1	71	74	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Z6	Leptomonas seymouri	70%	92%
A0A0S4IW89	Bodo saltans	35%	100%
A0A1X0P3U7	Trypanosomatidae	50%	93%
A0A3S7X701	Leishmania donovani	95%	100%
A0A422P030	Trypanosoma rangeli	51%	96%
A4HLW2	Leishmania braziliensis	87%	100%
D0A659	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	91%
E9AHR9	Leishmania infantum	95%	100%
Q4Q3T6	Leishmania major	93%	100%
V5BP67	Trypanosoma cruzi	50%	98%