Kinesin motor domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B466_LEIMU

TriTrypDb:

LmxM.32.2270

Length:

811

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B466

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B466

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	1
GO:0003777	microtubule motor activity	2	1
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	50	54	PF00656	0.575
CLV_NRD_NRD_1	777	779	PF00675	0.544
CLV_PCSK_KEX2_1	776	778	PF00082	0.548
CLV_PCSK_PC7_1	773	779	PF00082	0.511
CLV_PCSK_SKI1_1	109	113	PF00082	0.581
CLV_PCSK_SKI1_1	736	740	PF00082	0.508
CLV_PCSK_SKI1_1	748	752	PF00082	0.537
CLV_PCSK_SKI1_1	86	90	PF00082	0.560
DEG_APCC_DBOX_1	99	107	PF00400	0.549
DEG_Nend_UBRbox_3	1	3	PF02207	0.582
DEG_SPOP_SBC_1	141	145	PF00917	0.465
DEG_SPOP_SBC_1	180	184	PF00917	0.521
DEG_SPOP_SBC_1	219	223	PF00917	0.529
DEG_SPOP_SBC_1	258	262	PF00917	0.531
DEG_SPOP_SBC_1	297	301	PF00917	0.546
DEG_SPOP_SBC_1	336	340	PF00917	0.503
DEG_SPOP_SBC_1	375	379	PF00917	0.552
DEG_SPOP_SBC_1	414	418	PF00917	0.541
DEG_SPOP_SBC_1	44	48	PF00917	0.668
DEG_SPOP_SBC_1	453	457	PF00917	0.545
DEG_SPOP_SBC_1	492	496	PF00917	0.538
DEG_SPOP_SBC_1	531	535	PF00917	0.551
DEG_SPOP_SBC_1	570	574	PF00917	0.531
DEG_SPOP_SBC_1	609	613	PF00917	0.521
DEG_SPOP_SBC_1	648	652	PF00917	0.499
DOC_CYCLIN_RxL_1	114	124	PF00134	0.539
DOC_MAPK_MEF2A_6	8	16	PF00069	0.620
DOC_USP7_MATH_1	110	114	PF00917	0.607
DOC_USP7_MATH_1	140	144	PF00917	0.626
DOC_USP7_MATH_1	179	183	PF00917	0.606
DOC_USP7_MATH_1	218	222	PF00917	0.608
DOC_USP7_MATH_1	257	261	PF00917	0.544
DOC_USP7_MATH_1	296	300	PF00917	0.563
DOC_USP7_MATH_1	335	339	PF00917	0.516
DOC_USP7_MATH_1	374	378	PF00917	0.616
DOC_USP7_MATH_1	413	417	PF00917	0.606
DOC_USP7_MATH_1	452	456	PF00917	0.626
DOC_USP7_MATH_1	491	495	PF00917	0.556
DOC_USP7_MATH_1	530	534	PF00917	0.560
DOC_USP7_MATH_1	569	573	PF00917	0.546
DOC_USP7_MATH_1	608	612	PF00917	0.605
DOC_USP7_MATH_1	647	651	PF00917	0.582
DOC_USP7_MATH_1	781	785	PF00917	0.544
DOC_USP7_UBL2_3	710	714	PF12436	0.595
DOC_WW_Pin1_4	8	13	PF00397	0.650
LIG_14-3-3_CanoR_1	38	45	PF00244	0.673
LIG_BRCT_BRCA1_1	701	705	PF00533	0.526
LIG_Clathr_ClatBox_1	120	124	PF01394	0.489
LIG_FHA_1	116	122	PF00498	0.546
LIG_FHA_1	750	756	PF00498	0.474
LIG_FHA_2	110	116	PF00498	0.551
LIG_FHA_2	50	56	PF00498	0.601
LIG_GBD_Chelix_1	721	729	PF00786	0.530
LIG_LIR_Gen_1	55	64	PF02991	0.534
LIG_LIR_Gen_1	95	106	PF02991	0.451
LIG_LIR_Nem_3	55	60	PF02991	0.585
LIG_LIR_Nem_3	95	101	PF02991	0.437
LIG_RPA_C_Fungi	161	173	PF08784	0.478
LIG_RPA_C_Fungi	200	212	PF08784	0.518
LIG_RPA_C_Fungi	239	251	PF08784	0.543
LIG_RPA_C_Fungi	278	290	PF08784	0.497
LIG_RPA_C_Fungi	317	329	PF08784	0.543
LIG_RPA_C_Fungi	356	368	PF08784	0.543
LIG_RPA_C_Fungi	395	407	PF08784	0.534
LIG_RPA_C_Fungi	434	446	PF08784	0.539
LIG_RPA_C_Fungi	473	485	PF08784	0.539
LIG_RPA_C_Fungi	512	524	PF08784	0.530
LIG_RPA_C_Fungi	551	563	PF08784	0.539
LIG_RPA_C_Fungi	590	602	PF08784	0.518
LIG_RPA_C_Fungi	629	641	PF08784	0.508
LIG_RPA_C_Fungi	668	680	PF08784	0.484
LIG_SH2_CRK	57	61	PF00017	0.568
LIG_SH2_GRB2like	57	60	PF00017	0.538
LIG_SH2_STAT5	33	36	PF00017	0.679
LIG_SH3_3	11	17	PF00018	0.707
LIG_SH3_3	692	698	PF00018	0.575
LIG_SUMO_SIM_par_1	118	124	PF11976	0.487
LIG_TRAF2_1	789	792	PF00917	0.613
MOD_CAAXbox	808	811	PF01239	0.594
MOD_CK1_1	29	35	PF00069	0.675
MOD_CK1_1	37	43	PF00069	0.819
MOD_CK1_1	46	52	PF00069	0.687
MOD_CK2_1	109	115	PF00069	0.567
MOD_CK2_1	140	146	PF00069	0.547
MOD_CK2_1	179	185	PF00069	0.698
MOD_CK2_1	218	224	PF00069	0.615
MOD_CK2_1	257	263	PF00069	0.547
MOD_CK2_1	296	302	PF00069	0.566
MOD_CK2_1	335	341	PF00069	0.520
MOD_CK2_1	374	380	PF00069	0.620
MOD_CK2_1	413	419	PF00069	0.610
MOD_CK2_1	452	458	PF00069	0.630
MOD_CK2_1	49	55	PF00069	0.610
MOD_CK2_1	491	497	PF00069	0.559
MOD_CK2_1	530	536	PF00069	0.565
MOD_CK2_1	569	575	PF00069	0.550
MOD_CK2_1	608	614	PF00069	0.607
MOD_CK2_1	647	653	PF00069	0.584
MOD_CK2_1	786	792	PF00069	0.547
MOD_GlcNHglycan	40	43	PF01048	0.693
MOD_GlcNHglycan	49	52	PF01048	0.634
MOD_GlcNHglycan	701	704	PF01048	0.579
MOD_GlcNHglycan	783	787	PF01048	0.663
MOD_GlcNHglycan	788	791	PF01048	0.716
MOD_GSK3_1	142	149	PF00069	0.467
MOD_GSK3_1	181	188	PF00069	0.524
MOD_GSK3_1	20	27	PF00069	0.671
MOD_GSK3_1	220	227	PF00069	0.537
MOD_GSK3_1	259	266	PF00069	0.535
MOD_GSK3_1	28	35	PF00069	0.621
MOD_GSK3_1	298	305	PF00069	0.552
MOD_GSK3_1	337	344	PF00069	0.556
MOD_GSK3_1	36	43	PF00069	0.675
MOD_GSK3_1	376	383	PF00069	0.554
MOD_GSK3_1	415	422	PF00069	0.546
MOD_GSK3_1	45	52	PF00069	0.583
MOD_GSK3_1	454	461	PF00069	0.551
MOD_GSK3_1	493	500	PF00069	0.543
MOD_GSK3_1	532	539	PF00069	0.557
MOD_GSK3_1	571	578	PF00069	0.535
MOD_GSK3_1	610	617	PF00069	0.525
MOD_GSK3_1	649	656	PF00069	0.501
MOD_GSK3_1	782	789	PF00069	0.580
MOD_LATS_1	36	42	PF00433	0.645
MOD_N-GLC_1	24	29	PF02516	0.788
MOD_N-GLC_1	699	704	PF02516	0.517
MOD_NEK2_1	81	86	PF00069	0.587
MOD_PIKK_1	26	32	PF00454	0.671
MOD_PKA_2	37	43	PF00069	0.643
MOD_PKA_2	82	88	PF00069	0.711
MOD_Plk_1	20	26	PF00069	0.738
MOD_Plk_4	40	46	PF00069	0.672
MOD_ProDKin_1	8	14	PF00069	0.650
MOD_SUMO_for_1	60	63	PF00179	0.527
TRG_AP2beta_CARGO_1	95	105	PF09066	0.447
TRG_DiLeu_BaEn_1	735	740	PF01217	0.448
TRG_DiLeu_BaEn_1	783	788	PF01217	0.614
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.497
TRG_ENDOCYTIC_2	57	60	PF00928	0.572
TRG_ENDOCYTIC_2	78	81	PF00928	0.713
TRG_ER_diArg_1	775	778	PF00400	0.550
TRG_NES_CRM1_1	681	697	PF08389	0.460
TRG_Pf-PMV_PEXEL_1	119	124	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6W4	Leishmania donovani	80%	77%
A4HLU0	Leishmania braziliensis	62%	100%
C9ZSW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	98%
E9AHP6	Leishmania infantum	76%	100%
Q4Q3W0	Leishmania major	77%	100%