Ribonuclease P

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ribonuclease P

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B432_LEIMU

TriTrypDb:

LmxM.32.1950

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9B432

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B432

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006396	RNA processing	6	9
GO:0006399	tRNA metabolic process	7	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008033	tRNA processing	8	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0034470	ncRNA processing	7	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0034660	ncRNA metabolic process	6	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:0000966	RNA 5'-end processing	7	1
GO:0001682	tRNA 5'-leader removal	9	1
GO:0099116	tRNA 5'-end processing	8	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004518	nuclease activity	4	9
GO:0004519	endonuclease activity	5	8
GO:0004521	RNA endonuclease activity	5	8
GO:0004526	ribonuclease P activity	6	8
GO:0004540	RNA nuclease activity	4	8
GO:0004549	tRNA-specific ribonuclease activity	5	8
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	8
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	8
GO:0140098	catalytic activity, acting on RNA	3	8
GO:0140101	catalytic activity, acting on a tRNA	4	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.425
CLV_NRD_NRD_1	154	156	PF00675	0.273
CLV_NRD_NRD_1	2	4	PF00675	0.374
CLV_NRD_NRD_1	326	328	PF00675	0.386
CLV_NRD_NRD_1	87	89	PF00675	0.322
CLV_PCSK_FUR_1	324	328	PF00082	0.476
CLV_PCSK_KEX2_1	153	155	PF00082	0.258
CLV_PCSK_KEX2_1	2	4	PF00082	0.383
CLV_PCSK_KEX2_1	326	328	PF00082	0.394
CLV_PCSK_KEX2_1	336	338	PF00082	0.275
CLV_PCSK_KEX2_1	571	573	PF00082	0.516
CLV_PCSK_KEX2_1	87	89	PF00082	0.346
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.450
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.516
CLV_PCSK_PC7_1	149	155	PF00082	0.205
CLV_PCSK_PC7_1	567	573	PF00082	0.467
CLV_PCSK_SKI1_1	154	158	PF00082	0.281
CLV_PCSK_SKI1_1	21	25	PF00082	0.466
CLV_PCSK_SKI1_1	212	216	PF00082	0.383
CLV_PCSK_SKI1_1	312	316	PF00082	0.346
CLV_PCSK_SKI1_1	326	330	PF00082	0.314
CLV_PCSK_SKI1_1	440	444	PF00082	0.268
CLV_PCSK_SKI1_1	519	523	PF00082	0.352
CLV_PCSK_SKI1_1	529	533	PF00082	0.229
CLV_PCSK_SKI1_1	55	59	PF00082	0.468
DEG_APCC_DBOX_1	425	433	PF00400	0.271
DEG_Nend_UBRbox_1	1	4	PF02207	0.410
DEG_SPOP_SBC_1	280	284	PF00917	0.391
DOC_CDC14_PxL_1	247	255	PF14671	0.469
DOC_MAPK_gen_1	231	239	PF00069	0.454
DOC_MAPK_gen_1	324	332	PF00069	0.447
DOC_MAPK_gen_1	523	532	PF00069	0.253
DOC_MAPK_MEF2A_6	212	221	PF00069	0.460
DOC_MAPK_MEF2A_6	233	241	PF00069	0.428
DOC_MAPK_MEF2A_6	401	409	PF00069	0.361
DOC_PP1_RVXF_1	527	533	PF00149	0.268
DOC_PP2B_LxvP_1	317	320	PF13499	0.383
DOC_PP2B_LxvP_1	547	550	PF13499	0.328
DOC_USP7_MATH_1	204	208	PF00917	0.402
DOC_USP7_MATH_1	272	276	PF00917	0.571
DOC_USP7_MATH_1	305	309	PF00917	0.543
DOC_USP7_MATH_1	322	326	PF00917	0.292
DOC_USP7_MATH_1	37	41	PF00917	0.553
DOC_USP7_MATH_1	573	577	PF00917	0.572
DOC_USP7_MATH_1	590	594	PF00917	0.759
DOC_USP7_MATH_1	597	601	PF00917	0.508
DOC_USP7_MATH_1	604	608	PF00917	0.431
DOC_USP7_MATH_1	612	616	PF00917	0.510
DOC_USP7_MATH_1	628	632	PF00917	0.441
DOC_WW_Pin1_4	254	259	PF00397	0.664
DOC_WW_Pin1_4	268	273	PF00397	0.432
DOC_WW_Pin1_4	424	429	PF00397	0.447
DOC_WW_Pin1_4	459	464	PF00397	0.267
DOC_WW_Pin1_4	483	488	PF00397	0.293
DOC_WW_Pin1_4	493	498	PF00397	0.250
DOC_WW_Pin1_4	514	519	PF00397	0.250
DOC_WW_Pin1_4	571	576	PF00397	0.722
DOC_WW_Pin1_4	586	591	PF00397	0.600
DOC_WW_Pin1_4	618	623	PF00397	0.576
LIG_14-3-3_CanoR_1	135	140	PF00244	0.257
LIG_14-3-3_CanoR_1	2	8	PF00244	0.428
LIG_14-3-3_CanoR_1	384	392	PF00244	0.385
LIG_14-3-3_CanoR_1	55	63	PF00244	0.383
LIG_14-3-3_CanoR_1	87	94	PF00244	0.390
LIG_Actin_WH2_2	121	139	PF00022	0.250
LIG_APCC_ABBA_1	349	354	PF00400	0.399
LIG_APCC_ABBAyCdc20_2	348	354	PF00400	0.389
LIG_Clathr_ClatBox_1	329	333	PF01394	0.423
LIG_FHA_1	120	126	PF00498	0.412
LIG_FHA_1	30	36	PF00498	0.410
LIG_FHA_1	313	319	PF00498	0.302
LIG_FHA_1	445	451	PF00498	0.383
LIG_FHA_1	593	599	PF00498	0.559
LIG_FHA_1	94	100	PF00498	0.472
LIG_FHA_2	384	390	PF00498	0.496
LIG_FHA_2	685	691	PF00498	0.408
LIG_HP1_1	217	221	PF01393	0.271
LIG_HP1_1	428	432	PF01393	0.328
LIG_LIR_Apic_2	542	548	PF02991	0.383
LIG_LIR_Apic_2	559	564	PF02991	0.612
LIG_LIR_Apic_2	600	604	PF02991	0.354
LIG_LIR_Gen_1	172	183	PF02991	0.256
LIG_LIR_Gen_1	216	226	PF02991	0.466
LIG_LIR_Gen_1	438	449	PF02991	0.216
LIG_LIR_Nem_3	140	145	PF02991	0.266
LIG_LIR_Nem_3	172	178	PF02991	0.288
LIG_LIR_Nem_3	191	196	PF02991	0.192
LIG_LIR_Nem_3	27	31	PF02991	0.454
LIG_LIR_Nem_3	333	338	PF02991	0.312
LIG_LIR_Nem_3	364	369	PF02991	0.411
LIG_LIR_Nem_3	438	444	PF02991	0.216
LIG_LIR_Nem_3	510	516	PF02991	0.250
LIG_Pex14_1	601	605	PF04695	0.376
LIG_SH2_CRK	460	464	PF00017	0.250
LIG_SH2_CRK	474	478	PF00017	0.250
LIG_SH2_CRK	561	565	PF00017	0.454
LIG_SH2_NCK_1	561	565	PF00017	0.454
LIG_SH2_SRC	127	130	PF00017	0.150
LIG_SH2_SRC	338	341	PF00017	0.415
LIG_SH2_STAP1	160	164	PF00017	0.250
LIG_SH2_STAP1	551	555	PF00017	0.250
LIG_SH2_STAP1	623	627	PF00017	0.452
LIG_SH2_STAT5	127	130	PF00017	0.383
LIG_SH2_STAT5	145	148	PF00017	0.383
LIG_SH2_STAT5	175	178	PF00017	0.250
LIG_SH2_STAT5	338	341	PF00017	0.415
LIG_SH2_STAT5	460	463	PF00017	0.250
LIG_SH3_3	182	188	PF00018	0.328
LIG_SH3_3	211	217	PF00018	0.268
LIG_SH3_3	252	258	PF00018	0.575
LIG_SH3_3	567	573	PF00018	0.548
LIG_SH3_3	584	590	PF00018	0.533
LIG_SUMO_SIM_anti_2	78	85	PF11976	0.383
LIG_SUMO_SIM_par_1	427	434	PF11976	0.243
LIG_TYR_ITIM	358	363	PF00017	0.289
MOD_CDC14_SPxK_1	496	499	PF00782	0.440
MOD_CDK_SPK_2	514	519	PF00069	0.250
MOD_CDK_SPxK_1	493	499	PF00069	0.440
MOD_CDK_SPxxK_3	618	625	PF00069	0.445
MOD_CK1_1	254	260	PF00069	0.641
MOD_CK1_1	383	389	PF00069	0.436
MOD_CK1_1	40	46	PF00069	0.644
MOD_CK1_1	56	62	PF00069	0.165
MOD_CK1_1	562	568	PF00069	0.664
MOD_CK1_1	78	84	PF00069	0.438
MOD_CK1_1	92	98	PF00069	0.255
MOD_CK2_1	562	568	PF00069	0.537
MOD_CK2_1	628	634	PF00069	0.587
MOD_CK2_1	684	690	PF00069	0.394
MOD_GlcNHglycan	139	142	PF01048	0.362
MOD_GlcNHglycan	262	265	PF01048	0.696
MOD_GlcNHglycan	274	277	PF01048	0.637
MOD_GlcNHglycan	296	300	PF01048	0.446
MOD_GlcNHglycan	39	42	PF01048	0.747
MOD_GlcNHglycan	398	401	PF01048	0.539
MOD_GlcNHglycan	47	50	PF01048	0.689
MOD_GlcNHglycan	493	496	PF01048	0.271
MOD_GlcNHglycan	561	564	PF01048	0.523
MOD_GlcNHglycan	610	613	PF01048	0.512
MOD_GlcNHglycan	614	617	PF01048	0.623
MOD_GlcNHglycan	630	633	PF01048	0.448
MOD_GlcNHglycan	651	654	PF01048	0.596
MOD_GlcNHglycan	77	80	PF01048	0.314
MOD_GlcNHglycan	91	94	PF01048	0.284
MOD_GSK3_1	254	261	PF00069	0.671
MOD_GSK3_1	268	275	PF00069	0.533
MOD_GSK3_1	40	47	PF00069	0.677
MOD_GSK3_1	440	447	PF00069	0.305
MOD_GSK3_1	482	489	PF00069	0.272
MOD_GSK3_1	493	500	PF00069	0.269
MOD_GSK3_1	53	60	PF00069	0.544
MOD_GSK3_1	562	569	PF00069	0.637
MOD_GSK3_1	578	585	PF00069	0.726
MOD_GSK3_1	586	593	PF00069	0.559
MOD_GSK3_1	604	611	PF00069	0.437
MOD_GSK3_1	623	630	PF00069	0.476
MOD_GSK3_1	88	95	PF00069	0.314
MOD_N-GLC_1	618	623	PF02516	0.499
MOD_NEK2_1	31	36	PF00069	0.469
MOD_NEK2_1	444	449	PF00069	0.300
MOD_NEK2_1	532	537	PF00069	0.270
MOD_NEK2_1	566	571	PF00069	0.459
MOD_NEK2_2	188	193	PF00069	0.250
MOD_PIKK_1	281	287	PF00454	0.458
MOD_PK_1	135	141	PF00069	0.248
MOD_PKA_1	87	93	PF00069	0.314
MOD_PKA_2	383	389	PF00069	0.436
MOD_PKA_2	532	538	PF00069	0.271
MOD_PKA_2	566	572	PF00069	0.528
MOD_PKA_2	87	93	PF00069	0.314
MOD_PKB_1	135	143	PF00069	0.268
MOD_Plk_1	623	629	PF00069	0.740
MOD_Plk_4	103	109	PF00069	0.282
MOD_Plk_4	188	194	PF00069	0.373
MOD_Plk_4	3	9	PF00069	0.380
MOD_Plk_4	362	368	PF00069	0.303
MOD_Plk_4	78	84	PF00069	0.383
MOD_ProDKin_1	254	260	PF00069	0.666
MOD_ProDKin_1	268	274	PF00069	0.434
MOD_ProDKin_1	424	430	PF00069	0.447
MOD_ProDKin_1	459	465	PF00069	0.267
MOD_ProDKin_1	483	489	PF00069	0.293
MOD_ProDKin_1	493	499	PF00069	0.250
MOD_ProDKin_1	514	520	PF00069	0.250
MOD_ProDKin_1	571	577	PF00069	0.722
MOD_ProDKin_1	586	592	PF00069	0.596
MOD_ProDKin_1	618	624	PF00069	0.575
MOD_SUMO_rev_2	434	442	PF00179	0.293
TRG_DiLeu_BaEn_1	129	134	PF01217	0.383
TRG_DiLeu_BaEn_1	313	318	PF01217	0.378
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.328
TRG_ENDOCYTIC_2	175	178	PF00928	0.250
TRG_ENDOCYTIC_2	360	363	PF00928	0.304
TRG_ENDOCYTIC_2	474	477	PF00928	0.250
TRG_ER_diArg_1	1	3	PF00400	0.420
TRG_ER_diArg_1	134	137	PF00400	0.267
TRG_ER_diArg_1	153	155	PF00400	0.163
TRG_ER_diArg_1	324	327	PF00400	0.378
TRG_ER_diArg_1	527	530	PF00400	0.263
TRG_ER_diArg_1	86	88	PF00400	0.388
TRG_NES_CRM1_1	468	481	PF08389	0.383
TRG_Pf-PMV_PEXEL_1	312	316	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	553	557	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM55	Leptomonas seymouri	54%	92%
A0A1X0P3X4	Trypanosomatidae	46%	100%
A0A3Q8IHV9	Leishmania donovani	91%	100%
A0A422MWI6	Trypanosoma rangeli	47%	100%
A4HLQ7	Leishmania braziliensis	80%	100%
A4I957	Leishmania infantum	91%	100%
D0A6B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
F4JKB6	Arabidopsis thaliana	22%	100%
Q4Q3Z2	Leishmania major	90%	100%
Q680B9	Arabidopsis thaliana	21%	100%
V5BPA7	Trypanosoma cruzi	46%	100%