Putative Golgi reassembly stacking protein (GRASP homologue)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Golgi reassembly stacking protein (GRASP homologue), putative

Species:

Leishmania mexicana

UniProt:

E9B477_LEIMU

TriTrypDb:

LmxM.32.2380

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	7
GO:0016020	membrane	2	6
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9B477

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B477

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.388
CLV_C14_Caspase3-7	244	248	PF00656	0.279
CLV_NRD_NRD_1	207	209	PF00675	0.312
CLV_NRD_NRD_1	540	542	PF00675	0.502
CLV_PCSK_KEX2_1	540	542	PF00082	0.684
CLV_PCSK_SKI1_1	203	207	PF00082	0.312
CLV_PCSK_SKI1_1	209	213	PF00082	0.312
CLV_PCSK_SKI1_1	75	79	PF00082	0.431
DOC_CYCLIN_yCln2_LP_2	309	315	PF00134	0.605
DOC_CYCLIN_yCln2_LP_2	528	534	PF00134	0.594
DOC_MAPK_DCC_7	216	224	PF00069	0.267
DOC_MAPK_MEF2A_6	216	224	PF00069	0.267
DOC_MAPK_MEF2A_6	523	530	PF00069	0.655
DOC_PP2B_LxvP_1	309	312	PF13499	0.525
DOC_PP2B_LxvP_1	503	506	PF13499	0.500
DOC_PP4_MxPP_1	524	527	PF00568	0.570
DOC_USP7_MATH_1	158	162	PF00917	0.291
DOC_USP7_MATH_1	21	25	PF00917	0.560
DOC_USP7_MATH_1	273	277	PF00917	0.526
DOC_USP7_MATH_1	278	282	PF00917	0.402
DOC_USP7_MATH_1	323	327	PF00917	0.554
DOC_USP7_MATH_1	364	368	PF00917	0.669
DOC_USP7_MATH_1	37	41	PF00917	0.440
DOC_USP7_MATH_1	392	396	PF00917	0.623
DOC_WW_Pin1_4	153	158	PF00397	0.312
DOC_WW_Pin1_4	23	28	PF00397	0.532
DOC_WW_Pin1_4	307	312	PF00397	0.588
DOC_WW_Pin1_4	313	318	PF00397	0.670
DOC_WW_Pin1_4	348	353	PF00397	0.594
DOC_WW_Pin1_4	427	432	PF00397	0.623
DOC_WW_Pin1_4	466	471	PF00397	0.587
DOC_WW_Pin1_4	478	483	PF00397	0.548
DOC_WW_Pin1_4	492	497	PF00397	0.611
DOC_WW_Pin1_4	53	58	PF00397	0.389
DOC_WW_Pin1_4	539	544	PF00397	0.550
LIG_14-3-3_CanoR_1	513	517	PF00244	0.533
LIG_APCC_ABBA_1	63	68	PF00400	0.325
LIG_BIR_III_2	140	144	PF00653	0.388
LIG_BRCT_BRCA1_1	429	433	PF00533	0.513
LIG_BRCT_BRCA1_1	99	103	PF00533	0.281
LIG_CSL_BTD_1	374	377	PF09270	0.510
LIG_deltaCOP1_diTrp_1	196	204	PF00928	0.352
LIG_EH_1	422	426	PF12763	0.707
LIG_EH1_1	46	54	PF00400	0.341
LIG_EVH1_1	388	392	PF00568	0.543
LIG_EVH1_1	503	507	PF00568	0.541
LIG_EVH1_2	526	530	PF00568	0.654
LIG_FHA_1	103	109	PF00498	0.485
LIG_FHA_1	254	260	PF00498	0.312
LIG_FHA_1	308	314	PF00498	0.805
LIG_FHA_1	467	473	PF00498	0.509
LIG_FHA_1	512	518	PF00498	0.532
LIG_FHA_2	110	116	PF00498	0.340
LIG_FHA_2	135	141	PF00498	0.331
LIG_FHA_2	174	180	PF00498	0.291
LIG_FHA_2	232	238	PF00498	0.313
LIG_FHA_2	242	248	PF00498	0.319
LIG_FHA_2	456	462	PF00498	0.515
LIG_FHA_2	69	75	PF00498	0.345
LIG_LIR_Apic_2	115	120	PF02991	0.312
LIG_LIR_Apic_2	367	371	PF02991	0.642
LIG_LIR_Apic_2	498	502	PF02991	0.639
LIG_LIR_Gen_1	100	109	PF02991	0.205
LIG_LIR_Gen_1	190	196	PF02991	0.312
LIG_LIR_Gen_1	281	291	PF02991	0.455
LIG_LIR_Gen_1	430	441	PF02991	0.703
LIG_LIR_Gen_1	45	55	PF02991	0.330
LIG_LIR_Nem_3	100	106	PF02991	0.280
LIG_LIR_Nem_3	110	116	PF02991	0.331
LIG_LIR_Nem_3	190	195	PF02991	0.312
LIG_LIR_Nem_3	281	286	PF02991	0.406
LIG_LIR_Nem_3	430	436	PF02991	0.668
LIG_LIR_Nem_3	45	50	PF02991	0.315
LIG_LIR_Nem_3	465	471	PF02991	0.642
LIG_LIR_Nem_3	87	92	PF02991	0.422
LIG_PCNA_yPIPBox_3	178	189	PF02747	0.312
LIG_PDZ_Class_1	539	544	PF00595	0.502
LIG_REV1ctd_RIR_1	86	94	PF16727	0.452
LIG_SH2_CRK	117	121	PF00017	0.312
LIG_SH2_CRK	468	472	PF00017	0.508
LIG_SH2_SRC	170	173	PF00017	0.291
LIG_SH2_STAP1	109	113	PF00017	0.340
LIG_SH2_STAP1	464	468	PF00017	0.647
LIG_SH2_STAT5	117	120	PF00017	0.347
LIG_SH2_STAT5	170	173	PF00017	0.312
LIG_SH2_STAT5	468	471	PF00017	0.507
LIG_SH2_STAT5	92	95	PF00017	0.352
LIG_SH3_1	368	374	PF00018	0.591
LIG_SH3_1	499	505	PF00018	0.627
LIG_SH3_1	51	57	PF00018	0.358
LIG_SH3_3	214	220	PF00018	0.312
LIG_SH3_3	331	337	PF00018	0.626
LIG_SH3_3	357	363	PF00018	0.682
LIG_SH3_3	368	374	PF00018	0.564
LIG_SH3_3	386	392	PF00018	0.595
LIG_SH3_3	395	401	PF00018	0.695
LIG_SH3_3	418	424	PF00018	0.623
LIG_SH3_3	499	505	PF00018	0.712
LIG_SH3_3	51	57	PF00018	0.394
LIG_SH3_3	528	534	PF00018	0.594
LIG_SUMO_SIM_anti_2	179	187	PF11976	0.340
LIG_SUMO_SIM_par_1	148	154	PF11976	0.312
LIG_TRAF2_1	176	179	PF00917	0.291
LIG_TRAF2_1	234	237	PF00917	0.340
LIG_TRAF2_1	338	341	PF00917	0.579
LIG_UBA3_1	181	189	PF00899	0.350
LIG_UBA3_1	69	75	PF00899	0.312
LIG_WRC_WIRS_1	103	108	PF05994	0.340
LIG_WRC_WIRS_1	393	398	PF05994	0.648
LIG_WRC_WIRS_1	516	521	PF05994	0.624
LIG_WW_1	496	499	PF00397	0.526
LIG_WW_3	400	404	PF00397	0.652
MOD_CDK_SPK_2	313	318	PF00069	0.539
MOD_CDK_SPxxK_3	53	60	PF00069	0.364
MOD_CK1_1	253	259	PF00069	0.312
MOD_CK1_1	26	32	PF00069	0.597
MOD_CK1_1	264	270	PF00069	0.518
MOD_CK1_1	326	332	PF00069	0.611
MOD_CK1_1	463	469	PF00069	0.541
MOD_CK1_1	481	487	PF00069	0.606
MOD_CK1_1	495	501	PF00069	0.627
MOD_CK2_1	173	179	PF00069	0.294
MOD_CK2_1	190	196	PF00069	0.385
MOD_CK2_1	231	237	PF00069	0.313
MOD_CK2_1	335	341	PF00069	0.585
MOD_CK2_1	455	461	PF00069	0.519
MOD_CK2_1	495	501	PF00069	0.527
MOD_GlcNHglycan	267	270	PF01048	0.550
MOD_GlcNHglycan	30	33	PF01048	0.543
MOD_GlcNHglycan	478	481	PF01048	0.661
MOD_GSK3_1	130	137	PF00069	0.300
MOD_GSK3_1	173	180	PF00069	0.340
MOD_GSK3_1	227	234	PF00069	0.312
MOD_GSK3_1	261	268	PF00069	0.621
MOD_GSK3_1	278	285	PF00069	0.383
MOD_GSK3_1	323	330	PF00069	0.667
MOD_GSK3_1	456	463	PF00069	0.650
MOD_GSK3_1	466	473	PF00069	0.566
MOD_GSK3_1	511	518	PF00069	0.601
MOD_GSK3_1	84	91	PF00069	0.458
MOD_GSK3_1	97	104	PF00069	0.307
MOD_N-GLC_1	486	491	PF02516	0.712
MOD_NEK2_1	184	189	PF00069	0.340
MOD_NEK2_1	35	40	PF00069	0.412
MOD_NEK2_1	460	465	PF00069	0.509
MOD_NEK2_1	486	491	PF00069	0.640
MOD_NEK2_1	511	516	PF00069	0.659
MOD_NEK2_1	517	522	PF00069	0.573
MOD_NEK2_1	88	93	PF00069	0.416
MOD_NEK2_2	84	89	PF00069	0.402
MOD_NMyristoyl	1	7	PF02799	0.622
MOD_PIKK_1	184	190	PF00454	0.340
MOD_PIKK_1	327	333	PF00454	0.569
MOD_PIKK_1	336	342	PF00454	0.523
MOD_PIKK_1	481	487	PF00454	0.533
MOD_PIKK_1	518	524	PF00454	0.638
MOD_PK_1	282	288	PF00069	0.545
MOD_PK_1	97	103	PF00069	0.289
MOD_PKA_2	512	518	PF00069	0.532
MOD_Plk_1	21	27	PF00069	0.656
MOD_Plk_1	305	311	PF00069	0.669
MOD_Plk_1	460	466	PF00069	0.583
MOD_Plk_1	97	103	PF00069	0.251
MOD_Plk_2-3	231	237	PF00069	0.312
MOD_Plk_4	177	183	PF00069	0.350
MOD_Plk_4	286	292	PF00069	0.504
MOD_Plk_4	512	518	PF00069	0.539
MOD_Plk_4	84	90	PF00069	0.395
MOD_ProDKin_1	153	159	PF00069	0.312
MOD_ProDKin_1	23	29	PF00069	0.531
MOD_ProDKin_1	307	313	PF00069	0.591
MOD_ProDKin_1	348	354	PF00069	0.594
MOD_ProDKin_1	427	433	PF00069	0.622
MOD_ProDKin_1	466	472	PF00069	0.587
MOD_ProDKin_1	478	484	PF00069	0.551
MOD_ProDKin_1	492	498	PF00069	0.611
MOD_ProDKin_1	53	59	PF00069	0.389
MOD_SUMO_rev_2	201	211	PF00179	0.340
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.508
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.340
TRG_ENDOCYTIC_2	113	116	PF00928	0.312
TRG_ENDOCYTIC_2	192	195	PF00928	0.312
TRG_ENDOCYTIC_2	468	471	PF00928	0.640
TRG_ER_diArg_1	292	295	PF00400	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILQ2	Leptomonas seymouri	56%	91%
A0A3Q8IU65	Leishmania donovani	84%	100%
A4HLV0	Leishmania braziliensis	66%	100%
E9AHQ6	Leishmania infantum	84%	100%
Q4Q3U9	Leishmania major	82%	99%