HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B441_LEIMU

TriTrypDb:

LmxM.32.2030

Length:

820

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B441

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B441

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.640
CLV_C14_Caspase3-7	644	648	PF00656	0.475
CLV_NRD_NRD_1	303	305	PF00675	0.523
CLV_NRD_NRD_1	307	309	PF00675	0.512
CLV_NRD_NRD_1	609	611	PF00675	0.415
CLV_PCSK_KEX2_1	303	305	PF00082	0.523
CLV_PCSK_KEX2_1	307	309	PF00082	0.512
CLV_PCSK_PC7_1	303	309	PF00082	0.431
CLV_PCSK_SKI1_1	149	153	PF00082	0.402
CLV_PCSK_SKI1_1	547	551	PF00082	0.423
CLV_PCSK_SKI1_1	596	600	PF00082	0.404
CLV_PCSK_SKI1_1	806	810	PF00082	0.557
CLV_Separin_Metazoa	204	208	PF03568	0.519
DEG_SPOP_SBC_1	314	318	PF00917	0.717
DOC_CKS1_1	533	538	PF01111	0.459
DOC_CYCLIN_RxL_1	146	155	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	358	361	PF00134	0.609
DOC_MAPK_DCC_7	596	605	PF00069	0.540
DOC_MAPK_gen_1	610	617	PF00069	0.626
DOC_MAPK_MEF2A_6	55	64	PF00069	0.571
DOC_MAPK_MEF2A_6	596	605	PF00069	0.596
DOC_MAPK_MEF2A_6	702	711	PF00069	0.242
DOC_PP2B_LxvP_1	257	260	PF13499	0.669
DOC_PP2B_LxvP_1	358	361	PF13499	0.678
DOC_PP2B_LxvP_1	566	569	PF13499	0.662
DOC_PP2B_LxvP_1	7	10	PF13499	0.786
DOC_USP7_MATH_1	128	132	PF00917	0.769
DOC_USP7_MATH_1	133	137	PF00917	0.711
DOC_USP7_MATH_1	28	32	PF00917	0.720
DOC_USP7_MATH_1	314	318	PF00917	0.647
DOC_USP7_MATH_1	403	407	PF00917	0.654
DOC_USP7_MATH_1	489	493	PF00917	0.605
DOC_USP7_MATH_1	502	506	PF00917	0.568
DOC_USP7_MATH_1	51	55	PF00917	0.695
DOC_USP7_MATH_1	522	526	PF00917	0.453
DOC_USP7_MATH_1	635	639	PF00917	0.362
DOC_WW_Pin1_4	336	341	PF00397	0.689
DOC_WW_Pin1_4	498	503	PF00397	0.634
DOC_WW_Pin1_4	532	537	PF00397	0.481
DOC_WW_Pin1_4	568	573	PF00397	0.552
DOC_WW_Pin1_4	584	589	PF00397	0.594
DOC_WW_Pin1_4	596	601	PF00397	0.500
DOC_WW_Pin1_4	609	614	PF00397	0.533
DOC_WW_Pin1_4	730	735	PF00397	0.352
DOC_WW_Pin1_4	77	82	PF00397	0.642
LIG_14-3-3_CanoR_1	118	125	PF00244	0.641
LIG_14-3-3_CanoR_1	132	141	PF00244	0.600
LIG_14-3-3_CanoR_1	386	392	PF00244	0.579
LIG_14-3-3_CanoR_1	402	411	PF00244	0.548
LIG_14-3-3_CanoR_1	547	552	PF00244	0.679
LIG_14-3-3_CanoR_1	753	760	PF00244	0.442
LIG_Actin_WH2_2	704	719	PF00022	0.314
LIG_APCC_ABBA_1	559	564	PF00400	0.587
LIG_BRCT_BRCA1_1	376	380	PF00533	0.547
LIG_BRCT_BRCA1_1	491	495	PF00533	0.574
LIG_BRCT_BRCA1_1	629	633	PF00533	0.329
LIG_CtBP_PxDLS_1	430	434	PF00389	0.553
LIG_EH1_1	160	168	PF00400	0.622
LIG_eIF4E_1	146	152	PF01652	0.490
LIG_eIF4E_1	659	665	PF01652	0.343
LIG_EVH1_1	566	570	PF00568	0.588
LIG_FHA_1	153	159	PF00498	0.475
LIG_FHA_1	177	183	PF00498	0.514
LIG_FHA_1	194	200	PF00498	0.495
LIG_FHA_1	239	245	PF00498	0.669
LIG_FHA_1	283	289	PF00498	0.721
LIG_FHA_1	441	447	PF00498	0.601
LIG_FHA_1	478	484	PF00498	0.625
LIG_FHA_1	533	539	PF00498	0.535
LIG_FHA_1	544	550	PF00498	0.547
LIG_FHA_1	597	603	PF00498	0.518
LIG_FHA_1	680	686	PF00498	0.327
LIG_FHA_1	78	84	PF00498	0.601
LIG_FHA_1	91	97	PF00498	0.468
LIG_FHA_2	465	471	PF00498	0.618
LIG_FHA_2	495	501	PF00498	0.723
LIG_FHA_2	753	759	PF00498	0.363
LIG_GBD_Chelix_1	510	518	PF00786	0.326
LIG_LIR_Gen_1	172	180	PF02991	0.484
LIG_LIR_Gen_1	40	48	PF02991	0.566
LIG_LIR_Gen_1	545	555	PF02991	0.654
LIG_LIR_Gen_1	618	629	PF02991	0.329
LIG_LIR_Gen_1	657	667	PF02991	0.427
LIG_LIR_Nem_3	40	44	PF02991	0.584
LIG_LIR_Nem_3	420	425	PF02991	0.516
LIG_LIR_Nem_3	545	551	PF02991	0.620
LIG_LIR_Nem_3	630	636	PF02991	0.336
LIG_LIR_Nem_3	657	662	PF02991	0.428
LIG_MLH1_MIPbox_1	629	633	PF16413	0.329
LIG_NRBOX	661	667	PF00104	0.315
LIG_PDZ_Class_1	815	820	PF00595	0.467
LIG_Pex14_2	632	636	PF04695	0.345
LIG_Pex14_2	98	102	PF04695	0.540
LIG_PTB_Apo_2	325	332	PF02174	0.722
LIG_PTB_Apo_2	625	632	PF02174	0.329
LIG_PTB_Apo_2	684	691	PF02174	0.325
LIG_PTB_Phospho_1	625	631	PF10480	0.329
LIG_PTB_Phospho_1	684	690	PF10480	0.326
LIG_SH2_CRK	659	663	PF00017	0.410
LIG_SH2_GRB2like	690	693	PF00017	0.349
LIG_SH2_NCK_1	690	694	PF00017	0.351
LIG_SH2_PTP2	548	551	PF00017	0.618
LIG_SH2_STAP1	146	150	PF00017	0.486
LIG_SH2_STAP1	750	754	PF00017	0.338
LIG_SH2_STAT3	754	757	PF00017	0.433
LIG_SH2_STAT5	114	117	PF00017	0.664
LIG_SH2_STAT5	531	534	PF00017	0.659
LIG_SH2_STAT5	548	551	PF00017	0.446
LIG_SH2_STAT5	621	624	PF00017	0.334
LIG_SH2_STAT5	631	634	PF00017	0.347
LIG_SH2_STAT5	669	672	PF00017	0.330
LIG_SH2_STAT5	690	693	PF00017	0.349
LIG_SH2_STAT5	750	753	PF00017	0.343
LIG_SH2_STAT5	754	757	PF00017	0.357
LIG_SH3_3	164	170	PF00018	0.589
LIG_SH3_3	256	262	PF00018	0.670
LIG_SH3_3	530	536	PF00018	0.572
LIG_SH3_3	548	554	PF00018	0.608
LIG_SH3_3	564	570	PF00018	0.564
LIG_SH3_3	585	591	PF00018	0.605
LIG_SH3_3	595	601	PF00018	0.635
LIG_SH3_3	636	642	PF00018	0.300
LIG_SH3_3	735	741	PF00018	0.340
LIG_SUMO_SIM_anti_2	504	512	PF11976	0.631
LIG_SUMO_SIM_anti_2	704	710	PF11976	0.321
LIG_SUMO_SIM_par_1	154	160	PF11976	0.534
LIG_SUMO_SIM_par_1	534	542	PF11976	0.506
LIG_TRAF2_1	501	504	PF00917	0.708
LIG_TRAF2_1	527	530	PF00917	0.481
LIG_TRAF2_1	765	768	PF00917	0.442
LIG_TRFH_1	356	360	PF08558	0.686
LIG_TYR_ITSM	544	551	PF00017	0.562
LIG_UBA3_1	605	611	PF00899	0.643
LIG_UBA3_1	62	67	PF00899	0.535
LIG_WW_3	359	363	PF00397	0.692
MOD_CDC14_SPxK_1	733	736	PF00782	0.358
MOD_CDK_SPxK_1	730	736	PF00069	0.350
MOD_CK1_1	117	123	PF00069	0.625
MOD_CK1_1	136	142	PF00069	0.605
MOD_CK1_1	172	178	PF00069	0.477
MOD_CK1_1	269	275	PF00069	0.779
MOD_CK1_1	334	340	PF00069	0.710
MOD_CK1_1	627	633	PF00069	0.425
MOD_CK1_1	657	663	PF00069	0.389
MOD_CK1_1	73	79	PF00069	0.688
MOD_CK1_1	749	755	PF00069	0.423
MOD_CK1_1	791	797	PF00069	0.383
MOD_CK2_1	117	123	PF00069	0.622
MOD_CK2_1	425	431	PF00069	0.553
MOD_CK2_1	498	504	PF00069	0.751
MOD_CK2_1	51	57	PF00069	0.641
MOD_CMANNOS	223	226	PF00535	0.326
MOD_DYRK1A_RPxSP_1	596	600	PF00069	0.545
MOD_GlcNHglycan	126	129	PF01048	0.521
MOD_GlcNHglycan	135	138	PF01048	0.384
MOD_GlcNHglycan	268	271	PF01048	0.582
MOD_GlcNHglycan	272	275	PF01048	0.547
MOD_GlcNHglycan	279	282	PF01048	0.471
MOD_GlcNHglycan	290	293	PF01048	0.464
MOD_GlcNHglycan	336	339	PF01048	0.470
MOD_GlcNHglycan	405	408	PF01048	0.416
MOD_GlcNHglycan	551	554	PF01048	0.477
MOD_GlcNHglycan	75	78	PF01048	0.378
MOD_GlcNHglycan	817	820	PF01048	0.672
MOD_GSK3_1	113	120	PF00069	0.569
MOD_GSK3_1	124	131	PF00069	0.717
MOD_GSK3_1	133	140	PF00069	0.569
MOD_GSK3_1	172	179	PF00069	0.569
MOD_GSK3_1	238	245	PF00069	0.611
MOD_GSK3_1	265	272	PF00069	0.787
MOD_GSK3_1	273	280	PF00069	0.705
MOD_GSK3_1	327	334	PF00069	0.689
MOD_GSK3_1	339	346	PF00069	0.703
MOD_GSK3_1	494	501	PF00069	0.621
MOD_GSK3_1	543	550	PF00069	0.613
MOD_GSK3_1	654	661	PF00069	0.325
MOD_GSK3_1	675	682	PF00069	0.316
MOD_GSK3_1	69	76	PF00069	0.633
MOD_GSK3_1	748	755	PF00069	0.351
MOD_GSK3_1	788	795	PF00069	0.395
MOD_N-GLC_1	327	332	PF02516	0.450
MOD_N-GLC_1	627	632	PF02516	0.329
MOD_N-GLC_1	686	691	PF02516	0.539
MOD_N-GLC_1	727	732	PF02516	0.527
MOD_N-GLC_1	815	820	PF02516	0.515
MOD_N-GLC_2	447	449	PF02516	0.414
MOD_N-GLC_2	701	703	PF02516	0.544
MOD_N-GLC_2	721	723	PF02516	0.478
MOD_NEK2_1	152	157	PF00069	0.616
MOD_NEK2_1	176	181	PF00069	0.641
MOD_NEK2_1	266	271	PF00069	0.785
MOD_NEK2_1	302	307	PF00069	0.708
MOD_NEK2_1	331	336	PF00069	0.788
MOD_NEK2_1	380	385	PF00069	0.456
MOD_NEK2_1	425	430	PF00069	0.558
MOD_NEK2_1	494	499	PF00069	0.712
MOD_NEK2_1	509	514	PF00069	0.460
MOD_NEK2_1	562	567	PF00069	0.744
MOD_NEK2_1	594	599	PF00069	0.531
MOD_NEK2_1	615	620	PF00069	0.568
MOD_NEK2_1	624	629	PF00069	0.343
MOD_NEK2_1	658	663	PF00069	0.393
MOD_NEK2_1	70	75	PF00069	0.574
MOD_NEK2_1	727	732	PF00069	0.327
MOD_NEK2_1	743	748	PF00069	0.378
MOD_NEK2_1	815	820	PF00069	0.394
MOD_NEK2_1	91	96	PF00069	0.527
MOD_PIKK_1	302	308	PF00454	0.667
MOD_PIKK_1	39	45	PF00454	0.594
MOD_PIKK_1	489	495	PF00454	0.540
MOD_PKA_1	308	314	PF00069	0.741
MOD_PKA_2	11	17	PF00069	0.770
MOD_PKA_2	117	123	PF00069	0.608
MOD_PKA_2	193	199	PF00069	0.589
MOD_PKA_2	288	294	PF00069	0.737
MOD_PKA_2	302	308	PF00069	0.650
MOD_PKA_2	385	391	PF00069	0.553
MOD_PKA_2	562	568	PF00069	0.559
MOD_PKA_2	752	758	PF00069	0.361
MOD_PKB_1	263	271	PF00069	0.732
MOD_Plk_1	255	261	PF00069	0.843
MOD_Plk_1	327	333	PF00069	0.649
MOD_Plk_1	39	45	PF00069	0.613
MOD_Plk_1	503	509	PF00069	0.659
MOD_Plk_1	627	633	PF00069	0.329
MOD_Plk_1	675	681	PF00069	0.313
MOD_Plk_1	686	692	PF00069	0.421
MOD_Plk_2-3	169	175	PF00069	0.626
MOD_Plk_2-3	452	458	PF00069	0.530
MOD_Plk_4	152	158	PF00069	0.508
MOD_Plk_4	172	178	PF00069	0.418
MOD_Plk_4	339	345	PF00069	0.641
MOD_Plk_4	410	416	PF00069	0.529
MOD_Plk_4	417	423	PF00069	0.503
MOD_Plk_4	441	447	PF00069	0.525
MOD_Plk_4	627	633	PF00069	0.331
MOD_Plk_4	654	660	PF00069	0.419
MOD_Plk_4	743	749	PF00069	0.363
MOD_Plk_4	91	97	PF00069	0.508
MOD_ProDKin_1	336	342	PF00069	0.691
MOD_ProDKin_1	498	504	PF00069	0.631
MOD_ProDKin_1	532	538	PF00069	0.476
MOD_ProDKin_1	568	574	PF00069	0.547
MOD_ProDKin_1	584	590	PF00069	0.497
MOD_ProDKin_1	596	602	PF00069	0.497
MOD_ProDKin_1	609	615	PF00069	0.527
MOD_ProDKin_1	730	736	PF00069	0.350
MOD_ProDKin_1	77	83	PF00069	0.631
TRG_DiLeu_BaEn_1	204	209	PF01217	0.615
TRG_DiLeu_BaEn_1	367	372	PF01217	0.524
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.626
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.507
TRG_DiLeu_LyEn_5	204	209	PF01217	0.615
TRG_ENDOCYTIC_2	422	425	PF00928	0.506
TRG_ENDOCYTIC_2	548	551	PF00928	0.618
TRG_ENDOCYTIC_2	621	624	PF00928	0.347
TRG_ENDOCYTIC_2	659	662	PF00928	0.412
TRG_ER_diArg_1	260	263	PF00400	0.791
TRG_ER_diArg_1	302	304	PF00400	0.715
TRG_NLS_MonoExtN_4	307	312	PF00514	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8G1	Leptomonas seymouri	47%	76%
A0A3S7X6Z4	Leishmania donovani	88%	100%
A4HLR5	Leishmania braziliensis	70%	100%
A4I941	Leishmania infantum	88%	100%
Q4Q3Y4	Leishmania major	89%	100%