Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B487_LEIMU

TriTrypDb:

LmxM.32.2480

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B487

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B487

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	541	545	PF00656	0.561
CLV_NRD_NRD_1	171	173	PF00675	0.516
CLV_NRD_NRD_1	29	31	PF00675	0.532
CLV_NRD_NRD_1	485	487	PF00675	0.533
CLV_NRD_NRD_1	568	570	PF00675	0.363
CLV_PCSK_FUR_1	11	15	PF00082	0.679
CLV_PCSK_KEX2_1	13	15	PF00082	0.738
CLV_PCSK_KEX2_1	171	173	PF00082	0.456
CLV_PCSK_KEX2_1	29	31	PF00082	0.440
CLV_PCSK_KEX2_1	372	374	PF00082	0.617
CLV_PCSK_KEX2_1	484	486	PF00082	0.555
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.679
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.617
CLV_PCSK_SKI1_1	339	343	PF00082	0.490
CLV_PCSK_SKI1_1	583	587	PF00082	0.706
CLV_PCSK_SKI1_1	99	103	PF00082	0.468
DEG_SCF_FBW7_2	326	331	PF00400	0.513
DEG_SPOP_SBC_1	69	73	PF00917	0.569
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.631
DOC_MAPK_RevD_3	473	486	PF00069	0.408
DOC_PP1_RVXF_1	337	344	PF00149	0.613
DOC_SPAK_OSR1_1	472	476	PF12202	0.443
DOC_USP7_MATH_1	134	138	PF00917	0.720
DOC_USP7_MATH_1	154	158	PF00917	0.656
DOC_USP7_MATH_1	371	375	PF00917	0.673
DOC_USP7_MATH_1	510	514	PF00917	0.715
DOC_USP7_MATH_1	516	520	PF00917	0.714
DOC_USP7_MATH_1	538	542	PF00917	0.629
DOC_USP7_MATH_1	69	73	PF00917	0.609
DOC_USP7_MATH_1	7	11	PF00917	0.600
DOC_USP7_MATH_2	256	262	PF00917	0.508
DOC_WW_Pin1_4	208	213	PF00397	0.511
DOC_WW_Pin1_4	324	329	PF00397	0.704
DOC_WW_Pin1_4	388	393	PF00397	0.663
DOC_WW_Pin1_4	404	409	PF00397	0.500
LIG_14-3-3_CanoR_1	29	33	PF00244	0.593
LIG_14-3-3_CanoR_1	300	306	PF00244	0.623
LIG_14-3-3_CanoR_1	363	368	PF00244	0.502
LIG_14-3-3_CanoR_1	373	378	PF00244	0.602
LIG_14-3-3_CanoR_1	456	462	PF00244	0.576
LIG_14-3-3_CanoR_1	484	492	PF00244	0.586
LIG_14-3-3_CanoR_1	68	75	PF00244	0.551
LIG_14-3-3_CanoR_1	93	101	PF00244	0.499
LIG_BRCT_BRCA1_1	176	180	PF00533	0.534
LIG_EVH1_1	575	579	PF00568	0.699
LIG_FHA_1	148	154	PF00498	0.656
LIG_FHA_1	209	215	PF00498	0.552
LIG_FHA_1	31	37	PF00498	0.559
LIG_FHA_1	385	391	PF00498	0.661
LIG_FHA_1	41	47	PF00498	0.542
LIG_FHA_1	412	418	PF00498	0.552
LIG_FHA_1	547	553	PF00498	0.644
LIG_FHA_1	554	560	PF00498	0.500
LIG_FHA_1	77	83	PF00498	0.513
LIG_FHA_2	310	316	PF00498	0.700
LIG_FHA_2	47	53	PF00498	0.396
LIG_LIR_Apic_2	574	578	PF02991	0.604
LIG_LIR_Gen_1	177	187	PF02991	0.469
LIG_LIR_Gen_1	414	424	PF02991	0.513
LIG_LIR_Gen_1	426	436	PF02991	0.487
LIG_LIR_Gen_1	49	55	PF02991	0.607
LIG_LIR_Nem_3	177	183	PF02991	0.452
LIG_LIR_Nem_3	414	419	PF02991	0.518
LIG_LIR_Nem_3	426	432	PF02991	0.489
LIG_LIR_Nem_3	49	53	PF02991	0.498
LIG_LIR_Nem_3	547	553	PF02991	0.599
LIG_LIR_Nem_3	55	60	PF02991	0.515
LIG_MYND_1	271	275	PF01753	0.481
LIG_NRBOX	473	479	PF00104	0.461
LIG_PCNA_APIM_2	470	476	PF02747	0.441
LIG_PCNA_PIPBox_1	467	476	PF02747	0.555
LIG_PCNA_yPIPBox_3	467	476	PF02747	0.555
LIG_Pex14_1	176	180	PF04695	0.534
LIG_Pex14_2	202	206	PF04695	0.595
LIG_SH2_CRK	243	247	PF00017	0.463
LIG_SH2_CRK	429	433	PF00017	0.540
LIG_SH2_NCK_1	243	247	PF00017	0.608
LIG_SH2_NCK_1	358	362	PF00017	0.338
LIG_SH2_NCK_1	429	433	PF00017	0.540
LIG_SH2_STAP1	243	247	PF00017	0.515
LIG_SH2_STAP1	32	36	PF00017	0.568
LIG_SH2_STAP1	351	355	PF00017	0.484
LIG_SH2_STAP1	358	362	PF00017	0.530
LIG_SH2_STAT5	163	166	PF00017	0.515
LIG_SH2_STAT5	301	304	PF00017	0.603
LIG_SH2_STAT5	32	35	PF00017	0.564
LIG_SH2_STAT5	358	361	PF00017	0.499
LIG_SH2_STAT5	64	67	PF00017	0.654
LIG_SH3_3	116	122	PF00018	0.747
LIG_SH3_3	268	274	PF00018	0.489
LIG_SH3_3	386	392	PF00018	0.658
LIG_SH3_3	495	501	PF00018	0.666
LIG_SH3_3	573	579	PF00018	0.711
LIG_SUMO_SIM_anti_2	186	191	PF11976	0.491
LIG_SUMO_SIM_par_1	363	370	PF11976	0.603
LIG_SxIP_EBH_1	508	521	PF03271	0.581
LIG_TRAF2_1	376	379	PF00917	0.768
LIG_TYR_ITIM	241	246	PF00017	0.694
MOD_CK1_1	110	116	PF00069	0.677
MOD_CK1_1	142	148	PF00069	0.688
MOD_CK1_1	391	397	PF00069	0.744
MOD_CK1_1	457	463	PF00069	0.605
MOD_CK2_1	233	239	PF00069	0.576
MOD_CK2_1	363	369	PF00069	0.549
MOD_CK2_1	373	379	PF00069	0.537
MOD_CK2_1	530	536	PF00069	0.490
MOD_CK2_1	70	76	PF00069	0.634
MOD_CK2_1	86	92	PF00069	0.399
MOD_GlcNHglycan	112	115	PF01048	0.601
MOD_GlcNHglycan	146	149	PF01048	0.749
MOD_GlcNHglycan	190	193	PF01048	0.527
MOD_GlcNHglycan	228	231	PF01048	0.685
MOD_GlcNHglycan	260	263	PF01048	0.569
MOD_GlcNHglycan	333	336	PF01048	0.687
MOD_GlcNHglycan	359	362	PF01048	0.513
MOD_GlcNHglycan	393	396	PF01048	0.544
MOD_GlcNHglycan	450	453	PF01048	0.703
MOD_GlcNHglycan	512	515	PF01048	0.663
MOD_GlcNHglycan	88	91	PF01048	0.582
MOD_GSK3_1	139	146	PF00069	0.658
MOD_GSK3_1	188	195	PF00069	0.495
MOD_GSK3_1	254	261	PF00069	0.569
MOD_GSK3_1	28	35	PF00069	0.552
MOD_GSK3_1	295	302	PF00069	0.492
MOD_GSK3_1	326	333	PF00069	0.603
MOD_GSK3_1	363	370	PF00069	0.622
MOD_GSK3_1	384	391	PF00069	0.700
MOD_GSK3_1	527	534	PF00069	0.734
MOD_GSK3_1	538	545	PF00069	0.651
MOD_GSK3_1	70	77	PF00069	0.501
MOD_GSK3_1	93	100	PF00069	0.583
MOD_LATS_1	66	72	PF00433	0.701
MOD_N-GLC_1	142	147	PF02516	0.478
MOD_NEK2_1	190	195	PF00069	0.493
MOD_NEK2_1	233	238	PF00069	0.677
MOD_NEK2_1	242	247	PF00069	0.528
MOD_NEK2_1	28	33	PF00069	0.560
MOD_NEK2_1	349	354	PF00069	0.453
MOD_NEK2_1	553	558	PF00069	0.503
MOD_NEK2_1	559	564	PF00069	0.458
MOD_NEK2_2	295	300	PF00069	0.470
MOD_NEK2_2	548	553	PF00069	0.374
MOD_PIKK_1	446	452	PF00454	0.515
MOD_PIKK_1	538	544	PF00454	0.735
MOD_PIKK_1	553	559	PF00454	0.264
MOD_PIKK_1	70	76	PF00454	0.469
MOD_PIKK_1	93	99	PF00454	0.484
MOD_PK_1	363	369	PF00069	0.549
MOD_PK_1	373	379	PF00069	0.537
MOD_PKA_1	485	491	PF00069	0.493
MOD_PKA_2	110	116	PF00069	0.574
MOD_PKA_2	28	34	PF00069	0.599
MOD_PKA_2	299	305	PF00069	0.616
MOD_PKA_2	40	46	PF00069	0.488
MOD_PKA_2	446	452	PF00069	0.706
MOD_PKA_2	455	461	PF00069	0.552
MOD_PKA_2	485	491	PF00069	0.493
MOD_Plk_2-3	76	82	PF00069	0.487
MOD_Plk_4	179	185	PF00069	0.250
MOD_Plk_4	349	355	PF00069	0.424
MOD_Plk_4	363	369	PF00069	0.539
MOD_Plk_4	411	417	PF00069	0.487
MOD_ProDKin_1	208	214	PF00069	0.515
MOD_ProDKin_1	324	330	PF00069	0.701
MOD_ProDKin_1	388	394	PF00069	0.663
MOD_ProDKin_1	404	410	PF00069	0.492
MOD_SUMO_for_1	101	104	PF00179	0.465
MOD_SUMO_for_1	321	324	PF00179	0.758
TRG_DiLeu_BaEn_1	221	226	PF01217	0.479
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.515
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.458
TRG_ENDOCYTIC_2	243	246	PF00928	0.544
TRG_ENDOCYTIC_2	351	354	PF00928	0.473
TRG_ENDOCYTIC_2	429	432	PF00928	0.490
TRG_ER_diArg_1	171	173	PF00400	0.456
TRG_ER_diArg_1	28	30	PF00400	0.523
TRG_ER_diArg_1	483	486	PF00400	0.552
TRG_ER_diArg_1	521	524	PF00400	0.761
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8S0	Leptomonas seymouri	36%	99%
A0A3S7X715	Leishmania donovani	80%	100%
A4HLV9	Leishmania braziliensis	62%	99%
E9AHR6	Leishmania infantum	81%	100%
Q4Q3T9	Leishmania major	82%	100%