ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KH-associated protein 1

Species:

Leishmania mexicana

UniProt:

E9B483_LEIMU

TriTrypDb:

LmxM.32.2440

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B483

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B483

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.507
CLV_NRD_NRD_1	262	264	PF00675	0.560
CLV_NRD_NRD_1	347	349	PF00675	0.550
CLV_NRD_NRD_1	423	425	PF00675	0.696
CLV_PCSK_KEX2_1	205	207	PF00082	0.426
CLV_PCSK_KEX2_1	211	213	PF00082	0.482
CLV_PCSK_KEX2_1	222	224	PF00082	0.535
CLV_PCSK_KEX2_1	262	264	PF00082	0.534
CLV_PCSK_KEX2_1	29	31	PF00082	0.686
CLV_PCSK_KEX2_1	423	425	PF00082	0.698
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.475
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.507
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.561
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.622
CLV_PCSK_SKI1_1	104	108	PF00082	0.654
CLV_PCSK_SKI1_1	342	346	PF00082	0.558
CLV_PCSK_SKI1_1	351	355	PF00082	0.546
CLV_PCSK_SKI1_1	367	371	PF00082	0.472
DEG_Nend_UBRbox_1	1	4	PF02207	0.736
DOC_PP4_MxPP_1	391	394	PF00568	0.499
DOC_USP7_MATH_1	230	234	PF00917	0.494
DOC_USP7_MATH_1	400	404	PF00917	0.607
DOC_USP7_MATH_1	410	414	PF00917	0.545
DOC_USP7_MATH_1	433	437	PF00917	0.800
DOC_USP7_MATH_1	449	453	PF00917	0.570
DOC_USP7_MATH_1	473	477	PF00917	0.678
DOC_USP7_MATH_1	489	493	PF00917	0.689
DOC_USP7_UBL2_3	279	283	PF12436	0.630
DOC_WW_Pin1_4	10	15	PF00397	0.767
DOC_WW_Pin1_4	29	34	PF00397	0.813
DOC_WW_Pin1_4	469	474	PF00397	0.522
LIG_14-3-3_CanoR_1	121	129	PF00244	0.572
LIG_14-3-3_CanoR_1	167	172	PF00244	0.325
LIG_14-3-3_CanoR_1	2	10	PF00244	0.726
LIG_14-3-3_CanoR_1	206	211	PF00244	0.540
LIG_14-3-3_CanoR_1	212	221	PF00244	0.539
LIG_14-3-3_CanoR_1	225	232	PF00244	0.483
LIG_14-3-3_CanoR_1	262	268	PF00244	0.476
LIG_14-3-3_CanoR_1	423	431	PF00244	0.758
LIG_14-3-3_CanoR_1	435	440	PF00244	0.685
LIG_14-3-3_CanoR_1	484	489	PF00244	0.686
LIG_Actin_WH2_2	195	213	PF00022	0.484
LIG_BRCT_BRCA1_1	4	8	PF00533	0.727
LIG_FHA_1	293	299	PF00498	0.584
LIG_FHA_1	339	345	PF00498	0.635
LIG_FHA_1	358	364	PF00498	0.455
LIG_FHA_2	168	174	PF00498	0.359
LIG_FHA_2	181	187	PF00498	0.576
LIG_Integrin_isoDGR_2	48	50	PF01839	0.540
LIG_LIR_Gen_1	416	422	PF02991	0.630
LIG_LIR_Nem_3	364	368	PF02991	0.469
LIG_MYND_3	111	115	PF01753	0.498
LIG_PCNA_yPIPBox_3	188	199	PF02747	0.566
LIG_RPA_C_Fungi	220	232	PF08784	0.443
LIG_SH2_GRB2like	380	383	PF00017	0.719
LIG_SH2_SRC	380	383	PF00017	0.719
LIG_SH2_SRC	431	434	PF00017	0.507
LIG_SH2_STAP1	380	384	PF00017	0.761
LIG_SH2_STAT5	171	174	PF00017	0.391
LIG_SH2_STAT5	198	201	PF00017	0.466
LIG_SH2_STAT5	79	82	PF00017	0.674
LIG_SH3_3	48	54	PF00018	0.557
LIG_SH3_3	57	63	PF00018	0.580
LIG_TRAF2_1	113	116	PF00917	0.609
LIG_TRAF2_1	183	186	PF00917	0.583
LIG_TRAF2_1	191	194	PF00917	0.574
LIG_TRAF2_1	215	218	PF00917	0.644
LIG_TRAF2_1	233	236	PF00917	0.517
LIG_TRAF2_1	414	417	PF00917	0.513
MOD_CDK_SPxK_1	469	475	PF00069	0.495
MOD_CDK_SPxxK_3	29	36	PF00069	0.534
MOD_CK1_1	110	116	PF00069	0.635
MOD_CK1_1	216	222	PF00069	0.522
MOD_CK1_1	266	272	PF00069	0.426
MOD_CK1_1	292	298	PF00069	0.541
MOD_CK1_1	373	379	PF00069	0.660
MOD_CK1_1	383	389	PF00069	0.605
MOD_CK1_1	398	404	PF00069	0.753
MOD_CK1_1	411	417	PF00069	0.557
MOD_CK1_1	447	453	PF00069	0.782
MOD_CK1_1	478	484	PF00069	0.702
MOD_CK1_1	492	498	PF00069	0.738
MOD_CK1_1	74	80	PF00069	0.676
MOD_CK2_1	110	116	PF00069	0.623
MOD_CK2_1	167	173	PF00069	0.344
MOD_CK2_1	180	186	PF00069	0.529
MOD_CK2_1	188	194	PF00069	0.468
MOD_CK2_1	230	236	PF00069	0.489
MOD_CK2_1	410	416	PF00069	0.625
MOD_GlcNHglycan	73	76	PF01048	0.616
MOD_GSK3_1	266	273	PF00069	0.556
MOD_GSK3_1	292	299	PF00069	0.342
MOD_GSK3_1	376	383	PF00069	0.682
MOD_GSK3_1	423	430	PF00069	0.709
MOD_GSK3_1	431	438	PF00069	0.742
MOD_GSK3_1	469	476	PF00069	0.648
MOD_N-GLC_1	2	7	PF02516	0.725
MOD_N-GLC_1	36	41	PF02516	0.526
MOD_N-GLC_1	370	375	PF02516	0.744
MOD_N-GLC_1	55	60	PF02516	0.651
MOD_NEK2_1	289	294	PF00069	0.545
MOD_NEK2_1	370	375	PF00069	0.521
MOD_NEK2_1	395	400	PF00069	0.763
MOD_NEK2_1	444	449	PF00069	0.728
MOD_PIKK_1	213	219	PF00454	0.643
MOD_PIKK_1	244	250	PF00454	0.591
MOD_PIKK_1	318	324	PF00454	0.591
MOD_PIKK_1	400	406	PF00454	0.539
MOD_PIKK_1	433	439	PF00454	0.801
MOD_PIKK_1	449	455	PF00454	0.650
MOD_PK_1	475	481	PF00069	0.676
MOD_PKA_1	423	429	PF00069	0.709
MOD_PKA_2	122	128	PF00069	0.576
MOD_PKA_2	166	172	PF00069	0.327
MOD_PKA_2	376	382	PF00069	0.737
MOD_PKA_2	411	417	PF00069	0.685
MOD_PKA_2	423	429	PF00069	0.666
MOD_PKA_2	490	496	PF00069	0.632
MOD_PKB_1	223	231	PF00069	0.576
MOD_Plk_1	102	108	PF00069	0.647
MOD_Plk_1	172	178	PF00069	0.570
MOD_Plk_1	180	186	PF00069	0.576
MOD_Plk_1	43	49	PF00069	0.649
MOD_Plk_4	167	173	PF00069	0.387
MOD_Plk_4	216	222	PF00069	0.366
MOD_Plk_4	475	481	PF00069	0.807
MOD_ProDKin_1	10	16	PF00069	0.769
MOD_ProDKin_1	29	35	PF00069	0.812
MOD_ProDKin_1	469	475	PF00069	0.526
MOD_SUMO_rev_2	234	244	PF00179	0.581
MOD_SUMO_rev_2	99	106	PF00179	0.637
TRG_DiLeu_BaEn_1	350	355	PF01217	0.534
TRG_DiLeu_BaEn_3	416	422	PF01217	0.513
TRG_ENDOCYTIC_2	365	368	PF00928	0.688
TRG_ER_diArg_1	121	124	PF00400	0.513
TRG_ER_diArg_1	261	263	PF00400	0.534
TRG_ER_diArg_1	422	424	PF00400	0.683
TRG_NLS_Bipartite_1	205	226	PF00514	0.577
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMH4	Leptomonas seymouri	60%	100%
A0A1X0P3T7	Trypanosomatidae	41%	100%
A0A3S7X729	Leishmania donovani	82%	99%
A0A422P039	Trypanosoma rangeli	38%	100%
A4HLV5	Leishmania braziliensis	56%	100%
E9AHR2	Leishmania infantum	82%	99%
Q4Q3U3	Leishmania major	80%	100%