Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B460_LEIMU

TriTrypDb:

LmxM.32.2210

Length:

193

Annotations

LeishMANIAdb annotations

A divergent protein family loosely similar in structure to the FAM210 family of poorly-known mitochondrial proteins.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B460

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B460

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.646
CLV_NRD_NRD_1	35	37	PF00675	0.425
CLV_NRD_NRD_1	41	43	PF00675	0.414
CLV_PCSK_FUR_1	32	36	PF00082	0.449
CLV_PCSK_KEX2_1	34	36	PF00082	0.473
CLV_PCSK_KEX2_1	80	82	PF00082	0.379
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.396
CLV_PCSK_SKI1_1	129	133	PF00082	0.604
CLV_PCSK_SKI1_1	171	175	PF00082	0.383
CLV_PCSK_SKI1_1	4	8	PF00082	0.456
CLV_PCSK_SKI1_1	47	51	PF00082	0.483
CLV_PCSK_SKI1_1	84	88	PF00082	0.374
DEG_APCC_DBOX_1	170	178	PF00400	0.491
DOC_CYCLIN_yCln2_LP_2	158	164	PF00134	0.429
DOC_MAPK_gen_1	20	29	PF00069	0.707
DOC_MAPK_gen_1	42	51	PF00069	0.554
DOC_MAPK_gen_1	80	91	PF00069	0.493
DOC_MAPK_RevD_3	59	74	PF00069	0.519
DOC_PP1_RVXF_1	127	134	PF00149	0.344
DOC_PP1_RVXF_1	66	73	PF00149	0.548
DOC_USP7_UBL2_3	80	84	PF12436	0.657
DOC_WD40_RPTOR_TOS_1	57	62	PF00400	0.686
LIG_BRCT_BRCA1_1	25	29	PF00533	0.712
LIG_deltaCOP1_diTrp_1	137	145	PF00928	0.389
LIG_deltaCOP1_diTrp_1	69	78	PF00928	0.711
LIG_FHA_1	54	60	PF00498	0.623
LIG_FHA_2	123	129	PF00498	0.398
LIG_LIR_Gen_1	113	123	PF02991	0.351
LIG_LIR_Gen_1	130	138	PF02991	0.330
LIG_LIR_Gen_1	140	150	PF02991	0.322
LIG_LIR_Gen_1	154	165	PF02991	0.254
LIG_LIR_Nem_3	113	119	PF02991	0.328
LIG_LIR_Nem_3	130	136	PF02991	0.314
LIG_LIR_Nem_3	137	142	PF02991	0.433
LIG_LIR_Nem_3	154	160	PF02991	0.267
LIG_LIR_Nem_3	44	49	PF02991	0.600
LIG_Pex14_1	72	76	PF04695	0.716
LIG_Pex14_2	116	120	PF04695	0.404
LIG_Pex14_2	122	126	PF04695	0.438
LIG_Pex14_2	145	149	PF04695	0.327
LIG_PTB_Apo_2	141	148	PF02174	0.370
LIG_REV1ctd_RIR_1	130	139	PF16727	0.424
LIG_SH2_GRB2like	142	145	PF00017	0.384
LIG_SH2_PTP2	94	97	PF00017	0.448
LIG_SH2_STAT5	102	105	PF00017	0.318
LIG_SH2_STAT5	90	93	PF00017	0.318
LIG_SH2_STAT5	94	97	PF00017	0.318
LIG_WRC_WIRS_1	123	128	PF05994	0.474
MOD_CK1_1	19	25	PF00069	0.674
MOD_CK2_1	27	33	PF00069	0.575
MOD_CK2_1	6	12	PF00069	0.690
MOD_GlcNHglycan	106	109	PF01048	0.479
MOD_GlcNHglycan	29	32	PF01048	0.373
MOD_GSK3_1	12	19	PF00069	0.655
MOD_GSK3_1	23	30	PF00069	0.650
MOD_LATS_1	2	8	PF00433	0.706
MOD_LATS_1	82	88	PF00433	0.383
MOD_N-GLC_1	151	156	PF02516	0.626
MOD_NEK2_1	122	127	PF00069	0.463
MOD_NEK2_1	27	32	PF00069	0.675
MOD_PKB_1	45	53	PF00069	0.581
MOD_Plk_1	151	157	PF00069	0.433
MOD_Plk_1	47	53	PF00069	0.685
MOD_Plk_2-3	12	18	PF00069	0.628
MOD_Plk_4	122	128	PF00069	0.446
MOD_Plk_4	181	187	PF00069	0.663
MOD_Plk_4	23	29	PF00069	0.708
MOD_SUMO_rev_2	12	22	PF00179	0.679
TRG_DiLeu_BaEn_2	152	158	PF01217	0.324
TRG_ENDOCYTIC_2	102	105	PF00928	0.329
TRG_ENDOCYTIC_2	142	145	PF00928	0.380
TRG_ER_diArg_1	34	36	PF00400	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I761	Leptomonas seymouri	66%	70%
A0A0S4J7U8	Bodo saltans	41%	76%
A0A1X0P4I8	Trypanosomatidae	55%	75%
A0A3S7X712	Leishmania donovani	93%	100%
A0A422NI31	Trypanosoma rangeli	53%	75%
A4HLT4	Leishmania braziliensis	85%	100%
D0A692	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	71%
E9AHP0	Leishmania infantum	94%	100%
Q4Q3W6	Leishmania major	93%	100%