Radial spoke head protein 9 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Radial spokehead-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9B489_LEIMU

TriTrypDb:

LmxM.32.2500

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0001534	radial spoke	2	7
GO:0032991	protein-containing complex	1	7
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B489

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B489

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	7
GO:0006996	organelle organization	4	7
GO:0007017	microtubule-based process	2	7
GO:0007018	microtubule-based movement	3	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0022607	cellular component assembly	4	7
GO:0030030	cell projection organization	4	7
GO:0030031	cell projection assembly	5	7
GO:0044782	cilium organization	5	7
GO:0060271	cilium assembly	6	7
GO:0060294	cilium movement involved in cell motility	5	7
GO:0070925	organelle assembly	5	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0120031	plasma membrane bounded cell projection assembly	6	7
GO:0120036	plasma membrane bounded cell projection organization	5	7
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0001578	microtubule bundle formation	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0035082	axoneme assembly	5	1
GO:0044458	motile cilium assembly	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.522
CLV_NRD_NRD_1	197	199	PF00675	0.542
CLV_NRD_NRD_1	228	230	PF00675	0.427
CLV_NRD_NRD_1	37	39	PF00675	0.264
CLV_PCSK_KEX2_1	197	199	PF00082	0.427
CLV_PCSK_KEX2_1	228	230	PF00082	0.427
CLV_PCSK_KEX2_1	234	236	PF00082	0.473
CLV_PCSK_KEX2_1	37	39	PF00082	0.253
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.268
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.253
CLV_PCSK_PC7_1	193	199	PF00082	0.443
CLV_PCSK_SKI1_1	149	153	PF00082	0.305
CLV_PCSK_SKI1_1	174	178	PF00082	0.545
CLV_PCSK_SKI1_1	228	232	PF00082	0.458
CLV_PCSK_SKI1_1	241	245	PF00082	0.506
DOC_MAPK_gen_1	37	43	PF00069	0.513
DOC_MAPK_MEF2A_6	108	115	PF00069	0.452
DOC_MAPK_MEF2A_6	145	154	PF00069	0.294
DOC_MAPK_NFAT4_5	108	116	PF00069	0.458
DOC_PP1_RVXF_1	281	288	PF00149	0.394
DOC_USP7_MATH_1	256	260	PF00917	0.388
DOC_WW_Pin1_4	135	140	PF00397	0.502
DOC_WW_Pin1_4	15	20	PF00397	0.513
LIG_14-3-3_CanoR_1	197	206	PF00244	0.403
LIG_14-3-3_CanoR_1	22	32	PF00244	0.511
LIG_14-3-3_CanoR_1	235	239	PF00244	0.355
LIG_14-3-3_CanoR_1	78	83	PF00244	0.498
LIG_Actin_WH2_2	206	224	PF00022	0.383
LIG_APCC_ABBA_1	150	155	PF00400	0.283
LIG_APCC_ABBAyCdc20_2	149	155	PF00400	0.284
LIG_BRCT_BRCA1_1	86	90	PF00533	0.359
LIG_FHA_1	136	142	PF00498	0.380
LIG_FHA_1	175	181	PF00498	0.652
LIG_FHA_1	24	30	PF00498	0.530
LIG_FHA_1	266	272	PF00498	0.498
LIG_FHA_1	77	83	PF00498	0.397
LIG_FHA_2	182	188	PF00498	0.555
LIG_FHA_2	71	77	PF00498	0.439
LIG_IBAR_NPY_1	225	227	PF08397	0.394
LIG_LIR_Apic_2	290	296	PF02991	0.254
LIG_LIR_Gen_1	254	265	PF02991	0.400
LIG_LIR_Gen_1	274	281	PF02991	0.183
LIG_LIR_Gen_1	53	60	PF02991	0.410
LIG_LIR_Gen_1	79	86	PF02991	0.287
LIG_LIR_Gen_1	8	17	PF02991	0.428
LIG_LIR_Nem_3	106	110	PF02991	0.496
LIG_LIR_Nem_3	200	205	PF02991	0.401
LIG_LIR_Nem_3	254	260	PF02991	0.324
LIG_LIR_Nem_3	274	279	PF02991	0.198
LIG_LIR_Nem_3	290	295	PF02991	0.138
LIG_LIR_Nem_3	298	304	PF02991	0.280
LIG_LIR_Nem_3	53	57	PF02991	0.410
LIG_LIR_Nem_3	69	74	PF02991	0.294
LIG_LIR_Nem_3	79	83	PF02991	0.274
LIG_LIR_Nem_3	85	89	PF02991	0.221
LIG_Pex14_1	269	273	PF04695	0.324
LIG_Pex14_1	44	48	PF04695	0.410
LIG_Pex14_2	153	157	PF04695	0.399
LIG_Pex14_2	7	11	PF04695	0.319
LIG_Pex14_2	86	90	PF04695	0.432
LIG_SH2_CRK	227	231	PF00017	0.463
LIG_SH2_CRK	301	305	PF00017	0.318
LIG_SH2_PTP2	54	57	PF00017	0.458
LIG_SH2_SRC	54	57	PF00017	0.477
LIG_SH2_STAP1	125	129	PF00017	0.357
LIG_SH2_STAP1	9	13	PF00017	0.462
LIG_SH2_STAT5	54	57	PF00017	0.428
LIG_SH2_STAT5	72	75	PF00017	0.386
LIG_SH3_3	62	68	PF00018	0.326
LIG_SUMO_SIM_par_1	30	36	PF11976	0.462
LIG_TRAF2_1	18	21	PF00917	0.435
LIG_TRAF2_1	243	246	PF00917	0.428
LIG_WRC_WIRS_1	83	88	PF05994	0.437
MOD_CDK_SPxxK_3	15	22	PF00069	0.462
MOD_CK1_1	130	136	PF00069	0.575
MOD_CK1_1	33	39	PF00069	0.513
MOD_CK1_1	88	94	PF00069	0.532
MOD_CK1_1	97	103	PF00069	0.386
MOD_CK2_1	140	146	PF00069	0.345
MOD_CK2_1	15	21	PF00069	0.410
MOD_CK2_1	181	187	PF00069	0.667
MOD_CK2_1	239	245	PF00069	0.372
MOD_CK2_1	256	262	PF00069	0.334
MOD_CK2_1	70	76	PF00069	0.365
MOD_CK2_1	97	103	PF00069	0.326
MOD_GlcNHglycan	241	244	PF01048	0.357
MOD_GlcNHglycan	265	268	PF01048	0.466
MOD_GlcNHglycan	287	290	PF01048	0.326
MOD_GlcNHglycan	99	102	PF01048	0.477
MOD_GSK3_1	127	134	PF00069	0.480
MOD_GSK3_1	140	147	PF00069	0.357
MOD_GSK3_1	176	183	PF00069	0.634
MOD_GSK3_1	78	85	PF00069	0.413
MOD_N-GLC_1	130	135	PF02516	0.488
MOD_NEK2_1	239	244	PF00069	0.500
MOD_NEK2_1	25	30	PF00069	0.416
MOD_NEK2_1	287	292	PF00069	0.317
MOD_NEK2_1	82	87	PF00069	0.409
MOD_NEK2_2	211	216	PF00069	0.451
MOD_OFUCOSY	93	99	PF10250	0.366
MOD_PKA_1	197	203	PF00069	0.504
MOD_PKA_1	234	240	PF00069	0.387
MOD_PKA_2	127	133	PF00069	0.526
MOD_PKA_2	197	203	PF00069	0.504
MOD_PKA_2	234	240	PF00069	0.465
MOD_PKA_2	285	291	PF00069	0.352
MOD_Plk_2-3	140	146	PF00069	0.426
MOD_Plk_4	234	240	PF00069	0.412
MOD_Plk_4	287	293	PF00069	0.302
MOD_Plk_4	300	306	PF00069	0.246
MOD_Plk_4	85	91	PF00069	0.382
MOD_ProDKin_1	135	141	PF00069	0.495
MOD_ProDKin_1	15	21	PF00069	0.513
MOD_SUMO_for_1	170	173	PF00179	0.513
MOD_SUMO_rev_2	100	110	PF00179	0.478
TRG_DiLeu_BaEn_1	106	111	PF01217	0.203
TRG_DiLeu_BaEn_4	20	26	PF01217	0.435
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.491
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.423
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.421
TRG_ENDOCYTIC_2	218	221	PF00928	0.282
TRG_ENDOCYTIC_2	227	230	PF00928	0.318
TRG_ENDOCYTIC_2	273	276	PF00928	0.344
TRG_ENDOCYTIC_2	301	304	PF00928	0.312
TRG_ENDOCYTIC_2	54	57	PF00928	0.428
TRG_ENDOCYTIC_2	71	74	PF00928	0.374
TRG_ENDOCYTIC_2	9	12	PF00928	0.546
TRG_ER_diArg_1	196	198	PF00400	0.534
TRG_ER_diArg_1	227	229	PF00400	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E1	Leptomonas seymouri	72%	100%
A0A0S4IRW1	Bodo saltans	35%	100%
A0A0S4J8G1	Bodo saltans	24%	97%
A0A1X0P3V0	Trypanosomatidae	48%	100%
A0A3Q8IKD9	Leishmania donovani	94%	100%
A0A3S7WQ16	Leishmania donovani	24%	89%
A0A422P0B0	Trypanosoma rangeli	48%	100%
A4H541	Leishmania braziliensis	24%	90%
A4HLW1	Leishmania braziliensis	85%	100%
A4HTB7	Leishmania infantum	24%	91%
D0A660	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AHR8	Leishmania infantum	94%	100%
E9ALB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	93%
Q2KIU7	Bos taurus	26%	100%
Q4Q3T7	Leishmania major	93%	100%
Q4QIJ4	Leishmania major	25%	87%
Q5TYW6	Danio rerio	31%	100%
Q6DFN5	Xenopus tropicalis	28%	100%
Q9D9V4	Mus musculus	27%	100%
Q9H1X1	Homo sapiens	27%	100%
V5B8M6	Trypanosoma cruzi	47%	100%