LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B482_LEIMU
TriTrypDb:
LmxM.32.2430
Length:
649

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B482
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B482

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 174 178 PF00656 0.374
CLV_C14_Caspase3-7 292 296 PF00656 0.326
CLV_C14_Caspase3-7 9 13 PF00656 0.329
CLV_NRD_NRD_1 279 281 PF00675 0.378
CLV_NRD_NRD_1 536 538 PF00675 0.440
CLV_NRD_NRD_1 540 542 PF00675 0.427
CLV_NRD_NRD_1 99 101 PF00675 0.473
CLV_PCSK_FUR_1 277 281 PF00082 0.442
CLV_PCSK_FUR_1 534 538 PF00082 0.482
CLV_PCSK_KEX2_1 279 281 PF00082 0.412
CLV_PCSK_KEX2_1 536 538 PF00082 0.446
CLV_PCSK_KEX2_1 540 542 PF00082 0.433
CLV_PCSK_KEX2_1 99 101 PF00082 0.473
CLV_PCSK_PC7_1 536 542 PF00082 0.483
CLV_PCSK_SKI1_1 197 201 PF00082 0.489
CLV_PCSK_SKI1_1 280 284 PF00082 0.384
CLV_PCSK_SKI1_1 375 379 PF00082 0.498
CLV_PCSK_SKI1_1 455 459 PF00082 0.400
CLV_PCSK_SKI1_1 536 540 PF00082 0.434
CLV_PCSK_SKI1_1 67 71 PF00082 0.359
CLV_Separin_Metazoa 426 430 PF03568 0.450
DEG_APCC_DBOX_1 279 287 PF00400 0.409
DEG_APCC_DBOX_1 535 543 PF00400 0.482
DEG_Nend_Nbox_1 1 3 PF02207 0.323
DOC_CDC14_PxL_1 517 525 PF14671 0.401
DOC_CKS1_1 16 21 PF01111 0.377
DOC_CYCLIN_RxL_1 450 461 PF00134 0.428
DOC_CYCLIN_yCln2_LP_2 409 415 PF00134 0.340
DOC_MAPK_gen_1 161 171 PF00069 0.464
DOC_MAPK_gen_1 185 193 PF00069 0.366
DOC_MAPK_gen_1 372 381 PF00069 0.559
DOC_MAPK_gen_1 99 107 PF00069 0.441
DOC_MAPK_MEF2A_6 164 171 PF00069 0.469
DOC_MAPK_MEF2A_6 187 195 PF00069 0.321
DOC_MAPK_MEF2A_6 518 525 PF00069 0.297
DOC_MAPK_MEF2A_6 99 107 PF00069 0.393
DOC_MAPK_NFAT4_5 100 108 PF00069 0.386
DOC_PP1_SILK_1 286 291 PF00149 0.444
DOC_PP2B_LxvP_1 362 365 PF13499 0.469
DOC_PP2B_LxvP_1 409 412 PF13499 0.317
DOC_USP7_MATH_1 387 391 PF00917 0.673
DOC_USP7_MATH_1 394 398 PF00917 0.717
DOC_USP7_MATH_1 558 562 PF00917 0.622
DOC_USP7_MATH_1 612 616 PF00917 0.500
DOC_USP7_MATH_1 65 69 PF00917 0.336
DOC_WW_Pin1_4 15 20 PF00397 0.370
DOC_WW_Pin1_4 240 245 PF00397 0.450
DOC_WW_Pin1_4 29 34 PF00397 0.407
DOC_WW_Pin1_4 304 309 PF00397 0.611
DOC_WW_Pin1_4 385 390 PF00397 0.674
DOC_WW_Pin1_4 474 479 PF00397 0.634
DOC_WW_Pin1_4 641 646 PF00397 0.567
DOC_WW_Pin1_4 82 87 PF00397 0.584
LIG_14-3-3_CanoR_1 148 156 PF00244 0.580
LIG_14-3-3_CanoR_1 217 222 PF00244 0.348
LIG_14-3-3_CanoR_1 280 289 PF00244 0.448
LIG_Actin_WH2_2 44 59 PF00022 0.432
LIG_APCC_ABBA_1 514 519 PF00400 0.505
LIG_BRCT_BRCA1_1 31 35 PF00533 0.467
LIG_BRCT_BRCA1_1 416 420 PF00533 0.408
LIG_BRCT_BRCA1_1 439 443 PF00533 0.358
LIG_BRCT_BRCA1_2 439 445 PF00533 0.368
LIG_deltaCOP1_diTrp_1 467 473 PF00928 0.580
LIG_DLG_GKlike_1 217 225 PF00625 0.341
LIG_eIF4E_1 331 337 PF01652 0.418
LIG_FHA_1 107 113 PF00498 0.228
LIG_FHA_1 151 157 PF00498 0.469
LIG_FHA_1 240 246 PF00498 0.500
LIG_FHA_1 376 382 PF00498 0.630
LIG_FHA_1 51 57 PF00498 0.462
LIG_FHA_1 543 549 PF00498 0.539
LIG_FHA_2 172 178 PF00498 0.426
LIG_FHA_2 184 190 PF00498 0.305
LIG_FHA_2 299 305 PF00498 0.610
LIG_FHA_2 50 56 PF00498 0.344
LIG_FHA_2 508 514 PF00498 0.432
LIG_FHA_2 619 625 PF00498 0.481
LIG_FHA_2 633 639 PF00498 0.481
LIG_FHA_2 7 13 PF00498 0.413
LIG_FHA_2 70 76 PF00498 0.476
LIG_GBD_Chelix_1 403 411 PF00786 0.386
LIG_Integrin_isoDGR_2 23 25 PF01839 0.475
LIG_KLC1_Yacidic_2 189 194 PF13176 0.456
LIG_LIR_Gen_1 189 200 PF02991 0.240
LIG_LIR_Gen_1 215 226 PF02991 0.473
LIG_LIR_Gen_1 440 448 PF02991 0.443
LIG_LIR_Gen_1 519 528 PF02991 0.468
LIG_LIR_Gen_1 565 573 PF02991 0.534
LIG_LIR_Nem_3 189 195 PF02991 0.322
LIG_LIR_Nem_3 220 225 PF02991 0.389
LIG_LIR_Nem_3 3 8 PF02991 0.439
LIG_LIR_Nem_3 32 38 PF02991 0.379
LIG_LIR_Nem_3 440 446 PF02991 0.426
LIG_LIR_Nem_3 515 520 PF02991 0.417
LIG_LIR_Nem_3 565 569 PF02991 0.536
LIG_LIR_Nem_3 582 588 PF02991 0.523
LIG_LIR_Nem_3 60 66 PF02991 0.383
LIG_LIR_Nem_3 72 76 PF02991 0.463
LIG_MLH1_MIPbox_1 416 420 PF16413 0.408
LIG_NRBOX 358 364 PF00104 0.424
LIG_NRBOX 453 459 PF00104 0.476
LIG_NRBOX 601 607 PF00104 0.473
LIG_Pex14_1 271 275 PF04695 0.346
LIG_Pex14_1 469 473 PF04695 0.588
LIG_Pex14_2 416 420 PF04695 0.330
LIG_PTB_Apo_2 584 591 PF02174 0.424
LIG_PTB_Phospho_1 584 590 PF10480 0.431
LIG_SH2_GRB2like 76 79 PF00017 0.300
LIG_SH2_SRC 26 29 PF00017 0.486
LIG_SH2_SRC 293 296 PF00017 0.493
LIG_SH2_STAP1 127 131 PF00017 0.390
LIG_SH2_STAP1 331 335 PF00017 0.453
LIG_SH2_STAP1 512 516 PF00017 0.410
LIG_SH2_STAP1 566 570 PF00017 0.489
LIG_SH2_STAT3 331 334 PF00017 0.475
LIG_SH2_STAT5 108 111 PF00017 0.340
LIG_SH2_STAT5 192 195 PF00017 0.403
LIG_SH2_STAT5 228 231 PF00017 0.323
LIG_SH2_STAT5 26 29 PF00017 0.374
LIG_SH2_STAT5 275 278 PF00017 0.415
LIG_SH2_STAT5 293 296 PF00017 0.392
LIG_SH2_STAT5 300 303 PF00017 0.528
LIG_SH2_STAT5 419 422 PF00017 0.390
LIG_SH2_STAT5 456 459 PF00017 0.359
LIG_SH2_STAT5 590 593 PF00017 0.362
LIG_SH2_STAT5 76 79 PF00017 0.454
LIG_SH3_3 238 244 PF00018 0.449
LIG_SH3_3 260 266 PF00018 0.535
LIG_SH3_3 383 389 PF00018 0.644
LIG_SH3_3 552 558 PF00018 0.595
LIG_SH3_3 59 65 PF00018 0.339
LIG_SUMO_SIM_par_1 103 109 PF11976 0.318
LIG_SUMO_SIM_par_1 242 249 PF11976 0.491
LIG_TRAF2_1 524 527 PF00917 0.238
LIG_TRAF2_1 72 75 PF00917 0.368
LIG_TYR_ITIM 226 231 PF00017 0.451
LIG_UBA3_1 246 252 PF00899 0.439
LIG_WRC_WIRS_1 355 360 PF05994 0.360
LIG_WRC_WIRS_1 66 71 PF05994 0.286
LIG_WW_3 96 100 PF00397 0.511
MOD_CDK_SPK_2 476 481 PF00069 0.586
MOD_CDK_SPxK_1 15 21 PF00069 0.367
MOD_CDK_SPxK_1 304 310 PF00069 0.544
MOD_CDK_SPxxK_3 474 481 PF00069 0.652
MOD_CDK_SPxxK_3 641 648 PF00069 0.580
MOD_CK1_1 106 112 PF00069 0.310
MOD_CK1_1 150 156 PF00069 0.539
MOD_CK1_1 388 394 PF00069 0.683
MOD_CK1_1 449 455 PF00069 0.397
MOD_CK1_1 547 553 PF00069 0.465
MOD_CK2_1 183 189 PF00069 0.395
MOD_CK2_1 507 513 PF00069 0.436
MOD_CK2_1 521 527 PF00069 0.414
MOD_CK2_1 562 568 PF00069 0.624
MOD_CK2_1 618 624 PF00069 0.521
MOD_CK2_1 69 75 PF00069 0.466
MOD_GlcNHglycan 128 131 PF01048 0.485
MOD_GlcNHglycan 157 161 PF01048 0.529
MOD_GlcNHglycan 177 180 PF01048 0.436
MOD_GlcNHglycan 200 203 PF01048 0.491
MOD_GlcNHglycan 365 368 PF01048 0.510
MOD_GlcNHglycan 575 578 PF01048 0.531
MOD_GSK3_1 11 18 PF00069 0.331
MOD_GSK3_1 171 178 PF00069 0.434
MOD_GSK3_1 375 382 PF00069 0.560
MOD_GSK3_1 385 392 PF00069 0.631
MOD_GSK3_1 437 444 PF00069 0.433
MOD_GSK3_1 558 565 PF00069 0.572
MOD_GSK3_1 569 576 PF00069 0.529
MOD_GSK3_1 65 72 PF00069 0.469
MOD_GSK3_1 82 89 PF00069 0.568
MOD_N-GLC_2 47 49 PF02516 0.297
MOD_NEK2_1 103 108 PF00069 0.294
MOD_NEK2_1 11 16 PF00069 0.328
MOD_NEK2_1 246 251 PF00069 0.563
MOD_NEK2_1 542 547 PF00069 0.533
MOD_NEK2_1 569 574 PF00069 0.529
MOD_NEK2_1 69 74 PF00069 0.430
MOD_NEK2_2 512 517 PF00069 0.407
MOD_OFUCOSY 170 175 PF10250 0.372
MOD_PIKK_1 212 218 PF00454 0.434
MOD_PIKK_1 315 321 PF00454 0.609
MOD_PIKK_1 483 489 PF00454 0.555
MOD_PIKK_1 526 532 PF00454 0.510
MOD_PIKK_1 542 548 PF00454 0.394
MOD_PIKK_1 558 564 PF00454 0.515
MOD_PK_1 544 550 PF00069 0.442
MOD_PKA_2 147 153 PF00069 0.522
MOD_PKA_2 171 177 PF00069 0.348
MOD_PKA_2 309 315 PF00069 0.763
MOD_PKA_2 612 618 PF00069 0.518
MOD_Plk_1 375 381 PF00069 0.651
MOD_Plk_1 512 518 PF00069 0.409
MOD_Plk_4 103 109 PF00069 0.376
MOD_Plk_4 11 17 PF00069 0.350
MOD_Plk_4 117 123 PF00069 0.333
MOD_Plk_4 150 156 PF00069 0.488
MOD_Plk_4 217 223 PF00069 0.505
MOD_Plk_4 251 257 PF00069 0.543
MOD_Plk_4 354 360 PF00069 0.353
MOD_Plk_4 437 443 PF00069 0.386
MOD_Plk_4 512 518 PF00069 0.424
MOD_ProDKin_1 15 21 PF00069 0.376
MOD_ProDKin_1 240 246 PF00069 0.453
MOD_ProDKin_1 29 35 PF00069 0.404
MOD_ProDKin_1 304 310 PF00069 0.612
MOD_ProDKin_1 385 391 PF00069 0.675
MOD_ProDKin_1 474 480 PF00069 0.630
MOD_ProDKin_1 641 647 PF00069 0.574
MOD_ProDKin_1 82 88 PF00069 0.594
MOD_SUMO_rev_2 265 273 PF00179 0.512
TRG_DiLeu_BaEn_1 324 329 PF01217 0.457
TRG_DiLeu_BaLyEn_6 241 246 PF01217 0.454
TRG_ENDOCYTIC_2 192 195 PF00928 0.253
TRG_ENDOCYTIC_2 218 221 PF00928 0.322
TRG_ENDOCYTIC_2 228 231 PF00928 0.374
TRG_ENDOCYTIC_2 26 29 PF00928 0.355
TRG_ENDOCYTIC_2 498 501 PF00928 0.437
TRG_ENDOCYTIC_2 5 8 PF00928 0.426
TRG_ENDOCYTIC_2 566 569 PF00928 0.539
TRG_ENDOCYTIC_2 63 66 PF00928 0.334
TRG_ER_diArg_1 184 187 PF00400 0.376
TRG_ER_diArg_1 276 279 PF00400 0.419
TRG_ER_diArg_1 534 537 PF00400 0.460
TRG_ER_diArg_1 539 541 PF00400 0.459
TRG_ER_diArg_1 98 100 PF00400 0.500
TRG_Pf-PMV_PEXEL_1 57 61 PF00026 0.379
TRG_PTS1 646 649 PF00515 0.587

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PF78 Leptomonas seymouri 64% 100%
A0A0S4IPL3 Bodo saltans 31% 100%
A0A1X0P3T8 Trypanosomatidae 34% 100%
A0A3Q8IHN4 Leishmania donovani 90% 100%
A0A3R7MTT7 Trypanosoma rangeli 36% 100%
A4HLV4 Leishmania braziliensis 75% 100%
D0A669 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9AHR1 Leishmania infantum 90% 100%
Q4Q3U4 Leishmania major 92% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS