Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B472_LEIMU

TriTrypDb:

LmxM.32.2330

Length:

1060

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B472

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B472

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1050	1054	PF00656	0.518
CLV_C14_Caspase3-7	177	181	PF00656	0.448
CLV_C14_Caspase3-7	373	377	PF00656	0.522
CLV_C14_Caspase3-7	516	520	PF00656	0.597
CLV_C14_Caspase3-7	750	754	PF00656	0.577
CLV_C14_Caspase3-7	944	948	PF00656	0.567
CLV_MEL_PAP_1	431	437	PF00089	0.540
CLV_NRD_NRD_1	123	125	PF00675	0.415
CLV_NRD_NRD_1	190	192	PF00675	0.473
CLV_NRD_NRD_1	200	202	PF00675	0.397
CLV_NRD_NRD_1	254	256	PF00675	0.516
CLV_NRD_NRD_1	381	383	PF00675	0.524
CLV_NRD_NRD_1	507	509	PF00675	0.593
CLV_NRD_NRD_1	799	801	PF00675	0.701
CLV_NRD_NRD_1	937	939	PF00675	0.588
CLV_NRD_NRD_1	981	983	PF00675	0.587
CLV_PCSK_KEX2_1	123	125	PF00082	0.415
CLV_PCSK_KEX2_1	143	145	PF00082	0.340
CLV_PCSK_KEX2_1	190	192	PF00082	0.481
CLV_PCSK_KEX2_1	507	509	PF00082	0.593
CLV_PCSK_KEX2_1	617	619	PF00082	0.460
CLV_PCSK_KEX2_1	801	803	PF00082	0.672
CLV_PCSK_KEX2_1	937	939	PF00082	0.589
CLV_PCSK_KEX2_1	983	985	PF00082	0.587
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.362
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.460
CLV_PCSK_PC1ET2_1	801	803	PF00082	0.639
CLV_PCSK_PC1ET2_1	983	985	PF00082	0.539
CLV_PCSK_SKI1_1	143	147	PF00082	0.522
CLV_PCSK_SKI1_1	425	429	PF00082	0.582
CLV_PCSK_SKI1_1	451	455	PF00082	0.542
CLV_PCSK_SKI1_1	640	644	PF00082	0.495
CLV_PCSK_SKI1_1	671	675	PF00082	0.525
CLV_PCSK_SKI1_1	694	698	PF00082	0.509
CLV_PCSK_SKI1_1	814	818	PF00082	0.585
CLV_PCSK_SKI1_1	843	847	PF00082	0.542
CLV_Separin_Metazoa	879	883	PF03568	0.472
DEG_APCC_DBOX_1	424	432	PF00400	0.538
DEG_SPOP_SBC_1	17	21	PF00917	0.531
DEG_SPOP_SBC_1	677	681	PF00917	0.515
DOC_ANK_TNKS_1	1048	1055	PF00023	0.611
DOC_ANK_TNKS_1	771	778	PF00023	0.528
DOC_CKS1_1	384	389	PF01111	0.574
DOC_CYCLIN_yCln2_LP_2	35	38	PF00134	0.506
DOC_CYCLIN_yCln2_LP_2	393	399	PF00134	0.776
DOC_CYCLIN_yCln2_LP_2	72	78	PF00134	0.669
DOC_MAPK_gen_1	1014	1023	PF00069	0.527
DOC_MAPK_gen_1	422	432	PF00069	0.537
DOC_MAPK_gen_1	507	513	PF00069	0.592
DOC_MAPK_MEF2A_6	425	432	PF00069	0.594
DOC_PP1_RVXF_1	5	12	PF00149	0.511
DOC_PP1_RVXF_1	902	908	PF00149	0.559
DOC_PP1_SILK_1	694	699	PF00149	0.577
DOC_PP2B_LxvP_1	35	38	PF13499	0.506
DOC_PP2B_LxvP_1	393	396	PF13499	0.711
DOC_PP2B_LxvP_1	72	75	PF13499	0.671
DOC_PP4_FxxP_1	354	357	PF00568	0.774
DOC_PP4_FxxP_1	739	742	PF00568	0.510
DOC_PP4_FxxP_1	786	789	PF00568	0.517
DOC_USP7_MATH_1	22	26	PF00917	0.620
DOC_USP7_MATH_1	270	274	PF00917	0.637
DOC_USP7_MATH_1	433	437	PF00917	0.527
DOC_USP7_MATH_1	500	504	PF00917	0.600
DOC_USP7_MATH_1	531	535	PF00917	0.599
DOC_USP7_MATH_1	65	69	PF00917	0.711
DOC_USP7_MATH_1	677	681	PF00917	0.726
DOC_USP7_MATH_1	792	796	PF00917	0.686
DOC_USP7_MATH_1	839	843	PF00917	0.699
DOC_USP7_MATH_1	853	857	PF00917	0.629
DOC_USP7_MATH_1	883	887	PF00917	0.598
DOC_USP7_MATH_1	889	893	PF00917	0.538
DOC_USP7_MATH_1	89	93	PF00917	0.537
DOC_USP7_UBL2_3	1047	1051	PF12436	0.613
DOC_WW_Pin1_4	11	16	PF00397	0.646
DOC_WW_Pin1_4	20	25	PF00397	0.669
DOC_WW_Pin1_4	353	358	PF00397	0.651
DOC_WW_Pin1_4	359	364	PF00397	0.604
DOC_WW_Pin1_4	383	388	PF00397	0.596
DOC_WW_Pin1_4	43	48	PF00397	0.625
DOC_WW_Pin1_4	50	55	PF00397	0.702
DOC_WW_Pin1_4	671	676	PF00397	0.740
DOC_WW_Pin1_4	678	683	PF00397	0.570
DOC_WW_Pin1_4	785	790	PF00397	0.723
DOC_WW_Pin1_4	830	835	PF00397	0.654
DOC_WW_Pin1_4	858	863	PF00397	0.661
DOC_WW_Pin1_4	864	869	PF00397	0.714
LIG_14-3-3_CanoR_1	138	146	PF00244	0.523
LIG_14-3-3_CanoR_1	201	205	PF00244	0.479
LIG_14-3-3_CanoR_1	212	219	PF00244	0.415
LIG_14-3-3_CanoR_1	263	271	PF00244	0.358
LIG_14-3-3_CanoR_1	434	442	PF00244	0.590
LIG_14-3-3_CanoR_1	507	512	PF00244	0.635
LIG_14-3-3_CanoR_1	574	579	PF00244	0.532
LIG_14-3-3_CanoR_1	618	626	PF00244	0.538
LIG_14-3-3_CanoR_1	627	635	PF00244	0.611
LIG_14-3-3_CanoR_1	67	73	PF00244	0.704
LIG_14-3-3_CanoR_1	716	725	PF00244	0.621
LIG_14-3-3_CanoR_1	800	809	PF00244	0.780
LIG_14-3-3_CanoR_1	882	890	PF00244	0.593
LIG_Actin_WH2_2	186	203	PF00022	0.409
LIG_Actin_WH2_2	559	576	PF00022	0.593
LIG_Actin_WH2_2	903	920	PF00022	0.517
LIG_BIR_II_1	1	5	PF00653	0.490
LIG_BIR_III_2	306	310	PF00653	0.481
LIG_BIR_III_3	1	5	PF00653	0.490
LIG_BIR_III_4	403	407	PF00653	0.627
LIG_BRCT_BRCA1_1	314	318	PF00533	0.636
LIG_BRCT_BRCA1_1	350	354	PF00533	0.601
LIG_BRCT_BRCA1_1	560	564	PF00533	0.432
LIG_FHA_1	182	188	PF00498	0.342
LIG_FHA_1	245	251	PF00498	0.492
LIG_FHA_1	337	343	PF00498	0.508
LIG_FHA_1	392	398	PF00498	0.651
LIG_FHA_1	40	46	PF00498	0.543
LIG_FHA_1	499	505	PF00498	0.609
LIG_FHA_1	513	519	PF00498	0.532
LIG_FHA_1	57	63	PF00498	0.609
LIG_FHA_1	578	584	PF00498	0.584
LIG_FHA_1	585	591	PF00498	0.579
LIG_FHA_1	67	73	PF00498	0.615
LIG_FHA_1	706	712	PF00498	0.609
LIG_FHA_1	89	95	PF00498	0.506
LIG_FHA_1	912	918	PF00498	0.601
LIG_FHA_2	222	228	PF00498	0.343
LIG_FHA_2	263	269	PF00498	0.369
LIG_FHA_2	362	368	PF00498	0.617
LIG_FHA_2	579	585	PF00498	0.531
LIG_FHA_2	648	654	PF00498	0.476
LIG_FHA_2	725	731	PF00498	0.479
LIG_LIR_Apic_2	351	357	PF02991	0.578
LIG_LIR_Apic_2	737	742	PF02991	0.514
LIG_LIR_Gen_1	436	447	PF02991	0.596
LIG_LIR_Gen_1	685	696	PF02991	0.530
LIG_LIR_Gen_1	713	721	PF02991	0.596
LIG_LIR_Gen_1	733	742	PF02991	0.527
LIG_LIR_Nem_3	436	442	PF02991	0.589
LIG_LIR_Nem_3	534	540	PF02991	0.470
LIG_LIR_Nem_3	685	691	PF02991	0.540
LIG_LIR_Nem_3	713	717	PF02991	0.591
LIG_LIR_Nem_3	733	739	PF02991	0.572
LIG_MYND_1	396	400	PF01753	0.632
LIG_MYND_1	79	83	PF01753	0.536
LIG_NRBOX	110	116	PF00104	0.460
LIG_PDZ_Class_2	1055	1060	PF00595	0.665
LIG_Pex14_2	782	786	PF04695	0.528
LIG_SH2_CRK	439	443	PF00017	0.564
LIG_SH2_CRK	714	718	PF00017	0.594
LIG_SH2_NCK_1	869	873	PF00017	0.478
LIG_SH2_SRC	545	548	PF00017	0.606
LIG_SH2_STAP1	161	165	PF00017	0.463
LIG_SH2_STAP1	545	549	PF00017	0.734
LIG_SH2_STAP1	578	582	PF00017	0.684
LIG_SH2_STAP1	736	740	PF00017	0.594
LIG_SH2_STAP1	869	873	PF00017	0.478
LIG_SH2_STAT3	161	164	PF00017	0.465
LIG_SH2_STAT3	562	565	PF00017	0.474
LIG_SH2_STAT5	562	565	PF00017	0.691
LIG_SH2_STAT5	736	739	PF00017	0.598
LIG_SH2_STAT5	873	876	PF00017	0.675
LIG_SH3_3	1027	1033	PF00018	0.640
LIG_SH3_3	12	18	PF00018	0.518
LIG_SH3_3	357	363	PF00018	0.487
LIG_SH3_3	393	399	PF00018	0.649
LIG_SH3_3	520	526	PF00018	0.587
LIG_SUMO_SIM_par_1	144	149	PF11976	0.518
LIG_TRAF2_1	160	163	PF00917	0.397
LIG_TRAF2_1	544	547	PF00917	0.484
LIG_TRAF2_1	650	653	PF00917	0.479
LIG_TRAF2_1	913	916	PF00917	0.551
LIG_TRFH_1	33	37	PF08558	0.520
LIG_UBA3_1	563	568	PF00899	0.427
LIG_WRC_WIRS_1	736	741	PF05994	0.521
LIG_WW_3	740	744	PF00397	0.572
MOD_CDK_SPxK_1	20	26	PF00069	0.542
MOD_CDK_SPxxK_3	50	57	PF00069	0.644
MOD_CDK_SPxxK_3	858	865	PF00069	0.524
MOD_CK1_1	1038	1044	PF00069	0.670
MOD_CK1_1	16	22	PF00069	0.678
MOD_CK1_1	25	31	PF00069	0.520
MOD_CK1_1	273	279	PF00069	0.527
MOD_CK1_1	348	354	PF00069	0.521
MOD_CK1_1	361	367	PF00069	0.747
MOD_CK1_1	377	383	PF00069	0.680
MOD_CK1_1	39	45	PF00069	0.639
MOD_CK1_1	402	408	PF00069	0.539
MOD_CK1_1	46	52	PF00069	0.642
MOD_CK1_1	53	59	PF00069	0.651
MOD_CK1_1	572	578	PF00069	0.558
MOD_CK1_1	68	74	PF00069	0.800
MOD_CK1_1	796	802	PF00069	0.680
MOD_CK1_1	820	826	PF00069	0.625
MOD_CK1_1	830	836	PF00069	0.703
MOD_CK1_1	861	867	PF00069	0.751
MOD_CK2_1	221	227	PF00069	0.347
MOD_CK2_1	262	268	PF00069	0.356
MOD_CK2_1	340	346	PF00069	0.476
MOD_CK2_1	361	367	PF00069	0.749
MOD_CK2_1	578	584	PF00069	0.551
MOD_CK2_1	647	653	PF00069	0.478
MOD_CK2_1	660	666	PF00069	0.506
MOD_CK2_1	724	730	PF00069	0.476
MOD_GlcNHglycan	320	323	PF01048	0.592
MOD_GlcNHglycan	342	345	PF01048	0.572
MOD_GlcNHglycan	346	350	PF01048	0.588
MOD_GlcNHglycan	403	407	PF01048	0.758
MOD_GlcNHglycan	48	51	PF01048	0.696
MOD_GlcNHglycan	621	624	PF01048	0.457
MOD_GlcNHglycan	662	665	PF01048	0.543
MOD_GlcNHglycan	749	752	PF01048	0.629
MOD_GlcNHglycan	795	798	PF01048	0.653
MOD_GlcNHglycan	819	822	PF01048	0.585
MOD_GlcNHglycan	855	858	PF01048	0.678
MOD_GlcNHglycan	876	879	PF01048	0.538
MOD_GlcNHglycan	891	894	PF01048	0.668
MOD_GlcNHglycan	899	902	PF01048	0.466
MOD_GlcNHglycan	956	959	PF01048	0.428
MOD_GlcNHglycan	997	1000	PF01048	0.574
MOD_GSK3_1	1038	1045	PF00069	0.689
MOD_GSK3_1	16	23	PF00069	0.660
MOD_GSK3_1	181	188	PF00069	0.376
MOD_GSK3_1	278	285	PF00069	0.445
MOD_GSK3_1	313	320	PF00069	0.677
MOD_GSK3_1	336	343	PF00069	0.688
MOD_GSK3_1	348	355	PF00069	0.603
MOD_GSK3_1	370	377	PF00069	0.754
MOD_GSK3_1	39	46	PF00069	0.671
MOD_GSK3_1	398	405	PF00069	0.538
MOD_GSK3_1	48	55	PF00069	0.628
MOD_GSK3_1	569	576	PF00069	0.572
MOD_GSK3_1	578	585	PF00069	0.533
MOD_GSK3_1	63	70	PF00069	0.577
MOD_GSK3_1	656	663	PF00069	0.566
MOD_GSK3_1	7	14	PF00069	0.671
MOD_GSK3_1	731	738	PF00069	0.650
MOD_GSK3_1	741	748	PF00069	0.597
MOD_GSK3_1	792	799	PF00069	0.616
MOD_GSK3_1	828	835	PF00069	0.783
MOD_GSK3_1	860	867	PF00069	0.646
MOD_GSK3_1	889	896	PF00069	0.692
MOD_N-GLC_1	377	382	PF02516	0.690
MOD_N-GLC_1	827	832	PF02516	0.542
MOD_N-GLC_1	858	863	PF02516	0.652
MOD_NEK2_1	318	323	PF00069	0.493
MOD_NEK2_1	345	350	PF00069	0.606
MOD_NEK2_1	358	363	PF00069	0.622
MOD_NEK2_1	470	475	PF00069	0.624
MOD_NEK2_1	573	578	PF00069	0.604
MOD_NEK2_1	586	591	PF00069	0.536
MOD_NEK2_1	619	624	PF00069	0.645
MOD_NEK2_1	747	752	PF00069	0.689
MOD_NEK2_1	817	822	PF00069	0.733
MOD_NEK2_1	827	832	PF00069	0.628
MOD_PIKK_1	155	161	PF00454	0.408
MOD_PIKK_1	221	227	PF00454	0.346
MOD_PIKK_1	273	279	PF00454	0.535
MOD_PIKK_1	386	392	PF00454	0.671
MOD_PIKK_1	470	476	PF00454	0.589
MOD_PIKK_1	498	504	PF00454	0.641
MOD_PIKK_1	531	537	PF00454	0.448
MOD_PIKK_1	741	747	PF00454	0.677
MOD_PIKK_1	89	95	PF00454	0.412
MOD_PIKK_1	911	917	PF00454	0.600
MOD_PK_1	507	513	PF00069	0.592
MOD_PKA_1	507	513	PF00069	0.592
MOD_PKA_1	800	806	PF00069	0.755
MOD_PKA_2	1038	1044	PF00069	0.641
MOD_PKA_2	200	206	PF00069	0.487
MOD_PKA_2	211	217	PF00069	0.383
MOD_PKA_2	25	31	PF00069	0.536
MOD_PKA_2	262	268	PF00069	0.356
MOD_PKA_2	411	417	PF00069	0.525
MOD_PKA_2	433	439	PF00069	0.584
MOD_PKA_2	506	512	PF00069	0.635
MOD_PKA_2	573	579	PF00069	0.606
MOD_PKA_2	647	653	PF00069	0.529
MOD_PKA_2	66	72	PF00069	0.696
MOD_PKA_2	853	859	PF00069	0.569
MOD_Plk_1	282	288	PF00069	0.593
MOD_Plk_1	470	476	PF00069	0.466
MOD_Plk_1	558	564	PF00069	0.623
MOD_Plk_1	827	833	PF00069	0.541
MOD_Plk_4	1053	1059	PF00069	0.617
MOD_Plk_4	500	506	PF00069	0.594
MOD_Plk_4	578	584	PF00069	0.588
MOD_Plk_4	692	698	PF00069	0.633
MOD_Plk_4	706	712	PF00069	0.551
MOD_Plk_4	962	968	PF00069	0.652
MOD_ProDKin_1	11	17	PF00069	0.644
MOD_ProDKin_1	20	26	PF00069	0.667
MOD_ProDKin_1	353	359	PF00069	0.651
MOD_ProDKin_1	383	389	PF00069	0.595
MOD_ProDKin_1	43	49	PF00069	0.627
MOD_ProDKin_1	50	56	PF00069	0.702
MOD_ProDKin_1	671	677	PF00069	0.736
MOD_ProDKin_1	678	684	PF00069	0.571
MOD_ProDKin_1	785	791	PF00069	0.722
MOD_ProDKin_1	830	836	PF00069	0.652
MOD_ProDKin_1	858	864	PF00069	0.657
MOD_SUMO_for_1	238	241	PF00179	0.504
MOD_SUMO_for_1	453	456	PF00179	0.593
MOD_SUMO_rev_2	1022	1030	PF00179	0.524
MOD_SUMO_rev_2	302	310	PF00179	0.584
MOD_SUMO_rev_2	456	466	PF00179	0.570
MOD_SUMO_rev_2	613	619	PF00179	0.451
TRG_DiLeu_BaEn_1	103	108	PF01217	0.363
TRG_DiLeu_BaEn_1	471	476	PF01217	0.472
TRG_DiLeu_BaEn_1	812	817	PF01217	0.609
TRG_DiLeu_BaLyEn_6	679	684	PF01217	0.579
TRG_ENDOCYTIC_2	439	442	PF00928	0.561
TRG_ENDOCYTIC_2	714	717	PF00928	0.593
TRG_ENDOCYTIC_2	736	739	PF00928	0.532
TRG_ENDOCYTIC_2	810	813	PF00928	0.557
TRG_ER_diArg_1	123	125	PF00400	0.437
TRG_ER_diArg_1	189	191	PF00400	0.510
TRG_ER_diArg_1	409	412	PF00400	0.636
TRG_ER_diArg_1	419	422	PF00400	0.583
TRG_ER_diArg_1	643	646	PF00400	0.543
TRG_ER_diArg_1	846	849	PF00400	0.540
TRG_NES_CRM1_1	105	120	PF08389	0.450
TRG_NES_CRM1_1	249	262	PF08389	0.460
TRG_Pf-PMV_PEXEL_1	144	149	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	554	559	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	772	776	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	814	818	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD26	Leptomonas seymouri	29%	79%
A0A3S5H7V0	Leishmania donovani	80%	100%
A4HLU6	Leishmania braziliensis	57%	100%
E9AHQ1	Leishmania infantum	80%	100%
Q4Q3V4	Leishmania major	79%	100%