Putative glycerolphosphate mutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerolphosphate mutase, putative

Species:

Leishmania mexicana

UniProt:

E9B448_LEIMU

TriTrypDb:

LmxM.32.2100

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B448

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B448

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.714
CLV_C14_Caspase3-7	204	208	PF00656	0.691
CLV_C14_Caspase3-7	446	450	PF00656	0.733
CLV_C14_Caspase3-7	490	494	PF00656	0.508
CLV_MEL_PAP_1	159	165	PF00089	0.411
CLV_NRD_NRD_1	102	104	PF00675	0.411
CLV_NRD_NRD_1	22	24	PF00675	0.640
CLV_NRD_NRD_1	254	256	PF00675	0.799
CLV_NRD_NRD_1	31	33	PF00675	0.472
CLV_NRD_NRD_1	419	421	PF00675	0.760
CLV_NRD_NRD_1	8	10	PF00675	0.653
CLV_PCSK_FUR_1	417	421	PF00082	0.589
CLV_PCSK_KEX2_1	102	104	PF00082	0.411
CLV_PCSK_KEX2_1	22	24	PF00082	0.622
CLV_PCSK_KEX2_1	254	256	PF00082	0.751
CLV_PCSK_KEX2_1	31	33	PF00082	0.472
CLV_PCSK_KEX2_1	419	421	PF00082	0.596
CLV_PCSK_KEX2_1	427	429	PF00082	0.599
CLV_PCSK_KEX2_1	7	9	PF00082	0.655
CLV_PCSK_KEX2_1	73	75	PF00082	0.411
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.565
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.411
CLV_PCSK_SKI1_1	140	144	PF00082	0.411
CLV_PCSK_SKI1_1	22	26	PF00082	0.502
CLV_PCSK_SKI1_1	277	281	PF00082	0.707
CLV_PCSK_SKI1_1	31	35	PF00082	0.411
CLV_PCSK_SKI1_1	349	353	PF00082	0.473
DEG_APCC_DBOX_1	94	102	PF00400	0.383
DEG_MDM2_SWIB_1	307	314	PF02201	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.761
DEG_SPOP_SBC_1	246	250	PF00917	0.807
DEG_SPOP_SBC_1	421	425	PF00917	0.657
DOC_CYCLIN_RxL_1	346	355	PF00134	0.508
DOC_MAPK_gen_1	310	318	PF00069	0.411
DOC_MAPK_gen_1	93	101	PF00069	0.222
DOC_MAPK_MEF2A_6	172	179	PF00069	0.530
DOC_MAPK_NFAT4_5	172	180	PF00069	0.535
DOC_PP2B_LxvP_1	177	180	PF13499	0.632
DOC_PP4_FxxP_1	312	315	PF00568	0.411
DOC_USP7_MATH_1	246	250	PF00917	0.702
DOC_USP7_MATH_1	404	408	PF00917	0.730
DOC_USP7_MATH_1	421	425	PF00917	0.571
DOC_USP7_MATH_1	426	430	PF00917	0.769
DOC_USP7_MATH_1	431	435	PF00917	0.681
DOC_USP7_MATH_1	448	452	PF00917	0.535
DOC_WW_Pin1_4	209	214	PF00397	0.559
DOC_WW_Pin1_4	216	221	PF00397	0.523
DOC_WW_Pin1_4	237	242	PF00397	0.817
DOC_WW_Pin1_4	427	432	PF00397	0.830
DOC_WW_Pin1_4	476	481	PF00397	0.763
DOC_WW_Pin1_4	50	55	PF00397	0.360
DOC_WW_Pin1_4	86	91	PF00397	0.411
LIG_14-3-3_CanoR_1	102	106	PF00244	0.411
LIG_14-3-3_CanoR_1	23	29	PF00244	0.563
LIG_14-3-3_CanoR_1	258	262	PF00244	0.648
LIG_14-3-3_CanoR_1	341	351	PF00244	0.497
LIG_14-3-3_CanoR_1	93	99	PF00244	0.411
LIG_Actin_RPEL_3	16	35	PF02755	0.401
LIG_Actin_WH2_2	156	174	PF00022	0.513
LIG_BRCT_BRCA1_1	163	167	PF00533	0.411
LIG_deltaCOP1_diTrp_1	134	143	PF00928	0.389
LIG_deltaCOP1_diTrp_1	367	376	PF00928	0.570
LIG_FHA_2	202	208	PF00498	0.704
LIG_FHA_2	95	101	PF00498	0.411
LIG_GBD_Chelix_1	298	306	PF00786	0.411
LIG_LIR_Apic_2	53	59	PF02991	0.411
LIG_LIR_Gen_1	164	175	PF02991	0.411
LIG_LIR_Gen_1	317	326	PF02991	0.411
LIG_LIR_Gen_1	483	492	PF02991	0.645
LIG_LIR_Nem_3	164	170	PF02991	0.411
LIG_LIR_Nem_3	374	379	PF02991	0.700
LIG_LIR_Nem_3	483	487	PF02991	0.684
LIG_LIR_Nem_3	82	88	PF02991	0.411
LIG_MLH1_MIPbox_1	163	167	PF16413	0.411
LIG_Pex14_2	307	311	PF04695	0.411
LIG_SH2_CRK	127	131	PF00017	0.513
LIG_SH2_CRK	148	152	PF00017	0.411
LIG_SH2_GRB2like	50	53	PF00017	0.513
LIG_SH2_STAT5	11	14	PF00017	0.461
LIG_SH2_STAT5	85	88	PF00017	0.411
LIG_SH3_2	412	417	PF14604	0.812
LIG_SH3_3	207	213	PF00018	0.511
LIG_SH3_3	222	228	PF00018	0.494
LIG_SH3_3	259	265	PF00018	0.638
LIG_SH3_3	406	412	PF00018	0.647
LIG_SH3_3	466	472	PF00018	0.600
LIG_SH3_5	480	484	PF00018	0.707
LIG_SH3_CIN85_PxpxPR_1	412	417	PF14604	0.812
LIG_SUMO_SIM_par_1	329	334	PF11976	0.411
LIG_TRAF2_1	220	223	PF00917	0.525
LIG_TRAF2_1	385	388	PF00917	0.765
LIG_TRAF2_2	129	134	PF00917	0.436
LIG_WW_3	414	418	PF00397	0.823
MOD_CDK_SPxK_1	476	482	PF00069	0.708
MOD_CDK_SPxxK_3	50	57	PF00069	0.411
MOD_CDK_SPxxK_3	86	93	PF00069	0.411
MOD_CK1_1	422	428	PF00069	0.809
MOD_CK1_1	429	435	PF00069	0.853
MOD_CK1_1	438	444	PF00069	0.593
MOD_CK1_1	451	457	PF00069	0.608
MOD_CK2_1	101	107	PF00069	0.411
MOD_CK2_1	285	291	PF00069	0.389
MOD_CK2_1	440	446	PF00069	0.837
MOD_CK2_1	94	100	PF00069	0.411
MOD_Cter_Amidation	71	74	PF01082	0.411
MOD_GlcNHglycan	154	157	PF01048	0.355
MOD_GlcNHglycan	163	166	PF01048	0.357
MOD_GlcNHglycan	233	236	PF01048	0.816
MOD_GlcNHglycan	249	252	PF01048	0.559
MOD_GlcNHglycan	406	409	PF01048	0.627
MOD_GlcNHglycan	433	436	PF01048	0.739
MOD_GlcNHglycan	439	443	PF01048	0.741
MOD_GlcNHglycan	446	449	PF01048	0.788
MOD_GlcNHglycan	450	453	PF01048	0.539
MOD_GSK3_1	101	108	PF00069	0.390
MOD_GSK3_1	171	178	PF00069	0.616
MOD_GSK3_1	201	208	PF00069	0.613
MOD_GSK3_1	214	221	PF00069	0.674
MOD_GSK3_1	227	234	PF00069	0.800
MOD_GSK3_1	235	242	PF00069	0.829
MOD_GSK3_1	253	260	PF00069	0.545
MOD_GSK3_1	422	429	PF00069	0.761
MOD_GSK3_1	431	438	PF00069	0.761
MOD_GSK3_1	440	447	PF00069	0.509
MOD_N-GLC_2	183	185	PF02516	0.736
MOD_NEK2_1	1	6	PF00069	0.719
MOD_NEK2_1	105	110	PF00069	0.381
MOD_NEK2_1	152	157	PF00069	0.411
MOD_NEK2_1	166	171	PF00069	0.411
MOD_NEK2_1	253	258	PF00069	0.696
MOD_PIKK_1	105	111	PF00454	0.411
MOD_PIKK_1	218	224	PF00454	0.822
MOD_PKA_1	419	425	PF00069	0.854
MOD_PKA_2	101	107	PF00069	0.411
MOD_PKA_2	161	167	PF00069	0.411
MOD_PKA_2	171	177	PF00069	0.411
MOD_PKA_2	253	259	PF00069	0.695
MOD_PKA_2	419	425	PF00069	0.562
MOD_PKA_2	94	100	PF00069	0.411
MOD_PKB_1	417	425	PF00069	0.851
MOD_Plk_1	105	111	PF00069	0.411
MOD_Plk_1	133	139	PF00069	0.411
MOD_Plk_1	366	372	PF00069	0.563
MOD_Plk_4	166	172	PF00069	0.429
MOD_Plk_4	24	30	PF00069	0.613
MOD_Plk_4	94	100	PF00069	0.222
MOD_ProDKin_1	209	215	PF00069	0.562
MOD_ProDKin_1	216	222	PF00069	0.524
MOD_ProDKin_1	237	243	PF00069	0.815
MOD_ProDKin_1	427	433	PF00069	0.830
MOD_ProDKin_1	476	482	PF00069	0.762
MOD_ProDKin_1	50	56	PF00069	0.360
MOD_ProDKin_1	86	92	PF00069	0.411
MOD_SUMO_rev_2	51	59	PF00179	0.411
TRG_DiLeu_BaEn_1	292	297	PF01217	0.319
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.469
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.524
TRG_ENDOCYTIC_2	127	130	PF00928	0.411
TRG_ENDOCYTIC_2	147	150	PF00928	0.411
TRG_ENDOCYTIC_2	484	487	PF00928	0.725
TRG_ER_diArg_1	101	103	PF00400	0.411
TRG_ER_diArg_1	22	24	PF00400	0.622
TRG_ER_diArg_1	253	255	PF00400	0.798
TRG_ER_diArg_1	30	32	PF00400	0.479
TRG_ER_diArg_1	416	419	PF00400	0.752
TRG_ER_diArg_1	7	9	PF00400	0.655
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHK5	Leptomonas seymouri	66%	100%
A0A3Q8IU44	Leishmania donovani	90%	100%
A4HLS2	Leishmania braziliensis	79%	100%
A4I981	Leishmania infantum	90%	100%
Q4Q3X7	Leishmania major	90%	100%