LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B463_LEIMU
TriTrypDb:
LmxM.32.2240
Length:
311

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B463
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B463

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 136 138 PF00675 0.613
CLV_NRD_NRD_1 181 183 PF00675 0.590
CLV_NRD_NRD_1 204 206 PF00675 0.647
CLV_NRD_NRD_1 284 286 PF00675 0.496
CLV_NRD_NRD_1 34 36 PF00675 0.385
CLV_NRD_NRD_1 4 6 PF00675 0.665
CLV_NRD_NRD_1 55 57 PF00675 0.521
CLV_PCSK_KEX2_1 136 138 PF00082 0.668
CLV_PCSK_KEX2_1 181 183 PF00082 0.544
CLV_PCSK_KEX2_1 204 206 PF00082 0.698
CLV_PCSK_KEX2_1 284 286 PF00082 0.496
CLV_PCSK_KEX2_1 34 36 PF00082 0.494
CLV_PCSK_KEX2_1 4 6 PF00082 0.690
CLV_PCSK_KEX2_1 55 57 PF00082 0.521
CLV_PCSK_PC7_1 51 57 PF00082 0.506
CLV_PCSK_SKI1_1 124 128 PF00082 0.531
CLV_PCSK_SKI1_1 5 9 PF00082 0.477
CLV_PCSK_SKI1_1 51 55 PF00082 0.505
DEG_Nend_UBRbox_3 1 3 PF02207 0.675
DOC_CKS1_1 66 71 PF01111 0.659
DOC_MAPK_gen_1 103 110 PF00069 0.449
DOC_MAPK_gen_1 169 177 PF00069 0.633
DOC_PP1_RVXF_1 159 166 PF00149 0.634
DOC_WW_Pin1_4 65 70 PF00397 0.654
LIG_14-3-3_CanoR_1 136 140 PF00244 0.710
LIG_14-3-3_CanoR_1 204 213 PF00244 0.539
LIG_14-3-3_CanoR_1 4 14 PF00244 0.616
LIG_APCC_ABBAyCdc20_2 137 143 PF00400 0.665
LIG_BRCT_BRCA1_1 22 26 PF00533 0.477
LIG_BRCT_BRCA1_1 230 234 PF00533 0.650
LIG_Clathr_ClatBox_1 29 33 PF01394 0.350
LIG_FHA_1 140 146 PF00498 0.606
LIG_FHA_1 155 161 PF00498 0.517
LIG_FHA_1 301 307 PF00498 0.705
LIG_FHA_1 78 84 PF00498 0.476
LIG_FHA_2 130 136 PF00498 0.667
LIG_KLC1_Yacidic_2 257 262 PF13176 0.617
LIG_LIR_Apic_2 142 147 PF02991 0.563
LIG_LIR_Gen_1 16 27 PF02991 0.564
LIG_LIR_Gen_1 162 173 PF02991 0.604
LIG_LIR_Nem_3 122 126 PF02991 0.529
LIG_LIR_Nem_3 162 168 PF02991 0.648
LIG_LIR_Nem_3 23 29 PF02991 0.542
LIG_LIR_Nem_3 231 237 PF02991 0.606
LIG_LIR_Nem_3 255 261 PF02991 0.573
LIG_LIR_Nem_3 52 57 PF02991 0.509
LIG_LYPXL_S_1 26 30 PF13949 0.625
LIG_PDZ_Class_1 306 311 PF00595 0.745
LIG_Pex14_2 123 127 PF04695 0.506
LIG_Pex14_2 26 30 PF04695 0.608
LIG_Pex14_2 73 77 PF04695 0.617
LIG_PTB_Apo_2 56 63 PF02174 0.555
LIG_PTB_Apo_2 71 78 PF02174 0.404
LIG_PTB_Phospho_1 56 62 PF10480 0.550
LIG_SH2_CRK 93 97 PF00017 0.496
LIG_SH2_PTP2 144 147 PF00017 0.628
LIG_SH2_STAT5 144 147 PF00017 0.600
LIG_SH2_STAT5 260 263 PF00017 0.540
LIG_SH3_1 63 69 PF00018 0.574
LIG_SH3_3 63 69 PF00018 0.589
LIG_SH3_3 9 15 PF00018 0.645
LIG_SH3_3 98 104 PF00018 0.597
LIG_SH3_4 218 225 PF00018 0.588
LIG_SUMO_SIM_anti_2 84 90 PF11976 0.404
LIG_SUMO_SIM_par_1 79 84 PF11976 0.605
LIG_TRAF2_1 238 241 PF00917 0.564
MOD_CK1_1 125 131 PF00069 0.578
MOD_CK1_1 167 173 PF00069 0.581
MOD_CK1_1 296 302 PF00069 0.676
MOD_CK1_1 95 101 PF00069 0.522
MOD_CK2_1 129 135 PF00069 0.627
MOD_GSK3_1 125 132 PF00069 0.522
MOD_GSK3_1 135 142 PF00069 0.529
MOD_GSK3_1 159 166 PF00069 0.557
MOD_GSK3_1 271 278 PF00069 0.514
MOD_GSK3_1 296 303 PF00069 0.641
MOD_N-GLC_1 163 168 PF02516 0.420
MOD_N-GLC_1 306 311 PF02516 0.745
MOD_N-GLC_1 42 47 PF02516 0.389
MOD_NEK2_1 159 164 PF00069 0.473
MOD_NEK2_1 195 200 PF00069 0.679
MOD_NEK2_1 213 218 PF00069 0.585
MOD_NEK2_1 44 49 PF00069 0.601
MOD_PIKK_1 187 193 PF00454 0.693
MOD_PIKK_1 5 11 PF00454 0.676
MOD_PKA_1 5 11 PF00069 0.453
MOD_PKA_2 135 141 PF00069 0.713
MOD_PKA_2 214 220 PF00069 0.624
MOD_PKA_2 271 277 PF00069 0.772
MOD_Plk_1 154 160 PF00069 0.639
MOD_Plk_1 163 169 PF00069 0.607
MOD_Plk_4 264 270 PF00069 0.539
MOD_Plk_4 300 306 PF00069 0.469
MOD_Plk_4 84 90 PF00069 0.463
MOD_Plk_4 92 98 PF00069 0.441
MOD_ProDKin_1 65 71 PF00069 0.656
MOD_SUMO_rev_2 208 213 PF00179 0.551
TRG_DiLeu_BaEn_1 84 89 PF01217 0.579
TRG_ENDOCYTIC_2 27 30 PF00928 0.508
TRG_ENDOCYTIC_2 93 96 PF00928 0.488
TRG_ER_diArg_1 204 206 PF00400 0.637
TRG_ER_diArg_1 284 286 PF00400 0.496
TRG_ER_diArg_1 54 56 PF00400 0.491

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE06 Leptomonas seymouri 64% 100%
A0A0S4JDA2 Bodo saltans 24% 97%
A0A1X0P3S3 Trypanosomatidae 41% 100%
A0A3S7X717 Leishmania donovani 90% 100%
A0A422NI03 Trypanosoma rangeli 40% 100%
A4HLT7 Leishmania braziliensis 77% 97%
D0A689 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9AHP3 Leishmania infantum 90% 100%
Q4Q3W3 Leishmania major 91% 100%
V5DQC4 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS