Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B451_LEIMU

TriTrypDb:

LmxM.32.2130

Length:

923

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B451

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B451

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.564
CLV_NRD_NRD_1	142	144	PF00675	0.665
CLV_NRD_NRD_1	312	314	PF00675	0.599
CLV_NRD_NRD_1	706	708	PF00675	0.635
CLV_NRD_NRD_1	885	887	PF00675	0.767
CLV_PCSK_KEX2_1	132	134	PF00082	0.709
CLV_PCSK_KEX2_1	706	708	PF00082	0.635
CLV_PCSK_KEX2_1	885	887	PF00082	0.777
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.721
CLV_PCSK_SKI1_1	274	278	PF00082	0.489
CLV_PCSK_SKI1_1	52	56	PF00082	0.466
DEG_Nend_Nbox_1	1	3	PF02207	0.720
DEG_SPOP_SBC_1	243	247	PF00917	0.551
DEG_SPOP_SBC_1	431	435	PF00917	0.741
DOC_CKS1_1	860	865	PF01111	0.814
DOC_CKS1_1	87	92	PF01111	0.798
DOC_CKS1_1	912	917	PF01111	0.701
DOC_MAPK_MEF2A_6	697	704	PF00069	0.663
DOC_PP1_RVXF_1	547	553	PF00149	0.675
DOC_PP2B_LxvP_1	477	480	PF13499	0.781
DOC_PP2B_LxvP_1	799	802	PF13499	0.497
DOC_PP2B_LxvP_1	822	825	PF13499	0.576
DOC_PP4_FxxP_1	784	787	PF00568	0.686
DOC_PP4_MxPP_1	451	454	PF00568	0.690
DOC_PP4_MxPP_1	830	833	PF00568	0.735
DOC_USP7_MATH_1	134	138	PF00917	0.643
DOC_USP7_MATH_1	243	247	PF00917	0.551
DOC_USP7_MATH_1	265	269	PF00917	0.710
DOC_USP7_MATH_1	420	424	PF00917	0.738
DOC_USP7_MATH_1	454	458	PF00917	0.818
DOC_USP7_MATH_1	503	507	PF00917	0.728
DOC_USP7_MATH_1	569	573	PF00917	0.829
DOC_USP7_MATH_1	628	632	PF00917	0.764
DOC_USP7_MATH_1	787	791	PF00917	0.690
DOC_WW_Pin1_4	239	244	PF00397	0.841
DOC_WW_Pin1_4	251	256	PF00397	0.645
DOC_WW_Pin1_4	267	272	PF00397	0.486
DOC_WW_Pin1_4	302	307	PF00397	0.598
DOC_WW_Pin1_4	355	360	PF00397	0.492
DOC_WW_Pin1_4	466	471	PF00397	0.746
DOC_WW_Pin1_4	480	485	PF00397	0.782
DOC_WW_Pin1_4	520	525	PF00397	0.817
DOC_WW_Pin1_4	534	539	PF00397	0.577
DOC_WW_Pin1_4	562	567	PF00397	0.700
DOC_WW_Pin1_4	595	600	PF00397	0.414
DOC_WW_Pin1_4	723	728	PF00397	0.793
DOC_WW_Pin1_4	751	756	PF00397	0.774
DOC_WW_Pin1_4	811	816	PF00397	0.761
DOC_WW_Pin1_4	859	864	PF00397	0.813
DOC_WW_Pin1_4	86	91	PF00397	0.696
DOC_WW_Pin1_4	899	904	PF00397	0.736
DOC_WW_Pin1_4	911	916	PF00397	0.742
LIG_14-3-3_CanoR_1	135	145	PF00244	0.794
LIG_14-3-3_CanoR_1	289	295	PF00244	0.466
LIG_14-3-3_CanoR_1	392	397	PF00244	0.637
LIG_14-3-3_CanoR_1	505	513	PF00244	0.814
LIG_14-3-3_CanoR_1	549	553	PF00244	0.670
LIG_14-3-3_CanoR_1	669	679	PF00244	0.609
LIG_14-3-3_CanoR_1	690	696	PF00244	0.550
LIG_14-3-3_CanoR_1	885	890	PF00244	0.613
LIG_BRCT_BRCA1_1	292	296	PF00533	0.452
LIG_BRCT_BRCA1_1	602	606	PF00533	0.473
LIG_BRCT_BRCA1_1	69	73	PF00533	0.656
LIG_EVH1_1	799	803	PF00568	0.496
LIG_EVH1_1	822	826	PF00568	0.520
LIG_EVH1_2	832	836	PF00568	0.721
LIG_FHA_1	200	206	PF00498	0.538
LIG_FHA_1	245	251	PF00498	0.592
LIG_FHA_1	383	389	PF00498	0.560
LIG_FHA_1	524	530	PF00498	0.734
LIG_FHA_1	610	616	PF00498	0.415
LIG_FHA_1	650	656	PF00498	0.510
LIG_FHA_1	837	843	PF00498	0.672
LIG_FHA_1	894	900	PF00498	0.556
LIG_FHA_2	103	109	PF00498	0.716
LIG_FHA_2	338	344	PF00498	0.303
LIG_FHA_2	37	43	PF00498	0.690
LIG_FHA_2	595	601	PF00498	0.406
LIG_FHA_2	839	845	PF00498	0.647
LIG_FHA_2	867	873	PF00498	0.577
LIG_Integrin_isoDGR_2	317	319	PF01839	0.668
LIG_LIR_Apic_2	176	182	PF02991	0.518
LIG_LIR_Apic_2	353	359	PF02991	0.496
LIG_LIR_Apic_2	844	850	PF02991	0.643
LIG_LIR_Apic_2	86	90	PF02991	0.721
LIG_LIR_Gen_1	603	614	PF02991	0.491
LIG_LIR_Gen_1	89	98	PF02991	0.647
LIG_LIR_Nem_3	175	181	PF02991	0.544
LIG_LIR_Nem_3	535	539	PF02991	0.736
LIG_LIR_Nem_3	551	555	PF02991	0.664
LIG_LIR_Nem_3	854	860	PF02991	0.749
LIG_LIR_Nem_3	89	95	PF02991	0.645
LIG_LYPXL_yS_3	746	749	PF13949	0.789
LIG_NRBOX	159	165	PF00104	0.593
LIG_Pex14_2	778	782	PF04695	0.707
LIG_PTAP_UEV_1	565	570	PF05743	0.714
LIG_Rb_LxCxE_1	343	366	PF01857	0.531
LIG_SH2_CRK	179	183	PF00017	0.558
LIG_SH2_CRK	455	459	PF00017	0.759
LIG_SH2_CRK	847	851	PF00017	0.632
LIG_SH2_NCK_1	282	286	PF00017	0.514
LIG_SH2_NCK_1	38	42	PF00017	0.689
LIG_SH2_PTP2	356	359	PF00017	0.493
LIG_SH2_STAT3	681	684	PF00017	0.363
LIG_SH2_STAT5	159	162	PF00017	0.614
LIG_SH2_STAT5	349	352	PF00017	0.497
LIG_SH2_STAT5	356	359	PF00017	0.493
LIG_SH2_STAT5	38	41	PF00017	0.693
LIG_SH2_STAT5	482	485	PF00017	0.819
LIG_SH2_STAT5	555	558	PF00017	0.691
LIG_SH2_STAT5	601	604	PF00017	0.481
LIG_SH2_STAT5	729	732	PF00017	0.758
LIG_SH2_STAT5	87	90	PF00017	0.697
LIG_SH2_STAT6	91	95	PF00017	0.722
LIG_SH3_1	563	569	PF00018	0.613
LIG_SH3_3	378	384	PF00018	0.662
LIG_SH3_3	455	461	PF00018	0.734
LIG_SH3_3	563	569	PF00018	0.711
LIG_SH3_3	627	633	PF00018	0.800
LIG_SH3_3	741	747	PF00018	0.712
LIG_SH3_3	749	755	PF00018	0.655
LIG_SH3_3	759	765	PF00018	0.522
LIG_SH3_3	797	803	PF00018	0.727
LIG_SH3_3	820	826	PF00018	0.765
LIG_SH3_3	829	835	PF00018	0.729
LIG_SH3_3	857	863	PF00018	0.807
LIG_SH3_3	909	915	PF00018	0.723
LIG_SUMO_SIM_anti_2	116	121	PF11976	0.596
LIG_SUMO_SIM_par_1	370	377	PF11976	0.607
LIG_SUMO_SIM_par_1	385	391	PF11976	0.546
LIG_SUMO_SIM_par_1	838	844	PF11976	0.741
LIG_TRAF2_1	197	200	PF00917	0.711
LIG_TRFH_1	92	96	PF08558	0.697
LIG_TYR_ITIM	280	285	PF00017	0.499
LIG_UBA3_1	163	169	PF00899	0.619
LIG_WW_1	452	455	PF00397	0.689
LIG_WW_1	460	463	PF00397	0.725
LIG_WW_1	479	482	PF00397	0.766
LIG_WW_2	832	835	PF00397	0.526
MOD_CDK_SPK_2	239	244	PF00069	0.763
MOD_CDK_SPK_2	899	904	PF00069	0.639
MOD_CDK_SPxxK_3	267	274	PF00069	0.637
MOD_CK1_1	137	143	PF00069	0.534
MOD_CK1_1	162	168	PF00069	0.405
MOD_CK1_1	215	221	PF00069	0.753
MOD_CK1_1	237	243	PF00069	0.798
MOD_CK1_1	246	252	PF00069	0.740
MOD_CK1_1	258	264	PF00069	0.573
MOD_CK1_1	267	273	PF00069	0.631
MOD_CK1_1	305	311	PF00069	0.614
MOD_CK1_1	37	43	PF00069	0.712
MOD_CK1_1	405	411	PF00069	0.726
MOD_CK1_1	435	441	PF00069	0.842
MOD_CK1_1	485	491	PF00069	0.693
MOD_CK1_1	506	512	PF00069	0.765
MOD_CK1_1	519	525	PF00069	0.556
MOD_CK1_1	572	578	PF00069	0.770
MOD_CK1_1	607	613	PF00069	0.557
MOD_CK1_1	631	637	PF00069	0.604
MOD_CK1_1	64	70	PF00069	0.689
MOD_CK1_1	649	655	PF00069	0.534
MOD_CK1_1	692	698	PF00069	0.668
MOD_CK1_1	709	715	PF00069	0.528
MOD_CK1_1	718	724	PF00069	0.746
MOD_CK1_1	785	791	PF00069	0.691
MOD_CK2_1	162	168	PF00069	0.430
MOD_CK2_1	226	232	PF00069	0.730
MOD_CK2_1	36	42	PF00069	0.779
MOD_CK2_1	866	872	PF00069	0.574
MOD_CK2_1	894	900	PF00069	0.848
MOD_Cter_Amidation	141	144	PF01082	0.663
MOD_Cter_Amidation	883	886	PF01082	0.775
MOD_DYRK1A_RPxSP_1	251	255	PF00069	0.770
MOD_GlcNHglycan	140	143	PF01048	0.672
MOD_GlcNHglycan	214	217	PF01048	0.682
MOD_GlcNHglycan	227	231	PF01048	0.589
MOD_GlcNHglycan	234	237	PF01048	0.509
MOD_GlcNHglycan	286	289	PF01048	0.499
MOD_GlcNHglycan	39	42	PF01048	0.775
MOD_GlcNHglycan	404	408	PF01048	0.745
MOD_GlcNHglycan	423	426	PF01048	0.745
MOD_GlcNHglycan	435	438	PF01048	0.782
MOD_GlcNHglycan	463	466	PF01048	0.781
MOD_GlcNHglycan	470	473	PF01048	0.817
MOD_GlcNHglycan	514	517	PF01048	0.734
MOD_GlcNHglycan	518	521	PF01048	0.704
MOD_GlcNHglycan	539	542	PF01048	0.684
MOD_GlcNHglycan	571	574	PF01048	0.837
MOD_GlcNHglycan	580	583	PF01048	0.617
MOD_GlcNHglycan	630	633	PF01048	0.765
MOD_GlcNHglycan	638	641	PF01048	0.694
MOD_GlcNHglycan	65	69	PF01048	0.742
MOD_GlcNHglycan	681	684	PF01048	0.553
MOD_GlcNHglycan	708	711	PF01048	0.714
MOD_GlcNHglycan	717	720	PF01048	0.701
MOD_GlcNHglycan	73	76	PF01048	0.677
MOD_GlcNHglycan	740	743	PF01048	0.789
MOD_GlcNHglycan	789	792	PF01048	0.668
MOD_GlcNHglycan	8	11	PF01048	0.699
MOD_GlcNHglycan	889	893	PF01048	0.753
MOD_GlcNHglycan	99	102	PF01048	0.564
MOD_GSK3_1	134	141	PF00069	0.728
MOD_GSK3_1	191	198	PF00069	0.728
MOD_GSK3_1	215	222	PF00069	0.775
MOD_GSK3_1	232	239	PF00069	0.812
MOD_GSK3_1	242	249	PF00069	0.722
MOD_GSK3_1	251	258	PF00069	0.737
MOD_GSK3_1	30	37	PF00069	0.740
MOD_GSK3_1	322	329	PF00069	0.551
MOD_GSK3_1	403	410	PF00069	0.794
MOD_GSK3_1	431	438	PF00069	0.816
MOD_GSK3_1	461	468	PF00069	0.649
MOD_GSK3_1	478	485	PF00069	0.773
MOD_GSK3_1	501	508	PF00069	0.798
MOD_GSK3_1	512	519	PF00069	0.650
MOD_GSK3_1	569	576	PF00069	0.784
MOD_GSK3_1	600	607	PF00069	0.461
MOD_GSK3_1	609	616	PF00069	0.452
MOD_GSK3_1	67	74	PF00069	0.673
MOD_GSK3_1	717	724	PF00069	0.737
MOD_GSK3_1	782	789	PF00069	0.613
MOD_GSK3_1	899	906	PF00069	0.661
MOD_GSK3_1	916	923	PF00069	0.741
MOD_LATS_1	430	436	PF00433	0.726
MOD_N-GLC_1	441	446	PF02516	0.831
MOD_N-GLC_1	644	649	PF02516	0.654
MOD_N-GLC_1	826	831	PF02516	0.746
MOD_N-GLC_1	894	899	PF02516	0.555
MOD_NEK2_1	191	196	PF00069	0.707
MOD_NEK2_1	447	452	PF00069	0.536
MOD_NEK2_1	56	61	PF00069	0.768
MOD_NEK2_1	574	579	PF00069	0.817
MOD_NEK2_1	609	614	PF00069	0.493
MOD_NEK2_1	646	651	PF00069	0.672
MOD_NEK2_1	671	676	PF00069	0.614
MOD_NEK2_1	738	743	PF00069	0.642
MOD_NEK2_2	326	331	PF00069	0.495
MOD_PIKK_1	173	179	PF00454	0.555
MOD_PIKK_1	244	250	PF00454	0.631
MOD_PIKK_1	523	529	PF00454	0.708
MOD_PK_1	115	121	PF00069	0.547
MOD_PKA_1	706	712	PF00069	0.696
MOD_PKA_1	885	891	PF00069	0.633
MOD_PKA_2	134	140	PF00069	0.723
MOD_PKA_2	312	318	PF00069	0.636
MOD_PKA_2	402	408	PF00069	0.766
MOD_PKA_2	431	437	PF00069	0.711
MOD_PKA_2	447	453	PF00069	0.517
MOD_PKA_2	504	510	PF00069	0.812
MOD_PKA_2	548	554	PF00069	0.672
MOD_PKA_2	689	695	PF00069	0.550
MOD_PKA_2	706	712	PF00069	0.672
MOD_PKA_2	885	891	PF00069	0.653
MOD_PKB_1	133	141	PF00069	0.755
MOD_PKB_1	380	388	PF00069	0.600
MOD_Plk_1	692	698	PF00069	0.660
MOD_Plk_1	826	832	PF00069	0.745
MOD_Plk_2-3	337	343	PF00069	0.306
MOD_Plk_4	115	121	PF00069	0.573
MOD_Plk_4	159	165	PF00069	0.706
MOD_Plk_4	290	296	PF00069	0.457
MOD_Plk_4	305	311	PF00069	0.513
MOD_Plk_4	326	332	PF00069	0.492
MOD_Plk_4	337	343	PF00069	0.496
MOD_Plk_4	507	513	PF00069	0.735
MOD_Plk_4	583	589	PF00069	0.650
MOD_Plk_4	600	606	PF00069	0.413
MOD_Plk_4	753	759	PF00069	0.493
MOD_ProDKin_1	239	245	PF00069	0.841
MOD_ProDKin_1	251	257	PF00069	0.644
MOD_ProDKin_1	267	273	PF00069	0.467
MOD_ProDKin_1	302	308	PF00069	0.598
MOD_ProDKin_1	355	361	PF00069	0.494
MOD_ProDKin_1	466	472	PF00069	0.747
MOD_ProDKin_1	480	486	PF00069	0.782
MOD_ProDKin_1	520	526	PF00069	0.817
MOD_ProDKin_1	534	540	PF00069	0.577
MOD_ProDKin_1	562	568	PF00069	0.700
MOD_ProDKin_1	595	601	PF00069	0.406
MOD_ProDKin_1	723	729	PF00069	0.795
MOD_ProDKin_1	751	757	PF00069	0.774
MOD_ProDKin_1	811	817	PF00069	0.761
MOD_ProDKin_1	859	865	PF00069	0.814
MOD_ProDKin_1	86	92	PF00069	0.697
MOD_ProDKin_1	899	905	PF00069	0.736
MOD_ProDKin_1	911	917	PF00069	0.739
MOD_SUMO_rev_2	198	202	PF00179	0.633
TRG_ENDOCYTIC_2	282	285	PF00928	0.507
TRG_ENDOCYTIC_2	455	458	PF00928	0.829
TRG_ENDOCYTIC_2	746	749	PF00928	0.719
TRG_ENDOCYTIC_2	92	95	PF00928	0.652
TRG_ER_diArg_1	706	708	PF00400	0.635
TRG_ER_diArg_1	885	887	PF00400	0.777
TRG_ER_FFAT_2	32	43	PF00635	0.685
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N1	Leptomonas seymouri	46%	100%
A0A3S7X6V6	Leishmania donovani	87%	100%
A4HLS5	Leishmania braziliensis	70%	100%
A4I984	Leishmania infantum	87%	100%
Q9GRN4	Leishmania major	87%	100%