Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B440_LEIMU

TriTrypDb:

LmxM.32.2020

Length:

868

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B440

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B440

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.461
CLV_NRD_NRD_1	551	553	PF00675	0.400
CLV_NRD_NRD_1	583	585	PF00675	0.850
CLV_NRD_NRD_1	680	682	PF00675	0.492
CLV_PCSK_FUR_1	98	102	PF00082	0.436
CLV_PCSK_KEX2_1	100	102	PF00082	0.461
CLV_PCSK_KEX2_1	38	40	PF00082	0.612
CLV_PCSK_KEX2_1	551	553	PF00082	0.400
CLV_PCSK_KEX2_1	583	585	PF00082	0.834
CLV_PCSK_KEX2_1	680	682	PF00082	0.492
CLV_PCSK_KEX2_1	774	776	PF00082	0.500
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.612
CLV_PCSK_PC1ET2_1	774	776	PF00082	0.481
CLV_PCSK_SKI1_1	14	18	PF00082	0.372
CLV_PCSK_SKI1_1	3	7	PF00082	0.427
CLV_PCSK_SKI1_1	302	306	PF00082	0.553
CLV_PCSK_SKI1_1	47	51	PF00082	0.679
CLV_PCSK_SKI1_1	735	739	PF00082	0.476
CLV_Separin_Metazoa	505	509	PF03568	0.654
DEG_APCC_DBOX_1	639	647	PF00400	0.722
DEG_APCC_DBOX_1	734	742	PF00400	0.466
DEG_MDM2_SWIB_1	633	641	PF02201	0.233
DEG_Nend_Nbox_1	1	3	PF02207	0.595
DEG_SCF_FBW7_1	496	501	PF00400	0.705
DEG_SCF_FBW7_2	498	505	PF00400	0.649
DEG_SPOP_SBC_1	176	180	PF00917	0.656
DEG_SPOP_SBC_1	181	185	PF00917	0.644
DEG_SPOP_SBC_1	437	441	PF00917	0.652
DOC_CKS1_1	229	234	PF01111	0.771
DOC_CKS1_1	825	830	PF01111	0.742
DOC_CYCLIN_yCln2_LP_2	71	77	PF00134	0.366
DOC_CYCLIN_yCln2_LP_2	852	855	PF00134	0.774
DOC_MAPK_FxFP_2	256	259	PF00069	0.641
DOC_MAPK_gen_1	680	688	PF00069	0.662
DOC_MAPK_gen_1	732	741	PF00069	0.590
DOC_MAPK_MEF2A_6	735	743	PF00069	0.456
DOC_PP1_RVXF_1	558	565	PF00149	0.383
DOC_PP2B_LxvP_1	146	149	PF13499	0.684
DOC_PP2B_LxvP_1	200	203	PF13499	0.784
DOC_PP2B_LxvP_1	459	462	PF13499	0.800
DOC_PP2B_LxvP_1	845	848	PF13499	0.770
DOC_PP2B_LxvP_1	852	855	PF13499	0.774
DOC_PP4_FxxP_1	229	232	PF00568	0.794
DOC_PP4_FxxP_1	256	259	PF00568	0.641
DOC_PP4_FxxP_1	444	447	PF00568	0.708
DOC_USP7_MATH_1	176	180	PF00917	0.796
DOC_USP7_MATH_1	181	185	PF00917	0.768
DOC_USP7_MATH_1	240	244	PF00917	0.719
DOC_USP7_MATH_1	277	281	PF00917	0.689
DOC_USP7_MATH_1	297	301	PF00917	0.725
DOC_USP7_MATH_1	325	329	PF00917	0.703
DOC_USP7_MATH_1	356	360	PF00917	0.777
DOC_USP7_MATH_1	432	436	PF00917	0.712
DOC_USP7_MATH_1	452	456	PF00917	0.751
DOC_USP7_MATH_1	528	532	PF00917	0.742
DOC_USP7_MATH_1	550	554	PF00917	0.705
DOC_USP7_MATH_1	574	578	PF00917	0.552
DOC_USP7_MATH_1	585	589	PF00917	0.469
DOC_USP7_MATH_1	672	676	PF00917	0.653
DOC_USP7_MATH_1	861	865	PF00917	0.726
DOC_USP7_UBL2_3	197	201	PF12436	0.667
DOC_WW_Pin1_4	191	196	PF00397	0.760
DOC_WW_Pin1_4	204	209	PF00397	0.721
DOC_WW_Pin1_4	228	233	PF00397	0.778
DOC_WW_Pin1_4	273	278	PF00397	0.803
DOC_WW_Pin1_4	373	378	PF00397	0.658
DOC_WW_Pin1_4	394	399	PF00397	0.712
DOC_WW_Pin1_4	421	426	PF00397	0.665
DOC_WW_Pin1_4	457	462	PF00397	0.845
DOC_WW_Pin1_4	494	499	PF00397	0.705
DOC_WW_Pin1_4	572	577	PF00397	0.577
DOC_WW_Pin1_4	663	668	PF00397	0.616
DOC_WW_Pin1_4	789	794	PF00397	0.638
DOC_WW_Pin1_4	808	813	PF00397	0.738
DOC_WW_Pin1_4	821	826	PF00397	0.650
LIG_14-3-3_CanoR_1	135	141	PF00244	0.653
LIG_14-3-3_CanoR_1	302	311	PF00244	0.692
LIG_14-3-3_CanoR_1	47	52	PF00244	0.443
LIG_14-3-3_CanoR_1	491	498	PF00244	0.778
LIG_14-3-3_CanoR_1	508	513	PF00244	0.649
LIG_14-3-3_CanoR_1	541	550	PF00244	0.778
LIG_14-3-3_CanoR_1	551	559	PF00244	0.516
LIG_14-3-3_CanoR_1	584	590	PF00244	0.553
LIG_14-3-3_CanoR_1	714	720	PF00244	0.659
LIG_14-3-3_CanoR_1	808	812	PF00244	0.762
LIG_14-3-3_CanoR_1	837	843	PF00244	0.821
LIG_APCC_ABBA_1	659	664	PF00400	0.562
LIG_BIR_III_4	348	352	PF00653	0.642
LIG_BRCT_BRCA1_1	252	256	PF00533	0.754
LIG_BRCT_BRCA1_1	656	660	PF00533	0.673
LIG_BRCT_BRCA1_1	703	707	PF00533	0.682
LIG_Clathr_ClatBox_1	638	642	PF01394	0.407
LIG_deltaCOP1_diTrp_1	654	660	PF00928	0.720
LIG_EH_1	441	445	PF12763	0.767
LIG_eIF4E_1	733	739	PF01652	0.383
LIG_EVH1_1	229	233	PF00568	0.677
LIG_EVH1_2	447	451	PF00568	0.644
LIG_FHA_1	129	135	PF00498	0.674
LIG_FHA_1	21	27	PF00498	0.329
LIG_FHA_1	334	340	PF00498	0.818
LIG_FHA_1	414	420	PF00498	0.646
LIG_FHA_1	458	464	PF00498	0.805
LIG_FHA_1	495	501	PF00498	0.783
LIG_FHA_1	608	614	PF00498	0.414
LIG_FHA_1	664	670	PF00498	0.669
LIG_FHA_1	740	746	PF00498	0.316
LIG_FHA_1	759	765	PF00498	0.449
LIG_FHA_1	785	791	PF00498	0.601
LIG_FHA_2	138	144	PF00498	0.716
LIG_FHA_2	262	268	PF00498	0.760
LIG_FHA_2	325	331	PF00498	0.639
LIG_FHA_2	343	349	PF00498	0.613
LIG_FHA_2	406	412	PF00498	0.661
LIG_FHA_2	422	428	PF00498	0.647
LIG_FHA_2	48	54	PF00498	0.441
LIG_LIR_Apic_2	253	259	PF02991	0.639
LIG_LIR_Apic_2	441	447	PF02991	0.707
LIG_LIR_Gen_1	609	620	PF02991	0.271
LIG_LIR_Gen_1	654	662	PF02991	0.677
LIG_LIR_Gen_1	717	727	PF02991	0.705
LIG_LIR_Gen_1	734	745	PF02991	0.453
LIG_LIR_Gen_1	766	776	PF02991	0.653
LIG_LIR_Nem_3	257	261	PF02991	0.757
LIG_LIR_Nem_3	305	311	PF02991	0.632
LIG_LIR_Nem_3	609	615	PF02991	0.515
LIG_LIR_Nem_3	654	659	PF02991	0.697
LIG_LIR_Nem_3	717	722	PF02991	0.711
LIG_LIR_Nem_3	734	740	PF02991	0.453
LIG_LIR_Nem_3	766	772	PF02991	0.652
LIG_LIR_Nem_3	841	845	PF02991	0.768
LIG_LYPXL_S_1	83	87	PF13949	0.401
LIG_LYPXL_yS_3	84	87	PF13949	0.664
LIG_MYND_1	198	202	PF01753	0.720
LIG_MYND_1	457	461	PF01753	0.748
LIG_Pex14_1	364	368	PF04695	0.634
LIG_Pex14_1	656	660	PF04695	0.720
LIG_Pex14_1	92	96	PF04695	0.634
LIG_Pex14_2	633	637	PF04695	0.383
LIG_SH2_CRK	10	14	PF00017	0.616
LIG_SH2_CRK	769	773	PF00017	0.726
LIG_SH2_GRB2like	605	608	PF00017	0.357
LIG_SH2_NCK_1	332	336	PF00017	0.755
LIG_SH2_NCK_1	694	698	PF00017	0.678
LIG_SH2_NCK_1	733	737	PF00017	0.383
LIG_SH2_SRC	332	335	PF00017	0.754
LIG_SH2_SRC	662	665	PF00017	0.680
LIG_SH2_SRC	727	730	PF00017	0.662
LIG_SH2_STAP1	733	737	PF00017	0.383
LIG_SH2_STAT5	368	371	PF00017	0.691
LIG_SH2_STAT5	42	45	PF00017	0.469
LIG_SH2_STAT5	605	608	PF00017	0.479
LIG_SH2_STAT5	620	623	PF00017	0.355
LIG_SH2_STAT5	631	634	PF00017	0.383
LIG_SH2_STAT5	733	736	PF00017	0.433
LIG_SH3_1	227	233	PF00018	0.657
LIG_SH3_3	192	198	PF00018	0.743
LIG_SH3_3	199	205	PF00018	0.796
LIG_SH3_3	227	233	PF00018	0.678
LIG_SH3_3	265	271	PF00018	0.644
LIG_SH3_3	355	361	PF00018	0.784
LIG_SH3_3	371	377	PF00018	0.709
LIG_SH3_3	46	52	PF00018	0.439
LIG_SH3_3	522	528	PF00018	0.810
LIG_SH3_3	593	599	PF00018	0.562
LIG_SH3_3	700	706	PF00018	0.601
LIG_SH3_3	79	85	PF00018	0.399
LIG_SH3_3	822	828	PF00018	0.706
LIG_SH3_4	197	204	PF00018	0.661
LIG_SUMO_SIM_anti_2	414	422	PF11976	0.646
LIG_SUMO_SIM_anti_2	742	748	PF11976	0.316
LIG_SUMO_SIM_par_1	207	212	PF11976	0.762
LIG_SUMO_SIM_par_1	414	422	PF11976	0.646
LIG_TRAF2_1	521	524	PF00917	0.810
LIG_TYR_ITIM	43	48	PF00017	0.433
LIG_TYR_ITIM	767	772	PF00017	0.723
LIG_TYR_ITIM	82	87	PF00017	0.562
LIG_WRC_WIRS_1	22	27	PF05994	0.332
LIG_WRC_WIRS_1	716	721	PF05994	0.676
LIG_WRC_WIRS_1	839	844	PF05994	0.769
MOD_CDC14_SPxK_1	194	197	PF00782	0.658
MOD_CDK_SPxK_1	191	197	PF00069	0.660
MOD_CDK_SPxxK_3	275	282	PF00069	0.770
MOD_CDK_SPxxK_3	789	796	PF00069	0.619
MOD_CK1_1	102	108	PF00069	0.616
MOD_CK1_1	128	134	PF00069	0.636
MOD_CK1_1	137	143	PF00069	0.691
MOD_CK1_1	172	178	PF00069	0.798
MOD_CK1_1	179	185	PF00069	0.717
MOD_CK1_1	207	213	PF00069	0.710
MOD_CK1_1	243	249	PF00069	0.809
MOD_CK1_1	367	373	PF00069	0.772
MOD_CK1_1	376	382	PF00069	0.680
MOD_CK1_1	397	403	PF00069	0.690
MOD_CK1_1	455	461	PF00069	0.749
MOD_CK1_1	472	478	PF00069	0.734
MOD_CK1_1	485	491	PF00069	0.778
MOD_CK1_1	553	559	PF00069	0.490
MOD_CK1_1	588	594	PF00069	0.567
MOD_CK1_1	648	654	PF00069	0.676
MOD_CK1_1	717	723	PF00069	0.693
MOD_CK1_1	748	754	PF00069	0.399
MOD_CK1_1	758	764	PF00069	0.383
MOD_CK1_1	823	829	PF00069	0.767
MOD_CK2_1	259	265	PF00069	0.791
MOD_CK2_1	277	283	PF00069	0.675
MOD_CK2_1	508	514	PF00069	0.792
MOD_CK2_1	518	524	PF00069	0.738
MOD_CK2_1	648	654	PF00069	0.676
MOD_CK2_1	770	776	PF00069	0.726
MOD_CK2_1	789	795	PF00069	0.590
MOD_DYRK1A_RPxSP_1	808	812	PF00069	0.778
MOD_GlcNHglycan	101	104	PF01048	0.508
MOD_GlcNHglycan	127	130	PF01048	0.491
MOD_GlcNHglycan	136	139	PF01048	0.490
MOD_GlcNHglycan	214	217	PF01048	0.583
MOD_GlcNHglycan	299	302	PF01048	0.565
MOD_GlcNHglycan	305	308	PF01048	0.539
MOD_GlcNHglycan	384	387	PF01048	0.501
MOD_GlcNHglycan	492	495	PF01048	0.598
MOD_GlcNHglycan	545	548	PF01048	0.645
MOD_GlcNHglycan	552	555	PF01048	0.350
MOD_GlcNHglycan	585	588	PF01048	0.700
MOD_GlcNHglycan	59	62	PF01048	0.641
MOD_GlcNHglycan	65	68	PF01048	0.379
MOD_GlcNHglycan	682	685	PF01048	0.449
MOD_GlcNHglycan	695	698	PF01048	0.386
MOD_GlcNHglycan	848	851	PF01048	0.567
MOD_GlcNHglycan	865	868	PF01048	0.589
MOD_GSK3_1	133	140	PF00069	0.690
MOD_GSK3_1	166	173	PF00069	0.843
MOD_GSK3_1	175	182	PF00069	0.771
MOD_GSK3_1	207	214	PF00069	0.722
MOD_GSK3_1	21	28	PF00069	0.386
MOD_GSK3_1	250	257	PF00069	0.793
MOD_GSK3_1	273	280	PF00069	0.766
MOD_GSK3_1	338	345	PF00069	0.656
MOD_GSK3_1	432	439	PF00069	0.852
MOD_GSK3_1	446	453	PF00069	0.681
MOD_GSK3_1	479	486	PF00069	0.809
MOD_GSK3_1	490	497	PF00069	0.719
MOD_GSK3_1	529	536	PF00069	0.756
MOD_GSK3_1	568	575	PF00069	0.714
MOD_GSK3_1	585	592	PF00069	0.498
MOD_GSK3_1	607	614	PF00069	0.467
MOD_GSK3_1	680	687	PF00069	0.694
MOD_GSK3_1	689	696	PF00069	0.623
MOD_GSK3_1	717	724	PF00069	0.681
MOD_GSK3_1	727	734	PF00069	0.624
MOD_GSK3_1	741	748	PF00069	0.199
MOD_GSK3_1	800	807	PF00069	0.782
MOD_GSK3_1	820	827	PF00069	0.616
MOD_N-GLC_1	432	437	PF02516	0.617
MOD_N-GLC_1	533	538	PF02516	0.466
MOD_N-GLC_1	56	61	PF02516	0.624
MOD_N-GLC_1	689	694	PF02516	0.477
MOD_N-GLC_1	701	706	PF02516	0.381
MOD_NEK2_1	133	138	PF00069	0.690
MOD_NEK2_1	211	216	PF00069	0.827
MOD_NEK2_1	25	30	PF00069	0.369
MOD_NEK2_1	412	417	PF00069	0.632
MOD_NEK2_1	451	456	PF00069	0.772
MOD_NEK2_1	589	594	PF00069	0.521
MOD_NEK2_1	611	616	PF00069	0.461
MOD_NEK2_1	63	68	PF00069	0.409
MOD_NEK2_1	715	720	PF00069	0.675
MOD_NEK2_1	741	746	PF00069	0.466
MOD_NEK2_1	784	789	PF00069	0.748
MOD_NEK2_1	800	805	PF00069	0.642
MOD_NEK2_1	863	868	PF00069	0.805
MOD_NEK2_1	99	104	PF00069	0.650
MOD_NEK2_2	462	467	PF00069	0.716
MOD_OFUCOSY	753	759	PF10250	0.383
MOD_PIKK_1	220	226	PF00454	0.661
MOD_PIKK_1	474	480	PF00454	0.777
MOD_PIKK_1	533	539	PF00454	0.804
MOD_PIKK_1	574	580	PF00454	0.555
MOD_PIKK_1	708	714	PF00454	0.715
MOD_PIKK_1	717	723	PF00454	0.633
MOD_PK_1	508	514	PF00069	0.709
MOD_PKA_1	3	9	PF00069	0.577
MOD_PKA_1	583	589	PF00069	0.552
MOD_PKA_1	680	686	PF00069	0.664
MOD_PKA_2	134	140	PF00069	0.686
MOD_PKA_2	490	496	PF00069	0.767
MOD_PKA_2	550	556	PF00069	0.435
MOD_PKA_2	583	589	PF00069	0.556
MOD_PKA_2	680	686	PF00069	0.700
MOD_PKA_2	731	737	PF00069	0.590
MOD_PKA_2	807	813	PF00069	0.819
MOD_PKA_2	99	105	PF00069	0.666
MOD_Plk_1	333	339	PF00069	0.756
MOD_Plk_1	482	488	PF00069	0.763
MOD_Plk_1	689	695	PF00069	0.681
MOD_Plk_4	21	27	PF00069	0.249
MOD_Plk_4	270	276	PF00069	0.650
MOD_Plk_4	364	370	PF00069	0.764
MOD_Plk_4	446	452	PF00069	0.643
MOD_Plk_4	585	591	PF00069	0.527
MOD_Plk_4	607	613	PF00069	0.474
MOD_Plk_4	645	651	PF00069	0.769
MOD_Plk_4	741	747	PF00069	0.506
MOD_Plk_4	854	860	PF00069	0.730
MOD_ProDKin_1	191	197	PF00069	0.761
MOD_ProDKin_1	204	210	PF00069	0.722
MOD_ProDKin_1	228	234	PF00069	0.777
MOD_ProDKin_1	273	279	PF00069	0.801
MOD_ProDKin_1	373	379	PF00069	0.659
MOD_ProDKin_1	394	400	PF00069	0.712
MOD_ProDKin_1	421	427	PF00069	0.667
MOD_ProDKin_1	457	463	PF00069	0.847
MOD_ProDKin_1	494	500	PF00069	0.706
MOD_ProDKin_1	572	578	PF00069	0.579
MOD_ProDKin_1	663	669	PF00069	0.613
MOD_ProDKin_1	789	795	PF00069	0.640
MOD_ProDKin_1	808	814	PF00069	0.738
MOD_ProDKin_1	821	827	PF00069	0.650
TRG_DiLeu_BaEn_4	283	289	PF01217	0.650
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.332
TRG_DiLeu_BaLyEn_6	711	716	PF01217	0.611
TRG_DiLeu_BaLyEn_6	809	814	PF01217	0.626
TRG_ENDOCYTIC_2	10	13	PF00928	0.665
TRG_ENDOCYTIC_2	308	311	PF00928	0.631
TRG_ENDOCYTIC_2	45	48	PF00928	0.443
TRG_ENDOCYTIC_2	619	622	PF00928	0.480
TRG_ENDOCYTIC_2	662	665	PF00928	0.680
TRG_ENDOCYTIC_2	769	772	PF00928	0.729
TRG_ENDOCYTIC_2	84	87	PF00928	0.664
TRG_ENDOCYTIC_2	96	99	PF00928	0.603
TRG_ER_diArg_1	550	552	PF00400	0.609
TRG_ER_diArg_1	583	585	PF00400	0.505
TRG_ER_diArg_1	87	90	PF00400	0.671
TRG_ER_diArg_1	98	101	PF00400	0.618
TRG_NES_CRM1_1	642	654	PF08389	0.678
TRG_PTS2	1	22	PF00400	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7U8	Leishmania donovani	78%	100%
A4HLR4	Leishmania braziliensis	51%	97%
A4I964	Leishmania infantum	79%	100%
Q4Q3Y5	Leishmania major	77%	100%