Phosphoglycerate mutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoglycerate mutase

Species:

Leishmania mexicana

UniProt:

E9B449_LEIMU

TriTrypDb:

LmxM.32.2110

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B449

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B449

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	1
GO:0006082	organic acid metabolic process	3	1
GO:0006090	pyruvate metabolic process	7	1
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006096	glycolytic process	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006757	obsolete ATP generation from ADP	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009132	nucleoside diphosphate metabolic process	5	1
GO:0009135	purine nucleoside diphosphate metabolic process	6	1
GO:0009141	nucleoside triphosphate metabolic process	5	1
GO:0009144	purine nucleoside triphosphate metabolic process	6	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	1
GO:0009185	ribonucleoside diphosphate metabolic process	6	1
GO:0009199	ribonucleoside triphosphate metabolic process	6	1
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016052	carbohydrate catabolic process	4	1
GO:0016310	phosphorylation	5	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046031	ADP metabolic process	7	1
GO:0046034	ATP metabolic process	7	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046939	obsolete nucleotide phosphorylation	6	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004619	phosphoglycerate mutase activity	5	1
GO:0005488	binding	1	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0016853	isomerase activity	2	1
GO:0016866	intramolecular transferase activity	3	1
GO:0016868	intramolecular transferase activity, phosphotransferases	4	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0050897	cobalt ion binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.558
CLV_C14_Caspase3-7	326	330	PF00656	0.684
CLV_C14_Caspase3-7	405	409	PF00656	0.411
CLV_C14_Caspase3-7	57	61	PF00656	0.557
CLV_C14_Caspase3-7	90	94	PF00656	0.539
CLV_NRD_NRD_1	15	17	PF00675	0.732
CLV_PCSK_KEX2_1	15	17	PF00082	0.820
CLV_PCSK_KEX2_1	189	191	PF00082	0.444
CLV_PCSK_KEX2_1	223	225	PF00082	0.447
CLV_PCSK_KEX2_1	437	439	PF00082	0.411
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.481
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.447
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.411
CLV_PCSK_PC7_1	11	17	PF00082	0.723
CLV_PCSK_PC7_1	433	439	PF00082	0.411
CLV_PCSK_SKI1_1	190	194	PF00082	0.354
CLV_PCSK_SKI1_1	257	261	PF00082	0.411
CLV_PCSK_SKI1_1	30	34	PF00082	0.809
CLV_PCSK_SKI1_1	497	501	PF00082	0.630
DEG_APCC_DBOX_1	252	260	PF00400	0.352
DEG_MDM2_SWIB_1	435	442	PF02201	0.398
DEG_SPOP_SBC_1	111	115	PF00917	0.699
DEG_SPOP_SBC_1	128	132	PF00917	0.650
DEG_SPOP_SBC_1	49	53	PF00917	0.689
DEG_SPOP_SBC_1	70	74	PF00917	0.763
DOC_CKS1_1	209	214	PF01111	0.411
DOC_CYCLIN_RxL_1	493	504	PF00134	0.602
DOC_CYCLIN_yClb5_NLxxxL_5	477	486	PF00134	0.576
DOC_MAPK_gen_1	437	444	PF00069	0.354
DOC_PP1_RVXF_1	412	418	PF00149	0.411
DOC_PP2B_LxvP_1	313	316	PF13499	0.714
DOC_PP4_FxxP_1	184	187	PF00568	0.529
DOC_USP7_MATH_1	109	113	PF00917	0.811
DOC_USP7_MATH_1	120	124	PF00917	0.710
DOC_USP7_MATH_1	150	154	PF00917	0.835
DOC_USP7_MATH_1	155	159	PF00917	0.735
DOC_USP7_MATH_1	160	164	PF00917	0.655
DOC_USP7_MATH_1	173	177	PF00917	0.461
DOC_USP7_MATH_1	19	23	PF00917	0.727
DOC_USP7_MATH_1	292	296	PF00917	0.749
DOC_USP7_MATH_1	301	305	PF00917	0.566
DOC_USP7_MATH_1	316	320	PF00917	0.773
DOC_USP7_MATH_1	325	329	PF00917	0.768
DOC_USP7_MATH_1	49	53	PF00917	0.699
DOC_USP7_UBL2_3	493	497	PF12436	0.552
DOC_WW_Pin1_4	121	126	PF00397	0.688
DOC_WW_Pin1_4	153	158	PF00397	0.758
DOC_WW_Pin1_4	208	213	PF00397	0.352
DOC_WW_Pin1_4	244	249	PF00397	0.352
DOC_WW_Pin1_4	280	285	PF00397	0.507
DOC_WW_Pin1_4	307	312	PF00397	0.648
DOC_WW_Pin1_4	43	48	PF00397	0.737
DOC_WW_Pin1_4	449	454	PF00397	0.411
DOC_WW_Pin1_4	61	66	PF00397	0.689
LIG_14-3-3_CanoR_1	170	179	PF00244	0.710
LIG_14-3-3_CanoR_1	183	187	PF00244	0.529
LIG_14-3-3_CanoR_1	195	205	PF00244	0.411
LIG_14-3-3_CanoR_1	251	257	PF00244	0.352
LIG_14-3-3_CanoR_1	366	374	PF00244	0.509
LIG_14-3-3_CanoR_1	38	47	PF00244	0.825
LIG_14-3-3_CanoR_1	402	407	PF00244	0.352
LIG_14-3-3_CanoR_1	6	13	PF00244	0.730
LIG_14-3-3_CanoR_1	71	80	PF00244	0.824
LIG_14-3-3_CanoR_1	99	104	PF00244	0.554
LIG_Actin_WH2_2	346	362	PF00022	0.411
LIG_AP2alpha_1	406	410	PF02296	0.411
LIG_BIR_II_1	1	5	PF00653	0.805
LIG_BIR_III_2	141	145	PF00653	0.735
LIG_BRCT_BRCA1_1	23	27	PF00533	0.545
LIG_eIF4E_1	494	500	PF01652	0.588
LIG_FHA_1	183	189	PF00498	0.528
LIG_FHA_1	281	287	PF00498	0.649
LIG_FHA_1	308	314	PF00498	0.560
LIG_FHA_1	402	408	PF00498	0.411
LIG_FHA_1	419	425	PF00498	0.411
LIG_FHA_1	62	68	PF00498	0.588
LIG_FHA_1	98	104	PF00498	0.835
LIG_FHA_2	324	330	PF00498	0.780
LIG_FHA_2	366	372	PF00498	0.509
LIG_Integrin_isoDGR_2	196	198	PF01839	0.411
LIG_LIR_Apic_2	182	187	PF02991	0.651
LIG_LIR_Apic_2	211	217	PF02991	0.352
LIG_LIR_Gen_1	445	455	PF02991	0.352
LIG_LIR_Nem_3	240	246	PF02991	0.398
LIG_LIR_Nem_3	381	386	PF02991	0.411
LIG_LIR_Nem_3	488	492	PF02991	0.632
LIG_MYND_1	312	316	PF01753	0.710
LIG_PCNA_yPIPBox_3	195	209	PF02747	0.411
LIG_Pex14_2	386	390	PF04695	0.411
LIG_Pex14_2	406	410	PF04695	0.183
LIG_Pex14_2	435	439	PF04695	0.398
LIG_PTAP_UEV_1	125	130	PF05743	0.728
LIG_PTAP_UEV_1	156	161	PF05743	0.532
LIG_REV1ctd_RIR_1	384	390	PF16727	0.411
LIG_RPA_C_Fungi	339	351	PF08784	0.548
LIG_SH2_CRK	388	392	PF00017	0.352
LIG_SH2_NCK_1	367	371	PF00017	0.509
LIG_SH2_STAT3	258	261	PF00017	0.411
LIG_SH2_STAT5	208	211	PF00017	0.411
LIG_SH2_STAT5	243	246	PF00017	0.366
LIG_SH2_STAT5	249	252	PF00017	0.335
LIG_SH2_STAT5	258	261	PF00017	0.312
LIG_SH2_STAT5	367	370	PF00017	0.411
LIG_SH2_STAT5	441	444	PF00017	0.509
LIG_SH3_3	119	125	PF00018	0.761
LIG_SH3_3	141	147	PF00018	0.696
LIG_SH3_3	154	160	PF00018	0.630
LIG_SH3_3	206	212	PF00018	0.411
LIG_SH3_3	29	35	PF00018	0.551
LIG_SH3_3	312	318	PF00018	0.567
LIG_SH3_3	412	418	PF00018	0.411
LIG_SUMO_SIM_anti_2	420	427	PF11976	0.415
LIG_SUMO_SIM_par_1	420	427	PF11976	0.415
LIG_SUMO_SIM_par_1	482	488	PF11976	0.593
LIG_WRC_WIRS_1	403	408	PF05994	0.352
LIG_WRC_WIRS_1	444	449	PF05994	0.411
MOD_CDK_SPxxK_3	208	215	PF00069	0.352
MOD_CDK_SPxxK_3	244	251	PF00069	0.352
MOD_CK1_1	110	116	PF00069	0.802
MOD_CK1_1	124	130	PF00069	0.604
MOD_CK1_1	153	159	PF00069	0.774
MOD_CK1_1	168	174	PF00069	0.595
MOD_CK1_1	182	188	PF00069	0.628
MOD_CK1_1	252	258	PF00069	0.411
MOD_CK1_1	269	275	PF00069	0.642
MOD_CK1_1	319	325	PF00069	0.796
MOD_CK1_1	4	10	PF00069	0.704
MOD_CK1_1	457	463	PF00069	0.411
MOD_CK1_1	502	508	PF00069	0.618
MOD_CK1_1	73	79	PF00069	0.638
MOD_CK1_1	83	89	PF00069	0.733
MOD_CK2_1	301	307	PF00069	0.790
MOD_CK2_1	366	372	PF00069	0.509
MOD_CK2_1	38	44	PF00069	0.801
MOD_CK2_1	482	488	PF00069	0.554
MOD_Cter_Amidation	221	224	PF01082	0.447
MOD_GlcNHglycan	109	112	PF01048	0.817
MOD_GlcNHglycan	126	129	PF01048	0.566
MOD_GlcNHglycan	152	155	PF01048	0.717
MOD_GlcNHglycan	157	160	PF01048	0.641
MOD_GlcNHglycan	162	165	PF01048	0.704
MOD_GlcNHglycan	23	26	PF01048	0.807
MOD_GlcNHglycan	268	271	PF01048	0.687
MOD_GlcNHglycan	287	290	PF01048	0.497
MOD_GlcNHglycan	303	306	PF01048	0.680
MOD_GlcNHglycan	318	321	PF01048	0.672
MOD_GlcNHglycan	368	371	PF01048	0.416
MOD_GlcNHglycan	394	397	PF01048	0.352
MOD_GlcNHglycan	40	43	PF01048	0.600
MOD_GlcNHglycan	504	507	PF01048	0.608
MOD_GlcNHglycan	82	85	PF01048	0.723
MOD_GSK3_1	1	8	PF00069	0.777
MOD_GSK3_1	107	114	PF00069	0.757
MOD_GSK3_1	120	127	PF00069	0.656
MOD_GSK3_1	149	156	PF00069	0.755
MOD_GSK3_1	17	24	PF00069	0.728
MOD_GSK3_1	173	180	PF00069	0.768
MOD_GSK3_1	316	323	PF00069	0.692
MOD_GSK3_1	34	41	PF00069	0.521
MOD_GSK3_1	424	431	PF00069	0.411
MOD_GSK3_1	69	76	PF00069	0.576
MOD_GSK3_1	83	90	PF00069	0.757
MOD_GSK3_1	97	104	PF00069	0.662
MOD_N-GLC_1	301	306	PF02516	0.511
MOD_N-GLC_2	94	96	PF02516	0.735
MOD_NEK2_1	1	6	PF00069	0.726
MOD_NEK2_1	177	182	PF00069	0.655
MOD_NEK2_1	392	397	PF00069	0.523
MOD_NEK2_1	419	424	PF00069	0.416
MOD_NEK2_1	499	504	PF00069	0.638
MOD_PIKK_1	165	171	PF00454	0.800
MOD_PIKK_1	271	277	PF00454	0.613
MOD_PIKK_1	50	56	PF00454	0.838
MOD_PKA_2	182	188	PF00069	0.547
MOD_PKA_2	252	258	PF00069	0.352
MOD_PKA_2	266	272	PF00069	0.515
MOD_PKA_2	343	349	PF00069	0.560
MOD_PKA_2	365	371	PF00069	0.509
MOD_PKA_2	401	407	PF00069	0.352
MOD_PKA_2	5	11	PF00069	0.727
MOD_PKA_2	70	76	PF00069	0.822
MOD_Plk_1	419	425	PF00069	0.416
MOD_Plk_4	173	179	PF00069	0.758
MOD_Plk_4	336	342	PF00069	0.644
MOD_Plk_4	402	408	PF00069	0.352
MOD_Plk_4	419	425	PF00069	0.416
MOD_ProDKin_1	121	127	PF00069	0.690
MOD_ProDKin_1	153	159	PF00069	0.756
MOD_ProDKin_1	208	214	PF00069	0.352
MOD_ProDKin_1	244	250	PF00069	0.352
MOD_ProDKin_1	280	286	PF00069	0.509
MOD_ProDKin_1	307	313	PF00069	0.651
MOD_ProDKin_1	43	49	PF00069	0.733
MOD_ProDKin_1	449	455	PF00069	0.411
MOD_ProDKin_1	61	67	PF00069	0.688
MOD_SUMO_rev_2	87	97	PF00179	0.546
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.701
TRG_ENDOCYTIC_2	383	386	PF00928	0.457
TRG_ENDOCYTIC_2	441	444	PF00928	0.509
TRG_ER_diArg_1	250	253	PF00400	0.374
TRG_ER_diArg_1	357	360	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZZ8	Leptomonas seymouri	58%	85%
A0A3S7X6Z7	Leishmania donovani	93%	100%
A4HLS3	Leishmania braziliensis	75%	100%
A4I982	Leishmania infantum	93%	100%
Q4Q3X6	Leishmania major	91%	100%