Putative GTPase protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTPase protein, putative

Species:

Leishmania mexicana

UniProt:

E9B479_LEIMU

TriTrypDb:

LmxM.32.2400

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B479

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B479

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	4
GO:0003924	GTPase activity	7	4
GO:0003925	G protein activity	2	4
GO:0016462	pyrophosphatase activity	5	4
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	4
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	4
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	4
GO:0098772	molecular function regulator activity	1	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.339
CLV_C14_Caspase3-7	466	470	PF00656	0.331
CLV_C14_Caspase3-7	555	559	PF00656	0.585
CLV_NRD_NRD_1	132	134	PF00675	0.444
CLV_NRD_NRD_1	178	180	PF00675	0.475
CLV_NRD_NRD_1	230	232	PF00675	0.459
CLV_NRD_NRD_1	286	288	PF00675	0.389
CLV_NRD_NRD_1	299	301	PF00675	0.420
CLV_NRD_NRD_1	323	325	PF00675	0.241
CLV_NRD_NRD_1	444	446	PF00675	0.383
CLV_NRD_NRD_1	53	55	PF00675	0.582
CLV_PCSK_KEX2_1	131	133	PF00082	0.464
CLV_PCSK_KEX2_1	178	180	PF00082	0.475
CLV_PCSK_KEX2_1	286	288	PF00082	0.389
CLV_PCSK_KEX2_1	323	325	PF00082	0.241
CLV_PCSK_KEX2_1	444	446	PF00082	0.380
CLV_PCSK_KEX2_1	53	55	PF00082	0.644
CLV_PCSK_KEX2_1	545	547	PF00082	0.630
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.241
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.685
CLV_PCSK_SKI1_1	133	137	PF00082	0.482
CLV_PCSK_SKI1_1	187	191	PF00082	0.462
CLV_PCSK_SKI1_1	247	251	PF00082	0.542
CLV_PCSK_SKI1_1	29	33	PF00082	0.534
CLV_PCSK_SKI1_1	461	465	PF00082	0.329
CLV_PCSK_SKI1_1	520	524	PF00082	0.463
DEG_Kelch_Keap1_1	294	299	PF01344	0.483
DOC_CYCLIN_yCln2_LP_2	378	384	PF00134	0.332
DOC_MAPK_DCC_7	413	422	PF00069	0.472
DOC_MAPK_gen_1	131	140	PF00069	0.469
DOC_MAPK_gen_1	21	30	PF00069	0.692
DOC_MAPK_gen_1	231	238	PF00069	0.305
DOC_MAPK_gen_1	300	307	PF00069	0.349
DOC_MAPK_gen_1	323	330	PF00069	0.410
DOC_MAPK_gen_1	53	61	PF00069	0.611
DOC_MAPK_HePTP_8	128	140	PF00069	0.563
DOC_MAPK_MEF2A_6	131	140	PF00069	0.565
DOC_MAPK_MEF2A_6	231	238	PF00069	0.302
DOC_MAPK_MEF2A_6	300	307	PF00069	0.349
DOC_MAPK_NFAT4_5	133	141	PF00069	0.566
DOC_MIT_MIM_1	210	219	PF04212	0.342
DOC_PP2B_LxvP_1	35	38	PF13499	0.613
DOC_PP2B_LxvP_1	59	62	PF13499	0.635
DOC_USP7_MATH_1	272	276	PF00917	0.518
DOC_USP7_MATH_1	494	498	PF00917	0.632
DOC_USP7_MATH_1	505	509	PF00917	0.639
DOC_USP7_MATH_1	70	74	PF00917	0.643
DOC_USP7_MATH_1	75	79	PF00917	0.592
DOC_USP7_UBL2_3	29	33	PF12436	0.533
DOC_USP7_UBL2_3	544	548	PF12436	0.661
DOC_USP7_UBL2_3	6	10	PF12436	0.555
DOC_WW_Pin1_4	101	106	PF00397	0.591
DOC_WW_Pin1_4	356	361	PF00397	0.423
LIG_14-3-3_CanoR_1	141	149	PF00244	0.512
LIG_14-3-3_CanoR_1	215	223	PF00244	0.368
LIG_14-3-3_CanoR_1	224	228	PF00244	0.384
LIG_14-3-3_CanoR_1	286	292	PF00244	0.475
LIG_14-3-3_CanoR_1	374	382	PF00244	0.399
LIG_14-3-3_CanoR_1	493	501	PF00244	0.636
LIG_14-3-3_CanoR_1	520	525	PF00244	0.463
LIG_14-3-3_CanoR_1	53	59	PF00244	0.550
LIG_14-3-3_CanoR_1	546	554	PF00244	0.584
LIG_Actin_WH2_2	28	43	PF00022	0.549
LIG_deltaCOP1_diTrp_1	251	257	PF00928	0.349
LIG_Dynein_DLC8_1	44	50	PF01221	0.534
LIG_EH_1	379	383	PF12763	0.397
LIG_FHA_1	135	141	PF00498	0.477
LIG_FHA_1	527	533	PF00498	0.362
LIG_FHA_1	53	59	PF00498	0.622
LIG_FHA_2	125	131	PF00498	0.585
LIG_FHA_2	215	221	PF00498	0.368
LIG_FHA_2	224	230	PF00498	0.396
LIG_FHA_2	339	345	PF00498	0.441
LIG_FHA_2	508	514	PF00498	0.648
LIG_LIR_Apic_2	148	152	PF02991	0.609
LIG_LIR_Apic_2	551	557	PF02991	0.585
LIG_LIR_Gen_1	191	196	PF02991	0.326
LIG_LIR_Nem_3	191	195	PF02991	0.354
LIG_LIR_Nem_3	251	256	PF02991	0.355
LIG_LIR_Nem_3	282	288	PF02991	0.346
LIG_LIR_Nem_3	489	495	PF02991	0.541
LIG_LRP6_Inhibitor_1	368	374	PF00058	0.305
LIG_LYPXL_yS_3	310	313	PF13949	0.410
LIG_PDZ_Class_3	561	566	PF00595	0.709
LIG_Pex14_1	253	257	PF04695	0.293
LIG_Pex14_2	188	192	PF04695	0.340
LIG_REV1ctd_RIR_1	186	194	PF16727	0.454
LIG_SH2_CRK	475	479	PF00017	0.326
LIG_SH2_CRK	492	496	PF00017	0.549
LIG_SH2_NCK_1	554	558	PF00017	0.714
LIG_SH2_SRC	554	557	PF00017	0.587
LIG_SH2_STAT3	256	259	PF00017	0.372
LIG_SH2_STAT5	256	259	PF00017	0.440
LIG_SH2_STAT5	280	283	PF00017	0.321
LIG_SH2_STAT5	475	478	PF00017	0.336
LIG_SH3_3	354	360	PF00018	0.410
LIG_SH3_3	378	384	PF00018	0.332
LIG_SH3_3	99	105	PF00018	0.426
LIG_SUMO_SIM_par_1	136	144	PF11976	0.572
LIG_TYR_ITIM	308	313	PF00017	0.244
LIG_UBA3_1	318	325	PF00899	0.287
LIG_WRC_WIRS_1	527	532	PF05994	0.350
MOD_CDC14_SPxK_1	104	107	PF00782	0.411
MOD_CDK_SPxK_1	101	107	PF00069	0.417
MOD_CK1_1	101	107	PF00069	0.417
MOD_CK1_1	294	300	PF00069	0.529
MOD_CK1_1	5	11	PF00069	0.679
MOD_CK1_1	57	63	PF00069	0.579
MOD_CK1_1	73	79	PF00069	0.653
MOD_CK2_1	214	220	PF00069	0.391
MOD_CK2_1	223	229	PF00069	0.451
MOD_CK2_1	338	344	PF00069	0.244
MOD_CK2_1	356	362	PF00069	0.244
MOD_CK2_1	507	513	PF00069	0.614
MOD_GlcNHglycan	116	119	PF01048	0.570
MOD_GlcNHglycan	293	296	PF01048	0.623
MOD_GlcNHglycan	362	366	PF01048	0.358
MOD_GlcNHglycan	414	417	PF01048	0.430
MOD_GlcNHglycan	497	500	PF01048	0.607
MOD_GlcNHglycan	501	504	PF01048	0.607
MOD_GlcNHglycan	515	518	PF01048	0.467
MOD_GlcNHglycan	7	10	PF01048	0.700
MOD_GlcNHglycan	77	80	PF01048	0.693
MOD_GSK3_1	272	279	PF00069	0.485
MOD_GSK3_1	287	294	PF00069	0.379
MOD_GSK3_1	334	341	PF00069	0.248
MOD_GSK3_1	495	502	PF00069	0.587
MOD_N-GLC_1	495	500	PF02516	0.531
MOD_NEK2_1	276	281	PF00069	0.367
MOD_NEK2_1	412	417	PF00069	0.447
MOD_NEK2_1	47	52	PF00069	0.492
MOD_PIKK_1	214	220	PF00454	0.344
MOD_PIKK_1	424	430	PF00454	0.358
MOD_PIKK_1	45	51	PF00454	0.605
MOD_PIKK_1	507	513	PF00454	0.514
MOD_PK_1	54	60	PF00069	0.573
MOD_PKA_2	140	146	PF00069	0.595
MOD_PKA_2	214	220	PF00069	0.355
MOD_PKA_2	223	229	PF00069	0.382
MOD_PKA_2	373	379	PF00069	0.411
MOD_PKA_2	390	396	PF00069	0.424
MOD_PKA_2	412	418	PF00069	0.497
MOD_PKA_2	446	452	PF00069	0.539
MOD_PKA_2	45	51	PF00069	0.595
MOD_PKA_2	52	58	PF00069	0.582
MOD_PKA_2	73	79	PF00069	0.692
MOD_Plk_1	124	130	PF00069	0.525
MOD_Plk_1	181	187	PF00069	0.402
MOD_Plk_4	276	282	PF00069	0.371
MOD_Plk_4	314	320	PF00069	0.274
MOD_Plk_4	54	60	PF00069	0.608
MOD_ProDKin_1	101	107	PF00069	0.590
MOD_ProDKin_1	356	362	PF00069	0.263
MOD_SUMO_rev_2	225	234	PF00179	0.381
MOD_SUMO_rev_2	294	303	PF00179	0.531
MOD_SUMO_rev_2	34	43	PF00179	0.483
TRG_DiLeu_BaEn_3	229	235	PF01217	0.481
TRG_DiLeu_BaLyEn_6	384	389	PF01217	0.307
TRG_ENDOCYTIC_2	310	313	PF00928	0.278
TRG_ENDOCYTIC_2	492	495	PF00928	0.543
TRG_ER_diArg_1	131	133	PF00400	0.579
TRG_ER_diArg_1	285	287	PF00400	0.387
TRG_ER_diArg_1	443	445	PF00400	0.386
TRG_NES_CRM1_1	525	538	PF08389	0.517
TRG_NLS_MonoExtC_3	543	548	PF00514	0.652
TRG_NLS_MonoExtN_4	544	549	PF00514	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X1	Leptomonas seymouri	76%	100%
A0A1X0P4K3	Trypanosomatidae	56%	100%
A0A3R7M8S7	Trypanosoma rangeli	53%	100%
A0A3S7X732	Leishmania donovani	95%	100%
A4HLV2	Leishmania braziliensis	85%	100%
D0A671	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AHQ8	Leishmania infantum	95%	100%
Q4Q3U7	Leishmania major	95%	100%
Q9SHS8	Arabidopsis thaliana	26%	100%
V5B8N5	Trypanosoma cruzi	58%	100%