TBC1 domain family member 23

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab-GTPase-TBC domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B474_LEIMU

TriTrypDb:

LmxM.32.2350

Length:

860

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	12
GO:0005829	cytosol	2	16
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	16
GO:0005802	trans-Golgi network	4	2
GO:0031984	organelle subcompartment	2	2
GO:0098791	Golgi apparatus subcompartment	3	2

Expansion

Sequence features

E9B474

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B474

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0009987	cellular process	1	16
GO:0016192	vesicle-mediated transport	4	16
GO:0016197	endosomal transport	4	16
GO:0016482	cytosolic transport	4	16
GO:0042147	retrograde transport, endosome to Golgi	5	16
GO:0046907	intracellular transport	3	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16
GO:0051641	cellular localization	2	16
GO:0051649	establishment of localization in cell	3	16
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0099022	vesicle tethering	4	2
GO:0099041	vesicle tethering to Golgi	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.584
CLV_C14_Caspase3-7	81	85	PF00656	0.460
CLV_NRD_NRD_1	283	285	PF00675	0.327
CLV_NRD_NRD_1	323	325	PF00675	0.420
CLV_NRD_NRD_1	490	492	PF00675	0.515
CLV_NRD_NRD_1	777	779	PF00675	0.680
CLV_PCSK_KEX2_1	151	153	PF00082	0.405
CLV_PCSK_KEX2_1	283	285	PF00082	0.327
CLV_PCSK_KEX2_1	323	325	PF00082	0.420
CLV_PCSK_KEX2_1	435	437	PF00082	0.633
CLV_PCSK_KEX2_1	490	492	PF00082	0.519
CLV_PCSK_KEX2_1	569	571	PF00082	0.567
CLV_PCSK_KEX2_1	634	636	PF00082	0.640
CLV_PCSK_KEX2_1	777	779	PF00082	0.682
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.405
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.633
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.567
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.640
CLV_PCSK_SKI1_1	151	155	PF00082	0.607
CLV_PCSK_SKI1_1	217	221	PF00082	0.480
CLV_PCSK_SKI1_1	253	257	PF00082	0.352
CLV_PCSK_SKI1_1	283	287	PF00082	0.315
CLV_PCSK_SKI1_1	332	336	PF00082	0.522
CLV_PCSK_SKI1_1	373	377	PF00082	0.496
CLV_PCSK_SKI1_1	526	530	PF00082	0.457
CLV_PCSK_SKI1_1	73	77	PF00082	0.324
CLV_PCSK_SKI1_1	778	782	PF00082	0.644
DEG_APCC_DBOX_1	118	126	PF00400	0.487
DEG_APCC_DBOX_1	322	330	PF00400	0.387
DEG_Nend_UBRbox_2	1	3	PF02207	0.633
DEG_SCF_FBW7_1	25	30	PF00400	0.561
DEG_SCF_FBW7_1	366	371	PF00400	0.321
DEG_SCF_FBW7_1	385	390	PF00400	0.412
DEG_SIAH_1	766	774	PF03145	0.494
DEG_SPOP_SBC_1	246	250	PF00917	0.479
DEG_SPOP_SBC_1	802	806	PF00917	0.731
DOC_CYCLIN_RxL_1	321	331	PF00134	0.356
DOC_CYCLIN_yCln2_LP_2	305	311	PF00134	0.437
DOC_CYCLIN_yCln2_LP_2	760	766	PF00134	0.564
DOC_MAPK_gen_1	323	329	PF00069	0.416
DOC_MAPK_MEF2A_6	526	534	PF00069	0.478
DOC_MAPK_RevD_3	309	324	PF00069	0.341
DOC_PP1_RVXF_1	295	302	PF00149	0.437
DOC_PP1_RVXF_1	390	397	PF00149	0.477
DOC_PP2B_LxvP_1	344	347	PF13499	0.299
DOC_PP2B_LxvP_1	760	763	PF13499	0.561
DOC_PP2B_LxvP_1	780	783	PF13499	0.684
DOC_PP4_FxxP_1	258	261	PF00568	0.437
DOC_USP7_MATH_1	247	251	PF00917	0.406
DOC_USP7_MATH_1	28	32	PF00917	0.766
DOC_USP7_MATH_1	50	54	PF00917	0.840
DOC_USP7_MATH_1	618	622	PF00917	0.568
DOC_USP7_MATH_1	624	628	PF00917	0.587
DOC_USP7_MATH_1	650	654	PF00917	0.643
DOC_USP7_MATH_1	793	797	PF00917	0.714
DOC_USP7_MATH_1	803	807	PF00917	0.780
DOC_USP7_MATH_1	843	847	PF00917	0.643
DOC_WW_Pin1_4	23	28	PF00397	0.625
DOC_WW_Pin1_4	364	369	PF00397	0.620
DOC_WW_Pin1_4	383	388	PF00397	0.319
DOC_WW_Pin1_4	405	410	PF00397	0.412
DOC_WW_Pin1_4	416	421	PF00397	0.424
DOC_WW_Pin1_4	553	558	PF00397	0.528
DOC_WW_Pin1_4	57	62	PF00397	0.790
DOC_WW_Pin1_4	783	788	PF00397	0.774
DOC_WW_Pin1_4	798	803	PF00397	0.654
DOC_WW_Pin1_4	838	843	PF00397	0.609
LIG_14-3-3_CanoR_1	213	221	PF00244	0.417
LIG_14-3-3_CanoR_1	323	327	PF00244	0.443
LIG_14-3-3_CanoR_1	362	366	PF00244	0.493
LIG_14-3-3_CanoR_1	570	576	PF00244	0.507
LIG_14-3-3_CanoR_1	777	783	PF00244	0.641
LIG_14-3-3_CanoR_1	816	823	PF00244	0.674
LIG_Actin_WH2_2	728	746	PF00022	0.573
LIG_Clathr_ClatBox_1	125	129	PF01394	0.469
LIG_deltaCOP1_diTrp_1	300	303	PF00928	0.412
LIG_FHA_1	169	175	PF00498	0.462
LIG_FHA_1	204	210	PF00498	0.428
LIG_FHA_1	24	30	PF00498	0.529
LIG_FHA_1	246	252	PF00498	0.378
LIG_FHA_1	274	280	PF00498	0.329
LIG_FHA_1	334	340	PF00498	0.374
LIG_FHA_1	417	423	PF00498	0.556
LIG_FHA_1	540	546	PF00498	0.433
LIG_FHA_1	558	564	PF00498	0.405
LIG_FHA_1	65	71	PF00498	0.619
LIG_FHA_1	653	659	PF00498	0.619
LIG_FHA_1	663	669	PF00498	0.787
LIG_FHA_1	802	808	PF00498	0.600
LIG_FHA_2	173	179	PF00498	0.499
LIG_FHA_2	263	269	PF00498	0.437
LIG_FHA_2	406	412	PF00498	0.513
LIG_LIR_Gen_1	300	309	PF02991	0.308
LIG_LIR_Gen_1	449	456	PF02991	0.399
LIG_LIR_Gen_1	461	471	PF02991	0.410
LIG_LIR_Gen_1	828	838	PF02991	0.543
LIG_LIR_Nem_3	144	149	PF02991	0.551
LIG_LIR_Nem_3	223	228	PF02991	0.357
LIG_LIR_Nem_3	300	304	PF02991	0.308
LIG_LIR_Nem_3	395	399	PF02991	0.419
LIG_LIR_Nem_3	449	455	PF02991	0.407
LIG_LIR_Nem_3	461	466	PF02991	0.413
LIG_LIR_Nem_3	828	834	PF02991	0.537
LIG_MYND_1	783	787	PF01753	0.497
LIG_NRBOX	121	127	PF00104	0.520
LIG_PCNA_PIPBox_1	271	280	PF02747	0.437
LIG_PCNA_yPIPBox_3	213	225	PF02747	0.487
LIG_PCNA_yPIPBox_3	271	284	PF02747	0.437
LIG_Pex14_2	831	835	PF04695	0.545
LIG_SH2_CRK	123	127	PF00017	0.350
LIG_SH2_CRK	225	229	PF00017	0.418
LIG_SH2_GRB2like	193	196	PF00017	0.497
LIG_SH2_NCK_1	244	248	PF00017	0.475
LIG_SH2_PTP2	452	455	PF00017	0.325
LIG_SH2_PTP2	465	468	PF00017	0.405
LIG_SH2_SRC	244	247	PF00017	0.481
LIG_SH2_SRC	452	455	PF00017	0.483
LIG_SH2_STAP1	149	153	PF00017	0.569
LIG_SH2_STAP1	292	296	PF00017	0.434
LIG_SH2_STAT3	259	262	PF00017	0.406
LIG_SH2_STAT3	598	601	PF00017	0.642
LIG_SH2_STAT5	123	126	PF00017	0.380
LIG_SH2_STAT5	149	152	PF00017	0.531
LIG_SH2_STAT5	193	196	PF00017	0.501
LIG_SH2_STAT5	207	210	PF00017	0.366
LIG_SH2_STAT5	277	280	PF00017	0.387
LIG_SH2_STAT5	313	316	PF00017	0.315
LIG_SH2_STAT5	318	321	PF00017	0.306
LIG_SH2_STAT5	452	455	PF00017	0.354
LIG_SH2_STAT5	465	468	PF00017	0.368
LIG_SH2_STAT5	522	525	PF00017	0.428
LIG_SH2_STAT5	598	601	PF00017	0.642
LIG_SH3_2	739	744	PF14604	0.580
LIG_SH3_3	22	28	PF00018	0.647
LIG_SH3_3	306	312	PF00018	0.338
LIG_SH3_3	417	423	PF00018	0.493
LIG_SH3_3	463	469	PF00018	0.458
LIG_SH3_3	58	64	PF00018	0.619
LIG_SH3_3	702	708	PF00018	0.635
LIG_SH3_3	736	742	PF00018	0.659
LIG_SH3_3	745	751	PF00018	0.703
LIG_SH3_3	769	775	PF00018	0.761
LIG_SH3_3	796	802	PF00018	0.758
LIG_SUMO_SIM_anti_2	325	331	PF11976	0.422
LIG_SUMO_SIM_anti_2	728	737	PF11976	0.583
LIG_SUMO_SIM_par_1	124	133	PF11976	0.542
LIG_SUMO_SIM_par_1	284	291	PF11976	0.377
LIG_SUMO_SIM_par_1	752	757	PF11976	0.540
LIG_SUMO_SIM_par_1	78	87	PF11976	0.415
LIG_SxIP_EBH_1	536	549	PF03271	0.455
LIG_TRAF2_1	141	144	PF00917	0.715
LIG_TRAF2_1	408	411	PF00917	0.385
LIG_UBA3_1	227	233	PF00899	0.403
LIG_UBA3_1	326	332	PF00899	0.453
MOD_CK1_1	212	218	PF00069	0.484
MOD_CK1_1	238	244	PF00069	0.410
MOD_CK1_1	371	377	PF00069	0.359
MOD_CK1_1	4	10	PF00069	0.599
MOD_CK1_1	431	437	PF00069	0.397
MOD_CK1_1	459	465	PF00069	0.448
MOD_CK1_1	60	66	PF00069	0.716
MOD_CK1_1	641	647	PF00069	0.581
MOD_CK1_1	652	658	PF00069	0.652
MOD_CK1_1	666	672	PF00069	0.677
MOD_CK1_1	682	688	PF00069	0.762
MOD_CK1_1	691	697	PF00069	0.687
MOD_CK1_1	801	807	PF00069	0.630
MOD_CK1_1	96	102	PF00069	0.555
MOD_CK2_1	172	178	PF00069	0.469
MOD_CK2_1	28	34	PF00069	0.652
MOD_CK2_1	405	411	PF00069	0.515
MOD_CK2_1	636	642	PF00069	0.585
MOD_CK2_1	672	678	PF00069	0.601
MOD_CK2_1	719	725	PF00069	0.715
MOD_CK2_1	849	855	PF00069	0.675
MOD_Cter_Amidation	567	570	PF01082	0.481
MOD_GlcNHglycan	136	139	PF01048	0.662
MOD_GlcNHglycan	237	240	PF01048	0.352
MOD_GlcNHglycan	370	373	PF01048	0.382
MOD_GlcNHglycan	430	433	PF01048	0.607
MOD_GlcNHglycan	588	591	PF01048	0.679
MOD_GlcNHglycan	594	598	PF01048	0.716
MOD_GlcNHglycan	665	668	PF01048	0.709
MOD_GlcNHglycan	670	673	PF01048	0.656
MOD_GlcNHglycan	682	685	PF01048	0.702
MOD_GlcNHglycan	687	690	PF01048	0.668
MOD_GlcNHglycan	695	698	PF01048	0.688
MOD_GlcNHglycan	760	763	PF01048	0.690
MOD_GlcNHglycan	818	821	PF01048	0.665
MOD_GlcNHglycan	850	854	PF01048	0.699
MOD_GSK3_1	108	115	PF00069	0.356
MOD_GSK3_1	168	175	PF00069	0.511
MOD_GSK3_1	23	30	PF00069	0.660
MOD_GSK3_1	287	294	PF00069	0.439
MOD_GSK3_1	318	325	PF00069	0.463
MOD_GSK3_1	36	43	PF00069	0.799
MOD_GSK3_1	364	371	PF00069	0.582
MOD_GSK3_1	383	390	PF00069	0.354
MOD_GSK3_1	424	431	PF00069	0.481
MOD_GSK3_1	553	560	PF00069	0.323
MOD_GSK3_1	60	67	PF00069	0.746
MOD_GSK3_1	636	643	PF00069	0.594
MOD_GSK3_1	646	653	PF00069	0.562
MOD_GSK3_1	662	669	PF00069	0.722
MOD_GSK3_1	672	679	PF00069	0.654
MOD_GSK3_1	688	695	PF00069	0.738
MOD_GSK3_1	78	85	PF00069	0.528
MOD_GSK3_1	783	790	PF00069	0.761
MOD_GSK3_1	798	805	PF00069	0.670
MOD_GSK3_1	92	99	PF00069	0.547
MOD_N-GLC_1	405	410	PF02516	0.512
MOD_NEK2_1	134	139	PF00069	0.441
MOD_NEK2_1	203	208	PF00069	0.456
MOD_NEK2_1	220	225	PF00069	0.467
MOD_NEK2_1	235	240	PF00069	0.337
MOD_NEK2_1	279	284	PF00069	0.437
MOD_NEK2_1	327	332	PF00069	0.549
MOD_NEK2_1	342	347	PF00069	0.372
MOD_NEK2_1	502	507	PF00069	0.500
MOD_NEK2_1	539	544	PF00069	0.480
MOD_NEK2_1	663	668	PF00069	0.713
MOD_NEK2_1	734	739	PF00069	0.570
MOD_NEK2_1	743	748	PF00069	0.595
MOD_NEK2_1	758	763	PF00069	0.662
MOD_NEK2_2	93	98	PF00069	0.591
MOD_PIKK_1	333	339	PF00454	0.489
MOD_PIKK_1	387	393	PF00454	0.450
MOD_PIKK_1	711	717	PF00454	0.681
MOD_PKA_2	212	218	PF00069	0.429
MOD_PKA_2	322	328	PF00069	0.406
MOD_PKA_2	361	367	PF00069	0.598
MOD_PKA_2	459	465	PF00069	0.414
MOD_PKA_2	636	642	PF00069	0.578
MOD_PKA_2	711	717	PF00069	0.681
MOD_PKA_2	743	749	PF00069	0.668
MOD_Plk_1	144	150	PF00069	0.521
MOD_Plk_1	787	793	PF00069	0.492
MOD_Plk_1	836	842	PF00069	0.759
MOD_Plk_4	203	209	PF00069	0.302
MOD_Plk_4	247	253	PF00069	0.366
MOD_Plk_4	273	279	PF00069	0.416
MOD_Plk_4	371	377	PF00069	0.458
MOD_Plk_4	743	749	PF00069	0.658
MOD_ProDKin_1	23	29	PF00069	0.626
MOD_ProDKin_1	364	370	PF00069	0.616
MOD_ProDKin_1	383	389	PF00069	0.314
MOD_ProDKin_1	405	411	PF00069	0.416
MOD_ProDKin_1	416	422	PF00069	0.417
MOD_ProDKin_1	553	559	PF00069	0.523
MOD_ProDKin_1	57	63	PF00069	0.784
MOD_ProDKin_1	783	789	PF00069	0.773
MOD_ProDKin_1	798	804	PF00069	0.659
MOD_ProDKin_1	838	844	PF00069	0.609
MOD_SUMO_rev_2	63	72	PF00179	0.592
TRG_DiLeu_BaEn_1	511	516	PF01217	0.389
TRG_DiLeu_BaEn_1	730	735	PF01217	0.648
TRG_DiLeu_BaEn_4	511	517	PF01217	0.389
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.437
TRG_DiLeu_BaLyEn_6	541	546	PF01217	0.378
TRG_ENDOCYTIC_2	123	126	PF00928	0.352
TRG_ENDOCYTIC_2	225	228	PF00928	0.353
TRG_ENDOCYTIC_2	452	455	PF00928	0.320
TRG_ENDOCYTIC_2	465	468	PF00928	0.428
TRG_ER_diArg_1	283	285	PF00400	0.330
TRG_ER_diArg_1	489	491	PF00400	0.521
TRG_ER_diArg_1	546	549	PF00400	0.486
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P357	Leptomonas seymouri	57%	100%
A0A1X0P274	Trypanosomatidae	31%	100%
A0A3Q8IGR4	Leishmania donovani	91%	100%
A0A3R7MQU5	Trypanosoma rangeli	35%	100%
A0A3S7X2Z8	Leishmania donovani	91%	98%
A4HHY0	Leishmania braziliensis	74%	100%
A4HLU8	Leishmania braziliensis	74%	100%
A4I560	Leishmania infantum	91%	78%
C9ZQI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AHQ3	Leishmania infantum	91%	100%
E9B0F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q3V2	Leishmania major	88%	99%
Q4Q7S6	Leishmania major	90%	99%
V5DD41	Trypanosoma cruzi	33%	100%