CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B462_LEIMU

TriTrypDb:

LmxM.32.2230

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B462

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B462

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.453
CLV_C14_Caspase3-7	3	7	PF00656	0.698
CLV_C14_Caspase3-7	65	69	PF00656	0.657
CLV_C14_Caspase3-7	87	91	PF00656	0.663
CLV_NRD_NRD_1	36	38	PF00675	0.800
CLV_PCSK_KEX2_1	36	38	PF00082	0.654
CLV_PCSK_PC7_1	32	38	PF00082	0.563
CLV_PCSK_SKI1_1	117	121	PF00082	0.312
CLV_Separin_Metazoa	98	102	PF03568	0.445
DEG_APCC_DBOX_1	116	124	PF00400	0.267
DEG_SCF_FBW7_2	299	306	PF00400	0.599
DEG_SPOP_SBC_1	291	295	PF00917	0.435
DOC_ANK_TNKS_1	245	252	PF00023	0.557
DOC_CYCLIN_RxL_1	220	230	PF00134	0.305
DOC_MAPK_gen_1	170	179	PF00069	0.430
DOC_USP7_MATH_1	11	15	PF00917	0.550
DOC_USP7_MATH_1	84	88	PF00917	0.601
DOC_WW_Pin1_4	15	20	PF00397	0.666
DOC_WW_Pin1_4	215	220	PF00397	0.570
DOC_WW_Pin1_4	227	232	PF00397	0.372
DOC_WW_Pin1_4	299	304	PF00397	0.717
LIG_APCC_ABBA_1	224	229	PF00400	0.570
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_BIR_III_2	205	209	PF00653	0.420
LIG_BIR_III_2	90	94	PF00653	0.616
LIG_BRCT_BRCA1_1	253	257	PF00533	0.390
LIG_BRCT_BRCA1_1	77	81	PF00533	0.579
LIG_deltaCOP1_diTrp_1	279	285	PF00928	0.398
LIG_eIF4E_1	139	145	PF01652	0.495
LIG_FHA_1	184	190	PF00498	0.420
LIG_FHA_2	193	199	PF00498	0.562
LIG_LIR_Nem_3	143	148	PF02991	0.386
LIG_LIR_Nem_3	169	174	PF02991	0.358
LIG_LIR_Nem_3	221	227	PF02991	0.496
LIG_LIR_Nem_3	254	260	PF02991	0.546
LIG_LIR_Nem_3	282	288	PF02991	0.402
LIG_LIR_Nem_3	327	332	PF02991	0.471
LIG_MYND_3	225	229	PF01753	0.461
LIG_Pex14_1	281	285	PF04695	0.393
LIG_Pex14_2	253	257	PF04695	0.365
LIG_Rb_LxCxE_1	230	250	PF01857	0.580
LIG_REV1ctd_RIR_1	169	177	PF16727	0.382
LIG_SH2_NCK_1	258	262	PF00017	0.591
LIG_SH2_STAT5	129	132	PF00017	0.560
LIG_SH2_STAT5	148	151	PF00017	0.377
LIG_SH3_3	90	96	PF00018	0.568
LIG_SUMO_SIM_anti_2	198	205	PF11976	0.474
LIG_SUMO_SIM_anti_2	267	272	PF11976	0.400
LIG_SUMO_SIM_par_1	192	199	PF11976	0.440
LIG_SUMO_SIM_par_1	287	295	PF11976	0.425
LIG_TRAF2_1	18	21	PF00917	0.545
LIG_TYR_ITIM	146	151	PF00017	0.395
MOD_CDK_SPK_2	227	232	PF00069	0.466
MOD_CDK_SPxxK_3	15	22	PF00069	0.548
MOD_CK1_1	15	21	PF00069	0.654
MOD_CK1_1	230	236	PF00069	0.427
MOD_CK1_1	290	296	PF00069	0.442
MOD_CK1_1	67	73	PF00069	0.519
MOD_CK2_1	15	21	PF00069	0.548
MOD_CK2_1	192	198	PF00069	0.550
MOD_CK2_1	77	83	PF00069	0.554
MOD_GlcNHglycan	161	164	PF01048	0.521
MOD_GlcNHglycan	198	201	PF01048	0.597
MOD_GlcNHglycan	42	45	PF01048	0.674
MOD_GlcNHglycan	86	89	PF01048	0.587
MOD_GSK3_1	192	199	PF00069	0.468
MOD_GSK3_1	214	221	PF00069	0.296
MOD_GSK3_1	287	294	PF00069	0.517
MOD_GSK3_1	304	311	PF00069	0.569
MOD_GSK3_1	9	16	PF00069	0.706
MOD_N-GLC_1	291	296	PF02516	0.507
MOD_NEK2_1	192	197	PF00069	0.387
MOD_PK_1	264	270	PF00069	0.440
MOD_PKA_2	35	41	PF00069	0.768
MOD_Plk_1	12	18	PF00069	0.679
MOD_Plk_1	291	297	PF00069	0.524
MOD_Plk_1	67	73	PF00069	0.654
MOD_Plk_1	75	81	PF00069	0.634
MOD_Plk_2-3	77	83	PF00069	0.672
MOD_Plk_4	292	298	PF00069	0.607
MOD_ProDKin_1	15	21	PF00069	0.668
MOD_ProDKin_1	215	221	PF00069	0.567
MOD_ProDKin_1	227	233	PF00069	0.369
MOD_ProDKin_1	299	305	PF00069	0.715
MOD_SUMO_rev_2	269	278	PF00179	0.437
TRG_DiLeu_BaEn_2	153	159	PF01217	0.537
TRG_ENDOCYTIC_2	133	136	PF00928	0.454
TRG_ENDOCYTIC_2	148	151	PF00928	0.367
TRG_ER_diArg_1	172	175	PF00400	0.527
TRG_ER_diArg_1	244	247	PF00400	0.522
TRG_ER_diArg_1	36	39	PF00400	0.779
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J871	Bodo saltans	38%	76%
A0A1X0P3S1	Trypanosomatidae	53%	72%
A0A3R7KC26	Trypanosoma rangeli	52%	71%
A4HLT6	Leishmania braziliensis	77%	85%
Q4Q3W4	Leishmania major	93%	100%
V5BTU1	Trypanosoma cruzi	52%	70%