Putative cell division cycle 45 (CDC45)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell division cycle 45 (CDC45), putative

Species:

Leishmania mexicana

UniProt:

E9B471_LEIMU

TriTrypDb:

LmxM.32.2320

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0031261	DNA replication preinitiation complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9B471

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B471

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006270	DNA replication initiation	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0007049	cell cycle	2	9
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0051301	cell division	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0033554	cellular response to stress	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0071163	DNA replication preinitiation complex assembly	3	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902977	mitotic DNA replication preinitiation complex assembly	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003682	chromatin binding	2	1
GO:0003688	DNA replication origin binding	7	1
GO:0003690	double-stranded DNA binding	5	1
GO:0003697	single-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.503
CLV_NRD_NRD_1	128	130	PF00675	0.285
CLV_NRD_NRD_1	151	153	PF00675	0.265
CLV_NRD_NRD_1	163	165	PF00675	0.195
CLV_NRD_NRD_1	167	169	PF00675	0.168
CLV_NRD_NRD_1	179	181	PF00675	0.186
CLV_NRD_NRD_1	21	23	PF00675	0.345
CLV_NRD_NRD_1	296	298	PF00675	0.229
CLV_NRD_NRD_1	322	324	PF00675	0.263
CLV_NRD_NRD_1	448	450	PF00675	0.307
CLV_NRD_NRD_1	499	501	PF00675	0.266
CLV_NRD_NRD_1	581	583	PF00675	0.294
CLV_NRD_NRD_1	599	601	PF00675	0.352
CLV_NRD_NRD_1	602	604	PF00675	0.307
CLV_NRD_NRD_1	759	761	PF00675	0.689
CLV_PCSK_FUR_1	161	165	PF00082	0.224
CLV_PCSK_FUR_1	600	604	PF00082	0.278
CLV_PCSK_FUR_1	760	764	PF00082	0.629
CLV_PCSK_KEX2_1	128	130	PF00082	0.285
CLV_PCSK_KEX2_1	161	163	PF00082	0.233
CLV_PCSK_KEX2_1	166	168	PF00082	0.236
CLV_PCSK_KEX2_1	172	174	PF00082	0.246
CLV_PCSK_KEX2_1	179	181	PF00082	0.202
CLV_PCSK_KEX2_1	296	298	PF00082	0.225
CLV_PCSK_KEX2_1	322	324	PF00082	0.252
CLV_PCSK_KEX2_1	581	583	PF00082	0.295
CLV_PCSK_KEX2_1	598	600	PF00082	0.343
CLV_PCSK_KEX2_1	602	604	PF00082	0.307
CLV_PCSK_KEX2_1	762	764	PF00082	0.701
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.362
CLV_PCSK_PC1ET2_1	762	764	PF00082	0.579
CLV_PCSK_PC7_1	162	168	PF00082	0.235
CLV_PCSK_PC7_1	598	604	PF00082	0.278
CLV_PCSK_SKI1_1	323	327	PF00082	0.304
CLV_PCSK_SKI1_1	464	468	PF00082	0.307
CLV_PCSK_SKI1_1	47	51	PF00082	0.307
CLV_PCSK_SKI1_1	589	593	PF00082	0.308
CLV_PCSK_SKI1_1	603	607	PF00082	0.196
CLV_PCSK_SKI1_1	721	725	PF00082	0.433
CLV_PCSK_SKI1_1	744	748	PF00082	0.383
DEG_APCC_DBOX_1	385	393	PF00400	0.478
DEG_APCC_DBOX_1	743	751	PF00400	0.477
DEG_COP1_1	652	661	PF00400	0.392
DEG_SPOP_SBC_1	553	557	PF00917	0.507
DOC_CKS1_1	716	721	PF01111	0.540
DOC_CYCLIN_RxL_1	603	614	PF00134	0.515
DOC_CYCLIN_RxL_1	715	726	PF00134	0.431
DOC_CYCLIN_RxL_1	741	749	PF00134	0.459
DOC_CYCLIN_yCln2_LP_2	96	102	PF00134	0.467
DOC_MAPK_DCC_7	603	613	PF00069	0.445
DOC_MAPK_FxFP_2	49	52	PF00069	0.507
DOC_MAPK_gen_1	22	29	PF00069	0.292
DOC_MAPK_MEF2A_6	22	29	PF00069	0.292
DOC_MAPK_MEF2A_6	396	403	PF00069	0.478
DOC_MAPK_MEF2A_6	86	94	PF00069	0.463
DOC_PP1_RVXF_1	132	139	PF00149	0.424
DOC_PP1_RVXF_1	234	240	PF00149	0.450
DOC_PP1_RVXF_1	499	506	PF00149	0.478
DOC_PP1_RVXF_1	587	593	PF00149	0.507
DOC_PP2B_LxvP_1	28	31	PF13499	0.507
DOC_PP2B_LxvP_1	96	99	PF13499	0.467
DOC_PP4_FxxP_1	49	52	PF00568	0.507
DOC_PP4_FxxP_1	716	719	PF00568	0.411
DOC_USP7_MATH_1	2	6	PF00917	0.552
DOC_USP7_MATH_1	228	232	PF00917	0.429
DOC_USP7_MATH_1	260	264	PF00917	0.467
DOC_USP7_MATH_1	333	337	PF00917	0.523
DOC_USP7_MATH_1	36	40	PF00917	0.424
DOC_USP7_MATH_1	485	489	PF00917	0.446
DOC_USP7_MATH_1	541	545	PF00917	0.515
DOC_USP7_MATH_1	562	566	PF00917	0.489
DOC_USP7_MATH_1	57	61	PF00917	0.507
DOC_USP7_MATH_1	654	658	PF00917	0.577
DOC_USP7_MATH_1	659	663	PF00917	0.562
DOC_USP7_MATH_1	74	78	PF00917	0.507
DOC_USP7_MATH_2	10	16	PF00917	0.436
DOC_WW_Pin1_4	206	211	PF00397	0.349
DOC_WW_Pin1_4	226	231	PF00397	0.417
DOC_WW_Pin1_4	481	486	PF00397	0.450
DOC_WW_Pin1_4	568	573	PF00397	0.507
DOC_WW_Pin1_4	643	648	PF00397	0.365
DOC_WW_Pin1_4	715	720	PF00397	0.539
DOC_WW_Pin1_4	81	86	PF00397	0.349
LIG_14-3-3_CanoR_1	13	18	PF00244	0.369
LIG_14-3-3_CanoR_1	262	269	PF00244	0.471
LIG_14-3-3_CanoR_1	339	347	PF00244	0.520
LIG_14-3-3_CanoR_1	359	364	PF00244	0.424
LIG_14-3-3_CanoR_1	422	431	PF00244	0.462
LIG_14-3-3_CanoR_1	512	519	PF00244	0.526
LIG_14-3-3_CanoR_1	581	586	PF00244	0.451
LIG_14-3-3_CanoR_1	589	595	PF00244	0.429
LIG_14-3-3_CanoR_1	602	612	PF00244	0.450
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BIR_III_2	227	231	PF00653	0.507
LIG_BIR_III_3	1	5	PF00653	0.567
LIG_BIR_III_4	542	546	PF00653	0.444
LIG_CaM_IQ_9	314	329	PF13499	0.507
LIG_deltaCOP1_diTrp_1	62	73	PF00928	0.444
LIG_FHA_1	107	113	PF00498	0.444
LIG_FHA_1	301	307	PF00498	0.468
LIG_FHA_1	457	463	PF00498	0.436
LIG_FHA_1	644	650	PF00498	0.385
LIG_FHA_1	736	742	PF00498	0.373
LIG_FHA_2	200	206	PF00498	0.524
LIG_FHA_2	360	366	PF00498	0.479
LIG_GBD_Chelix_1	586	594	PF00786	0.267
LIG_LIR_Apic_2	713	719	PF02991	0.412
LIG_LIR_Gen_1	361	369	PF02991	0.483
LIG_LIR_Gen_1	575	585	PF02991	0.529
LIG_LIR_Gen_1	58	68	PF02991	0.448
LIG_LIR_Gen_1	681	688	PF02991	0.425
LIG_LIR_Gen_1	88	99	PF02991	0.424
LIG_LIR_Gen_1	9	19	PF02991	0.343
LIG_LIR_Nem_3	103	108	PF02991	0.424
LIG_LIR_Nem_3	117	122	PF02991	0.417
LIG_LIR_Nem_3	300	304	PF02991	0.424
LIG_LIR_Nem_3	361	367	PF02991	0.520
LIG_LIR_Nem_3	58	64	PF02991	0.448
LIG_LIR_Nem_3	588	594	PF02991	0.508
LIG_LIR_Nem_3	681	687	PF02991	0.425
LIG_LIR_Nem_3	88	94	PF02991	0.424
LIG_LIR_Nem_3	9	14	PF02991	0.341
LIG_NBox_RRM_1	526	536	PF00076	0.424
LIG_NRBOX	388	394	PF00104	0.424
LIG_PCNA_PIPBox_1	144	153	PF02747	0.492
LIG_PCNA_yPIPBox_3	142	151	PF02747	0.491
LIG_PCNA_yPIPBox_3	422	431	PF02747	0.476
LIG_Pex14_2	49	53	PF04695	0.507
LIG_REV1ctd_RIR_1	148	157	PF16727	0.441
LIG_SH2_CRK	561	565	PF00017	0.441
LIG_SH2_NCK_1	561	565	PF00017	0.460
LIG_SH2_PTP2	684	687	PF00017	0.526
LIG_SH2_SRC	249	252	PF00017	0.427
LIG_SH2_STAP1	269	273	PF00017	0.424
LIG_SH2_STAP1	301	305	PF00017	0.478
LIG_SH2_STAP1	369	373	PF00017	0.459
LIG_SH2_STAP1	453	457	PF00017	0.424
LIG_SH2_STAT3	369	372	PF00017	0.507
LIG_SH2_STAT5	105	108	PF00017	0.507
LIG_SH2_STAT5	249	252	PF00017	0.427
LIG_SH2_STAT5	294	297	PF00017	0.453
LIG_SH2_STAT5	304	307	PF00017	0.394
LIG_SH2_STAT5	356	359	PF00017	0.492
LIG_SH2_STAT5	44	47	PF00017	0.507
LIG_SH2_STAT5	479	482	PF00017	0.507
LIG_SH2_STAT5	684	687	PF00017	0.542
LIG_SH2_STAT5	740	743	PF00017	0.533
LIG_SH3_1	561	567	PF00018	0.441
LIG_SH3_2	564	569	PF14604	0.478
LIG_SH3_3	469	475	PF00018	0.460
LIG_SH3_3	561	567	PF00018	0.441
LIG_SH3_3	634	640	PF00018	0.478
LIG_SH3_3	697	703	PF00018	0.388
LIG_SUMO_SIM_anti_2	270	275	PF11976	0.424
LIG_SUMO_SIM_anti_2	776	784	PF11976	0.680
LIG_SUMO_SIM_par_1	111	117	PF11976	0.390
LIG_SUMO_SIM_par_1	514	520	PF11976	0.510
LIG_SUMO_SIM_par_1	609	614	PF11976	0.461
LIG_SUMO_SIM_par_1	684	689	PF11976	0.511
LIG_SUMO_SIM_par_1	743	749	PF11976	0.433
LIG_SUMO_SIM_par_1	776	784	PF11976	0.526
LIG_SUMO_SIM_par_1	98	104	PF11976	0.448
LIG_TRAF2_1	203	206	PF00917	0.534
LIG_TRAF2_1	310	313	PF00917	0.482
LIG_TRAF2_1	490	493	PF00917	0.496
LIG_TRAF2_2	230	235	PF00917	0.507
LIG_TRFH_1	53	57	PF08558	0.424
LIG_UBA3_1	745	751	PF00899	0.474
LIG_WRC_WIRS_1	334	339	PF05994	0.349
LIG_WRC_WIRS_1	457	462	PF05994	0.425
LIG_WRC_WIRS_1	574	579	PF05994	0.424
LIG_WRPW_2	119	122	PF00400	0.424
LIG_WW_3	718	722	PF00397	0.560
MOD_CDK_SPK_2	81	86	PF00069	0.349
MOD_CDK_SPxK_1	715	721	PF00069	0.541
MOD_CK1_1	195	201	PF00069	0.457
MOD_CK1_1	209	215	PF00069	0.410
MOD_CK1_1	341	347	PF00069	0.425
MOD_CK1_1	488	494	PF00069	0.475
MOD_CK1_1	565	571	PF00069	0.502
MOD_CK1_1	576	582	PF00069	0.509
MOD_CK1_1	652	658	PF00069	0.517
MOD_CK1_1	660	666	PF00069	0.569
MOD_CK2_1	199	205	PF00069	0.524
MOD_CK2_1	261	267	PF00069	0.467
MOD_CK2_1	345	351	PF00069	0.482
MOD_CK2_1	487	493	PF00069	0.525
MOD_CK2_1	57	63	PF00069	0.507
MOD_CK2_1	74	80	PF00069	0.507
MOD_GlcNHglycan	184	188	PF01048	0.188
MOD_GlcNHglycan	240	243	PF01048	0.278
MOD_GlcNHglycan	263	266	PF01048	0.243
MOD_GlcNHglycan	374	377	PF01048	0.300
MOD_GlcNHglycan	4	7	PF01048	0.558
MOD_GlcNHglycan	513	516	PF01048	0.278
MOD_GlcNHglycan	542	546	PF01048	0.155
MOD_GlcNHglycan	629	632	PF01048	0.310
MOD_GlcNHglycan	633	636	PF01048	0.321
MOD_GlcNHglycan	637	640	PF01048	0.295
MOD_GlcNHglycan	654	657	PF01048	0.363
MOD_GlcNHglycan	659	662	PF01048	0.371
MOD_GSK3_1	13	20	PF00069	0.460
MOD_GSK3_1	192	199	PF00069	0.455
MOD_GSK3_1	226	233	PF00069	0.424
MOD_GSK3_1	313	320	PF00069	0.507
MOD_GSK3_1	341	348	PF00069	0.432
MOD_GSK3_1	36	43	PF00069	0.424
MOD_GSK3_1	368	375	PF00069	0.551
MOD_GSK3_1	410	417	PF00069	0.478
MOD_GSK3_1	451	458	PF00069	0.448
MOD_GSK3_1	481	488	PF00069	0.421
MOD_GSK3_1	590	597	PF00069	0.510
MOD_GSK3_1	620	627	PF00069	0.526
MOD_GSK3_1	631	638	PF00069	0.502
MOD_GSK3_1	746	753	PF00069	0.448
MOD_N-GLC_1	278	283	PF02516	0.192
MOD_N-GLC_1	649	654	PF02516	0.192
MOD_N-GLC_1	736	741	PF02516	0.432
MOD_NEK2_1	106	111	PF00069	0.467
MOD_NEK2_1	278	283	PF00069	0.444
MOD_NEK2_1	317	322	PF00069	0.524
MOD_NEK2_1	345	350	PF00069	0.478
MOD_NEK2_1	358	363	PF00069	0.453
MOD_NEK2_1	392	397	PF00069	0.524
MOD_NEK2_1	40	45	PF00069	0.467
MOD_NEK2_1	590	595	PF00069	0.452
MOD_NEK2_1	611	616	PF00069	0.507
MOD_NEK2_1	746	751	PF00069	0.481
MOD_NEK2_2	333	338	PF00069	0.349
MOD_PIKK_1	228	234	PF00454	0.426
MOD_PIKK_1	368	374	PF00454	0.575
MOD_PIKK_1	387	393	PF00454	0.429
MOD_PK_1	581	587	PF00069	0.492
MOD_PKA_1	581	587	PF00069	0.492
MOD_PKA_2	12	18	PF00069	0.456
MOD_PKA_2	261	267	PF00069	0.507
MOD_PKA_2	338	344	PF00069	0.530
MOD_PKA_2	358	364	PF00069	0.520
MOD_PKA_2	387	393	PF00069	0.522
MOD_PKA_2	511	517	PF00069	0.478
MOD_PKA_2	581	587	PF00069	0.467
MOD_PKA_2	620	626	PF00069	0.365
MOD_PKA_2	652	658	PF00069	0.465
MOD_PKB_1	443	451	PF00069	0.504
MOD_PKB_1	733	741	PF00069	0.441
MOD_Plk_1	195	201	PF00069	0.478
MOD_Plk_1	269	275	PF00069	0.507
MOD_Plk_1	278	284	PF00069	0.507
MOD_Plk_1	455	461	PF00069	0.426
MOD_Plk_1	485	491	PF00069	0.444
MOD_Plk_1	735	741	PF00069	0.478
MOD_Plk_2-3	192	198	PF00069	0.515
MOD_Plk_2-3	456	462	PF00069	0.441
MOD_Plk_4	13	19	PF00069	0.456
MOD_Plk_4	269	275	PF00069	0.507
MOD_Plk_4	278	284	PF00069	0.507
MOD_Plk_4	300	306	PF00069	0.424
MOD_Plk_4	359	365	PF00069	0.442
MOD_Plk_4	40	46	PF00069	0.444
MOD_Plk_4	474	480	PF00069	0.507
MOD_Plk_4	543	549	PF00069	0.483
MOD_Plk_4	581	587	PF00069	0.467
MOD_Plk_4	736	742	PF00069	0.411
MOD_ProDKin_1	206	212	PF00069	0.349
MOD_ProDKin_1	226	232	PF00069	0.417
MOD_ProDKin_1	481	487	PF00069	0.450
MOD_ProDKin_1	568	574	PF00069	0.507
MOD_ProDKin_1	643	649	PF00069	0.365
MOD_ProDKin_1	715	721	PF00069	0.541
MOD_ProDKin_1	81	87	PF00069	0.349
MOD_SUMO_rev_2	59	67	PF00179	0.453
TRG_AP2beta_CARGO_1	588	598	PF09066	0.507
TRG_DiLeu_BaEn_1	353	358	PF01217	0.507
TRG_DiLeu_BaEn_1	743	748	PF01217	0.469
TRG_DiLeu_BaEn_2	62	68	PF01217	0.507
TRG_DiLeu_BaEn_4	492	498	PF01217	0.444
TRG_DiLeu_BaLyEn_6	607	612	PF01217	0.482
TRG_DiLeu_BaLyEn_6	697	702	PF01217	0.484
TRG_ENDOCYTIC_2	105	108	PF00928	0.470
TRG_ENDOCYTIC_2	119	122	PF00928	0.376
TRG_ENDOCYTIC_2	61	64	PF00928	0.441
TRG_ENDOCYTIC_2	684	687	PF00928	0.555
TRG_ER_diArg_1	127	129	PF00400	0.485
TRG_ER_diArg_1	161	164	PF00400	0.429
TRG_ER_diArg_1	166	168	PF00400	0.430
TRG_ER_diArg_1	179	182	PF00400	0.432
TRG_ER_diArg_1	295	297	PF00400	0.426
TRG_ER_diArg_1	321	323	PF00400	0.452
TRG_ER_diArg_1	386	389	PF00400	0.478
TRG_ER_diArg_1	440	443	PF00400	0.482
TRG_ER_diArg_1	580	582	PF00400	0.494
TRG_ER_diArg_1	598	600	PF00400	0.552
TRG_ER_diArg_1	732	735	PF00400	0.399
TRG_NES_CRM1_1	307	319	PF08389	0.507
TRG_NLS_MonoCore_2	759	764	PF00514	0.580
TRG_NLS_MonoExtC_3	151	157	PF00514	0.444
TRG_NLS_MonoExtC_3	760	765	PF00514	0.579
TRG_NLS_MonoExtN_4	760	765	PF00514	0.579
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.224
TRG_Pf-PMV_PEXEL_1	721	726	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5R4	Leptomonas seymouri	67%	95%
A0A3Q8IF06	Leishmania donovani	93%	100%
A0A422P0B5	Trypanosoma rangeli	42%	100%
A4HLU5	Leishmania braziliensis	82%	100%
D0A683	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AHQ0	Leishmania infantum	92%	100%
Q08032	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
Q4Q3V5	Leishmania major	92%	100%
V5BP84	Trypanosoma cruzi	43%	100%