Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitogen-activated protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B445_LEIMU

TriTrypDb:

LmxM.32.2070

Length:

992

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B445

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B445

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0007165	signal transduction	2	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004707	MAP kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.328
CLV_C14_Caspase3-7	466	470	PF00656	0.629
CLV_C14_Caspase3-7	876	880	PF00656	0.515
CLV_NRD_NRD_1	439	441	PF00675	0.444
CLV_NRD_NRD_1	49	51	PF00675	0.285
CLV_NRD_NRD_1	665	667	PF00675	0.599
CLV_PCSK_KEX2_1	49	51	PF00082	0.285
CLV_PCSK_KEX2_1	631	633	PF00082	0.643
CLV_PCSK_KEX2_1	664	666	PF00082	0.595
CLV_PCSK_KEX2_1	867	869	PF00082	0.538
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.609
CLV_PCSK_PC1ET2_1	867	869	PF00082	0.538
CLV_PCSK_PC7_1	661	667	PF00082	0.595
CLV_PCSK_SKI1_1	207	211	PF00082	0.285
CLV_PCSK_SKI1_1	290	294	PF00082	0.285
CLV_PCSK_SKI1_1	545	549	PF00082	0.558
CLV_PCSK_SKI1_1	7	11	PF00082	0.285
CLV_PCSK_SKI1_1	741	745	PF00082	0.518
CLV_PCSK_SKI1_1	975	979	PF00082	0.394
DEG_COP1_1	647	656	PF00400	0.505
DEG_SCF_FBW7_1	409	414	PF00400	0.415
DEG_SCF_FBW7_2	315	321	PF00400	0.285
DEG_SPOP_SBC_1	411	415	PF00917	0.429
DEG_SPOP_SBC_1	952	956	PF00917	0.440
DOC_CKS1_1	315	320	PF01111	0.285
DOC_CKS1_1	481	486	PF01111	0.517
DOC_MAPK_gen_1	207	216	PF00069	0.285
DOC_MAPK_gen_1	49	60	PF00069	0.285
DOC_MAPK_MEF2A_6	210	218	PF00069	0.285
DOC_MAPK_MEF2A_6	303	312	PF00069	0.285
DOC_MAPK_NFAT4_5	303	311	PF00069	0.285
DOC_PP1_RVXF_1	370	377	PF00149	0.285
DOC_PP2B_LxvP_1	705	708	PF13499	0.504
DOC_PP2B_PxIxI_1	265	271	PF00149	0.328
DOC_PP4_FxxP_1	753	756	PF00568	0.476
DOC_PP4_FxxP_1	91	94	PF00568	0.595
DOC_PP4_FxxP_1	912	915	PF00568	0.586
DOC_USP7_MATH_1	223	227	PF00917	0.285
DOC_USP7_MATH_1	239	243	PF00917	0.285
DOC_USP7_MATH_1	302	306	PF00917	0.317
DOC_USP7_MATH_1	341	345	PF00917	0.285
DOC_USP7_MATH_1	411	415	PF00917	0.448
DOC_USP7_MATH_1	500	504	PF00917	0.565
DOC_USP7_MATH_1	525	529	PF00917	0.614
DOC_USP7_MATH_1	693	697	PF00917	0.487
DOC_USP7_MATH_1	715	719	PF00917	0.546
DOC_USP7_MATH_1	850	854	PF00917	0.576
DOC_USP7_MATH_1	94	98	PF00917	0.502
DOC_USP7_MATH_1	952	956	PF00917	0.402
DOC_USP7_MATH_1	968	972	PF00917	0.427
DOC_USP7_UBL2_3	12	16	PF12436	0.267
DOC_USP7_UBL2_3	553	557	PF12436	0.510
DOC_WW_Pin1_4	262	267	PF00397	0.328
DOC_WW_Pin1_4	314	319	PF00397	0.285
DOC_WW_Pin1_4	407	412	PF00397	0.419
DOC_WW_Pin1_4	480	485	PF00397	0.525
DOC_WW_Pin1_4	601	606	PF00397	0.760
DOC_WW_Pin1_4	646	651	PF00397	0.590
DOC_WW_Pin1_4	785	790	PF00397	0.596
DOC_WW_Pin1_4	848	853	PF00397	0.580
DOC_WW_Pin1_4	868	873	PF00397	0.482
DOC_WW_Pin1_4	892	897	PF00397	0.572
DOC_WW_Pin1_4	943	948	PF00397	0.455
LIG_14-3-3_CanoR_1	163	171	PF00244	0.341
LIG_14-3-3_CanoR_1	173	181	PF00244	0.243
LIG_14-3-3_CanoR_1	440	444	PF00244	0.463
LIG_14-3-3_CanoR_1	494	500	PF00244	0.517
LIG_14-3-3_CanoR_1	632	638	PF00244	0.644
LIG_14-3-3_CanoR_1	692	698	PF00244	0.524
LIG_14-3-3_CanoR_1	741	751	PF00244	0.556
LIG_14-3-3_CanoR_1	889	898	PF00244	0.573
LIG_14-3-3_CanoR_1	921	926	PF00244	0.552
LIG_14-3-3_CanoR_1	939	944	PF00244	0.417
LIG_14-3-3_CanoR_1	970	978	PF00244	0.364
LIG_Actin_WH2_2	427	442	PF00022	0.417
LIG_APCC_ABBA_1	125	130	PF00400	0.328
LIG_APCC_ABBAyCdc20_2	124	130	PF00400	0.328
LIG_BRCT_BRCA1_1	87	91	PF00533	0.601
LIG_Clathr_ClatBox_1	215	219	PF01394	0.285
LIG_deltaCOP1_diTrp_1	269	277	PF00928	0.285
LIG_eIF4E_1	224	230	PF01652	0.285
LIG_FHA_1	225	231	PF00498	0.298
LIG_FHA_1	24	30	PF00498	0.328
LIG_FHA_1	242	248	PF00498	0.460
LIG_FHA_1	369	375	PF00498	0.285
LIG_FHA_1	647	653	PF00498	0.592
LIG_FHA_1	810	816	PF00498	0.516
LIG_FHA_1	952	958	PF00498	0.399
LIG_FHA_2	103	109	PF00498	0.458
LIG_FHA_2	138	144	PF00498	0.267
LIG_FHA_2	356	362	PF00498	0.289
LIG_FHA_2	421	427	PF00498	0.435
LIG_FHA_2	553	559	PF00498	0.585
LIG_FHA_2	580	586	PF00498	0.652
LIG_FHA_2	655	661	PF00498	0.666
LIG_FHA_2	698	704	PF00498	0.592
LIG_FHA_2	88	94	PF00498	0.533
LIG_FHA_2	980	986	PF00498	0.402
LIG_IBAR_NPY_1	222	224	PF08397	0.285
LIG_LIR_Apic_2	249	255	PF02991	0.285
LIG_LIR_Apic_2	844	850	PF02991	0.569
LIG_LIR_Apic_2	88	94	PF02991	0.597
LIG_LIR_Apic_2	909	915	PF02991	0.586
LIG_LIR_Gen_1	364	374	PF02991	0.285
LIG_LIR_Gen_1	521	527	PF02991	0.588
LIG_LIR_Gen_1	757	768	PF02991	0.543
LIG_LIR_Gen_1	835	846	PF02991	0.574
LIG_LIR_Nem_3	114	119	PF02991	0.402
LIG_LIR_Nem_3	157	162	PF02991	0.285
LIG_LIR_Nem_3	364	369	PF02991	0.285
LIG_LIR_Nem_3	521	526	PF02991	0.586
LIG_LIR_Nem_3	757	763	PF02991	0.569
LIG_LIR_Nem_3	835	841	PF02991	0.581
LIG_MAD2	889	897	PF02301	0.483
LIG_MYND_1	650	654	PF01753	0.565
LIG_NRBOX	973	979	PF00104	0.381
LIG_PDZ_Class_2	987	992	PF00595	0.516
LIG_Pex14_2	190	194	PF04695	0.285
LIG_Pex14_2	599	603	PF04695	0.508
LIG_SH2_CRK	116	120	PF00017	0.390
LIG_SH2_CRK	731	735	PF00017	0.579
LIG_SH2_CRK	760	764	PF00017	0.566
LIG_SH2_CRK	838	842	PF00017	0.586
LIG_SH2_GRB2like	43	46	PF00017	0.285
LIG_SH2_PTP2	8	11	PF00017	0.285
LIG_SH2_PTP2	847	850	PF00017	0.612
LIG_SH2_SRC	900	903	PF00017	0.588
LIG_SH2_STAP1	25	29	PF00017	0.328
LIG_SH2_STAP1	412	416	PF00017	0.438
LIG_SH2_STAP1	838	842	PF00017	0.620
LIG_SH2_STAP1	873	877	PF00017	0.551
LIG_SH2_STAT3	198	201	PF00017	0.465
LIG_SH2_STAT3	43	46	PF00017	0.285
LIG_SH2_STAT5	160	163	PF00017	0.285
LIG_SH2_STAT5	198	201	PF00017	0.465
LIG_SH2_STAT5	246	249	PF00017	0.285
LIG_SH2_STAT5	25	28	PF00017	0.285
LIG_SH2_STAT5	335	338	PF00017	0.285
LIG_SH2_STAT5	412	415	PF00017	0.422
LIG_SH2_STAT5	416	419	PF00017	0.475
LIG_SH2_STAT5	43	46	PF00017	0.196
LIG_SH2_STAT5	488	491	PF00017	0.598
LIG_SH2_STAT5	559	562	PF00017	0.632
LIG_SH2_STAT5	71	74	PF00017	0.285
LIG_SH2_STAT5	8	11	PF00017	0.285
LIG_SH2_STAT5	840	843	PF00017	0.576
LIG_SH2_STAT5	847	850	PF00017	0.570
LIG_SH2_STAT5	900	903	PF00017	0.588
LIG_SH2_STAT5	981	984	PF00017	0.385
LIG_SH3_2	626	631	PF14604	0.554
LIG_SH3_3	516	522	PF00018	0.579
LIG_SH3_3	532	538	PF00018	0.637
LIG_SH3_3	606	612	PF00018	0.537
LIG_SH3_3	620	626	PF00018	0.560
LIG_SH3_3	648	654	PF00018	0.571
LIG_SH3_3	753	759	PF00018	0.567
LIG_SH3_3	812	818	PF00018	0.627
LIG_SH3_5	484	488	PF00018	0.508
LIG_SUMO_SIM_anti_2	54	59	PF11976	0.285
LIG_TRAF2_1	21	24	PF00917	0.285
LIG_TRAF2_1	451	454	PF00917	0.591
LIG_TRAF2_1	638	641	PF00917	0.639
LIG_TRAF2_1	669	672	PF00917	0.639
LIG_TRFH_1	546	550	PF08558	0.643
LIG_TYR_ITIM	69	74	PF00017	0.285
LIG_WW_1	897	900	PF00397	0.572
MOD_CDK_SPK_2	262	267	PF00069	0.294
MOD_CDK_SPK_2	943	948	PF00069	0.436
MOD_CK1_1	166	172	PF00069	0.289
MOD_CK1_1	262	268	PF00069	0.285
MOD_CK1_1	419	425	PF00069	0.453
MOD_CK1_1	457	463	PF00069	0.622
MOD_CK1_1	464	470	PF00069	0.577
MOD_CK1_1	528	534	PF00069	0.596
MOD_CK1_1	604	610	PF00069	0.615
MOD_CK1_1	636	642	PF00069	0.597
MOD_CK1_1	871	877	PF00069	0.592
MOD_CK1_1	892	898	PF00069	0.575
MOD_CK1_1	903	909	PF00069	0.560
MOD_CK2_1	102	108	PF00069	0.590
MOD_CK2_1	117	123	PF00069	0.332
MOD_CK2_1	356	362	PF00069	0.285
MOD_CK2_1	420	426	PF00069	0.447
MOD_CK2_1	448	454	PF00069	0.595
MOD_CK2_1	469	475	PF00069	0.644
MOD_CK2_1	515	521	PF00069	0.584
MOD_CK2_1	579	585	PF00069	0.652
MOD_CK2_1	635	641	PF00069	0.642
MOD_CK2_1	697	703	PF00069	0.588
MOD_CK2_1	785	791	PF00069	0.596
MOD_CK2_1	953	959	PF00069	0.440
MOD_CK2_1	979	985	PF00069	0.399
MOD_GlcNHglycan	261	264	PF01048	0.285
MOD_GlcNHglycan	328	331	PF01048	0.328
MOD_GlcNHglycan	338	341	PF01048	0.255
MOD_GlcNHglycan	461	464	PF01048	0.626
MOD_GlcNHglycan	466	469	PF01048	0.632
MOD_GlcNHglycan	489	492	PF01048	0.612
MOD_GlcNHglycan	523	526	PF01048	0.544
MOD_GlcNHglycan	531	534	PF01048	0.650
MOD_GlcNHglycan	596	599	PF01048	0.623
MOD_GlcNHglycan	617	620	PF01048	0.520
MOD_GlcNHglycan	640	644	PF01048	0.708
MOD_GlcNHglycan	654	657	PF01048	0.739
MOD_GlcNHglycan	667	670	PF01048	0.536
MOD_GlcNHglycan	683	686	PF01048	0.534
MOD_GlcNHglycan	709	712	PF01048	0.595
MOD_GSK3_1	163	170	PF00069	0.328
MOD_GSK3_1	23	30	PF00069	0.328
MOD_GSK3_1	407	414	PF00069	0.436
MOD_GSK3_1	416	423	PF00069	0.465
MOD_GSK3_1	448	455	PF00069	0.602
MOD_GSK3_1	457	464	PF00069	0.595
MOD_GSK3_1	521	528	PF00069	0.592
MOD_GSK3_1	635	642	PF00069	0.595
MOD_GSK3_1	660	667	PF00069	0.636
MOD_GSK3_1	677	684	PF00069	0.501
MOD_GSK3_1	693	700	PF00069	0.499
MOD_GSK3_1	70	77	PF00069	0.297
MOD_GSK3_1	735	742	PF00069	0.593
MOD_GSK3_1	805	812	PF00069	0.584
MOD_GSK3_1	867	874	PF00069	0.627
MOD_GSK3_1	900	907	PF00069	0.605
MOD_GSK3_1	939	946	PF00069	0.469
MOD_GSK3_1	94	101	PF00069	0.532
MOD_GSK3_1	980	987	PF00069	0.361
MOD_N-GLC_1	458	463	PF02516	0.617
MOD_N-GLC_1	553	558	PF02516	0.605
MOD_N-GLC_1	85	90	PF02516	0.597
MOD_NEK2_1	164	169	PF00069	0.285
MOD_NEK2_1	174	179	PF00069	0.285
MOD_NEK2_1	218	223	PF00069	0.328
MOD_NEK2_1	336	341	PF00069	0.285
MOD_NEK2_1	399	404	PF00069	0.466
MOD_NEK2_1	439	444	PF00069	0.409
MOD_NEK2_1	458	463	PF00069	0.608
MOD_NEK2_1	526	531	PF00069	0.595
MOD_NEK2_1	633	638	PF00069	0.643
MOD_NEK2_1	697	702	PF00069	0.776
MOD_NEK2_1	735	740	PF00069	0.589
MOD_NEK2_1	984	989	PF00069	0.380
MOD_NEK2_2	654	659	PF00069	0.602
MOD_NEK2_2	70	75	PF00069	0.328
MOD_PIKK_1	164	170	PF00454	0.285
MOD_PIKK_1	341	347	PF00454	0.285
MOD_PIKK_1	761	767	PF00454	0.551
MOD_PIKK_1	901	907	PF00454	0.496
MOD_PK_1	921	927	PF00069	0.463
MOD_PKA_1	664	670	PF00069	0.603
MOD_PKA_1	867	873	PF00069	0.500
MOD_PKA_2	341	347	PF00069	0.285
MOD_PKA_2	380	386	PF00069	0.285
MOD_PKA_2	439	445	PF00069	0.465
MOD_PKA_2	475	481	PF00069	0.647
MOD_PKA_2	493	499	PF00069	0.504
MOD_PKA_2	500	506	PF00069	0.558
MOD_PKA_2	579	585	PF00069	0.640
MOD_PKA_2	594	600	PF00069	0.601
MOD_PKA_2	660	666	PF00069	0.593
MOD_PKA_2	867	873	PF00069	0.500
MOD_PKA_2	969	975	PF00069	0.381
MOD_PKB_1	937	945	PF00069	0.470
MOD_Plk_1	102	108	PF00069	0.483
MOD_Plk_1	453	459	PF00069	0.651
MOD_Plk_1	697	703	PF00069	0.588
MOD_Plk_1	907	913	PF00069	0.575
MOD_Plk_1	984	990	PF00069	0.389
MOD_Plk_2-3	448	454	PF00069	0.587
MOD_Plk_2-3	469	475	PF00069	0.775
MOD_Plk_2-3	515	521	PF00069	0.550
MOD_Plk_2-3	831	837	PF00069	0.604
MOD_Plk_2-3	87	93	PF00069	0.514
MOD_Plk_4	200	206	PF00069	0.285
MOD_Plk_4	241	247	PF00069	0.285
MOD_Plk_4	282	288	PF00069	0.285
MOD_Plk_4	559	565	PF00069	0.594
MOD_Plk_4	677	683	PF00069	0.591
MOD_Plk_4	907	913	PF00069	0.596
MOD_Plk_4	953	959	PF00069	0.440
MOD_Plk_4	985	991	PF00069	0.475
MOD_ProDKin_1	262	268	PF00069	0.328
MOD_ProDKin_1	314	320	PF00069	0.285
MOD_ProDKin_1	407	413	PF00069	0.426
MOD_ProDKin_1	480	486	PF00069	0.524
MOD_ProDKin_1	601	607	PF00069	0.760
MOD_ProDKin_1	646	652	PF00069	0.593
MOD_ProDKin_1	785	791	PF00069	0.596
MOD_ProDKin_1	848	854	PF00069	0.582
MOD_ProDKin_1	868	874	PF00069	0.482
MOD_ProDKin_1	892	898	PF00069	0.567
MOD_ProDKin_1	943	949	PF00069	0.446
MOD_SUMO_rev_2	203	211	PF00179	0.285
MOD_SUMO_rev_2	420	430	PF00179	0.422
MOD_SUMO_rev_2	672	679	PF00179	0.602
TRG_DiLeu_BaEn_1	47	52	PF01217	0.285
TRG_DiLeu_BaEn_1	674	679	PF01217	0.507
TRG_DiLeu_BaEn_1	973	978	PF01217	0.374
TRG_DiLeu_BaEn_3	130	136	PF01217	0.328
TRG_DiLeu_BaEn_4	453	459	PF01217	0.651
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.328
TRG_DiLeu_BaLyEn_6	723	728	PF01217	0.457
TRG_ENDOCYTIC_2	116	119	PF00928	0.390
TRG_ENDOCYTIC_2	396	399	PF00928	0.447
TRG_ENDOCYTIC_2	71	74	PF00928	0.285
TRG_ENDOCYTIC_2	740	743	PF00928	0.567
TRG_ENDOCYTIC_2	760	763	PF00928	0.495
TRG_ENDOCYTIC_2	8	11	PF00928	0.285
TRG_ENDOCYTIC_2	838	841	PF00928	0.579
TRG_ENDOCYTIC_2	981	984	PF00928	0.420
TRG_ER_diArg_1	124	127	PF00400	0.393
TRG_ER_diArg_1	49	51	PF00400	0.285
TRG_ER_diArg_1	664	666	PF00400	0.589
TRG_ER_diArg_1	936	939	PF00400	0.412
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.285
TRG_Pf-PMV_PEXEL_1	49	54	PF00026	0.285

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM53	Leptomonas seymouri	53%	97%
A0A3S7X6U9	Leishmania donovani	90%	99%
A4HLR9	Leishmania braziliensis	76%	99%
A4I945	Leishmania infantum	90%	100%
Q4Q3Y0	Leishmania major	87%	100%