Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin, putative

Species:

Leishmania mexicana

UniProt:

E9B452_LEIMU

TriTrypDb:

LmxM.32.2140

Length:

959

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	10
GO:0099080	supramolecular complex	2	10
GO:0099081	supramolecular polymer	3	10
GO:0099512	supramolecular fiber	4	10
GO:0099513	polymeric cytoskeletal fiber	5	10
GO:0110165	cellular anatomical entity	1	10
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9B452

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B452

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003774	cytoskeletal motor activity	1	11
GO:0003777	microtubule motor activity	2	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005524	ATP binding	5	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	4
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.335
CLV_C14_Caspase3-7	539	543	PF00656	0.624
CLV_C14_Caspase3-7	735	739	PF00656	0.700
CLV_C14_Caspase3-7	745	749	PF00656	0.681
CLV_C14_Caspase3-7	843	847	PF00656	0.732
CLV_NRD_NRD_1	170	172	PF00675	0.335
CLV_NRD_NRD_1	195	197	PF00675	0.402
CLV_NRD_NRD_1	248	250	PF00675	0.480
CLV_NRD_NRD_1	415	417	PF00675	0.513
CLV_NRD_NRD_1	428	430	PF00675	0.433
CLV_NRD_NRD_1	479	481	PF00675	0.541
CLV_NRD_NRD_1	584	586	PF00675	0.619
CLV_NRD_NRD_1	646	648	PF00675	0.607
CLV_NRD_NRD_1	650	652	PF00675	0.582
CLV_NRD_NRD_1	655	657	PF00675	0.531
CLV_NRD_NRD_1	730	732	PF00675	0.683
CLV_NRD_NRD_1	755	757	PF00675	0.689
CLV_NRD_NRD_1	798	800	PF00675	0.788
CLV_NRD_NRD_1	801	803	PF00675	0.769
CLV_NRD_NRD_1	838	840	PF00675	0.671
CLV_NRD_NRD_1	930	932	PF00675	0.657
CLV_PCSK_FUR_1	728	732	PF00082	0.743
CLV_PCSK_KEX2_1	104	106	PF00082	0.447
CLV_PCSK_KEX2_1	195	197	PF00082	0.402
CLV_PCSK_KEX2_1	248	250	PF00082	0.328
CLV_PCSK_KEX2_1	417	419	PF00082	0.508
CLV_PCSK_KEX2_1	479	481	PF00082	0.541
CLV_PCSK_KEX2_1	584	586	PF00082	0.597
CLV_PCSK_KEX2_1	593	595	PF00082	0.684
CLV_PCSK_KEX2_1	646	648	PF00082	0.607
CLV_PCSK_KEX2_1	650	652	PF00082	0.582
CLV_PCSK_KEX2_1	655	657	PF00082	0.531
CLV_PCSK_KEX2_1	730	732	PF00082	0.672
CLV_PCSK_KEX2_1	797	799	PF00082	0.765
CLV_PCSK_KEX2_1	838	840	PF00082	0.650
CLV_PCSK_KEX2_1	930	932	PF00082	0.652
CLV_PCSK_KEX2_1	934	936	PF00082	0.674
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.447
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.514
CLV_PCSK_PC1ET2_1	593	595	PF00082	0.802
CLV_PCSK_PC1ET2_1	934	936	PF00082	0.803
CLV_PCSK_PC7_1	646	652	PF00082	0.660
CLV_PCSK_PC7_1	930	936	PF00082	0.804
CLV_PCSK_SKI1_1	125	129	PF00082	0.335
CLV_PCSK_SKI1_1	233	237	PF00082	0.331
CLV_PCSK_SKI1_1	255	259	PF00082	0.327
CLV_PCSK_SKI1_1	298	302	PF00082	0.355
CLV_PCSK_SKI1_1	432	436	PF00082	0.501
CLV_PCSK_SKI1_1	556	560	PF00082	0.639
CLV_PCSK_SKI1_1	65	69	PF00082	0.335
CLV_PCSK_SKI1_1	741	745	PF00082	0.561
CLV_PCSK_SKI1_1	95	99	PF00082	0.338
DEG_APCC_DBOX_1	530	538	PF00400	0.732
DEG_APCC_DBOX_1	603	611	PF00400	0.535
DEG_APCC_DBOX_1	650	658	PF00400	0.691
DEG_APCC_KENBOX_2	865	869	PF00400	0.771
DEG_SPOP_SBC_1	767	771	PF00917	0.781
DEG_SPOP_SBC_1	790	794	PF00917	0.774
DOC_CYCLIN_RxL_1	230	237	PF00134	0.335
DOC_CYCLIN_RxL_1	95	102	PF00134	0.355
DOC_MAPK_gen_1	301	310	PF00069	0.459
DOC_MAPK_gen_1	462	471	PF00069	0.518
DOC_MAPK_gen_1	655	663	PF00069	0.654
DOC_MAPK_gen_1	95	103	PF00069	0.355
DOC_MAPK_MEF2A_6	184	191	PF00069	0.335
DOC_MAPK_MEF2A_6	301	310	PF00069	0.466
DOC_MAPK_MEF2A_6	464	473	PF00069	0.517
DOC_MAPK_MEF2A_6	95	103	PF00069	0.355
DOC_PP2B_LxvP_1	310	313	PF13499	0.537
DOC_USP7_MATH_1	363	367	PF00917	0.582
DOC_USP7_MATH_1	42	46	PF00917	0.447
DOC_USP7_MATH_1	766	770	PF00917	0.763
DOC_USP7_MATH_1	872	876	PF00917	0.751
DOC_USP7_MATH_1	879	883	PF00917	0.694
DOC_USP7_MATH_1	948	952	PF00917	0.739
DOC_WW_Pin1_4	104	109	PF00397	0.381
DOC_WW_Pin1_4	597	602	PF00397	0.685
DOC_WW_Pin1_4	671	676	PF00397	0.694
DOC_WW_Pin1_4	761	766	PF00397	0.672
DOC_WW_Pin1_4	920	925	PF00397	0.769
DOC_WW_Pin1_4	954	959	PF00397	0.668
LIG_14-3-3_CanoR_1	217	225	PF00244	0.335
LIG_14-3-3_CanoR_1	233	239	PF00244	0.335
LIG_14-3-3_CanoR_1	294	302	PF00244	0.335
LIG_14-3-3_CanoR_1	441	451	PF00244	0.522
LIG_14-3-3_CanoR_1	594	600	PF00244	0.728
LIG_14-3-3_CanoR_1	717	725	PF00244	0.591
LIG_14-3-3_CanoR_1	728	736	PF00244	0.724
LIG_14-3-3_CanoR_1	785	791	PF00244	0.782
LIG_14-3-3_CanoR_1	839	845	PF00244	0.731
LIG_14-3-3_CanoR_1	917	927	PF00244	0.555
LIG_APCC_ABBA_1	84	89	PF00400	0.188
LIG_BIR_II_1	1	5	PF00653	0.427
LIG_Clathr_ClatBox_1	472	476	PF01394	0.636
LIG_eIF4E_1	230	236	PF01652	0.434
LIG_FHA_1	188	194	PF00498	0.349
LIG_FHA_1	218	224	PF00498	0.417
LIG_FHA_1	258	264	PF00498	0.326
LIG_FHA_1	271	277	PF00498	0.330
LIG_FHA_1	31	37	PF00498	0.355
LIG_FHA_1	720	726	PF00498	0.744
LIG_FHA_2	154	160	PF00498	0.378
LIG_FHA_2	569	575	PF00498	0.648
LIG_FHA_2	841	847	PF00498	0.725
LIG_FHA_2	889	895	PF00498	0.679
LIG_HP1_1	306	310	PF01393	0.595
LIG_LIR_Apic_2	867	872	PF02991	0.762
LIG_LIR_Gen_1	155	165	PF02991	0.424
LIG_LIR_Gen_1	564	572	PF02991	0.400
LIG_LIR_Nem_3	155	160	PF02991	0.424
LIG_LIR_Nem_3	455	459	PF02991	0.484
LIG_LIR_Nem_3	564	569	PF02991	0.401
LIG_LIR_Nem_3	617	622	PF02991	0.720
LIG_NRBOX	258	264	PF00104	0.480
LIG_PCNA_yPIPBox_3	121	132	PF02747	0.355
LIG_PCNA_yPIPBox_3	853	866	PF02747	0.718
LIG_PTB_Apo_2	35	42	PF02174	0.480
LIG_PTB_Phospho_1	35	41	PF10480	0.480
LIG_REV1ctd_RIR_1	144	154	PF16727	0.480
LIG_SH2_CRK	37	41	PF00017	0.335
LIG_SH2_CRK	619	623	PF00017	0.679
LIG_SH2_CRK	889	893	PF00017	0.713
LIG_SH2_GRB2like	230	233	PF00017	0.434
LIG_SH2_NCK_1	116	120	PF00017	0.447
LIG_SH2_NCK_1	26	30	PF00017	0.447
LIG_SH2_NCK_1	37	41	PF00017	0.447
LIG_SH2_NCK_1	889	893	PF00017	0.713
LIG_SH2_SRC	736	739	PF00017	0.696
LIG_SH2_STAP1	116	120	PF00017	0.447
LIG_SH2_STAP1	485	489	PF00017	0.505
LIG_SH2_STAP1	889	893	PF00017	0.802
LIG_SH2_STAT3	361	364	PF00017	0.593
LIG_SH2_STAT3	395	398	PF00017	0.600
LIG_SH2_STAT5	116	119	PF00017	0.339
LIG_SH2_STAT5	230	233	PF00017	0.389
LIG_SH2_STAT5	251	254	PF00017	0.335
LIG_SH2_STAT5	349	352	PF00017	0.520
LIG_SH2_STAT5	35	38	PF00017	0.335
LIG_SH2_STAT5	889	892	PF00017	0.706
LIG_SH3_2	250	255	PF14604	0.408
LIG_SH3_3	247	253	PF00018	0.408
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.480
LIG_SUMO_SIM_anti_2	305	311	PF11976	0.491
LIG_SUMO_SIM_par_1	150	156	PF11976	0.447
LIG_SUMO_SIM_par_1	536	542	PF11976	0.707
LIG_TRAF2_1	407	410	PF00917	0.605
LIG_TRAF2_1	708	711	PF00917	0.790
LIG_TYR_ITIM	483	488	PF00017	0.597
LIG_UBA3_1	746	751	PF00899	0.686
LIG_UBA3_1	99	104	PF00899	0.355
LIG_WRC_WIRS_1	154	159	PF05994	0.480
LIG_WRC_WIRS_1	188	193	PF05994	0.335
MOD_CDK_SPxxK_3	104	111	PF00069	0.480
MOD_CDK_SPxxK_3	597	604	PF00069	0.633
MOD_CK1_1	182	188	PF00069	0.319
MOD_CK1_1	20	26	PF00069	0.443
MOD_CK1_1	234	240	PF00069	0.335
MOD_CK1_1	270	276	PF00069	0.355
MOD_CK1_1	356	362	PF00069	0.549
MOD_CK1_1	43	49	PF00069	0.337
MOD_CK1_1	446	452	PF00069	0.551
MOD_CK1_1	608	614	PF00069	0.707
MOD_CK1_1	664	670	PF00069	0.721
MOD_CK1_1	671	677	PF00069	0.676
MOD_CK1_1	732	738	PF00069	0.684
MOD_CK1_1	77	83	PF00069	0.324
MOD_CK1_1	789	795	PF00069	0.792
MOD_CK1_1	953	959	PF00069	0.643
MOD_CK2_1	16	22	PF00069	0.442
MOD_CK2_1	221	227	PF00069	0.343
MOD_CK2_1	404	410	PF00069	0.596
MOD_CK2_1	42	48	PF00069	0.480
MOD_CK2_1	425	431	PF00069	0.549
MOD_CK2_1	568	574	PF00069	0.598
MOD_CK2_1	622	628	PF00069	0.637
MOD_CK2_1	789	795	PF00069	0.805
MOD_CK2_1	827	833	PF00069	0.806
MOD_CK2_1	852	858	PF00069	0.707
MOD_CK2_1	888	894	PF00069	0.528
MOD_Cter_Amidation	728	731	PF01082	0.736
MOD_Cter_Amidation	800	803	PF01082	0.790
MOD_GlcNHglycan	19	22	PF01048	0.455
MOD_GlcNHglycan	213	216	PF01048	0.335
MOD_GlcNHglycan	269	272	PF01048	0.355
MOD_GlcNHglycan	506	509	PF01048	0.686
MOD_GlcNHglycan	515	518	PF01048	0.626
MOD_GlcNHglycan	521	524	PF01048	0.740
MOD_GlcNHglycan	595	598	PF01048	0.717
MOD_GlcNHglycan	676	679	PF01048	0.695
MOD_GlcNHglycan	732	735	PF01048	0.717
MOD_GlcNHglycan	76	79	PF01048	0.334
MOD_GlcNHglycan	780	783	PF01048	0.804
MOD_GlcNHglycan	829	832	PF01048	0.707
MOD_GlcNHglycan	846	849	PF01048	0.809
MOD_GlcNHglycan	874	877	PF01048	0.724
MOD_GSK3_1	16	23	PF00069	0.449
MOD_GSK3_1	209	216	PF00069	0.366
MOD_GSK3_1	217	224	PF00069	0.335
MOD_GSK3_1	289	296	PF00069	0.335
MOD_GSK3_1	314	321	PF00069	0.588
MOD_GSK3_1	349	356	PF00069	0.466
MOD_GSK3_1	42	49	PF00069	0.355
MOD_GSK3_1	421	428	PF00069	0.572
MOD_GSK3_1	442	449	PF00069	0.560
MOD_GSK3_1	589	596	PF00069	0.673
MOD_GSK3_1	657	664	PF00069	0.675
MOD_GSK3_1	690	697	PF00069	0.636
MOD_GSK3_1	742	749	PF00069	0.682
MOD_GSK3_1	786	793	PF00069	0.796
MOD_GSK3_1	840	847	PF00069	0.711
MOD_GSK3_1	848	855	PF00069	0.685
MOD_GSK3_1	948	955	PF00069	0.672
MOD_N-GLC_1	120	125	PF02516	0.335
MOD_N-GLC_1	231	236	PF02516	0.335
MOD_N-GLC_1	43	48	PF02516	0.340
MOD_N-GLC_1	605	610	PF02516	0.768
MOD_N-GLC_1	65	70	PF02516	0.438
MOD_N-GLC_1	852	857	PF02516	0.680
MOD_N-GLC_1	867	872	PF02516	0.706
MOD_NEK2_1	103	108	PF00069	0.480
MOD_NEK2_1	25	30	PF00069	0.335
MOD_NEK2_1	262	267	PF00069	0.373
MOD_NEK2_1	286	291	PF00069	0.391
MOD_NEK2_1	293	298	PF00069	0.330
MOD_NEK2_1	343	348	PF00069	0.581
MOD_NEK2_1	513	518	PF00069	0.669
MOD_NEK2_1	661	666	PF00069	0.684
MOD_NEK2_1	687	692	PF00069	0.778
MOD_NEK2_1	703	708	PF00069	0.716
MOD_NEK2_1	859	864	PF00069	0.496
MOD_NEK2_1	919	924	PF00069	0.575
MOD_NEK2_2	120	125	PF00069	0.346
MOD_NEK2_2	546	551	PF00069	0.680
MOD_PIKK_1	293	299	PF00454	0.335
MOD_PKA_1	593	599	PF00069	0.649
MOD_PKA_1	650	656	PF00069	0.652
MOD_PKA_1	730	736	PF00069	0.726
MOD_PKA_1	930	936	PF00069	0.512
MOD_PKA_2	293	299	PF00069	0.335
MOD_PKA_2	343	349	PF00069	0.678
MOD_PKA_2	404	410	PF00069	0.565
MOD_PKA_2	593	599	PF00069	0.762
MOD_PKA_2	650	656	PF00069	0.600
MOD_PKA_2	657	663	PF00069	0.568
MOD_PKA_2	664	670	PF00069	0.602
MOD_PKA_2	716	722	PF00069	0.504
MOD_PKA_2	729	735	PF00069	0.728
MOD_PKA_2	811	817	PF00069	0.510
MOD_PKA_2	9	15	PF00069	0.581
MOD_PKA_2	930	936	PF00069	0.605
MOD_PKB_1	728	736	PF00069	0.731
MOD_Plk_1	120	126	PF00069	0.334
MOD_Plk_1	231	237	PF00069	0.335
MOD_Plk_1	286	292	PF00069	0.320
MOD_Plk_1	46	52	PF00069	0.354
MOD_Plk_1	65	71	PF00069	0.216
MOD_Plk_1	805	811	PF00069	0.773
MOD_Plk_1	852	858	PF00069	0.663
MOD_Plk_2-3	153	159	PF00069	0.447
MOD_Plk_2-3	221	227	PF00069	0.331
MOD_Plk_2-3	852	858	PF00069	0.663
MOD_Plk_4	199	205	PF00069	0.447
MOD_Plk_4	20	26	PF00069	0.449
MOD_Plk_4	343	349	PF00069	0.540
MOD_Plk_4	353	359	PF00069	0.419
MOD_Plk_4	46	52	PF00069	0.354
MOD_Plk_4	533	539	PF00069	0.725
MOD_Plk_4	65	71	PF00069	0.216
MOD_Plk_4	742	748	PF00069	0.682
MOD_Plk_4	79	85	PF00069	0.335
MOD_ProDKin_1	104	110	PF00069	0.381
MOD_ProDKin_1	597	603	PF00069	0.682
MOD_ProDKin_1	671	677	PF00069	0.694
MOD_ProDKin_1	761	767	PF00069	0.673
MOD_ProDKin_1	920	926	PF00069	0.769
MOD_SUMO_for_1	434	437	PF00179	0.563
MOD_SUMO_rev_2	142	152	PF00179	0.312
MOD_SUMO_rev_2	421	428	PF00179	0.456
MOD_SUMO_rev_2	564	572	PF00179	0.691
MOD_SUMO_rev_2	635	641	PF00179	0.571
TRG_DiLeu_BaEn_1	468	473	PF01217	0.660
TRG_DiLeu_BaEn_1	637	642	PF01217	0.570
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.480
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.459
TRG_ENDOCYTIC_2	116	119	PF00928	0.447
TRG_ENDOCYTIC_2	37	40	PF00928	0.335
TRG_ENDOCYTIC_2	485	488	PF00928	0.601
TRG_ENDOCYTIC_2	619	622	PF00928	0.675
TRG_ENDOCYTIC_2	889	892	PF00928	0.711
TRG_ER_diArg_1	248	250	PF00400	0.480
TRG_ER_diArg_1	402	405	PF00400	0.551
TRG_ER_diArg_1	479	482	PF00400	0.536
TRG_ER_diArg_1	649	651	PF00400	0.612
TRG_ER_diArg_1	654	656	PF00400	0.564
TRG_ER_diArg_1	7	10	PF00400	0.391
TRG_ER_diArg_1	728	731	PF00400	0.677
TRG_ER_diArg_1	797	799	PF00400	0.778
TRG_NLS_MonoExtC_3	930	935	PF00514	0.726
TRG_NLS_MonoExtN_4	930	935	PF00514	0.726
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYU7	Leptomonas seymouri	68%	97%
A0A1X0P4H8	Trypanosomatidae	50%	100%
A0A3S7X6Y8	Leishmania donovani	94%	100%
A0A422NI32	Trypanosoma rangeli	53%	100%
A4HLS6	Leishmania braziliensis	84%	100%
A4I985	Leishmania infantum	94%	100%
D0A6A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q9GRN3	Leishmania major	92%	99%
V5BTV0	Trypanosoma cruzi	58%	100%