MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B481_LEIMU

TriTrypDb:

LmxM.32.2420

Length:

699

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B481

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B481

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.606
CLV_C14_Caspase3-7	421	425	PF00656	0.799
CLV_C14_Caspase3-7	498	502	PF00656	0.586
CLV_C14_Caspase3-7	545	549	PF00656	0.510
CLV_C14_Caspase3-7	69	73	PF00656	0.533
CLV_NRD_NRD_1	188	190	PF00675	0.783
CLV_NRD_NRD_1	371	373	PF00675	0.769
CLV_NRD_NRD_1	441	443	PF00675	0.792
CLV_NRD_NRD_1	45	47	PF00675	0.761
CLV_NRD_NRD_1	54	56	PF00675	0.582
CLV_NRD_NRD_1	642	644	PF00675	0.623
CLV_NRD_NRD_1	684	686	PF00675	0.419
CLV_PCSK_FUR_1	186	190	PF00082	0.529
CLV_PCSK_FUR_1	369	373	PF00082	0.655
CLV_PCSK_FUR_1	439	443	PF00082	0.526
CLV_PCSK_KEX2_1	185	187	PF00082	0.746
CLV_PCSK_KEX2_1	188	190	PF00082	0.783
CLV_PCSK_KEX2_1	371	373	PF00082	0.769
CLV_PCSK_KEX2_1	439	441	PF00082	0.789
CLV_PCSK_KEX2_1	45	47	PF00082	0.761
CLV_PCSK_KEX2_1	54	56	PF00082	0.582
CLV_PCSK_KEX2_1	659	661	PF00082	0.663
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.526
CLV_PCSK_PC1ET2_1	659	661	PF00082	0.567
CLV_PCSK_PC7_1	436	442	PF00082	0.528
CLV_PCSK_PC7_1	655	661	PF00082	0.666
CLV_PCSK_SKI1_1	446	450	PF00082	0.538
CLV_PCSK_SKI1_1	486	490	PF00082	0.720
CLV_PCSK_SKI1_1	515	519	PF00082	0.732
CLV_PCSK_SKI1_1	603	607	PF00082	0.643
CLV_PCSK_SKI1_1	627	631	PF00082	0.461
CLV_PCSK_SKI1_1	638	642	PF00082	0.596
CLV_PCSK_SKI1_1	685	689	PF00082	0.496
CLV_PCSK_SKI1_1	86	90	PF00082	0.745
DEG_SCF_FBW7_1	132	137	PF00400	0.699
DEG_SCF_FBW7_1	209	214	PF00400	0.632
DEG_SPOP_SBC_1	135	139	PF00917	0.765
DOC_CYCLIN_yCln2_LP_2	160	166	PF00134	0.797
DOC_PP2B_LxvP_1	6	9	PF13499	0.693
DOC_USP7_MATH_1	168	172	PF00917	0.588
DOC_USP7_MATH_1	211	215	PF00917	0.730
DOC_USP7_MATH_1	38	42	PF00917	0.609
DOC_USP7_MATH_1	571	575	PF00917	0.675
DOC_USP7_MATH_1	99	103	PF00917	0.825
DOC_WW_Pin1_4	1	6	PF00397	0.704
DOC_WW_Pin1_4	13	18	PF00397	0.710
DOC_WW_Pin1_4	130	135	PF00397	0.822
DOC_WW_Pin1_4	136	141	PF00397	0.613
DOC_WW_Pin1_4	207	212	PF00397	0.641
DOC_WW_Pin1_4	27	32	PF00397	0.791
DOC_WW_Pin1_4	607	612	PF00397	0.483
DOC_WW_Pin1_4	88	93	PF00397	0.680
LIG_14-3-3_CanoR_1	100	106	PF00244	0.788
LIG_14-3-3_CanoR_1	205	210	PF00244	0.801
LIG_14-3-3_CanoR_1	213	221	PF00244	0.635
LIG_14-3-3_CanoR_1	259	267	PF00244	0.553
LIG_14-3-3_CanoR_1	439	449	PF00244	0.580
LIG_14-3-3_CanoR_1	476	481	PF00244	0.683
LIG_14-3-3_CanoR_1	486	495	PF00244	0.796
LIG_14-3-3_CanoR_1	559	566	PF00244	0.799
LIG_14-3-3_CanoR_1	685	694	PF00244	0.348
LIG_BRCT_BRCA1_1	460	464	PF00533	0.808
LIG_FHA_1	131	137	PF00498	0.823
LIG_FHA_1	358	364	PF00498	0.542
LIG_FHA_1	522	528	PF00498	0.792
LIG_FHA_1	686	692	PF00498	0.498
LIG_FHA_2	165	171	PF00498	0.731
LIG_FHA_2	396	402	PF00498	0.618
LIG_FHA_2	610	616	PF00498	0.609
LIG_Integrin_RGD_1	393	395	PF01839	0.810
LIG_LIR_Apic_2	270	276	PF02991	0.483
LIG_LIR_Gen_1	342	349	PF02991	0.407
LIG_LIR_Nem_3	248	254	PF02991	0.734
LIG_LIR_Nem_3	342	348	PF02991	0.350
LIG_LIR_Nem_3	461	467	PF02991	0.807
LIG_LIR_Nem_3	526	531	PF02991	0.519
LIG_LIR_Nem_3	671	677	PF02991	0.642
LIG_PCNA_PIPBox_1	616	625	PF02747	0.647
LIG_PCNA_yPIPBox_3	614	623	PF02747	0.669
LIG_SH2_CRK	273	277	PF00017	0.567
LIG_SH2_CRK	345	349	PF00017	0.407
LIG_SH2_CRK	528	532	PF00017	0.534
LIG_SH2_GRB2like	591	594	PF00017	0.493
LIG_SH2_SRC	591	594	PF00017	0.493
LIG_SH2_STAT5	273	276	PF00017	0.437
LIG_SH2_STAT5	282	285	PF00017	0.484
LIG_SH2_STAT5	333	336	PF00017	0.407
LIG_SH2_STAT5	591	594	PF00017	0.643
LIG_SH3_1	11	17	PF00018	0.605
LIG_SH3_2	2	7	PF14604	0.545
LIG_SH3_3	11	17	PF00018	0.605
LIG_SH3_3	605	611	PF00018	0.630
LIG_Sin3_3	157	164	PF02671	0.518
LIG_SUMO_SIM_anti_2	596	602	PF11976	0.623
LIG_WRC_WIRS_1	464	469	PF05994	0.530
LIG_WW_3	42	46	PF00397	0.550
LIG_WW_3	8	12	PF00397	0.747
MOD_CDC14_SPxK_1	30	33	PF00782	0.696
MOD_CDC14_SPxK_1	4	7	PF00782	0.746
MOD_CDC14_SPxK_1	93	96	PF00782	0.520
MOD_CDK_SPxK_1	1	7	PF00069	0.749
MOD_CDK_SPxK_1	207	213	PF00069	0.639
MOD_CDK_SPxK_1	27	33	PF00069	0.768
MOD_CDK_SPxK_1	90	96	PF00069	0.525
MOD_CDK_SPxxK_3	136	143	PF00069	0.810
MOD_CDK_SPxxK_3	607	614	PF00069	0.477
MOD_CK1_1	107	113	PF00069	0.682
MOD_CK1_1	127	133	PF00069	0.552
MOD_CK1_1	16	22	PF00069	0.805
MOD_CK1_1	212	218	PF00069	0.637
MOD_CK1_1	224	230	PF00069	0.632
MOD_CK1_1	235	241	PF00069	0.656
MOD_CK1_1	260	266	PF00069	0.365
MOD_CK1_1	351	357	PF00069	0.493
MOD_CK1_1	430	436	PF00069	0.577
MOD_CK1_1	50	56	PF00069	0.729
MOD_CK1_1	516	522	PF00069	0.788
MOD_CK1_1	57	63	PF00069	0.793
MOD_CK1_1	583	589	PF00069	0.782
MOD_CK1_1	610	616	PF00069	0.479
MOD_CK2_1	164	170	PF00069	0.652
MOD_CK2_1	395	401	PF00069	0.714
MOD_CK2_1	410	416	PF00069	0.654
MOD_CK2_1	420	426	PF00069	0.527
MOD_CK2_1	593	599	PF00069	0.666
MOD_Cter_Amidation	183	186	PF01082	0.629
MOD_Cter_Amidation	657	660	PF01082	0.664
MOD_DYRK1A_RPxSP_1	90	94	PF00069	0.522
MOD_GlcNHglycan	124	127	PF01048	0.612
MOD_GlcNHglycan	150	153	PF01048	0.714
MOD_GlcNHglycan	174	177	PF01048	0.640
MOD_GlcNHglycan	18	21	PF01048	0.835
MOD_GlcNHglycan	197	200	PF01048	0.680
MOD_GlcNHglycan	202	205	PF01048	0.682
MOD_GlcNHglycan	218	221	PF01048	0.738
MOD_GlcNHglycan	22	25	PF01048	0.709
MOD_GlcNHglycan	223	226	PF01048	0.744
MOD_GlcNHglycan	234	237	PF01048	0.602
MOD_GlcNHglycan	329	332	PF01048	0.229
MOD_GlcNHglycan	383	386	PF01048	0.801
MOD_GlcNHglycan	458	461	PF01048	0.747
MOD_GlcNHglycan	535	538	PF01048	0.779
MOD_GlcNHglycan	548	552	PF01048	0.667
MOD_GlcNHglycan	56	59	PF01048	0.604
MOD_GlcNHglycan	633	638	PF01048	0.620
MOD_GlcNHglycan	81	84	PF01048	0.608
MOD_GSK3_1	100	107	PF00069	0.610
MOD_GSK3_1	124	131	PF00069	0.721
MOD_GSK3_1	144	151	PF00069	0.741
MOD_GSK3_1	164	171	PF00069	0.477
MOD_GSK3_1	205	212	PF00069	0.710
MOD_GSK3_1	235	242	PF00069	0.673
MOD_GSK3_1	25	32	PF00069	0.666
MOD_GSK3_1	253	260	PF00069	0.468
MOD_GSK3_1	348	355	PF00069	0.472
MOD_GSK3_1	426	433	PF00069	0.616
MOD_GSK3_1	458	465	PF00069	0.568
MOD_GSK3_1	471	478	PF00069	0.753
MOD_GSK3_1	480	487	PF00069	0.735
MOD_GSK3_1	50	57	PF00069	0.764
MOD_GSK3_1	523	530	PF00069	0.762
MOD_GSK3_1	554	561	PF00069	0.758
MOD_GSK3_1	579	586	PF00069	0.741
MOD_GSK3_1	9	16	PF00069	0.740
MOD_LATS_1	418	424	PF00433	0.814
MOD_LATS_1	52	58	PF00433	0.513
MOD_N-GLC_1	107	112	PF02516	0.694
MOD_N-GLC_1	115	120	PF02516	0.609
MOD_N-GLC_1	257	262	PF02516	0.475
MOD_N-GLC_1	401	406	PF02516	0.798
MOD_N-GLC_1	427	432	PF02516	0.574
MOD_N-GLC_1	533	538	PF02516	0.689
MOD_NEK2_1	221	226	PF00069	0.787
MOD_NEK2_1	410	415	PF00069	0.805
MOD_NEK2_1	435	440	PF00069	0.737
MOD_NEK2_1	527	532	PF00069	0.699
MOD_NEK2_1	547	552	PF00069	0.449
MOD_NEK2_1	558	563	PF00069	0.570
MOD_NEK2_1	56	61	PF00069	0.549
MOD_NEK2_1	623	628	PF00069	0.633
MOD_NEK2_1	647	652	PF00069	0.360
MOD_NEK2_2	319	324	PF00069	0.504
MOD_NEK2_2	431	436	PF00069	0.545
MOD_NEK2_2	463	468	PF00069	0.688
MOD_NEK2_2	471	476	PF00069	0.704
MOD_NEK2_2	523	528	PF00069	0.791
MOD_NEK2_2	554	559	PF00069	0.520
MOD_PIKK_1	317	323	PF00454	0.461
MOD_PIKK_1	373	379	PF00454	0.681
MOD_PIKK_1	450	456	PF00454	0.706
MOD_PIKK_1	488	494	PF00454	0.788
MOD_PIKK_1	552	558	PF00454	0.796
MOD_PIKK_1	593	599	PF00454	0.755
MOD_PIKK_1	685	691	PF00454	0.502
MOD_PK_1	205	211	PF00069	0.795
MOD_PKA_1	440	446	PF00069	0.806
MOD_PKA_1	54	60	PF00069	0.610
MOD_PKA_1	685	691	PF00069	0.502
MOD_PKA_2	212	218	PF00069	0.778
MOD_PKA_2	435	441	PF00069	0.788
MOD_PKA_2	475	481	PF00069	0.656
MOD_PKA_2	54	60	PF00069	0.743
MOD_PKA_2	558	564	PF00069	0.805
MOD_PKA_2	664	670	PF00069	0.505
MOD_PKA_2	99	105	PF00069	0.689
MOD_Plk_1	128	134	PF00069	0.543
MOD_Plk_1	144	150	PF00069	0.541
MOD_Plk_1	247	253	PF00069	0.486
MOD_Plk_1	341	347	PF00069	0.515
MOD_Plk_1	471	477	PF00069	0.534
MOD_Plk_4	101	107	PF00069	0.740
MOD_Plk_4	144	150	PF00069	0.723
MOD_Plk_4	523	529	PF00069	0.792
MOD_Plk_4	542	548	PF00069	0.478
MOD_Plk_4	580	586	PF00069	0.784
MOD_Plk_4	664	670	PF00069	0.505
MOD_ProDKin_1	1	7	PF00069	0.705
MOD_ProDKin_1	13	19	PF00069	0.710
MOD_ProDKin_1	130	136	PF00069	0.822
MOD_ProDKin_1	207	213	PF00069	0.639
MOD_ProDKin_1	27	33	PF00069	0.793
MOD_ProDKin_1	607	613	PF00069	0.479
MOD_ProDKin_1	88	94	PF00069	0.675
MOD_SUMO_for_1	669	672	PF00179	0.589
TRG_DiLeu_BaEn_1	144	149	PF01217	0.541
TRG_DiLeu_BaEn_3	663	669	PF01217	0.632
TRG_ENDOCYTIC_2	345	348	PF00928	0.357
TRG_ENDOCYTIC_2	497	500	PF00928	0.506
TRG_ENDOCYTIC_2	528	531	PF00928	0.522
TRG_ER_diArg_1	186	189	PF00400	0.656
TRG_ER_diArg_1	368	371	PF00400	0.773
TRG_ER_diArg_1	439	442	PF00400	0.802
TRG_ER_diArg_1	44	46	PF00400	0.756
TRG_ER_diArg_1	54	56	PF00400	0.569
TRG_ER_diArg_1	84	87	PF00400	0.633
TRG_NLS_MonoExtC_3	184	189	PF00514	0.522
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	627	631	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	685	689	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA3	Leptomonas seymouri	35%	95%
A0A3Q8IHZ5	Leishmania donovani	77%	98%
E9AHR0	Leishmania infantum	77%	98%
Q4Q3U5	Leishmania major	74%	100%