RNA editing complex protein MP46

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial

Species:

Leishmania mexicana

UniProt:

E9B435_LEIMU

TriTrypDb:

LmxM.32.1970

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B435

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B435

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	439	443	PF00656	0.538
CLV_NRD_NRD_1	148	150	PF00675	0.521
CLV_NRD_NRD_1	347	349	PF00675	0.643
CLV_NRD_NRD_1	365	367	PF00675	0.567
CLV_NRD_NRD_1	469	471	PF00675	0.589
CLV_NRD_NRD_1	76	78	PF00675	0.463
CLV_NRD_NRD_1	82	84	PF00675	0.389
CLV_PCSK_KEX2_1	148	150	PF00082	0.521
CLV_PCSK_KEX2_1	346	348	PF00082	0.645
CLV_PCSK_KEX2_1	365	367	PF00082	0.625
CLV_PCSK_KEX2_1	471	473	PF00082	0.581
CLV_PCSK_KEX2_1	81	83	PF00082	0.408
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.645
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.681
CLV_PCSK_PC7_1	361	367	PF00082	0.564
CLV_PCSK_PC7_1	77	83	PF00082	0.507
CLV_PCSK_SKI1_1	149	153	PF00082	0.488
CLV_PCSK_SKI1_1	96	100	PF00082	0.454
DEG_SCF_FBW7_1	20	27	PF00400	0.538
DEG_SCF_FBW7_1	48	53	PF00400	0.337
DEG_SCF_FBW7_2	107	114	PF00400	0.422
DEG_SPOP_SBC_1	251	255	PF00917	0.825
DOC_CKS1_1	47	52	PF01111	0.328
DOC_CKS1_1	483	488	PF01111	0.658
DOC_CYCLIN_yClb5_NLxxxL_5	315	322	PF00134	0.486
DOC_MAPK_RevD_3	64	78	PF00069	0.533
DOC_PP4_FxxP_1	47	50	PF00568	0.461
DOC_SPAK_OSR1_1	45	49	PF12202	0.538
DOC_USP7_MATH_1	219	223	PF00917	0.752
DOC_USP7_MATH_1	251	255	PF00917	0.738
DOC_USP7_MATH_1	385	389	PF00917	0.743
DOC_USP7_MATH_1	436	440	PF00917	0.671
DOC_USP7_MATH_1	50	54	PF00917	0.669
DOC_WW_Pin1_4	107	112	PF00397	0.642
DOC_WW_Pin1_4	20	25	PF00397	0.530
DOC_WW_Pin1_4	242	247	PF00397	0.798
DOC_WW_Pin1_4	252	257	PF00397	0.544
DOC_WW_Pin1_4	259	264	PF00397	0.665
DOC_WW_Pin1_4	388	393	PF00397	0.655
DOC_WW_Pin1_4	445	450	PF00397	0.621
DOC_WW_Pin1_4	46	51	PF00397	0.355
DOC_WW_Pin1_4	482	487	PF00397	0.722
LIG_14-3-3_CanoR_1	265	269	PF00244	0.611
LIG_14-3-3_CanoR_1	292	297	PF00244	0.528
LIG_14-3-3_CanoR_1	347	356	PF00244	0.668
LIG_14-3-3_CanoR_1	361	368	PF00244	0.703
LIG_Actin_WH2_2	53	71	PF00022	0.558
LIG_Actin_WH2_2	86	102	PF00022	0.403
LIG_BRCT_BRCA1_1	132	136	PF00533	0.444
LIG_BRCT_BRCA1_1	447	451	PF00533	0.585
LIG_deltaCOP1_diTrp_1	474	481	PF00928	0.676
LIG_FHA_1	126	132	PF00498	0.576
LIG_FHA_1	175	181	PF00498	0.471
LIG_FHA_1	21	27	PF00498	0.284
LIG_FHA_1	381	387	PF00498	0.726
LIG_FHA_1	464	470	PF00498	0.565
LIG_FHA_1	483	489	PF00498	0.784
LIG_FHA_2	1	7	PF00498	0.518
LIG_FHA_2	161	167	PF00498	0.486
LIG_FHA_2	429	435	PF00498	0.620
LIG_FHA_2	445	451	PF00498	0.712
LIG_LIR_Gen_1	448	455	PF02991	0.661
LIG_LIR_Gen_1	474	483	PF02991	0.715
LIG_LIR_Nem_3	410	415	PF02991	0.605
LIG_LIR_Nem_3	448	454	PF02991	0.684
LIG_LIR_Nem_3	459	465	PF02991	0.533
LIG_LIR_Nem_3	474	479	PF02991	0.630
LIG_NRBOX	188	194	PF00104	0.518
LIG_NRP_CendR_1	492	495	PF00754	0.745
LIG_SH2_STAT5	173	176	PF00017	0.466
LIG_SH2_STAT5	25	28	PF00017	0.518
LIG_SH2_STAT5	380	383	PF00017	0.614
LIG_SH2_STAT5	412	415	PF00017	0.581
LIG_SH3_3	258	264	PF00018	0.634
LIG_SH3_3	384	390	PF00018	0.770
LIG_SH3_3	391	397	PF00018	0.702
LIG_SH3_3	477	483	PF00018	0.660
LIG_SUMO_SIM_anti_2	185	191	PF11976	0.518
LIG_SUMO_SIM_anti_2	271	278	PF11976	0.256
LIG_SUMO_SIM_anti_2	450	459	PF11976	0.650
LIG_SUMO_SIM_par_1	127	134	PF11976	0.444
LIG_WW_3	262	266	PF00397	0.518
MOD_CDC14_SPxK_1	262	265	PF00782	0.602
MOD_CDK_SPK_2	388	393	PF00069	0.735
MOD_CDK_SPxK_1	259	265	PF00069	0.616
MOD_CDK_SPxK_1	46	52	PF00069	0.365
MOD_CDK_SPxxK_3	482	489	PF00069	0.725
MOD_CK1_1	102	108	PF00069	0.471
MOD_CK1_1	12	18	PF00069	0.589
MOD_CK1_1	125	131	PF00069	0.547
MOD_CK1_1	169	175	PF00069	0.443
MOD_CK1_1	229	235	PF00069	0.735
MOD_CK1_1	239	245	PF00069	0.716
MOD_CK1_1	295	301	PF00069	0.505
MOD_CK1_1	372	378	PF00069	0.643
MOD_CK1_1	388	394	PF00069	0.619
MOD_CK1_1	396	402	PF00069	0.602
MOD_CK2_1	160	166	PF00069	0.496
MOD_CK2_1	185	191	PF00069	0.482
MOD_CK2_1	24	30	PF00069	0.567
MOD_CK2_1	419	425	PF00069	0.675
MOD_CK2_1	428	434	PF00069	0.610
MOD_CK2_1	444	450	PF00069	0.647
MOD_CK2_1	481	487	PF00069	0.702
MOD_Cter_Amidation	79	82	PF01082	0.472
MOD_DYRK1A_RPxSP_1	393	397	PF00069	0.515
MOD_GlcNHglycan	124	127	PF01048	0.634
MOD_GlcNHglycan	221	224	PF01048	0.748
MOD_GlcNHglycan	371	374	PF01048	0.616
MOD_GlcNHglycan	401	404	PF01048	0.619
MOD_GlcNHglycan	421	424	PF01048	0.507
MOD_GlcNHglycan	436	439	PF01048	0.751
MOD_GSK3_1	102	109	PF00069	0.595
MOD_GSK3_1	169	176	PF00069	0.424
MOD_GSK3_1	20	27	PF00069	0.522
MOD_GSK3_1	207	214	PF00069	0.470
MOD_GSK3_1	236	243	PF00069	0.734
MOD_GSK3_1	441	448	PF00069	0.752
MOD_GSK3_1	450	457	PF00069	0.727
MOD_GSK3_1	46	53	PF00069	0.330
MOD_N-GLC_1	354	359	PF02516	0.612
MOD_NEK2_1	106	111	PF00069	0.604
MOD_NEK2_1	174	179	PF00069	0.445
MOD_NEK2_1	228	233	PF00069	0.683
MOD_NEK2_1	408	413	PF00069	0.624
MOD_NEK2_1	488	493	PF00069	0.674
MOD_NEK2_1	99	104	PF00069	0.425
MOD_PIKK_1	12	18	PF00454	0.494
MOD_PK_1	292	298	PF00069	0.511
MOD_PK_1	52	58	PF00069	0.607
MOD_PKA_2	264	270	PF00069	0.550
MOD_PKA_2	349	355	PF00069	0.604
MOD_PKA_2	360	366	PF00069	0.689
MOD_PKA_2	99	105	PF00069	0.388
MOD_Plk_1	185	191	PF00069	0.482
MOD_Plk_1	474	480	PF00069	0.463
MOD_Plk_2-3	185	191	PF00069	0.482
MOD_Plk_2-3	221	227	PF00069	0.665
MOD_Plk_4	102	108	PF00069	0.297
MOD_Plk_4	166	172	PF00069	0.388
MOD_Plk_4	185	191	PF00069	0.335
MOD_Plk_4	272	278	PF00069	0.295
MOD_Plk_4	332	338	PF00069	0.527
MOD_Plk_4	408	414	PF00069	0.581
MOD_Plk_4	52	58	PF00069	0.607
MOD_ProDKin_1	107	113	PF00069	0.647
MOD_ProDKin_1	20	26	PF00069	0.538
MOD_ProDKin_1	242	248	PF00069	0.798
MOD_ProDKin_1	252	258	PF00069	0.540
MOD_ProDKin_1	259	265	PF00069	0.663
MOD_ProDKin_1	388	394	PF00069	0.691
MOD_ProDKin_1	445	451	PF00069	0.622
MOD_ProDKin_1	46	52	PF00069	0.365
MOD_ProDKin_1	482	488	PF00069	0.724
MOD_SUMO_rev_2	267	275	PF00179	0.516
MOD_SUMO_rev_2	484	491	PF00179	0.729
MOD_SUMO_rev_2	61	71	PF00179	0.552
MOD_SUMO_rev_2	72	79	PF00179	0.522
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.491
TRG_ENDOCYTIC_2	412	415	PF00928	0.660
TRG_ER_diArg_1	147	149	PF00400	0.511
TRG_ER_diArg_1	347	350	PF00400	0.585
TRG_ER_diArg_1	469	472	PF00400	0.652
TRG_ER_diArg_1	81	83	PF00400	0.408
TRG_NLS_MonoExtC_3	345	350	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7J1	Leptomonas seymouri	42%	79%
A0A3S7X6X4	Leishmania donovani	90%	100%
A4HLQ9	Leishmania braziliensis	72%	98%
A4I959	Leishmania infantum	90%	100%
D0A6B3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q3Z0	Leishmania major	89%	100%
V5BYM8	Trypanosoma cruzi	37%	100%