Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9B459_LEIMU

TriTrypDb:

LmxM.32.2205

Length:

226

Annotations

LeishMANIAdb annotations

A divergent protein family loosely similar in structure to the FAM210 family of poorly-known mitochondrial proteins.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9B459

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B459

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.602
CLV_NRD_NRD_1	215	217	PF00675	0.403
CLV_NRD_NRD_1	99	101	PF00675	0.377
CLV_PCSK_KEX2_1	215	217	PF00082	0.393
CLV_PCSK_KEX2_1	99	101	PF00082	0.402
CLV_PCSK_SKI1_1	103	107	PF00082	0.414
CLV_Separin_Metazoa	182	186	PF03568	0.324
DEG_Nend_Nbox_1	1	3	PF02207	0.584
DOC_PP4_FxxP_1	115	118	PF00568	0.377
DOC_USP7_MATH_1	104	108	PF00917	0.542
DOC_USP7_MATH_1	11	15	PF00917	0.784
DOC_USP7_MATH_1	164	168	PF00917	0.425
DOC_USP7_MATH_1	41	45	PF00917	0.601
DOC_USP7_MATH_2	41	47	PF00917	0.601
DOC_WW_Pin1_4	31	36	PF00397	0.787
LIG_14-3-3_CanoR_1	103	112	PF00244	0.564
LIG_14-3-3_CanoR_1	216	226	PF00244	0.675
LIG_Actin_WH2_2	200	217	PF00022	0.533
LIG_BRCT_BRCA1_1	199	203	PF00533	0.592
LIG_FHA_1	23	29	PF00498	0.815
LIG_FHA_1	3	9	PF00498	0.640
LIG_FHA_1	53	59	PF00498	0.593
LIG_FHA_2	83	89	PF00498	0.625
LIG_LIR_Apic_2	113	118	PF02991	0.377
LIG_LIR_Gen_1	110	120	PF02991	0.496
LIG_LIR_Gen_1	123	131	PF02991	0.271
LIG_LIR_Gen_1	167	176	PF02991	0.360
LIG_LIR_Nem_3	110	115	PF02991	0.496
LIG_LIR_Nem_3	123	129	PF02991	0.271
LIG_Pex14_1	206	210	PF04695	0.462
LIG_Pex14_2	115	119	PF04695	0.377
LIG_Pex14_2	127	131	PF04695	0.377
LIG_SH2_STAT5	116	119	PF00017	0.297
LIG_SH2_STAT5	120	123	PF00017	0.289
LIG_SH2_STAT5	128	131	PF00017	0.283
LIG_SH2_STAT5	144	147	PF00017	0.338
LIG_SH2_STAT5	194	197	PF00017	0.407
LIG_SH3_3	181	187	PF00018	0.352
LIG_SH3_3	192	198	PF00018	0.411
LIG_SUMO_SIM_anti_2	179	185	PF11976	0.276
LIG_ULM_U2AF65_1	215	220	PF00076	0.560
LIG_WRC_WIRS_1	121	126	PF05994	0.187
MOD_CK1_1	107	113	PF00069	0.599
MOD_CK1_1	34	40	PF00069	0.763
MOD_CK1_1	4	10	PF00069	0.796
MOD_CK1_1	46	52	PF00069	0.671
MOD_CK1_1	63	69	PF00069	0.735
MOD_CK1_1	74	80	PF00069	0.760
MOD_CK2_1	82	88	PF00069	0.755
MOD_CMANNOS	165	168	PF00535	0.641
MOD_GlcNHglycan	13	16	PF01048	0.536
MOD_GlcNHglycan	43	46	PF01048	0.598
MOD_GlcNHglycan	9	12	PF01048	0.524
MOD_GSK3_1	27	34	PF00069	0.771
MOD_GSK3_1	46	53	PF00069	0.698
MOD_GSK3_1	7	14	PF00069	0.740
MOD_GSK3_1	71	78	PF00069	0.726
MOD_GSK3_1	82	89	PF00069	0.713
MOD_NEK2_1	1	6	PF00069	0.716
MOD_NEK2_1	129	134	PF00069	0.323
MOD_PIKK_1	60	66	PF00454	0.713
MOD_PIKK_1	72	78	PF00454	0.591
MOD_Plk_1	110	116	PF00069	0.529
MOD_Plk_4	120	126	PF00069	0.377
MOD_Plk_4	144	150	PF00069	0.436
MOD_ProDKin_1	31	37	PF00069	0.789
MOD_SUMO_for_1	105	108	PF00179	0.625
TRG_ENDOCYTIC_2	116	119	PF00928	0.321
TRG_ENDOCYTIC_2	128	131	PF00928	0.234
TRG_ENDOCYTIC_2	193	196	PF00928	0.354
TRG_ER_diArg_1	214	216	PF00400	0.584
TRG_ER_diArg_1	98	100	PF00400	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0G0	Leptomonas seymouri	47%	73%
A0A0N1I761	Leptomonas seymouri	28%	82%
A0A3Q8IMI4	Leishmania donovani	79%	73%
A0A422NI31	Trypanosoma rangeli	26%	88%
E9AEH3	Leishmania major	82%	100%
E9AHN9	Leishmania infantum	78%	73%