Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphate transport (Pho88), putative

Species:

Leishmania mexicana

UniProt:

E9B429_LEIMU

TriTrypDb:

LmxM.32.1920

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	11
GO:0016020	membrane	2	10
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9B429

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B429

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	11
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0033365	protein localization to organelle	5	11
GO:0045047	protein targeting to ER	6	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0070972	protein localization to endoplasmic reticulum	6	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0072594	establishment of protein localization to organelle	4	11
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.281
CLV_C14_Caspase3-7	19	23	PF00656	0.174
CLV_NRD_NRD_1	185	187	PF00675	0.708
CLV_PCSK_KEX2_1	187	189	PF00082	0.747
CLV_PCSK_KEX2_1	25	27	PF00082	0.511
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.723
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.481
CLV_PCSK_SKI1_1	25	29	PF00082	0.511
DEG_Nend_UBRbox_3	1	3	PF02207	0.260
DOC_MAPK_gen_1	80	89	PF00069	0.481
DOC_MAPK_MEF2A_6	80	89	PF00069	0.388
DOC_PP1_RVXF_1	23	30	PF00149	0.297
DOC_USP7_UBL2_3	162	166	PF12436	0.344
DOC_USP7_UBL2_3	183	187	PF12436	0.607
DOC_WW_Pin1_4	174	179	PF00397	0.537
LIG_Actin_WH2_2	88	104	PF00022	0.293
LIG_APCC_ABBA_1	43	48	PF00400	0.242
LIG_BRCT_BRCA1_1	122	126	PF00533	0.332
LIG_deltaCOP1_diTrp_1	151	157	PF00928	0.249
LIG_FHA_1	34	40	PF00498	0.359
LIG_FHA_1	6	12	PF00498	0.355
LIG_FHA_2	146	152	PF00498	0.402
LIG_FHA_2	17	23	PF00498	0.289
LIG_FHA_2	63	69	PF00498	0.432
LIG_LIR_Gen_1	96	106	PF02991	0.211
LIG_LIR_LC3C_4	83	86	PF02991	0.374
LIG_LIR_Nem_3	123	129	PF02991	0.284
LIG_LIR_Nem_3	96	101	PF02991	0.341
LIG_PCNA_PIPBox_1	67	76	PF02747	0.374
LIG_Pex14_2	46	50	PF04695	0.283
LIG_PTB_Apo_2	85	92	PF02174	0.293
LIG_SH2_SRC	76	79	PF00017	0.455
LIG_SH2_STAP1	122	126	PF00017	0.211
LIG_SH2_STAT3	64	67	PF00017	0.374
LIG_SH2_STAT5	106	109	PF00017	0.343
LIG_SH2_STAT5	44	47	PF00017	0.373
LIG_SH2_STAT5	64	67	PF00017	0.498
LIG_SH3_3	57	63	PF00018	0.541
LIG_SUMO_SIM_anti_2	83	88	PF11976	0.374
LIG_SUMO_SIM_par_1	107	113	PF11976	0.342
LIG_SUMO_SIM_par_1	8	13	PF11976	0.290
LIG_TRAF2_1	65	68	PF00917	0.404
LIG_TYR_ITIM	120	125	PF00017	0.211
LIG_UBA3_1	110	118	PF00899	0.332
LIG_UBA3_1	125	132	PF00899	0.332
LIG_WRC_WIRS_1	95	100	PF05994	0.293
MOD_CK1_1	15	21	PF00069	0.273
MOD_CK1_1	182	188	PF00069	0.523
MOD_CK2_1	145	151	PF00069	0.402
MOD_CK2_1	62	68	PF00069	0.532
MOD_GlcNHglycan	159	162	PF01048	0.500
MOD_GlcNHglycan	170	173	PF01048	0.648
MOD_GlcNHglycan	91	94	PF01048	0.396
MOD_GSK3_1	157	164	PF00069	0.322
MOD_GSK3_1	168	175	PF00069	0.478
MOD_GSK3_1	6	13	PF00069	0.262
MOD_GSK3_1	62	69	PF00069	0.538
MOD_GSK3_1	89	96	PF00069	0.307
MOD_NEK2_1	10	15	PF00069	0.326
MOD_NEK2_1	110	115	PF00069	0.294
MOD_NEK2_1	168	173	PF00069	0.488
MOD_PIKK_1	155	161	PF00454	0.182
MOD_PIKK_1	172	178	PF00454	0.396
MOD_Plk_1	53	59	PF00069	0.493
MOD_Plk_2-3	145	151	PF00069	0.314
MOD_Plk_2-3	62	68	PF00069	0.542
MOD_Plk_4	53	59	PF00069	0.538
MOD_Plk_4	6	12	PF00069	0.315
MOD_Plk_4	94	100	PF00069	0.411
MOD_ProDKin_1	174	180	PF00069	0.540
MOD_SUMO_for_1	130	133	PF00179	0.305
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.266
TRG_ENDOCYTIC_2	106	109	PF00928	0.293
TRG_ENDOCYTIC_2	122	125	PF00928	0.181
TRG_ENDOCYTIC_2	44	47	PF00928	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP6	Leptomonas seymouri	63%	100%
A0A0S4IMC9	Bodo saltans	34%	94%
A0A3S7X6X6	Leishmania donovani	85%	100%
A0A422N623	Trypanosoma rangeli	36%	100%
A4HJX0	Leishmania braziliensis	70%	100%
A4HLQ4	Leishmania braziliensis	70%	100%
A4I954	Leishmania infantum	84%	100%
D0A6C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q3Z5	Leishmania major	86%	100%