Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 12

Species:

Leishmania mexicana

UniProt:

E9B485_LEIMU

TriTrypDb:

LmxM.32.2460

Length:

1052

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B485

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B485

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.426
CLV_C14_Caspase3-7	200	204	PF00656	0.408
CLV_C14_Caspase3-7	465	469	PF00656	0.591
CLV_C14_Caspase3-7	490	494	PF00656	0.665
CLV_C14_Caspase3-7	661	665	PF00656	0.490
CLV_C14_Caspase3-7	684	688	PF00656	0.497
CLV_C14_Caspase3-7	989	993	PF00656	0.565
CLV_NRD_NRD_1	21	23	PF00675	0.421
CLV_NRD_NRD_1	215	217	PF00675	0.564
CLV_NRD_NRD_1	42	44	PF00675	0.614
CLV_NRD_NRD_1	52	54	PF00675	0.558
CLV_NRD_NRD_1	558	560	PF00675	0.472
CLV_NRD_NRD_1	590	592	PF00675	0.425
CLV_NRD_NRD_1	614	616	PF00675	0.422
CLV_NRD_NRD_1	765	767	PF00675	0.553
CLV_NRD_NRD_1	792	794	PF00675	0.391
CLV_PCSK_KEX2_1	112	114	PF00082	0.527
CLV_PCSK_KEX2_1	21	23	PF00082	0.420
CLV_PCSK_KEX2_1	214	216	PF00082	0.580
CLV_PCSK_KEX2_1	420	422	PF00082	0.573
CLV_PCSK_KEX2_1	453	455	PF00082	0.468
CLV_PCSK_KEX2_1	51	53	PF00082	0.613
CLV_PCSK_KEX2_1	590	592	PF00082	0.425
CLV_PCSK_KEX2_1	765	767	PF00082	0.553
CLV_PCSK_KEX2_1	792	794	PF00082	0.391
CLV_PCSK_KEX2_1	858	860	PF00082	0.394
CLV_PCSK_KEX2_1	952	954	PF00082	0.621
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.507
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.573
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.468
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.440
CLV_PCSK_PC1ET2_1	858	860	PF00082	0.394
CLV_PCSK_PC1ET2_1	952	954	PF00082	0.444
CLV_PCSK_SKI1_1	151	155	PF00082	0.387
CLV_PCSK_SKI1_1	289	293	PF00082	0.674
CLV_PCSK_SKI1_1	37	41	PF00082	0.567
CLV_PCSK_SKI1_1	600	604	PF00082	0.480
CLV_PCSK_SKI1_1	616	620	PF00082	0.501
CLV_PCSK_SKI1_1	792	796	PF00082	0.408
CLV_PCSK_SKI1_1	804	808	PF00082	0.499
DEG_APCC_DBOX_1	213	221	PF00400	0.573
DEG_APCC_DBOX_1	42	50	PF00400	0.615
DEG_APCC_DBOX_1	791	799	PF00400	0.376
DOC_ANK_TNKS_1	435	442	PF00023	0.512
DOC_CKS1_1	240	245	PF01111	0.461
DOC_CYCLIN_RxL_1	283	297	PF00134	0.552
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.313
DOC_CYCLIN_yCln2_LP_2	309	315	PF00134	0.473
DOC_MAPK_DCC_7	225	233	PF00069	0.590
DOC_MAPK_gen_1	366	374	PF00069	0.418
DOC_MAPK_gen_1	792	798	PF00069	0.402
DOC_MAPK_gen_1	951	957	PF00069	0.456
DOC_MAPK_MEF2A_6	225	233	PF00069	0.590
DOC_MAPK_MEF2A_6	53	62	PF00069	0.445
DOC_MAPK_MEF2A_6	841	849	PF00069	0.547
DOC_PP2B_LxvP_1	309	312	PF13499	0.605
DOC_PP2B_PxIxI_1	228	234	PF00149	0.585
DOC_PP2B_PxIxI_1	314	320	PF00149	0.576
DOC_PP4_FxxP_1	445	448	PF00568	0.545
DOC_PP4_FxxP_1	973	976	PF00568	0.441
DOC_PP4_MxPP_1	849	852	PF00568	0.438
DOC_USP7_MATH_1	1021	1025	PF00917	0.584
DOC_USP7_MATH_1	1042	1046	PF00917	0.607
DOC_USP7_MATH_1	235	239	PF00917	0.468
DOC_USP7_MATH_1	279	283	PF00917	0.583
DOC_USP7_MATH_1	448	452	PF00917	0.553
DOC_USP7_MATH_1	45	49	PF00917	0.543
DOC_USP7_MATH_1	693	697	PF00917	0.468
DOC_USP7_MATH_1	740	744	PF00917	0.481
DOC_USP7_MATH_1	761	765	PF00917	0.635
DOC_USP7_MATH_1	772	776	PF00917	0.415
DOC_USP7_MATH_1	777	781	PF00917	0.411
DOC_USP7_MATH_1	936	940	PF00917	0.654
DOC_USP7_UBL2_3	40	44	PF12436	0.547
DOC_WW_Pin1_4	1038	1043	PF00397	0.633
DOC_WW_Pin1_4	239	244	PF00397	0.468
DOC_WW_Pin1_4	470	475	PF00397	0.561
DOC_WW_Pin1_4	524	529	PF00397	0.685
DOC_WW_Pin1_4	62	67	PF00397	0.450
DOC_WW_Pin1_4	642	647	PF00397	0.476
DOC_WW_Pin1_4	755	760	PF00397	0.516
DOC_WW_Pin1_4	869	874	PF00397	0.400
DOC_WW_Pin1_4	928	933	PF00397	0.571
DOC_WW_Pin1_4	940	945	PF00397	0.534
DOC_WW_Pin1_4	972	977	PF00397	0.434
LIG_14-3-3_CanoR_1	1029	1037	PF00244	0.706
LIG_14-3-3_CanoR_1	151	161	PF00244	0.426
LIG_14-3-3_CanoR_1	21	25	PF00244	0.448
LIG_14-3-3_CanoR_1	215	221	PF00244	0.587
LIG_14-3-3_CanoR_1	52	56	PF00244	0.571
LIG_14-3-3_CanoR_1	574	583	PF00244	0.388
LIG_14-3-3_CanoR_1	813	821	PF00244	0.391
LIG_14-3-3_CanoR_1	965	974	PF00244	0.499
LIG_14-3-3_CanoR_1	984	989	PF00244	0.590
LIG_Actin_WH2_2	7	23	PF00022	0.467
LIG_APCC_ABBA_1	430	435	PF00400	0.561
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_BIR_III_2	776	780	PF00653	0.562
LIG_BIR_III_4	468	472	PF00653	0.599
LIG_BRCT_BRCA1_1	986	990	PF00533	0.494
LIG_Clathr_ClatBox_1	798	802	PF01394	0.451
LIG_deltaCOP1_diTrp_1	138	148	PF00928	0.373
LIG_DLG_GKlike_1	681	689	PF00625	0.396
LIG_EH1_1	582	590	PF00400	0.318
LIG_FHA_1	1029	1035	PF00498	0.640
LIG_FHA_1	264	270	PF00498	0.456
LIG_FHA_1	275	281	PF00498	0.549
LIG_FHA_1	314	320	PF00498	0.566
LIG_FHA_1	388	394	PF00498	0.313
LIG_FHA_1	427	433	PF00498	0.543
LIG_FHA_1	5	11	PF00498	0.492
LIG_FHA_1	57	63	PF00498	0.450
LIG_FHA_1	576	582	PF00498	0.349
LIG_FHA_1	672	678	PF00498	0.592
LIG_FHA_1	713	719	PF00498	0.628
LIG_FHA_1	833	839	PF00498	0.482
LIG_FHA_1	921	927	PF00498	0.576
LIG_FHA_2	171	177	PF00498	0.476
LIG_FHA_2	180	186	PF00498	0.401
LIG_FHA_2	240	246	PF00498	0.652
LIG_FHA_2	530	536	PF00498	0.580
LIG_FHA_2	537	543	PF00498	0.508
LIG_FHA_2	69	75	PF00498	0.438
LIG_FHA_2	905	911	PF00498	0.458
LIG_FHA_2	915	921	PF00498	0.420
LIG_LIR_Apic_2	237	243	PF02991	0.434
LIG_LIR_Apic_2	443	448	PF02991	0.535
LIG_LIR_Apic_2	79	83	PF02991	0.495
LIG_LIR_Gen_1	400	408	PF02991	0.415
LIG_LIR_Gen_1	664	673	PF02991	0.433
LIG_LIR_Nem_3	106	110	PF02991	0.406
LIG_LIR_Nem_3	400	405	PF02991	0.413
LIG_LIR_Nem_3	425	430	PF02991	0.535
LIG_LIR_Nem_3	476	482	PF02991	0.521
LIG_LIR_Nem_3	500	504	PF02991	0.607
LIG_LIR_Nem_3	664	669	PF02991	0.435
LIG_LIR_Nem_3	875	881	PF02991	0.524
LIG_MAD2	668	676	PF02301	0.490
LIG_MYND_2	646	650	PF01753	0.410
LIG_NRP_CendR_1	1051	1052	PF00754	0.674
LIG_PCNA_yPIPBox_3	337	350	PF02747	0.513
LIG_PTB_Apo_2	542	549	PF02174	0.438
LIG_PTB_Phospho_1	542	548	PF10480	0.439
LIG_SH2_CRK	375	379	PF00017	0.384
LIG_SH2_CRK	479	483	PF00017	0.522
LIG_SH2_CRK	548	552	PF00017	0.427
LIG_SH2_CRK	583	587	PF00017	0.403
LIG_SH2_CRK	666	670	PF00017	0.426
LIG_SH2_CRK	752	756	PF00017	0.440
LIG_SH2_NCK_1	136	140	PF00017	0.442
LIG_SH2_PTP2	80	83	PF00017	0.488
LIG_SH2_SRC	136	139	PF00017	0.443
LIG_SH2_SRC	730	733	PF00017	0.342
LIG_SH2_SRC	80	83	PF00017	0.488
LIG_SH2_SRC	881	884	PF00017	0.452
LIG_SH2_STAP1	136	140	PF00017	0.370
LIG_SH2_STAP1	399	403	PF00017	0.411
LIG_SH2_STAP1	548	552	PF00017	0.427
LIG_SH2_STAP1	666	670	PF00017	0.381
LIG_SH2_STAP1	878	882	PF00017	0.511
LIG_SH2_STAT3	247	250	PF00017	0.516
LIG_SH2_STAT5	170	173	PF00017	0.496
LIG_SH2_STAT5	240	243	PF00017	0.448
LIG_SH2_STAT5	28	31	PF00017	0.568
LIG_SH2_STAT5	302	305	PF00017	0.604
LIG_SH2_STAT5	730	733	PF00017	0.342
LIG_SH2_STAT5	80	83	PF00017	0.488
LIG_SH2_STAT5	827	830	PF00017	0.463
LIG_SH3_1	80	86	PF00018	0.505
LIG_SH3_3	309	315	PF00018	0.602
LIG_SH3_3	39	45	PF00018	0.648
LIG_SH3_3	499	505	PF00018	0.626
LIG_SH3_3	52	58	PF00018	0.452
LIG_SH3_3	522	528	PF00018	0.725
LIG_SH3_3	63	69	PF00018	0.468
LIG_SH3_3	654	660	PF00018	0.423
LIG_SH3_3	670	676	PF00018	0.421
LIG_SH3_3	701	707	PF00018	0.440
LIG_SH3_3	78	84	PF00018	0.509
LIG_SH3_3	867	873	PF00018	0.496
LIG_Sin3_3	547	554	PF02671	0.370
LIG_SUMO_SIM_par_1	265	271	PF11976	0.473
LIG_SUMO_SIM_par_1	389	394	PF11976	0.316
LIG_SUMO_SIM_par_1	601	607	PF11976	0.289
LIG_TRAF2_1	182	185	PF00917	0.448
LIG_TRAF2_1	242	245	PF00917	0.453
LIG_TRAF2_1	335	338	PF00917	0.403
LIG_TRAF2_1	604	607	PF00917	0.411
LIG_TYR_ITIM	581	586	PF00017	0.334
LIG_UBA3_1	339	345	PF00899	0.462
LIG_UBA3_1	414	420	PF00899	0.518
LIG_UBA3_1	798	804	PF00899	0.426
LIG_WW_1	77	80	PF00397	0.515
MOD_CDK_SPK_2	928	933	PF00069	0.571
MOD_CDK_SPxxK_3	239	246	PF00069	0.452
MOD_CDK_SPxxK_3	524	531	PF00069	0.493
MOD_CDK_SPxxK_3	972	979	PF00069	0.433
MOD_CK1_1	1005	1011	PF00069	0.716
MOD_CK1_1	1024	1030	PF00069	0.539
MOD_CK1_1	274	280	PF00069	0.478
MOD_CK1_1	380	386	PF00069	0.405
MOD_CK1_1	419	425	PF00069	0.546
MOD_CK1_1	494	500	PF00069	0.642
MOD_CK1_1	527	533	PF00069	0.641
MOD_CK1_1	645	651	PF00069	0.563
MOD_CK1_1	696	702	PF00069	0.530
MOD_CK1_1	928	934	PF00069	0.479
MOD_CK2_1	179	185	PF00069	0.433
MOD_CK2_1	239	245	PF00069	0.484
MOD_CK2_1	279	285	PF00069	0.622
MOD_CK2_1	357	363	PF00069	0.640
MOD_CK2_1	529	535	PF00069	0.566
MOD_CK2_1	536	542	PF00069	0.488
MOD_CK2_1	68	74	PF00069	0.423
MOD_CK2_1	914	920	PF00069	0.412
MOD_CK2_1	983	989	PF00069	0.525
MOD_Cter_Amidation	613	616	PF01082	0.429
MOD_GlcNHglycan	1044	1047	PF01048	0.600
MOD_GlcNHglycan	121	124	PF01048	0.485
MOD_GlcNHglycan	273	276	PF01048	0.579
MOD_GlcNHglycan	285	288	PF01048	0.546
MOD_GlcNHglycan	358	362	PF01048	0.657
MOD_GlcNHglycan	421	424	PF01048	0.619
MOD_GlcNHglycan	484	487	PF01048	0.711
MOD_GlcNHglycan	489	492	PF01048	0.729
MOD_GlcNHglycan	493	496	PF01048	0.719
MOD_GlcNHglycan	696	699	PF01048	0.600
MOD_GlcNHglycan	708	711	PF01048	0.503
MOD_GlcNHglycan	723	726	PF01048	0.521
MOD_GlcNHglycan	738	741	PF01048	0.336
MOD_GlcNHglycan	742	745	PF01048	0.304
MOD_GlcNHglycan	927	930	PF01048	0.593
MOD_GSK3_1	1003	1010	PF00069	0.720
MOD_GSK3_1	1024	1031	PF00069	0.684
MOD_GSK3_1	1036	1043	PF00069	0.649
MOD_GSK3_1	152	159	PF00069	0.379
MOD_GSK3_1	175	182	PF00069	0.474
MOD_GSK3_1	197	204	PF00069	0.463
MOD_GSK3_1	20	27	PF00069	0.392
MOD_GSK3_1	227	234	PF00069	0.620
MOD_GSK3_1	235	242	PF00069	0.651
MOD_GSK3_1	279	286	PF00069	0.570
MOD_GSK3_1	303	310	PF00069	0.728
MOD_GSK3_1	319	326	PF00069	0.481
MOD_GSK3_1	383	390	PF00069	0.346
MOD_GSK3_1	422	429	PF00069	0.550
MOD_GSK3_1	487	494	PF00069	0.614
MOD_GSK3_1	527	534	PF00069	0.648
MOD_GSK3_1	617	624	PF00069	0.468
MOD_GSK3_1	641	648	PF00069	0.545
MOD_GSK3_1	736	743	PF00069	0.602
MOD_GSK3_1	757	764	PF00069	0.542
MOD_GSK3_1	900	907	PF00069	0.589
MOD_GSK3_1	936	943	PF00069	0.598
MOD_GSK3_1	984	991	PF00069	0.467
MOD_N-GLC_1	1002	1007	PF02516	0.601
MOD_N-GLC_1	253	258	PF02516	0.432
MOD_N-GLC_1	263	268	PF02516	0.428
MOD_N-GLC_1	833	838	PF02516	0.550
MOD_N-GLC_1	885	890	PF02516	0.359
MOD_N-GLC_1	936	941	PF02516	0.551
MOD_N-GLC_1	965	970	PF02516	0.509
MOD_NEK2_1	121	126	PF00069	0.592
MOD_NEK2_1	154	159	PF00069	0.407
MOD_NEK2_1	20	25	PF00069	0.445
MOD_NEK2_1	263	268	PF00069	0.428
MOD_NEK2_1	292	297	PF00069	0.633
MOD_NEK2_1	357	362	PF00069	0.668
MOD_NEK2_1	622	627	PF00069	0.451
MOD_NEK2_1	911	916	PF00069	0.598
MOD_NEK2_2	235	240	PF00069	0.534
MOD_NEK2_2	428	433	PF00069	0.548
MOD_NEK2_2	448	453	PF00069	0.427
MOD_PIKK_1	1005	1011	PF00454	0.728
MOD_PIKK_1	121	127	PF00454	0.497
MOD_PIKK_1	128	134	PF00454	0.401
MOD_PIKK_1	292	298	PF00454	0.633
MOD_PIKK_1	4	10	PF00454	0.507
MOD_PK_1	216	222	PF00069	0.536
MOD_PK_1	953	959	PF00069	0.560
MOD_PKA_1	112	118	PF00069	0.476
MOD_PKA_1	51	57	PF00069	0.389
MOD_PKA_2	1028	1034	PF00069	0.642
MOD_PKA_2	112	118	PF00069	0.552
MOD_PKA_2	20	26	PF00069	0.453
MOD_PKA_2	51	57	PF00069	0.606
MOD_PKA_2	558	564	PF00069	0.518
MOD_PKA_2	812	818	PF00069	0.389
MOD_PKA_2	958	964	PF00069	0.563
MOD_PKA_2	983	989	PF00069	0.534
MOD_PKB_1	214	222	PF00069	0.538
MOD_Plk_1	141	147	PF00069	0.362
MOD_Plk_1	175	181	PF00069	0.428
MOD_Plk_1	263	269	PF00069	0.434
MOD_Plk_1	380	386	PF00069	0.405
MOD_Plk_1	572	578	PF00069	0.397
MOD_Plk_1	833	839	PF00069	0.449
MOD_Plk_1	885	891	PF00069	0.357
MOD_Plk_1	965	971	PF00069	0.525
MOD_Plk_2-3	920	926	PF00069	0.403
MOD_Plk_4	1008	1014	PF00069	0.704
MOD_Plk_4	197	203	PF00069	0.430
MOD_Plk_4	24	30	PF00069	0.414
MOD_Plk_4	263	269	PF00069	0.438
MOD_Plk_4	380	386	PF00069	0.442
MOD_Plk_4	398	404	PF00069	0.398
MOD_Plk_4	645	651	PF00069	0.466
MOD_Plk_4	681	687	PF00069	0.441
MOD_Plk_4	76	82	PF00069	0.459
MOD_Plk_4	834	840	PF00069	0.477
MOD_Plk_4	914	920	PF00069	0.483
MOD_Plk_4	958	964	PF00069	0.577
MOD_ProDKin_1	1038	1044	PF00069	0.628
MOD_ProDKin_1	239	245	PF00069	0.466
MOD_ProDKin_1	470	476	PF00069	0.560
MOD_ProDKin_1	524	530	PF00069	0.686
MOD_ProDKin_1	62	68	PF00069	0.446
MOD_ProDKin_1	642	648	PF00069	0.479
MOD_ProDKin_1	755	761	PF00069	0.519
MOD_ProDKin_1	869	875	PF00069	0.395
MOD_ProDKin_1	928	934	PF00069	0.571
MOD_ProDKin_1	940	946	PF00069	0.529
MOD_ProDKin_1	972	978	PF00069	0.428
MOD_SUMO_rev_2	238	248	PF00179	0.454
MOD_SUMO_rev_2	26	34	PF00179	0.635
MOD_SUMO_rev_2	800	806	PF00179	0.443
MOD_SUMO_rev_2	920	928	PF00179	0.470
TRG_DiLeu_BaEn_1	257	262	PF01217	0.433
TRG_DiLeu_BaEn_1	802	807	PF01217	0.421
TRG_DiLeu_BaLyEn_6	973	978	PF01217	0.416
TRG_ENDOCYTIC_2	136	139	PF00928	0.371
TRG_ENDOCYTIC_2	150	153	PF00928	0.439
TRG_ENDOCYTIC_2	249	252	PF00928	0.432
TRG_ENDOCYTIC_2	375	378	PF00928	0.378
TRG_ENDOCYTIC_2	479	482	PF00928	0.523
TRG_ENDOCYTIC_2	548	551	PF00928	0.353
TRG_ENDOCYTIC_2	583	586	PF00928	0.403
TRG_ENDOCYTIC_2	666	669	PF00928	0.432
TRG_ENDOCYTIC_2	827	830	PF00928	0.463
TRG_ER_diArg_1	20	22	PF00400	0.407
TRG_ER_diArg_1	214	216	PF00400	0.532
TRG_ER_diArg_1	456	459	PF00400	0.618
TRG_ER_diArg_1	589	591	PF00400	0.404
TRG_ER_diArg_1	765	767	PF00400	0.571
TRG_ER_diArg_1	792	794	PF00400	0.376
TRG_NES_CRM1_1	257	271	PF08389	0.462
TRG_NES_CRM1_1	381	394	PF08389	0.412
TRG_NES_CRM1_1	542	556	PF08389	0.263
TRG_NLS_MonoExtN_4	949	955	PF00514	0.448
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	979	983	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	99	104	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9F7	Leptomonas seymouri	55%	100%
A0A3S5H7V1	Leishmania donovani	91%	100%
A4HLV7	Leishmania braziliensis	70%	99%
E9AHR4	Leishmania infantum	91%	100%
Q4Q3U1	Leishmania major	88%	100%