Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B434_LEIMU

TriTrypDb:

LmxM.32.1960

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B434

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B434

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	383	387	PF00656	0.502
CLV_C14_Caspase3-7	433	437	PF00656	0.615
CLV_NRD_NRD_1	357	359	PF00675	0.608
CLV_NRD_NRD_1	392	394	PF00675	0.548
CLV_PCSK_KEX2_1	228	230	PF00082	0.652
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.652
CLV_PCSK_SKI1_1	130	134	PF00082	0.723
CLV_PCSK_SKI1_1	459	463	PF00082	0.632
DEG_Nend_Nbox_1	1	3	PF02207	0.702
DEG_SCF_FBW7_1	363	369	PF00400	0.705
DEG_SCF_SKP2-CKS1_1	221	228	PF00560	0.592
DEG_SPOP_SBC_1	366	370	PF00917	0.736
DEG_SPOP_SBC_1	431	435	PF00917	0.651
DOC_CKS1_1	349	354	PF01111	0.772
DOC_CKS1_1	363	368	PF01111	0.612
DOC_MAPK_DCC_7	130	138	PF00069	0.691
DOC_MAPK_DCC_7	323	331	PF00069	0.640
DOC_MAPK_FxFP_2	138	141	PF00069	0.735
DOC_MAPK_MEF2A_6	130	138	PF00069	0.691
DOC_MAPK_MEF2A_6	323	331	PF00069	0.640
DOC_PP1_RVXF_1	71	77	PF00149	0.674
DOC_PP4_FxxP_1	138	141	PF00568	0.811
DOC_PP4_FxxP_1	154	157	PF00568	0.602
DOC_USP7_MATH_1	124	128	PF00917	0.543
DOC_USP7_MATH_1	150	154	PF00917	0.660
DOC_USP7_MATH_1	203	207	PF00917	0.548
DOC_USP7_MATH_1	21	25	PF00917	0.671
DOC_USP7_MATH_1	235	239	PF00917	0.720
DOC_USP7_MATH_1	252	256	PF00917	0.514
DOC_USP7_MATH_1	27	31	PF00917	0.638
DOC_USP7_MATH_1	292	296	PF00917	0.734
DOC_USP7_MATH_1	301	305	PF00917	0.710
DOC_USP7_MATH_1	335	339	PF00917	0.638
DOC_USP7_MATH_1	366	370	PF00917	0.671
DOC_USP7_MATH_1	382	386	PF00917	0.502
DOC_USP7_MATH_1	431	435	PF00917	0.651
DOC_USP7_MATH_1	466	470	PF00917	0.596
DOC_USP7_MATH_1	480	484	PF00917	0.535
DOC_USP7_MATH_1	526	530	PF00917	0.728
DOC_USP7_MATH_2	231	237	PF00917	0.757
DOC_WW_Pin1_4	222	227	PF00397	0.591
DOC_WW_Pin1_4	23	28	PF00397	0.599
DOC_WW_Pin1_4	330	335	PF00397	0.580
DOC_WW_Pin1_4	348	353	PF00397	0.743
DOC_WW_Pin1_4	362	367	PF00397	0.611
DOC_WW_Pin1_4	427	432	PF00397	0.691
DOC_WW_Pin1_4	489	494	PF00397	0.668
LIG_14-3-3_CanoR_1	336	345	PF00244	0.758
LIG_14-3-3_CanoR_1	459	465	PF00244	0.676
LIG_14-3-3_CanoR_1	527	535	PF00244	0.693
LIG_BIR_III_2	314	318	PF00653	0.732
LIG_BIR_III_4	97	101	PF00653	0.715
LIG_BRCT_BRCA1_1	79	83	PF00533	0.651
LIG_eIF4E_1	489	495	PF01652	0.669
LIG_FHA_1	286	292	PF00498	0.567
LIG_FHA_1	411	417	PF00498	0.541
LIG_FHA_1	448	454	PF00498	0.643
LIG_FHA_1	466	472	PF00498	0.461
LIG_FHA_1	490	496	PF00498	0.667
LIG_FHA_2	381	387	PF00498	0.508
LIG_LIR_Apic_2	153	157	PF02991	0.621
LIG_LIR_Gen_1	77	83	PF02991	0.653
LIG_LIR_Gen_1	88	99	PF02991	0.582
LIG_LIR_Nem_3	77	81	PF02991	0.653
LIG_LIR_Nem_3	88	94	PF02991	0.572
LIG_MLH1_MIPbox_1	79	83	PF16413	0.651
LIG_NRBOX	504	510	PF00104	0.632
LIG_Pex14_2	15	19	PF04695	0.578
LIG_Pex14_2	78	82	PF04695	0.650
LIG_SH2_CRK	173	177	PF00017	0.772
LIG_SH2_NCK_1	173	177	PF00017	0.772
LIG_SH2_NCK_1	91	95	PF00017	0.524
LIG_SH2_SRC	162	165	PF00017	0.520
LIG_SH2_SRC	173	176	PF00017	0.529
LIG_SH2_SRC	91	94	PF00017	0.681
LIG_SH2_STAT5	116	119	PF00017	0.732
LIG_SH2_STAT5	162	165	PF00017	0.520
LIG_SH3_2	354	359	PF14604	0.607
LIG_SH3_3	199	205	PF00018	0.717
LIG_SH3_3	324	330	PF00018	0.731
LIG_SH3_3	346	352	PF00018	0.772
LIG_SH3_3	354	360	PF00018	0.683
LIG_SH3_3	368	374	PF00018	0.588
LIG_SH3_3	492	498	PF00018	0.644
LIG_SH3_3	520	526	PF00018	0.630
LIG_SUMO_SIM_par_1	500	506	PF11976	0.610
LIG_TRAF2_1	261	264	PF00917	0.668
LIG_TRAF2_1	6	9	PF00917	0.672
LIG_WRC_WIRS_1	78	83	PF05994	0.652
LIG_WW_3	325	329	PF00397	0.728
LIG_WW_3	333	337	PF00397	0.654
MOD_CDC14_SPxK_1	333	336	PF00782	0.562
MOD_CDC14_SPxK_1	356	359	PF00782	0.560
MOD_CDK_SPK_2	353	358	PF00069	0.734
MOD_CDK_SPxK_1	222	228	PF00069	0.594
MOD_CDK_SPxK_1	330	336	PF00069	0.565
MOD_CDK_SPxK_1	353	359	PF00069	0.613
MOD_CDK_SPxK_1	367	373	PF00069	0.714
MOD_CDK_SPxxK_3	222	229	PF00069	0.547
MOD_CK1_1	214	220	PF00069	0.644
MOD_CK1_1	265	271	PF00069	0.774
MOD_CK1_1	273	279	PF00069	0.681
MOD_CK1_1	283	289	PF00069	0.549
MOD_CK1_1	31	37	PF00069	0.715
MOD_CK1_1	319	325	PF00069	0.632
MOD_CK1_1	337	343	PF00069	0.536
MOD_CK1_1	367	373	PF00069	0.741
MOD_CK1_1	385	391	PF00069	0.526
MOD_CK1_1	426	432	PF00069	0.720
MOD_CK1_1	457	463	PF00069	0.685
MOD_CK2_1	233	239	PF00069	0.568
MOD_CK2_1	258	264	PF00069	0.655
MOD_CK2_1	273	279	PF00069	0.664
MOD_CK2_1	292	298	PF00069	0.530
MOD_CK2_1	41	47	PF00069	0.535
MOD_GlcNHglycan	120	123	PF01048	0.734
MOD_GlcNHglycan	164	167	PF01048	0.786
MOD_GlcNHglycan	181	184	PF01048	0.605
MOD_GlcNHglycan	19	22	PF01048	0.670
MOD_GlcNHglycan	205	208	PF01048	0.589
MOD_GlcNHglycan	305	308	PF01048	0.637
MOD_GlcNHglycan	426	429	PF01048	0.640
MOD_GlcNHglycan	43	46	PF01048	0.595
MOD_GlcNHglycan	455	459	PF01048	0.687
MOD_GlcNHglycan	49	52	PF01048	0.528
MOD_GlcNHglycan	536	540	PF01048	0.687
MOD_GlcNHglycan	55	58	PF01048	0.593
MOD_GlcNHglycan	87	90	PF01048	0.684
MOD_GSK3_1	17	24	PF00069	0.670
MOD_GSK3_1	203	210	PF00069	0.639
MOD_GSK3_1	258	265	PF00069	0.750
MOD_GSK3_1	27	34	PF00069	0.602
MOD_GSK3_1	280	287	PF00069	0.611
MOD_GSK3_1	330	337	PF00069	0.771
MOD_GSK3_1	362	369	PF00069	0.784
MOD_GSK3_1	382	389	PF00069	0.470
MOD_GSK3_1	422	429	PF00069	0.758
MOD_GSK3_1	447	454	PF00069	0.620
MOD_N-GLC_1	36	41	PF02516	0.715
MOD_N-GLC_2	294	296	PF02516	0.725
MOD_NEK2_1	17	22	PF00069	0.672
MOD_NEK2_1	422	427	PF00069	0.749
MOD_PIKK_1	262	268	PF00454	0.768
MOD_PKA_2	118	124	PF00069	0.607
MOD_PKA_2	273	279	PF00069	0.722
MOD_PKA_2	335	341	PF00069	0.751
MOD_PKA_2	451	457	PF00069	0.684
MOD_PKA_2	526	532	PF00069	0.726
MOD_Plk_1	242	248	PF00069	0.646
MOD_Plk_1	385	391	PF00069	0.712
MOD_Plk_2-3	280	286	PF00069	0.556
MOD_Plk_4	150	156	PF00069	0.738
MOD_Plk_4	157	163	PF00069	0.513
MOD_Plk_4	207	213	PF00069	0.837
MOD_Plk_4	286	292	PF00069	0.590
MOD_Plk_4	77	83	PF00069	0.653
MOD_ProDKin_1	222	228	PF00069	0.594
MOD_ProDKin_1	23	29	PF00069	0.602
MOD_ProDKin_1	330	336	PF00069	0.582
MOD_ProDKin_1	348	354	PF00069	0.743
MOD_ProDKin_1	362	368	PF00069	0.612
MOD_ProDKin_1	427	433	PF00069	0.686
MOD_ProDKin_1	489	495	PF00069	0.669
MOD_SUMO_rev_2	276	283	PF00179	0.606
MOD_SUMO_rev_2	62	71	PF00179	0.617
TRG_DiLeu_BaEn_1	375	380	PF01217	0.728
TRG_ENDOCYTIC_2	2	5	PF00928	0.692
TRG_ENDOCYTIC_2	91	94	PF00928	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6Z0	Leishmania donovani	84%	100%
A4HLQ8	Leishmania braziliensis	67%	100%
A4I958	Leishmania infantum	84%	100%
Q4Q3Z1	Leishmania major	84%	100%