Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B470_LEIMU

TriTrypDb:

LmxM.32.2310

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B470

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B470

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.587
CLV_C14_Caspase3-7	295	299	PF00656	0.588
CLV_C14_Caspase3-7	479	483	PF00656	0.572
CLV_NRD_NRD_1	1	3	PF00675	0.582
CLV_NRD_NRD_1	458	460	PF00675	0.416
CLV_NRD_NRD_1	463	465	PF00675	0.450
CLV_PCSK_KEX2_1	147	149	PF00082	0.458
CLV_PCSK_KEX2_1	458	460	PF00082	0.416
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.458
CLV_PCSK_PC7_1	143	149	PF00082	0.436
CLV_PCSK_SKI1_1	270	274	PF00082	0.511
CLV_PCSK_SKI1_1	327	331	PF00082	0.643
CLV_PCSK_SKI1_1	365	369	PF00082	0.478
DEG_APCC_DBOX_1	269	277	PF00400	0.530
DEG_APCC_DBOX_1	364	372	PF00400	0.478
DEG_Nend_UBRbox_1	1	4	PF02207	0.559
DEG_SPOP_SBC_1	337	341	PF00917	0.612
DOC_CKS1_1	442	447	PF01111	0.395
DOC_MAPK_gen_1	2	9	PF00069	0.524
DOC_MAPK_gen_1	44	53	PF00069	0.456
DOC_USP7_MATH_1	113	117	PF00917	0.485
DOC_USP7_MATH_1	156	160	PF00917	0.716
DOC_USP7_MATH_1	168	172	PF00917	0.652
DOC_USP7_MATH_1	250	254	PF00917	0.574
DOC_USP7_MATH_1	304	308	PF00917	0.669
DOC_USP7_MATH_1	348	352	PF00917	0.629
DOC_USP7_MATH_1	413	417	PF00917	0.525
DOC_WW_Pin1_4	148	153	PF00397	0.556
DOC_WW_Pin1_4	346	351	PF00397	0.739
DOC_WW_Pin1_4	370	375	PF00397	0.527
DOC_WW_Pin1_4	441	446	PF00397	0.401
DOC_WW_Pin1_4	77	82	PF00397	0.576
LIG_14-3-3_CanoR_1	130	135	PF00244	0.474
LIG_14-3-3_CanoR_1	136	140	PF00244	0.481
LIG_14-3-3_CanoR_1	198	204	PF00244	0.476
LIG_14-3-3_CanoR_1	2	9	PF00244	0.589
LIG_14-3-3_CanoR_1	23	31	PF00244	0.719
LIG_14-3-3_CanoR_1	303	309	PF00244	0.495
LIG_14-3-3_CanoR_1	325	332	PF00244	0.688
LIG_14-3-3_CanoR_1	379	385	PF00244	0.478
LIG_14-3-3_CanoR_1	88	92	PF00244	0.643
LIG_AP2alpha_2	83	85	PF02296	0.526
LIG_BRCT_BRCA1_1	414	418	PF00533	0.431
LIG_BRCT_BRCA1_1	69	73	PF00533	0.589
LIG_BRCT_BRCA1_2	69	75	PF00533	0.592
LIG_CaM_IQ_9	492	508	PF13499	0.334
LIG_deltaCOP1_diTrp_1	127	131	PF00928	0.493
LIG_EVH1_2	288	292	PF00568	0.605
LIG_EVH1_2	445	449	PF00568	0.448
LIG_FHA_1	2	8	PF00498	0.538
LIG_FHA_1	309	315	PF00498	0.563
LIG_FHA_1	381	387	PF00498	0.444
LIG_FHA_1	388	394	PF00498	0.338
LIG_FHA_1	514	520	PF00498	0.441
LIG_FHA_2	178	184	PF00498	0.638
LIG_FHA_2	317	323	PF00498	0.815
LIG_FHA_2	396	402	PF00498	0.442
LIG_FHA_2	418	424	PF00498	0.572
LIG_FHA_2	477	483	PF00498	0.587
LIG_FHA_2	53	59	PF00498	0.466
LIG_FHA_2	88	94	PF00498	0.590
LIG_Integrin_RGD_1	234	236	PF01839	0.632
LIG_LIR_Apic_2	89	94	PF02991	0.619
LIG_LIR_Gen_1	127	134	PF02991	0.484
LIG_LIR_Gen_1	201	211	PF02991	0.591
LIG_LIR_Gen_1	248	257	PF02991	0.601
LIG_LIR_Gen_1	415	425	PF02991	0.492
LIG_LIR_Nem_3	127	131	PF02991	0.493
LIG_LIR_Nem_3	197	203	PF02991	0.517
LIG_LIR_Nem_3	248	254	PF02991	0.635
LIG_LIR_Nem_3	38	43	PF02991	0.699
LIG_Pex14_2	124	128	PF04695	0.518
LIG_SH2_NCK_1	242	246	PF00017	0.603
LIG_SH2_STAP1	203	207	PF00017	0.476
LIG_SH3_3	26	32	PF00018	0.593
LIG_SH3_3	282	288	PF00018	0.625
LIG_SH3_3	439	445	PF00018	0.482
LIG_SH3_3	78	84	PF00018	0.531
LIG_SUMO_SIM_par_1	310	316	PF11976	0.485
LIG_TRAF2_1	180	183	PF00917	0.571
LIG_TRAF2_1	237	240	PF00917	0.476
LIG_WW_3	444	448	PF00397	0.479
MOD_CDK_SPxK_1	441	447	PF00069	0.397
MOD_CK1_1	151	157	PF00069	0.746
MOD_CK1_1	161	167	PF00069	0.590
MOD_CK1_1	171	177	PF00069	0.629
MOD_CK1_1	243	249	PF00069	0.629
MOD_CK1_1	316	322	PF00069	0.594
MOD_CK1_1	331	337	PF00069	0.543
MOD_CK1_1	349	355	PF00069	0.756
MOD_CK1_1	416	422	PF00069	0.591
MOD_CK2_1	177	183	PF00069	0.591
MOD_CK2_1	198	204	PF00069	0.569
MOD_CK2_1	223	229	PF00069	0.562
MOD_CK2_1	316	322	PF00069	0.679
MOD_CK2_1	330	336	PF00069	0.544
MOD_CK2_1	395	401	PF00069	0.428
MOD_CK2_1	52	58	PF00069	0.602
MOD_CK2_1	86	92	PF00069	0.619
MOD_DYRK1A_RPxSP_1	77	81	PF00069	0.565
MOD_GlcNHglycan	10	13	PF01048	0.618
MOD_GlcNHglycan	153	156	PF01048	0.786
MOD_GlcNHglycan	170	173	PF01048	0.622
MOD_GlcNHglycan	225	228	PF01048	0.595
MOD_GlcNHglycan	242	245	PF01048	0.758
MOD_GlcNHglycan	248	251	PF01048	0.647
MOD_GlcNHglycan	315	318	PF01048	0.650
MOD_GlcNHglycan	344	347	PF01048	0.732
MOD_GlcNHglycan	352	355	PF01048	0.594
MOD_GlcNHglycan	405	408	PF01048	0.599
MOD_GlcNHglycan	415	418	PF01048	0.652
MOD_GSK3_1	168	175	PF00069	0.802
MOD_GSK3_1	246	253	PF00069	0.640
MOD_GSK3_1	304	311	PF00069	0.714
MOD_GSK3_1	323	330	PF00069	0.756
MOD_GSK3_1	338	345	PF00069	0.574
MOD_GSK3_1	346	353	PF00069	0.660
MOD_GSK3_1	412	419	PF00069	0.638
MOD_GSK3_1	421	428	PF00069	0.550
MOD_GSK3_1	476	483	PF00069	0.611
MOD_GSK3_1	73	80	PF00069	0.679
MOD_N-GLC_1	111	116	PF02516	0.508
MOD_N-GLC_1	198	203	PF02516	0.534
MOD_NEK2_1	1	6	PF00069	0.637
MOD_NEK2_1	421	426	PF00069	0.445
MOD_NEK2_1	67	72	PF00069	0.605
MOD_NEK2_1	73	78	PF00069	0.585
MOD_NEK2_2	135	140	PF00069	0.474
MOD_OFUCOSY	49	56	PF10250	0.466
MOD_PIKK_1	113	119	PF00454	0.479
MOD_PIKK_1	158	164	PF00454	0.649
MOD_PIKK_1	172	178	PF00454	0.637
MOD_PK_1	3	9	PF00069	0.535
MOD_PKA_2	1	7	PF00069	0.608
MOD_PKA_2	129	135	PF00069	0.476
MOD_PKA_2	22	28	PF00069	0.610
MOD_PKA_2	35	41	PF00069	0.643
MOD_PKA_2	67	73	PF00069	0.614
MOD_PKA_2	87	93	PF00069	0.699
MOD_Plk_1	198	204	PF00069	0.538
MOD_Plk_1	421	427	PF00069	0.432
MOD_Plk_1	86	92	PF00069	0.619
MOD_Plk_2-3	87	93	PF00069	0.621
MOD_Plk_4	38	44	PF00069	0.646
MOD_Plk_4	395	401	PF00069	0.428
MOD_Plk_4	435	441	PF00069	0.408
MOD_Plk_4	513	519	PF00069	0.403
MOD_ProDKin_1	148	154	PF00069	0.562
MOD_ProDKin_1	346	352	PF00069	0.737
MOD_ProDKin_1	370	376	PF00069	0.524
MOD_ProDKin_1	441	447	PF00069	0.397
MOD_ProDKin_1	77	83	PF00069	0.568
MOD_SUMO_for_1	237	240	PF00179	0.524
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.530
TRG_ENDOCYTIC_2	193	196	PF00928	0.575
TRG_ENDOCYTIC_2	203	206	PF00928	0.570
TRG_ENDOCYTIC_2	40	43	PF00928	0.664
TRG_ER_diArg_1	189	192	PF00400	0.525
TRG_ER_diArg_1	43	46	PF00400	0.607
TRG_ER_diArg_1	457	459	PF00400	0.417
TRG_ER_diArg_1	467	470	PF00400	0.335
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	77	82	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF55	Leptomonas seymouri	53%	98%
A0A3S7X722	Leishmania donovani	85%	100%
A4HLU4	Leishmania braziliensis	72%	100%
D0A684	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AHP9	Leishmania infantum	86%	100%
Q4Q3V6	Leishmania major	84%	100%