Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B437_LEIMU

TriTrypDb:

LmxM.32.1990

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B437

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B437

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	253	257	PF00656	0.701
CLV_NRD_NRD_1	161	163	PF00675	0.641
CLV_NRD_NRD_1	262	264	PF00675	0.663
CLV_NRD_NRD_1	41	43	PF00675	0.594
CLV_PCSK_KEX2_1	161	163	PF00082	0.641
CLV_PCSK_KEX2_1	262	264	PF00082	0.675
CLV_PCSK_KEX2_1	497	499	PF00082	0.739
CLV_PCSK_KEX2_1	567	569	PF00082	0.511
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.739
CLV_PCSK_PC1ET2_1	567	569	PF00082	0.523
CLV_PCSK_SKI1_1	146	150	PF00082	0.529
CLV_PCSK_SKI1_1	559	563	PF00082	0.537
CLV_PCSK_SKI1_1	564	568	PF00082	0.487
DEG_Nend_UBRbox_4	1	3	PF02207	0.627
DEG_SPOP_SBC_1	222	226	PF00917	0.677
DEG_SPOP_SBC_1	228	232	PF00917	0.604
DEG_SPOP_SBC_1	476	480	PF00917	0.605
DOC_CYCLIN_RxL_1	371	381	PF00134	0.464
DOC_MAPK_gen_1	564	574	PF00069	0.655
DOC_PP2B_LxvP_1	192	195	PF13499	0.692
DOC_PP4_FxxP_1	445	448	PF00568	0.523
DOC_USP7_MATH_1	22	26	PF00917	0.544
DOC_USP7_MATH_1	220	224	PF00917	0.651
DOC_USP7_MATH_1	244	248	PF00917	0.679
DOC_USP7_MATH_1	340	344	PF00917	0.768
DOC_USP7_MATH_1	351	355	PF00917	0.619
DOC_USP7_MATH_1	419	423	PF00917	0.744
DOC_USP7_MATH_1	428	432	PF00917	0.574
DOC_USP7_MATH_1	460	464	PF00917	0.671
DOC_USP7_MATH_1	467	471	PF00917	0.617
DOC_USP7_MATH_1	77	81	PF00917	0.669
DOC_USP7_UBL2_3	508	512	PF12436	0.769
DOC_WW_Pin1_4	162	167	PF00397	0.775
DOC_WW_Pin1_4	169	174	PF00397	0.611
DOC_WW_Pin1_4	197	202	PF00397	0.771
DOC_WW_Pin1_4	211	216	PF00397	0.664
DOC_WW_Pin1_4	218	223	PF00397	0.635
DOC_WW_Pin1_4	572	577	PF00397	0.591
LIG_14-3-3_CanoR_1	132	140	PF00244	0.620
LIG_14-3-3_CanoR_1	144	149	PF00244	0.613
LIG_14-3-3_CanoR_1	262	268	PF00244	0.707
LIG_14-3-3_CanoR_1	536	545	PF00244	0.696
LIG_BRCT_BRCA1_1	94	98	PF00533	0.675
LIG_Clathr_ClatBox_1	286	290	PF01394	0.630
LIG_eIF4E_1	398	404	PF01652	0.459
LIG_FHA_1	185	191	PF00498	0.746
LIG_FHA_1	232	238	PF00498	0.731
LIG_FHA_1	250	256	PF00498	0.525
LIG_FHA_1	386	392	PF00498	0.476
LIG_FHA_1	477	483	PF00498	0.701
LIG_FHA_2	134	140	PF00498	0.677
LIG_FHA_2	145	151	PF00498	0.572
LIG_FHA_2	198	204	PF00498	0.632
LIG_FHA_2	311	317	PF00498	0.590
LIG_FHA_2	405	411	PF00498	0.562
LIG_Integrin_RGD_1	82	84	PF01839	0.773
LIG_LIR_Apic_2	444	448	PF02991	0.595
LIG_LIR_Apic_2	95	99	PF02991	0.623
LIG_LIR_Gen_1	276	283	PF02991	0.687
LIG_LIR_Nem_3	271	277	PF02991	0.736
LIG_LIR_Nem_3	31	35	PF02991	0.488
LIG_PCNA_yPIPBox_3	371	380	PF02747	0.580
LIG_Pex14_2	445	449	PF04695	0.569
LIG_SH2_NCK_1	245	249	PF00017	0.648
LIG_SH2_STAP1	124	128	PF00017	0.563
LIG_SH2_STAP1	245	249	PF00017	0.712
LIG_SH2_STAT3	113	116	PF00017	0.610
LIG_SH2_STAT5	113	116	PF00017	0.666
LIG_SH2_STAT5	267	270	PF00017	0.803
LIG_SH2_STAT5	32	35	PF00017	0.511
LIG_SH2_STAT5	398	401	PF00017	0.458
LIG_SH2_STAT5	7	10	PF00017	0.690
LIG_SH3_3	111	117	PF00018	0.569
LIG_SH3_3	178	184	PF00018	0.673
LIG_SH3_3	199	205	PF00018	0.702
LIG_SH3_3	353	359	PF00018	0.517
LIG_SH3_3	479	485	PF00018	0.708
LIG_SH3_3	61	67	PF00018	0.671
LIG_SH3_3	69	75	PF00018	0.599
LIG_SUMO_SIM_par_1	363	369	PF11976	0.664
LIG_SUMO_SIM_par_1	375	381	PF11976	0.323
LIG_SUMO_SIM_par_1	550	557	PF11976	0.656
LIG_TRAF2_1	407	410	PF00917	0.615
LIG_TYR_ITIM	36	41	PF00017	0.580
LIG_UBA3_1	562	567	PF00899	0.628
LIG_WRC_WIRS_1	140	145	PF05994	0.691
LIG_WRC_WIRS_1	412	417	PF05994	0.536
MOD_CK1_1	17	23	PF00069	0.744
MOD_CK1_1	214	220	PF00069	0.692
MOD_CK1_1	223	229	PF00069	0.624
MOD_CK1_1	232	238	PF00069	0.578
MOD_CK1_1	329	335	PF00069	0.596
MOD_CK1_1	343	349	PF00069	0.664
MOD_CK1_1	354	360	PF00069	0.642
MOD_CK1_1	414	420	PF00069	0.626
MOD_CK1_1	432	438	PF00069	0.687
MOD_CK1_1	470	476	PF00069	0.761
MOD_CK2_1	133	139	PF00069	0.678
MOD_CK2_1	144	150	PF00069	0.569
MOD_CK2_1	335	341	PF00069	0.712
MOD_CK2_1	387	393	PF00069	0.473
MOD_CK2_1	404	410	PF00069	0.607
MOD_CK2_1	441	447	PF00069	0.651
MOD_Cter_Amidation	159	162	PF01082	0.711
MOD_GlcNHglycan	178	181	PF01048	0.695
MOD_GlcNHglycan	206	209	PF01048	0.797
MOD_GlcNHglycan	226	229	PF01048	0.518
MOD_GlcNHglycan	24	27	PF01048	0.535
MOD_GlcNHglycan	246	249	PF01048	0.629
MOD_GlcNHglycan	252	255	PF01048	0.634
MOD_GlcNHglycan	337	340	PF01048	0.683
MOD_GlcNHglycan	353	356	PF01048	0.533
MOD_GlcNHglycan	422	425	PF01048	0.704
MOD_GlcNHglycan	431	434	PF01048	0.565
MOD_GlcNHglycan	472	475	PF01048	0.632
MOD_GlcNHglycan	479	482	PF01048	0.649
MOD_GlcNHglycan	541	544	PF01048	0.703
MOD_GlcNHglycan	9	12	PF01048	0.637
MOD_GSK3_1	214	221	PF00069	0.616
MOD_GSK3_1	222	229	PF00069	0.655
MOD_GSK3_1	231	238	PF00069	0.668
MOD_GSK3_1	299	306	PF00069	0.722
MOD_GSK3_1	326	333	PF00069	0.711
MOD_GSK3_1	342	349	PF00069	0.553
MOD_GSK3_1	411	418	PF00069	0.660
MOD_GSK3_1	428	435	PF00069	0.635
MOD_GSK3_1	437	444	PF00069	0.635
MOD_GSK3_1	470	477	PF00069	0.614
MOD_GSK3_1	535	542	PF00069	0.597
MOD_GSK3_1	568	575	PF00069	0.675
MOD_N-GLC_1	404	409	PF02516	0.542
MOD_N-GLC_1	467	472	PF02516	0.538
MOD_NEK2_1	154	159	PF00069	0.774
MOD_NEK2_1	233	238	PF00069	0.672
MOD_NEK2_1	385	390	PF00069	0.509
MOD_NEK2_1	394	399	PF00069	0.439
MOD_NEK2_1	415	420	PF00069	0.577
MOD_NEK2_1	437	442	PF00069	0.615
MOD_NEK2_2	2	7	PF00069	0.539
MOD_NEK2_2	77	82	PF00069	0.585
MOD_PIKK_1	296	302	PF00454	0.678
MOD_PIKK_1	327	333	PF00454	0.767
MOD_PIKK_1	340	346	PF00454	0.592
MOD_PIKK_1	385	391	PF00454	0.492
MOD_PK_1	568	574	PF00069	0.672
MOD_PKA_2	249	255	PF00069	0.745
MOD_PKA_2	310	316	PF00069	0.619
MOD_PKA_2	535	541	PF00069	0.663
MOD_Plk_1	467	473	PF00069	0.605
MOD_Plk_1	568	574	PF00069	0.672
MOD_Plk_1	77	83	PF00069	0.585
MOD_Plk_2-3	378	384	PF00069	0.583
MOD_Plk_4	144	150	PF00069	0.555
MOD_Plk_4	2	8	PF00069	0.535
MOD_Plk_4	387	393	PF00069	0.478
MOD_Plk_4	394	400	PF00069	0.463
MOD_Plk_4	411	417	PF00069	0.526
MOD_Plk_4	568	574	PF00069	0.632
MOD_Plk_4	92	98	PF00069	0.736
MOD_ProDKin_1	162	168	PF00069	0.776
MOD_ProDKin_1	169	175	PF00069	0.605
MOD_ProDKin_1	197	203	PF00069	0.775
MOD_ProDKin_1	211	217	PF00069	0.664
MOD_ProDKin_1	218	224	PF00069	0.635
TRG_DiLeu_BaEn_2	283	289	PF01217	0.510
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.454
TRG_DiLeu_BaLyEn_6	449	454	PF01217	0.661
TRG_DiLeu_BaLyEn_6	548	553	PF01217	0.592
TRG_ENDOCYTIC_2	274	277	PF00928	0.748
TRG_ENDOCYTIC_2	38	41	PF00928	0.485
TRG_ER_diArg_1	161	164	PF00400	0.641
TRG_ER_diArg_1	262	265	PF00400	0.668
TRG_NES_CRM1_1	284	297	PF08389	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2A9	Leptomonas seymouri	36%	96%
A0A3Q8IEY7	Leishmania donovani	87%	100%
A4HLR1	Leishmania braziliensis	70%	99%
A4I961	Leishmania infantum	87%	89%
Q4Q3Y8	Leishmania major	86%	98%