RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B464_LEIMU

TriTrypDb:

LmxM.32.2250

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B464

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B464

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.495
CLV_C14_Caspase3-7	395	399	PF00656	0.694
CLV_C14_Caspase3-7	425	429	PF00656	0.697
CLV_NRD_NRD_1	127	129	PF00675	0.545
CLV_NRD_NRD_1	378	380	PF00675	0.531
CLV_PCSK_KEX2_1	118	120	PF00082	0.576
CLV_PCSK_KEX2_1	306	308	PF00082	0.700
CLV_PCSK_KEX2_1	320	322	PF00082	0.657
CLV_PCSK_KEX2_1	378	380	PF00082	0.531
CLV_PCSK_KEX2_1	440	442	PF00082	0.599
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.659
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.700
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.657
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.650
CLV_PCSK_SKI1_1	138	142	PF00082	0.609
CLV_PCSK_SKI1_1	19	23	PF00082	0.549
CLV_PCSK_SKI1_1	229	233	PF00082	0.418
CLV_PCSK_SKI1_1	309	313	PF00082	0.725
CLV_PCSK_SKI1_1	378	382	PF00082	0.526
CLV_PCSK_SKI1_1	407	411	PF00082	0.600
DEG_APCC_DBOX_1	214	222	PF00400	0.563
DEG_APCC_DBOX_1	228	236	PF00400	0.430
DEG_Nend_UBRbox_2	1	3	PF02207	0.543
DEG_SPOP_SBC_1	368	372	PF00917	0.640
DOC_CYCLIN_yClb5_NLxxxL_5	417	424	PF00134	0.371
DOC_MAPK_HePTP_8	318	330	PF00069	0.602
DOC_MAPK_MEF2A_6	321	330	PF00069	0.596
DOC_PP2B_LxvP_1	427	430	PF13499	0.637
DOC_SPAK_OSR1_1	247	251	PF12202	0.484
DOC_USP7_MATH_1	14	18	PF00917	0.480
DOC_USP7_MATH_1	172	176	PF00917	0.788
DOC_USP7_MATH_1	202	206	PF00917	0.667
DOC_USP7_MATH_1	256	260	PF00917	0.496
DOC_USP7_MATH_1	341	345	PF00917	0.799
DOC_USP7_MATH_1	364	368	PF00917	0.737
DOC_USP7_MATH_1	374	378	PF00917	0.618
DOC_USP7_MATH_1	63	67	PF00917	0.631
DOC_USP7_MATH_1	74	78	PF00917	0.709
DOC_WW_Pin1_4	166	171	PF00397	0.695
DOC_WW_Pin1_4	183	188	PF00397	0.434
DOC_WW_Pin1_4	400	405	PF00397	0.766
LIG_14-3-3_CanoR_1	111	117	PF00244	0.503
LIG_14-3-3_CanoR_1	173	183	PF00244	0.743
LIG_14-3-3_CanoR_1	19	24	PF00244	0.497
LIG_14-3-3_CanoR_1	215	219	PF00244	0.595
LIG_14-3-3_CanoR_1	234	242	PF00244	0.560
LIG_14-3-3_CanoR_1	331	337	PF00244	0.708
LIG_14-3-3_CanoR_1	378	383	PF00244	0.633
LIG_14-3-3_CanoR_1	44	52	PF00244	0.536
LIG_14-3-3_CanoR_1	441	450	PF00244	0.465
LIG_BRCT_BRCA1_1	204	208	PF00533	0.703
LIG_FHA_1	111	117	PF00498	0.503
LIG_FHA_1	149	155	PF00498	0.578
LIG_FHA_1	284	290	PF00498	0.801
LIG_FHA_1	30	36	PF00498	0.498
LIG_FHA_1	353	359	PF00498	0.734
LIG_FHA_2	28	34	PF00498	0.542
LIG_FHA_2	379	385	PF00498	0.734
LIG_LIR_Gen_1	108	116	PF02991	0.453
LIG_LIR_Gen_1	17	26	PF02991	0.494
LIG_LIR_Gen_1	236	244	PF02991	0.444
LIG_LIR_Nem_3	108	112	PF02991	0.480
LIG_LIR_Nem_3	17	23	PF02991	0.488
LIG_MYND_1	70	74	PF01753	0.717
LIG_SH2_CRK	109	113	PF00017	0.459
LIG_SH2_CRK	7	11	PF00017	0.450
LIG_SH2_NCK_1	255	259	PF00017	0.535
LIG_SH2_STAT5	156	159	PF00017	0.447
LIG_SH2_STAT5	20	23	PF00017	0.500
LIG_SH3_2	326	331	PF14604	0.495
LIG_SH3_3	184	190	PF00018	0.626
LIG_SH3_3	20	26	PF00018	0.617
LIG_SH3_3	323	329	PF00018	0.667
LIG_SH3_3	67	73	PF00018	0.740
LIG_SUMO_SIM_par_1	112	117	PF11976	0.498
LIG_TRAF2_1	237	240	PF00917	0.501
LIG_TYR_ITIM	5	10	PF00017	0.442
LIG_UBA3_1	207	212	PF00899	0.722
MOD_CDK_SPK_2	168	173	PF00069	0.490
MOD_CDK_SPxxK_3	166	173	PF00069	0.703
MOD_CDK_SPxxK_3	400	407	PF00069	0.675
MOD_CK1_1	149	155	PF00069	0.690
MOD_CK1_1	276	282	PF00069	0.619
MOD_CK1_1	367	373	PF00069	0.787
MOD_CK1_1	75	81	PF00069	0.720
MOD_CK2_1	233	239	PF00069	0.490
MOD_CK2_1	254	260	PF00069	0.515
MOD_GlcNHglycan	148	151	PF01048	0.672
MOD_GlcNHglycan	16	19	PF01048	0.459
MOD_GlcNHglycan	176	179	PF01048	0.638
MOD_GlcNHglycan	235	238	PF01048	0.415
MOD_GlcNHglycan	256	259	PF01048	0.521
MOD_GlcNHglycan	276	279	PF01048	0.652
MOD_GlcNHglycan	343	346	PF01048	0.794
MOD_GlcNHglycan	366	369	PF01048	0.760
MOD_GlcNHglycan	374	377	PF01048	0.784
MOD_GlcNHglycan	391	394	PF01048	0.616
MOD_GlcNHglycan	400	403	PF01048	0.614
MOD_GlcNHglycan	433	436	PF01048	0.658
MOD_GlcNHglycan	443	446	PF01048	0.582
MOD_GlcNHglycan	65	68	PF01048	0.692
MOD_GlcNHglycan	76	80	PF01048	0.749
MOD_GlcNHglycan	84	87	PF01048	0.597
MOD_GSK3_1	110	117	PF00069	0.462
MOD_GSK3_1	168	175	PF00069	0.528
MOD_GSK3_1	250	257	PF00069	0.427
MOD_GSK3_1	276	283	PF00069	0.641
MOD_GSK3_1	284	291	PF00069	0.719
MOD_GSK3_1	339	346	PF00069	0.733
MOD_GSK3_1	363	370	PF00069	0.705
MOD_GSK3_1	374	381	PF00069	0.751
MOD_GSK3_1	385	392	PF00069	0.798
MOD_GSK3_1	57	64	PF00069	0.392
MOD_N-GLC_1	45	50	PF02516	0.478
MOD_NEK2_1	112	117	PF00069	0.453
MOD_NEK2_1	148	153	PF00069	0.608
MOD_NEK2_1	182	187	PF00069	0.551
MOD_NEK2_1	332	337	PF00069	0.607
MOD_NEK2_1	82	87	PF00069	0.778
MOD_OFUCOSY	249	254	PF10250	0.461
MOD_PIKK_1	202	208	PF00454	0.620
MOD_PKA_1	378	384	PF00069	0.522
MOD_PKA_2	110	116	PF00069	0.497
MOD_PKA_2	172	178	PF00069	0.767
MOD_PKA_2	214	220	PF00069	0.743
MOD_PKA_2	233	239	PF00069	0.497
MOD_PKA_2	378	384	PF00069	0.649
MOD_Plk_1	299	305	PF00069	0.735
MOD_Plk_1	45	51	PF00069	0.534
MOD_Plk_4	290	296	PF00069	0.700
MOD_Plk_4	314	320	PF00069	0.601
MOD_Plk_4	422	428	PF00069	0.616
MOD_ProDKin_1	166	172	PF00069	0.695
MOD_ProDKin_1	183	189	PF00069	0.430
MOD_ProDKin_1	400	406	PF00069	0.758
MOD_SUMO_for_1	311	314	PF00179	0.747
MOD_SUMO_rev_2	322	329	PF00179	0.632
TRG_DiLeu_BaEn_1	53	58	PF01217	0.522
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.442
TRG_ENDOCYTIC_2	109	112	PF00928	0.454
TRG_ENDOCYTIC_2	20	23	PF00928	0.488
TRG_ENDOCYTIC_2	7	10	PF00928	0.441
TRG_NES_CRM1_1	414	428	PF08389	0.605
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILE8	Leptomonas seymouri	47%	100%
A0A3Q8IH00	Leishmania donovani	89%	99%
A4HLT8	Leishmania braziliensis	72%	99%
D0A688	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AHP4	Leishmania infantum	89%	99%
Q4Q3W2	Leishmania major	88%	100%