Nucleoporin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Nucleoporin

Gene product:

Nucleoporin NUP59

Species:

Leishmania mexicana

UniProt:

E9B476_LEIMU

TriTrypDb:

LmxM.32.2370

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B476

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B476

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.433
CLV_NRD_NRD_1	191	193	PF00675	0.466
CLV_NRD_NRD_1	364	366	PF00675	0.595
CLV_NRD_NRD_1	399	401	PF00675	0.552
CLV_NRD_NRD_1	409	411	PF00675	0.513
CLV_NRD_NRD_1	505	507	PF00675	0.557
CLV_NRD_NRD_1	90	92	PF00675	0.564
CLV_PCSK_KEX2_1	173	175	PF00082	0.406
CLV_PCSK_KEX2_1	190	192	PF00082	0.405
CLV_PCSK_KEX2_1	21	23	PF00082	0.648
CLV_PCSK_KEX2_1	29	31	PF00082	0.607
CLV_PCSK_KEX2_1	363	365	PF00082	0.505
CLV_PCSK_KEX2_1	409	411	PF00082	0.422
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.484
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.613
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.554
CLV_PCSK_SKI1_1	174	178	PF00082	0.448
CLV_PCSK_SKI1_1	29	33	PF00082	0.519
CLV_PCSK_SKI1_1	349	353	PF00082	0.712
CLV_PCSK_SKI1_1	364	368	PF00082	0.438
CLV_PCSK_SKI1_1	390	394	PF00082	0.611
CLV_PCSK_SKI1_1	409	413	PF00082	0.412
CLV_PCSK_SKI1_1	515	519	PF00082	0.531
CLV_PCSK_SKI1_1	91	95	PF00082	0.464
DEG_APCC_DBOX_1	362	370	PF00400	0.577
DEG_APCC_DBOX_1	409	417	PF00400	0.500
DEG_SPOP_SBC_1	217	221	PF00917	0.623
DEG_SPOP_SBC_1	229	233	PF00917	0.613
DOC_CYCLIN_RxL_1	158	169	PF00134	0.617
DOC_CYCLIN_yCln2_LP_2	208	214	PF00134	0.601
DOC_MAPK_gen_1	349	358	PF00069	0.446
DOC_PIKK_1	57	65	PF02985	0.473
DOC_PP1_RVXF_1	144	150	PF00149	0.603
DOC_PP1_RVXF_1	513	520	PF00149	0.649
DOC_PP4_FxxP_1	215	218	PF00568	0.502
DOC_PP4_FxxP_1	75	78	PF00568	0.660
DOC_USP7_MATH_1	178	182	PF00917	0.552
DOC_USP7_MATH_1	197	201	PF00917	0.585
DOC_USP7_MATH_1	218	222	PF00917	0.628
DOC_USP7_MATH_1	246	250	PF00917	0.652
DOC_USP7_MATH_1	257	261	PF00917	0.670
DOC_USP7_MATH_1	272	276	PF00917	0.662
DOC_USP7_MATH_1	279	283	PF00917	0.755
DOC_USP7_MATH_1	284	288	PF00917	0.762
DOC_USP7_MATH_1	340	344	PF00917	0.707
DOC_USP7_MATH_1	440	444	PF00917	0.554
DOC_USP7_MATH_1	457	461	PF00917	0.290
DOC_USP7_MATH_1	498	502	PF00917	0.491
DOC_USP7_MATH_1	509	513	PF00917	0.557
DOC_USP7_UBL2_3	29	33	PF12436	0.611
DOC_USP7_UBL2_3	507	511	PF12436	0.494
DOC_USP7_UBL2_3	518	522	PF12436	0.666
DOC_WW_Pin1_4	207	212	PF00397	0.710
DOC_WW_Pin1_4	232	237	PF00397	0.642
DOC_WW_Pin1_4	240	245	PF00397	0.576
DOC_WW_Pin1_4	259	264	PF00397	0.665
DOC_WW_Pin1_4	303	308	PF00397	0.652
DOC_WW_Pin1_4	312	317	PF00397	0.658
DOC_WW_Pin1_4	98	103	PF00397	0.437
LIG_14-3-3_CanoR_1	191	199	PF00244	0.445
LIG_14-3-3_CanoR_1	349	358	PF00244	0.643
LIG_14-3-3_CanoR_1	363	373	PF00244	0.505
LIG_14-3-3_CanoR_1	73	78	PF00244	0.522
LIG_14-3-3_CanoR_1	97	102	PF00244	0.524
LIG_BRCT_BRCA1_1	209	213	PF00533	0.642
LIG_BRCT_BRCA1_1	248	252	PF00533	0.628
LIG_BRCT_BRCA1_1	291	295	PF00533	0.566
LIG_BRCT_BRCA1_1	308	312	PF00533	0.658
LIG_BRCT_BRCA1_1	459	463	PF00533	0.390
LIG_deltaCOP1_diTrp_1	428	437	PF00928	0.511
LIG_deltaCOP1_diTrp_1	86	90	PF00928	0.572
LIG_EH_1	555	559	PF12763	0.545
LIG_FHA_1	316	322	PF00498	0.566
LIG_FHA_1	351	357	PF00498	0.587
LIG_FHA_1	387	393	PF00498	0.510
LIG_FHA_1	66	72	PF00498	0.581
LIG_LIR_Apic_2	74	78	PF02991	0.653
LIG_LIR_Gen_1	460	471	PF02991	0.377
LIG_LIR_Gen_1	86	94	PF02991	0.485
LIG_LIR_Nem_3	169	175	PF02991	0.430
LIG_LIR_Nem_3	460	466	PF02991	0.406
LIG_LIR_Nem_3	512	517	PF02991	0.515
LIG_LIR_Nem_3	86	90	PF02991	0.483
LIG_OCRL_FandH_1	462	474	PF00620	0.474
LIG_PALB2_WD40_1	100	108	PF16756	0.445
LIG_PCNA_yPIPBox_3	33	45	PF02747	0.575
LIG_Pex14_2	265	269	PF04695	0.662
LIG_Pex14_2	293	297	PF04695	0.562
LIG_PTB_Apo_2	411	418	PF02174	0.354
LIG_PTB_Apo_2	465	472	PF02174	0.346
LIG_PTB_Phospho_1	465	471	PF10480	0.342
LIG_SH2_NCK_1	151	155	PF00017	0.635
LIG_SH2_SRC	128	131	PF00017	0.599
LIG_SH2_STAP1	471	475	PF00017	0.483
LIG_SH2_STAT5	128	131	PF00017	0.556
LIG_SH2_STAT5	143	146	PF00017	0.369
LIG_SH3_3	144	150	PF00018	0.603
LIG_SH3_3	298	304	PF00018	0.687
LIG_SH3_3	325	331	PF00018	0.679
LIG_SH3_3	543	549	PF00018	0.600
LIG_SUMO_SIM_par_1	480	487	PF11976	0.458
LIG_TRAF2_1	36	39	PF00917	0.585
LIG_UBA3_1	412	419	PF00899	0.399
LIG_UBA3_1	499	507	PF00899	0.500
LIG_WRPW_2	528	531	PF00400	0.555
LIG_WW_2	328	331	PF00397	0.617
MOD_CDK_SPK_2	98	103	PF00069	0.437
MOD_CK1_1	14	20	PF00069	0.580
MOD_CK1_1	220	226	PF00069	0.589
MOD_CK1_1	282	288	PF00069	0.676
MOD_CK1_1	3	9	PF00069	0.573
MOD_CK1_1	306	312	PF00069	0.629
MOD_CK1_1	315	321	PF00069	0.729
MOD_CK1_1	323	329	PF00069	0.762
MOD_CK1_1	535	541	PF00069	0.539
MOD_CK2_1	149	155	PF00069	0.494
MOD_CK2_1	272	278	PF00069	0.617
MOD_GlcNHglycan	17	20	PF01048	0.533
MOD_GlcNHglycan	195	198	PF01048	0.599
MOD_GlcNHglycan	199	202	PF01048	0.615
MOD_GlcNHglycan	220	223	PF01048	0.675
MOD_GlcNHglycan	244	247	PF01048	0.718
MOD_GlcNHglycan	248	251	PF01048	0.723
MOD_GlcNHglycan	259	262	PF01048	0.713
MOD_GlcNHglycan	278	282	PF01048	0.706
MOD_GlcNHglycan	284	287	PF01048	0.721
MOD_GlcNHglycan	322	325	PF01048	0.584
MOD_GlcNHglycan	341	345	PF01048	0.714
MOD_GlcNHglycan	374	377	PF01048	0.437
MOD_GlcNHglycan	442	445	PF01048	0.490
MOD_GlcNHglycan	510	514	PF01048	0.537
MOD_GlcNHglycan	534	537	PF01048	0.559
MOD_GlcNHglycan	6	9	PF01048	0.537
MOD_GSK3_1	11	18	PF00069	0.696
MOD_GSK3_1	193	200	PF00069	0.697
MOD_GSK3_1	216	223	PF00069	0.569
MOD_GSK3_1	228	235	PF00069	0.583
MOD_GSK3_1	242	249	PF00069	0.649
MOD_GSK3_1	251	258	PF00069	0.733
MOD_GSK3_1	284	291	PF00069	0.692
MOD_GSK3_1	73	80	PF00069	0.517
MOD_GSK3_1	93	100	PF00069	0.632
MOD_N-GLC_1	288	293	PF02516	0.613
MOD_N-GLC_1	457	462	PF02516	0.281
MOD_N-GLC_2	432	434	PF02516	0.462
MOD_NEK2_1	1	6	PF00069	0.497
MOD_NEK2_1	293	298	PF00069	0.599
MOD_NEK2_1	386	391	PF00069	0.573
MOD_NEK2_1	462	467	PF00069	0.415
MOD_NEK2_1	540	545	PF00069	0.476
MOD_NEK2_1	65	70	PF00069	0.472
MOD_PIKK_1	131	137	PF00454	0.468
MOD_PIKK_1	270	276	PF00454	0.466
MOD_PIKK_1	315	321	PF00454	0.699
MOD_PIKK_1	498	504	PF00454	0.570
MOD_PIKK_1	73	79	PF00454	0.612
MOD_PKA_1	11	17	PF00069	0.619
MOD_PKA_1	191	197	PF00069	0.443
MOD_PKA_1	364	370	PF00069	0.498
MOD_PKA_2	191	197	PF00069	0.514
MOD_PKA_2	364	370	PF00069	0.498
MOD_PKA_2	484	490	PF00069	0.548
MOD_Plk_2-3	121	127	PF00069	0.522
MOD_Plk_4	426	432	PF00069	0.501
MOD_ProDKin_1	207	213	PF00069	0.713
MOD_ProDKin_1	232	238	PF00069	0.646
MOD_ProDKin_1	240	246	PF00069	0.574
MOD_ProDKin_1	259	265	PF00069	0.667
MOD_ProDKin_1	303	309	PF00069	0.653
MOD_ProDKin_1	312	318	PF00069	0.661
MOD_ProDKin_1	98	104	PF00069	0.433
MOD_SUMO_rev_2	422	427	PF00179	0.369
MOD_SUMO_rev_2	501	509	PF00179	0.498
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.468
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.586
TRG_DiLeu_BaLyEn_6	512	517	PF01217	0.502
TRG_ENDOCYTIC_2	471	474	PF00928	0.411
TRG_ER_diArg_1	172	174	PF00400	0.444
TRG_ER_diArg_1	363	365	PF00400	0.612
TRG_ER_diArg_1	408	410	PF00400	0.485
TRG_ER_FFAT_2	249	258	PF00635	0.479
TRG_NLS_Bipartite_1	173	194	PF00514	0.451
TRG_NLS_MonoCore_2	189	194	PF00514	0.347
TRG_Pf-PMV_PEXEL_1	161	166	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8T0	Leptomonas seymouri	66%	100%
A0A0S4J4Z2	Bodo saltans	40%	100%
A0A1X0P580	Trypanosomatidae	47%	100%
A0A3R7NSX9	Trypanosoma rangeli	51%	100%
A0A3S7X6X9	Leishmania donovani	91%	100%
A4HHX8	Leishmania braziliensis	78%	100%
D0A676	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AHQ5	Leishmania infantum	91%	100%
Q4Q3V0	Leishmania major	91%	100%
V5BYJ7	Trypanosoma cruzi	46%	100%