LeishMANIAdb
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Acid Phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Acid Phosphatase
Gene product:
magnesium-dependent phosphatase-1/HAD phosphatase, family IIIC, putative
Species:
Leishmania mexicana
UniProt:
E9B454_LEIMU
TriTrypDb:
LmxM.32.2160
Length:
201

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B454
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B454

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 12
GO:0003993 acid phosphatase activity 6 1
GO:0016787 hydrolase activity 2 12
GO:0016788 hydrolase activity, acting on ester bonds 3 12
GO:0016791 phosphatase activity 5 12
GO:0042578 phosphoric ester hydrolase activity 4 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 194 196 PF00675 0.460
CLV_PCSK_KEX2_1 194 196 PF00082 0.433
CLV_PCSK_SKI1_1 67 71 PF00082 0.343
CLV_PCSK_SKI1_1 97 101 PF00082 0.500
DEG_APCC_DBOX_1 66 74 PF00400 0.349
DEG_SPOP_SBC_1 85 89 PF00917 0.349
DOC_CKS1_1 28 33 PF01111 0.496
DOC_MAPK_gen_1 130 138 PF00069 0.481
DOC_MAPK_gen_1 43 53 PF00069 0.420
DOC_MAPK_MEF2A_6 46 53 PF00069 0.460
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I5R9 Leptomonas seymouri 73% 100%
A0A0S4J859 Bodo saltans 45% 100%
A0A1X0P3P5 Trypanosomatidae 60% 99%
A0A3Q8IDV7 Leishmania donovani 96% 100%
A0A3S5IR86 Trypanosoma rangeli 60% 100%
A4HLS8 Leishmania braziliensis 86% 100%
A4I987 Leishmania infantum 96% 100%
D0A698 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 100%
O94279 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 100%
Q86V88 Homo sapiens 31% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS