Putative recombinase rad51

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

recombinase rad51, putative

Species:

Leishmania mexicana

UniProt:

E9B488_LEIMU

TriTrypDb:

LmxM.32.2490

Length:

683

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005657	replication fork	2	1
GO:0032991	protein-containing complex	1	1
GO:0033061	DNA recombinase mediator complex	2	1
GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex	3	1
GO:0033065	Rad51C-XRCC3 complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9B488

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B488

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	9
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	9
GO:0006974	DNA damage response	4	9
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0033554	cellular response to stress	3	9
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0050896	response to stimulus	1	9
GO:0051716	cellular response to stimulus	2	9
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0000707	meiotic DNA recombinase assembly	4	1
GO:0000730	DNA recombinase assembly	7	1
GO:0006310	DNA recombination	5	1
GO:0007131	reciprocal meiotic recombination	3	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0022607	cellular component assembly	4	1
GO:0035825	homologous recombination	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090735	DNA repair complex assembly	6	1
GO:0140527	reciprocal homologous recombination	7	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0008094	ATP-dependent activity, acting on DNA	2	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140097	catalytic activity, acting on DNA	3	10
GO:0140299	small molecule sensor activity	1	10
GO:0140612	DNA damage sensor activity	2	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:0140657	ATP-dependent activity	1	10
GO:0140664	ATP-dependent DNA damage sensor activity	3	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	42	46	PF00656	0.786
CLV_C14_Caspase3-7	421	425	PF00656	0.503
CLV_C14_Caspase3-7	464	468	PF00656	0.662
CLV_MEL_PAP_1	668	674	PF00089	0.428
CLV_NRD_NRD_1	501	503	PF00675	0.263
CLV_NRD_NRD_1	648	650	PF00675	0.606
CLV_NRD_NRD_1	664	666	PF00675	0.498
CLV_NRD_NRD_1	72	74	PF00675	0.798
CLV_NRD_NRD_1	75	77	PF00675	0.815
CLV_PCSK_FUR_1	73	77	PF00082	0.769
CLV_PCSK_KEX2_1	334	336	PF00082	0.746
CLV_PCSK_KEX2_1	501	503	PF00082	0.263
CLV_PCSK_KEX2_1	648	650	PF00082	0.447
CLV_PCSK_KEX2_1	664	666	PF00082	0.425
CLV_PCSK_KEX2_1	72	74	PF00082	0.818
CLV_PCSK_KEX2_1	75	77	PF00082	0.835
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.746
CLV_PCSK_SKI1_1	303	307	PF00082	0.476
CLV_PCSK_SKI1_1	436	440	PF00082	0.365
CLV_PCSK_SKI1_1	504	508	PF00082	0.271
CLV_PCSK_SKI1_1	582	586	PF00082	0.274
CLV_PCSK_SKI1_1	639	643	PF00082	0.402
DEG_SPOP_SBC_1	161	165	PF00917	0.624
DOC_CYCLIN_RxL_1	109	123	PF00134	0.685
DOC_CYCLIN_RxL_1	501	511	PF00134	0.502
DOC_CYCLIN_yClb3_PxF_3	166	172	PF00134	0.503
DOC_MAPK_gen_1	501	507	PF00069	0.585
DOC_MAPK_MEF2A_6	253	262	PF00069	0.445
DOC_PP1_RVXF_1	502	508	PF00149	0.494
DOC_USP7_MATH_1	111	115	PF00917	0.719
DOC_USP7_MATH_1	171	175	PF00917	0.643
DOC_USP7_MATH_1	187	191	PF00917	0.510
DOC_USP7_MATH_1	297	301	PF00917	0.488
DOC_USP7_MATH_1	409	413	PF00917	0.601
DOC_USP7_MATH_1	417	421	PF00917	0.717
DOC_USP7_MATH_1	446	450	PF00917	0.406
DOC_USP7_MATH_1	545	549	PF00917	0.535
DOC_USP7_MATH_1	593	597	PF00917	0.537
DOC_USP7_MATH_1	625	629	PF00917	0.453
DOC_USP7_MATH_1	654	658	PF00917	0.430
DOC_USP7_MATH_1	93	97	PF00917	0.705
DOC_WW_Pin1_4	162	167	PF00397	0.534
DOC_WW_Pin1_4	328	333	PF00397	0.692
DOC_WW_Pin1_4	335	340	PF00397	0.690
DOC_WW_Pin1_4	413	418	PF00397	0.644
DOC_WW_Pin1_4	486	491	PF00397	0.561
DOC_WW_Pin1_4	600	605	PF00397	0.497
DOC_WW_Pin1_4	61	66	PF00397	0.613
LIG_14-3-3_CanoR_1	379	387	PF00244	0.440
LIG_14-3-3_CanoR_1	410	417	PF00244	0.461
LIG_14-3-3_CanoR_1	515	521	PF00244	0.552
LIG_14-3-3_CanoR_1	53	59	PF00244	0.670
LIG_14-3-3_CanoR_1	563	567	PF00244	0.557
LIG_14-3-3_CanoR_1	582	588	PF00244	0.416
LIG_Actin_WH2_2	626	644	PF00022	0.547
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_BIR_III_4	573	577	PF00653	0.463
LIG_FHA_1	252	258	PF00498	0.471
LIG_FHA_1	294	300	PF00498	0.570
LIG_FHA_1	517	523	PF00498	0.568
LIG_FHA_1	530	536	PF00498	0.469
LIG_FHA_1	579	585	PF00498	0.459
LIG_FHA_2	118	124	PF00498	0.555
LIG_FHA_2	200	206	PF00498	0.465
LIG_FHA_2	509	515	PF00498	0.528
LIG_FHA_2	541	547	PF00498	0.372
LIG_FHA_2	76	82	PF00498	0.575
LIG_LIR_Apic_2	548	553	PF02991	0.372
LIG_LIR_Gen_1	114	124	PF02991	0.720
LIG_LIR_Gen_1	449	458	PF02991	0.479
LIG_LIR_Nem_3	114	119	PF02991	0.726
LIG_LIR_Nem_3	449	453	PF02991	0.441
LIG_LIR_Nem_3	56	62	PF02991	0.443
LIG_LIR_Nem_3	586	590	PF02991	0.543
LIG_MAD2	639	647	PF02301	0.526
LIG_NRBOX	382	388	PF00104	0.390
LIG_PCNA_yPIPBox_3	630	641	PF02747	0.441
LIG_Rb_LxCxE_1	1	14	PF01857	0.629
LIG_SH2_CRK	550	554	PF00017	0.372
LIG_SH2_CRK	590	594	PF00017	0.497
LIG_SH2_NCK_1	550	554	PF00017	0.372
LIG_SH2_NCK_1	590	594	PF00017	0.514
LIG_SH2_PTP2	377	380	PF00017	0.413
LIG_SH2_PTP2	62	65	PF00017	0.474
LIG_SH2_STAT5	25	28	PF00017	0.573
LIG_SH2_STAT5	279	282	PF00017	0.372
LIG_SH2_STAT5	377	380	PF00017	0.382
LIG_SH2_STAT5	475	478	PF00017	0.501
LIG_SH2_STAT5	62	65	PF00017	0.516
LIG_SH3_1	337	343	PF00018	0.637
LIG_SH3_1	62	68	PF00018	0.501
LIG_SH3_2	340	345	PF14604	0.593
LIG_SH3_3	164	170	PF00018	0.726
LIG_SH3_3	307	313	PF00018	0.566
LIG_SH3_3	337	343	PF00018	0.637
LIG_SH3_3	563	569	PF00018	0.505
LIG_SH3_3	595	601	PF00018	0.490
LIG_SH3_3	62	68	PF00018	0.629
LIG_SUMO_SIM_anti_2	27	36	PF11976	0.564
LIG_SUMO_SIM_par_1	27	36	PF11976	0.564
LIG_SUMO_SIM_par_1	436	442	PF11976	0.310
LIG_TYR_ITIM	375	380	PF00017	0.468
LIG_WRC_WIRS_1	222	227	PF05994	0.488
LIG_WRC_WIRS_1	447	452	PF05994	0.330
LIG_WRC_WIRS_1	584	589	PF05994	0.497
LIG_WW_3	165	169	PF00397	0.674
LIG_WW_3	338	342	PF00397	0.520
MOD_CDC14_SPxK_1	165	168	PF00782	0.546
MOD_CDC14_SPxK_1	331	334	PF00782	0.637
MOD_CDC14_SPxK_1	338	341	PF00782	0.568
MOD_CDC14_SPxK_1	489	492	PF00782	0.547
MOD_CDK_SPK_2	328	333	PF00069	0.639
MOD_CDK_SPxK_1	162	168	PF00069	0.538
MOD_CDK_SPxK_1	328	334	PF00069	0.641
MOD_CDK_SPxK_1	335	341	PF00069	0.573
MOD_CDK_SPxK_1	486	492	PF00069	0.557
MOD_CDK_SPxxK_3	328	335	PF00069	0.644
MOD_CK1_1	173	179	PF00069	0.761
MOD_CK1_1	392	398	PF00069	0.433
MOD_CK1_1	427	433	PF00069	0.623
MOD_CK1_1	461	467	PF00069	0.734
MOD_CK1_1	548	554	PF00069	0.526
MOD_CK1_1	617	623	PF00069	0.642
MOD_CK1_1	628	634	PF00069	0.541
MOD_CK1_1	9	15	PF00069	0.556
MOD_CK2_1	117	123	PF00069	0.543
MOD_CK2_1	148	154	PF00069	0.582
MOD_CK2_1	199	205	PF00069	0.481
MOD_CK2_1	392	398	PF00069	0.516
MOD_CK2_1	508	514	PF00069	0.528
MOD_CK2_1	540	546	PF00069	0.473
MOD_DYRK1A_RPxSP_1	600	604	PF00069	0.463
MOD_GlcNHglycan	150	153	PF01048	0.755
MOD_GlcNHglycan	175	178	PF01048	0.755
MOD_GlcNHglycan	193	196	PF01048	0.567
MOD_GlcNHglycan	244	248	PF01048	0.329
MOD_GlcNHglycan	355	359	PF01048	0.676
MOD_GlcNHglycan	411	414	PF01048	0.667
MOD_GlcNHglycan	420	423	PF01048	0.679
MOD_GlcNHglycan	429	432	PF01048	0.564
MOD_GlcNHglycan	463	466	PF01048	0.707
MOD_GlcNHglycan	478	481	PF01048	0.544
MOD_GlcNHglycan	49	52	PF01048	0.601
MOD_GlcNHglycan	543	546	PF01048	0.360
MOD_GlcNHglycan	547	550	PF01048	0.366
MOD_GlcNHglycan	556	560	PF01048	0.174
MOD_GlcNHglycan	643	646	PF01048	0.509
MOD_GlcNHglycan	77	81	PF01048	0.618
MOD_GlcNHglycan	93	96	PF01048	0.726
MOD_GSK3_1	187	194	PF00069	0.649
MOD_GSK3_1	217	224	PF00069	0.413
MOD_GSK3_1	293	300	PF00069	0.575
MOD_GSK3_1	315	322	PF00069	0.676
MOD_GSK3_1	409	416	PF00069	0.656
MOD_GSK3_1	423	430	PF00069	0.622
MOD_GSK3_1	457	464	PF00069	0.655
MOD_GSK3_1	524	531	PF00069	0.471
MOD_GSK3_1	536	543	PF00069	0.488
MOD_GSK3_1	6	13	PF00069	0.567
MOD_GSK3_1	624	631	PF00069	0.621
MOD_GSK3_1	666	673	PF00069	0.544
MOD_GSK3_1	91	98	PF00069	0.739
MOD_N-GLC_1	117	122	PF02516	0.655
MOD_N-GLC_1	314	319	PF02516	0.561
MOD_N-GLC_1	424	429	PF02516	0.482
MOD_N-GLC_1	540	545	PF02516	0.323
MOD_NEK2_1	10	15	PF00069	0.586
MOD_NEK2_1	260	265	PF00069	0.522
MOD_NEK2_1	32	37	PF00069	0.587
MOD_NEK2_1	389	394	PF00069	0.466
MOD_NEK2_1	439	444	PF00069	0.421
MOD_NEK2_1	458	463	PF00069	0.697
MOD_NEK2_1	473	478	PF00069	0.604
MOD_NEK2_1	507	512	PF00069	0.507
MOD_NEK2_1	516	521	PF00069	0.471
MOD_NEK2_1	535	540	PF00069	0.514
MOD_NEK2_1	562	567	PF00069	0.459
MOD_NEK2_1	583	588	PF00069	0.522
MOD_NEK2_1	641	646	PF00069	0.453
MOD_NEK2_1	653	658	PF00069	0.344
MOD_NEK2_2	199	204	PF00069	0.504
MOD_NEK2_2	625	630	PF00069	0.455
MOD_PIKK_1	251	257	PF00454	0.445
MOD_PIKK_1	305	311	PF00454	0.492
MOD_PIKK_1	666	672	PF00454	0.656
MOD_PKA_1	648	654	PF00069	0.418
MOD_PKA_1	75	81	PF00069	0.693
MOD_PKA_2	378	384	PF00069	0.422
MOD_PKA_2	409	415	PF00069	0.447
MOD_PKA_2	500	506	PF00069	0.463
MOD_PKA_2	562	568	PF00069	0.493
MOD_PKA_2	599	605	PF00069	0.463
MOD_PKA_2	648	654	PF00069	0.418
MOD_PKA_2	670	676	PF00069	0.433
MOD_PKA_2	68	74	PF00069	0.594
MOD_PKA_2	75	81	PF00069	0.641
MOD_PKB_1	312	320	PF00069	0.485
MOD_PKB_1	73	81	PF00069	0.522
MOD_Plk_1	111	117	PF00069	0.589
MOD_Plk_1	314	320	PF00069	0.618
MOD_Plk_1	364	370	PF00069	0.566
MOD_Plk_4	282	288	PF00069	0.445
MOD_Plk_4	297	303	PF00069	0.363
MOD_Plk_4	367	373	PF00069	0.508
MOD_Plk_4	392	398	PF00069	0.498
MOD_Plk_4	508	514	PF00069	0.568
MOD_Plk_4	54	60	PF00069	0.535
MOD_Plk_4	562	568	PF00069	0.514
MOD_Plk_4	593	599	PF00069	0.455
MOD_ProDKin_1	162	168	PF00069	0.538
MOD_ProDKin_1	328	334	PF00069	0.694
MOD_ProDKin_1	335	341	PF00069	0.692
MOD_ProDKin_1	413	419	PF00069	0.651
MOD_ProDKin_1	486	492	PF00069	0.557
MOD_ProDKin_1	600	606	PF00069	0.497
MOD_ProDKin_1	61	67	PF00069	0.615
MOD_SUMO_rev_2	398	408	PF00179	0.496
MOD_SUMO_rev_2	42	49	PF00179	0.594
TRG_DiLeu_BaEn_1	28	33	PF01217	0.504
TRG_DiLeu_BaEn_2	111	117	PF01217	0.579
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.643
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.423
TRG_DiLeu_BaLyEn_6	579	584	PF01217	0.445
TRG_ENDOCYTIC_2	377	380	PF00928	0.392
TRG_ENDOCYTIC_2	475	478	PF00928	0.454
TRG_ER_diArg_1	500	502	PF00400	0.480
TRG_ER_diArg_1	647	649	PF00400	0.520
TRG_ER_diArg_1	72	75	PF00400	0.798
TRG_NLS_MonoExtC_3	332	337	PF00514	0.738
TRG_NLS_MonoExtN_4	332	338	PF00514	0.741
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.725
TRG_Pf-PMV_PEXEL_1	504	508	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE01	Leptomonas seymouri	40%	100%
A0A1X0P3T9	Trypanosomatidae	33%	100%
A0A3Q8IGS3	Leishmania donovani	84%	99%
A4HLW0	Leishmania braziliensis	67%	100%
D0A661	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AHR7	Leishmania infantum	84%	99%
Q4Q3T8	Leishmania major	83%	100%
V5BTS0	Trypanosoma cruzi	36%	100%