Protein HGH1 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B443_LEIMU

TriTrypDb:

LmxM.32.2050

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B443

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B443

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.251
CLV_C14_Caspase3-7	393	397	PF00656	0.469
CLV_C14_Caspase3-7	70	74	PF00656	0.447
CLV_NRD_NRD_1	113	115	PF00675	0.295
CLV_NRD_NRD_1	191	193	PF00675	0.390
CLV_NRD_NRD_1	40	42	PF00675	0.351
CLV_PCSK_KEX2_1	191	193	PF00082	0.351
CLV_PCSK_SKI1_1	220	224	PF00082	0.318
CLV_PCSK_SKI1_1	331	335	PF00082	0.441
CLV_PCSK_SKI1_1	84	88	PF00082	0.477
DEG_APCC_DBOX_1	219	227	PF00400	0.357
DEG_APCC_KENBOX_2	52	56	PF00400	0.415
DEG_SPOP_SBC_1	4	8	PF00917	0.661
DOC_MAPK_gen_1	111	119	PF00069	0.354
DOC_MAPK_gen_1	53	62	PF00069	0.345
DOC_MAPK_MEF2A_6	134	143	PF00069	0.346
DOC_MAPK_MEF2A_6	220	229	PF00069	0.296
DOC_MAPK_MEF2A_6	53	62	PF00069	0.549
DOC_USP7_MATH_1	154	158	PF00917	0.240
DOC_USP7_MATH_1	16	20	PF00917	0.607
DOC_USP7_MATH_1	203	207	PF00917	0.623
DOC_USP7_MATH_1	49	53	PF00917	0.344
DOC_USP7_MATH_1	99	103	PF00917	0.432
DOC_USP7_UBL2_3	111	115	PF12436	0.381
DOC_WW_Pin1_4	211	216	PF00397	0.373
DOC_WW_Pin1_4	252	257	PF00397	0.458
DOC_WW_Pin1_4	271	276	PF00397	0.206
DOC_WW_Pin1_4	6	11	PF00397	0.698
DOC_WW_Pin1_4	61	66	PF00397	0.337
LIG_14-3-3_CanoR_1	180	187	PF00244	0.352
LIG_14-3-3_CanoR_1	246	256	PF00244	0.501
LIG_APCC_ABBA_1	174	179	PF00400	0.446
LIG_APCC_ABBA_1	387	392	PF00400	0.374
LIG_APCC_ABBAyCdc20_2	173	179	PF00400	0.449
LIG_deltaCOP1_diTrp_1	57	61	PF00928	0.407
LIG_FHA_1	138	144	PF00498	0.363
LIG_FHA_1	228	234	PF00498	0.492
LIG_FHA_1	378	384	PF00498	0.427
LIG_FHA_1	6	12	PF00498	0.562
LIG_FHA_1	90	96	PF00498	0.316
LIG_FHA_2	151	157	PF00498	0.427
LIG_FHA_2	288	294	PF00498	0.379
LIG_GBD_Chelix_1	308	316	PF00786	0.368
LIG_LIR_Apic_2	396	401	PF02991	0.553
LIG_LIR_Gen_1	28	36	PF02991	0.455
LIG_LIR_Gen_1	57	67	PF02991	0.379
LIG_LIR_Nem_3	28	33	PF02991	0.423
LIG_LIR_Nem_3	57	62	PF02991	0.368
LIG_NRBOX	222	228	PF00104	0.307
LIG_PCNA_yPIPBox_3	298	312	PF02747	0.472
LIG_Rb_LxCxE_1	290	310	PF01857	0.395
LIG_SH2_CRK	279	283	PF00017	0.462
LIG_SH2_PTP2	398	401	PF00017	0.593
LIG_SH2_SRC	78	81	PF00017	0.444
LIG_SH2_STAP1	178	182	PF00017	0.494
LIG_SH2_STAT5	132	135	PF00017	0.494
LIG_SH2_STAT5	170	173	PF00017	0.324
LIG_SH2_STAT5	262	265	PF00017	0.469
LIG_SH2_STAT5	390	393	PF00017	0.413
LIG_SH2_STAT5	398	401	PF00017	0.477
LIG_SH2_STAT5	78	81	PF00017	0.439
LIG_SH3_3	12	18	PF00018	0.532
LIG_SUMO_SIM_anti_2	138	143	PF11976	0.314
LIG_SUMO_SIM_anti_2	355	363	PF11976	0.613
LIG_SUMO_SIM_anti_2	89	95	PF11976	0.335
LIG_TRAF2_1	135	138	PF00917	0.356
LIG_TRAF2_1	195	198	PF00917	0.417
LIG_UBA3_1	75	84	PF00899	0.468
MOD_CDK_SPK_2	211	216	PF00069	0.373
MOD_CDK_SPK_2	271	276	PF00069	0.472
MOD_CDK_SPxxK_3	252	259	PF00069	0.460
MOD_CK1_1	150	156	PF00069	0.368
MOD_CK1_1	19	25	PF00069	0.579
MOD_CK1_1	251	257	PF00069	0.474
MOD_CK1_1	3	9	PF00069	0.681
MOD_CK1_1	341	347	PF00069	0.386
MOD_CK2_1	132	138	PF00069	0.391
MOD_CK2_1	180	186	PF00069	0.403
MOD_CK2_1	304	310	PF00069	0.479
MOD_CK2_1	311	317	PF00069	0.488
MOD_CK2_1	352	358	PF00069	0.626
MOD_CK2_1	375	381	PF00069	0.391
MOD_CK2_1	99	105	PF00069	0.390
MOD_GlcNHglycan	18	21	PF01048	0.556
MOD_GlcNHglycan	182	185	PF01048	0.484
MOD_GlcNHglycan	204	208	PF01048	0.568
MOD_GlcNHglycan	97	100	PF01048	0.450
MOD_GSK3_1	146	153	PF00069	0.359
MOD_GSK3_1	245	252	PF00069	0.393
MOD_GSK3_1	311	318	PF00069	0.485
MOD_GSK3_1	371	378	PF00069	0.418
MOD_GSK3_1	67	74	PF00069	0.537
MOD_GSK3_1	95	102	PF00069	0.480
MOD_N-GLC_1	145	150	PF02516	0.318
MOD_N-GLC_1	227	232	PF02516	0.317
MOD_N-GLC_1	95	100	PF02516	0.344
MOD_NEK2_1	147	152	PF00069	0.339
MOD_NEK2_1	227	232	PF00069	0.291
MOD_NEK2_1	249	254	PF00069	0.402
MOD_NEK2_1	311	316	PF00069	0.412
MOD_NEK2_1	383	388	PF00069	0.387
MOD_OFUCOSY	97	103	PF10250	0.389
MOD_PIKK_1	338	344	PF00454	0.430
MOD_PK_1	324	330	PF00069	0.499
MOD_PKA_2	245	251	PF00069	0.531
MOD_Plk_1	137	143	PF00069	0.322
MOD_Plk_1	216	222	PF00069	0.476
MOD_Plk_4	137	143	PF00069	0.333
MOD_Plk_4	154	160	PF00069	0.454
MOD_Plk_4	311	317	PF00069	0.493
MOD_Plk_4	383	389	PF00069	0.519
MOD_Plk_4	71	77	PF00069	0.345
MOD_Plk_4	89	95	PF00069	0.243
MOD_ProDKin_1	211	217	PF00069	0.353
MOD_ProDKin_1	252	258	PF00069	0.459
MOD_ProDKin_1	271	277	PF00069	0.206
MOD_ProDKin_1	6	12	PF00069	0.696
MOD_ProDKin_1	61	67	PF00069	0.335
TRG_DiLeu_BaEn_2	27	33	PF01217	0.370
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.358
TRG_ENDOCYTIC_2	178	181	PF00928	0.400
TRG_ENDOCYTIC_2	279	282	PF00928	0.529
TRG_ER_diArg_1	258	261	PF00400	0.383
TRG_Pf-PMV_PEXEL_1	231	236	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMC4	Leptomonas seymouri	69%	93%
A0A0S4J7H7	Bodo saltans	37%	100%
A0A1X0P3N1	Trypanosomatidae	48%	100%
A0A3Q8IGP7	Leishmania donovani	89%	99%
A0A422N467	Trypanosoma rangeli	49%	100%
A4HLR7	Leishmania braziliensis	77%	100%
A4I943	Leishmania infantum	89%	99%
D0A6A8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4Q3Y2	Leishmania major	87%	98%
V5BTV3	Trypanosoma cruzi	46%	91%