LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B444_LEIMU
TriTrypDb:
LmxM.32.2060
Length:
116

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B444
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B444

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 110 114 PF00656 0.647
CLV_NRD_NRD_1 13 15 PF00675 0.742
CLV_NRD_NRD_1 3 5 PF00675 0.624
CLV_PCSK_KEX2_1 13 15 PF00082 0.680
CLV_PCSK_KEX2_1 3 5 PF00082 0.630
CLV_PCSK_SKI1_1 4 8 PF00082 0.727
DEG_APCC_DBOX_1 3 11 PF00400 0.477
DEG_Nend_Nbox_1 1 3 PF02207 0.446
DOC_USP7_MATH_1 15 19 PF00917 0.496
LIG_14-3-3_CanoR_1 63 71 PF00244 0.624
LIG_FHA_2 81 87 PF00498 0.625
LIG_SH2_GRB2like 25 28 PF00017 0.518
LIG_SH2_STAT5 23 26 PF00017 0.419
LIG_SH2_STAT5 58 61 PF00017 0.512
LIG_UBA3_1 101 109 PF00899 0.599
MOD_CK1_1 34 40 PF00069 0.414
MOD_CK2_1 80 86 PF00069 0.629
MOD_Cter_Amidation 11 14 PF01082 0.681
MOD_GlcNHglycan 17 20 PF01048 0.702
MOD_GlcNHglycan 33 36 PF01048 0.501
MOD_GSK3_1 15 22 PF00069 0.484
MOD_NEK2_1 42 47 PF00069 0.302
MOD_PKA_2 62 68 PF00069 0.611
TRG_ENDOCYTIC_2 58 61 PF00928 0.467
TRG_ER_diArg_1 2 4 PF00400 0.430
TRG_Pf-PMV_PEXEL_1 3 8 PF00026 0.693

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDB8 Leptomonas seymouri 73% 100%
A0A0S4J4D8 Bodo saltans 51% 100%
A0A1X0P3Q8 Trypanosomatidae 61% 97%
A0A3S7X6Z5 Leishmania donovani 93% 100%
A0A422N431 Trypanosoma rangeli 62% 97%
A4HLR8 Leishmania braziliensis 84% 100%
A4I944 Leishmania infantum 93% 100%
D0A6A7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 74% 96%
Q4Q3Y1 Leishmania major 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS