Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B425_LEIMU

TriTrypDb:

LmxM.32.1890

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9B425

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B425

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.733
CLV_NRD_NRD_1	189	191	PF00675	0.627
CLV_NRD_NRD_1	426	428	PF00675	0.782
CLV_NRD_NRD_1	483	485	PF00675	0.660
CLV_NRD_NRD_1	551	553	PF00675	0.443
CLV_NRD_NRD_1	65	67	PF00675	0.681
CLV_PCSK_KEX2_1	153	155	PF00082	0.733
CLV_PCSK_KEX2_1	189	191	PF00082	0.663
CLV_PCSK_KEX2_1	426	428	PF00082	0.782
CLV_PCSK_KEX2_1	483	485	PF00082	0.660
CLV_PCSK_KEX2_1	522	524	PF00082	0.630
CLV_PCSK_KEX2_1	551	553	PF00082	0.443
CLV_PCSK_KEX2_1	65	67	PF00082	0.681
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.782
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.630
CLV_PCSK_PC7_1	422	428	PF00082	0.776
CLV_PCSK_SKI1_1	128	132	PF00082	0.593
CLV_PCSK_SKI1_1	193	197	PF00082	0.636
CLV_PCSK_SKI1_1	267	271	PF00082	0.464
CLV_PCSK_SKI1_1	483	487	PF00082	0.685
DEG_SPOP_SBC_1	332	336	PF00917	0.554
DEG_SPOP_SBC_1	452	456	PF00917	0.547
DEG_SPOP_SBC_1	75	79	PF00917	0.508
DEG_SPOP_SBC_1	88	92	PF00917	0.328
DOC_CKS1_1	44	49	PF01111	0.284
DOC_MAPK_gen_1	128	136	PF00069	0.375
DOC_MAPK_RevD_3	539	552	PF00069	0.362
DOC_PP2B_LxvP_1	85	88	PF13499	0.458
DOC_PP4_FxxP_1	358	361	PF00568	0.440
DOC_USP7_MATH_1	165	169	PF00917	0.375
DOC_USP7_MATH_1	217	221	PF00917	0.537
DOC_USP7_MATH_1	244	248	PF00917	0.568
DOC_USP7_MATH_1	286	290	PF00917	0.486
DOC_USP7_MATH_1	328	332	PF00917	0.530
DOC_USP7_MATH_1	338	342	PF00917	0.572
DOC_USP7_MATH_1	391	395	PF00917	0.557
DOC_USP7_MATH_1	4	8	PF00917	0.480
DOC_USP7_MATH_1	438	442	PF00917	0.542
DOC_USP7_MATH_1	444	448	PF00917	0.565
DOC_USP7_MATH_1	452	456	PF00917	0.518
DOC_USP7_MATH_1	502	506	PF00917	0.525
DOC_USP7_MATH_1	75	79	PF00917	0.539
DOC_USP7_MATH_1	88	92	PF00917	0.345
DOC_USP7_MATH_1	9	13	PF00917	0.435
DOC_USP7_UBL2_3	221	225	PF12436	0.442
DOC_USP7_UBL2_3	365	369	PF12436	0.488
DOC_USP7_UBL2_3	424	428	PF12436	0.564
DOC_USP7_UBL2_3	503	507	PF12436	0.472
DOC_USP7_UBL2_3	99	103	PF12436	0.467
DOC_WW_Pin1_4	112	117	PF00397	0.348
DOC_WW_Pin1_4	239	244	PF00397	0.563
DOC_WW_Pin1_4	313	318	PF00397	0.387
DOC_WW_Pin1_4	43	48	PF00397	0.286
DOC_WW_Pin1_4	447	452	PF00397	0.583
DOC_WW_Pin1_4	454	459	PF00397	0.540
DOC_WW_Pin1_4	473	478	PF00397	0.482
LIG_14-3-3_CanoR_1	189	193	PF00244	0.486
LIG_14-3-3_CanoR_1	28	33	PF00244	0.438
LIG_14-3-3_CanoR_1	551	556	PF00244	0.654
LIG_Actin_WH2_2	90	107	PF00022	0.434
LIG_BRCT_BRCA1_1	132	136	PF00533	0.394
LIG_deltaCOP1_diTrp_1	178	185	PF00928	0.407
LIG_eIF4E_1	528	534	PF01652	0.497
LIG_FHA_1	307	313	PF00498	0.403
LIG_FHA_1	408	414	PF00498	0.488
LIG_FHA_1	528	534	PF00498	0.398
LIG_FHA_1	88	94	PF00498	0.383
LIG_FHA_1	9	15	PF00498	0.380
LIG_FHA_2	31	37	PF00498	0.428
LIG_FHA_2	404	410	PF00498	0.467
LIG_FHA_2	459	465	PF00498	0.577
LIG_LIR_Gen_1	169	176	PF02991	0.393
LIG_LIR_Gen_1	291	302	PF02991	0.446
LIG_LIR_Nem_3	133	139	PF02991	0.392
LIG_LIR_Nem_3	169	175	PF02991	0.393
LIG_LIR_Nem_3	291	297	PF02991	0.453
LIG_LIR_Nem_3	354	360	PF02991	0.450
LIG_PDZ_Class_1	551	556	PF00595	0.654
LIG_Pex14_2	497	501	PF04695	0.493
LIG_SH2_NCK_1	325	329	PF00017	0.472
LIG_SH2_STAP1	528	532	PF00017	0.502
LIG_SH2_STAT3	106	109	PF00017	0.419
LIG_SH2_STAT5	106	109	PF00017	0.419
LIG_SH2_STAT5	357	360	PF00017	0.441
LIG_SH3_3	373	379	PF00018	0.494
LIG_SH3_3	41	47	PF00018	0.288
LIG_SUMO_SIM_anti_2	115	122	PF11976	0.382
LIG_SUMO_SIM_par_1	409	415	PF11976	0.445
LIG_SUMO_SIM_par_1	90	98	PF11976	0.408
LIG_TYR_ITIM	355	360	PF00017	0.443
LIG_WRC_WIRS_1	29	34	PF05994	0.446
MOD_CDK_SPK_2	313	318	PF00069	0.387
MOD_CDK_SPxxK_3	239	246	PF00069	0.471
MOD_CK1_1	115	121	PF00069	0.418
MOD_CK1_1	188	194	PF00069	0.405
MOD_CK1_1	331	337	PF00069	0.555
MOD_CK1_1	387	393	PF00069	0.584
MOD_CK1_1	418	424	PF00069	0.505
MOD_CK1_1	447	453	PF00069	0.584
MOD_CK1_1	78	84	PF00069	0.545
MOD_CK2_1	188	194	PF00069	0.440
MOD_CK2_1	197	203	PF00069	0.380
MOD_CK2_1	30	36	PF00069	0.454
MOD_CK2_1	403	409	PF00069	0.493
MOD_CK2_1	442	448	PF00069	0.495
MOD_CK2_1	458	464	PF00069	0.560
MOD_Cter_Amidation	424	427	PF01082	0.776
MOD_GlcNHglycan	11	14	PF01048	0.683
MOD_GlcNHglycan	247	250	PF01048	0.736
MOD_GlcNHglycan	329	333	PF01048	0.716
MOD_GlcNHglycan	347	350	PF01048	0.796
MOD_GlcNHglycan	387	390	PF01048	0.808
MOD_GlcNHglycan	393	396	PF01048	0.786
MOD_GlcNHglycan	431	434	PF01048	0.748
MOD_GlcNHglycan	440	443	PF01048	0.719
MOD_GlcNHglycan	444	447	PF01048	0.703
MOD_GlcNHglycan	504	507	PF01048	0.736
MOD_GlcNHglycan	534	537	PF01048	0.321
MOD_GlcNHglycan	6	9	PF01048	0.710
MOD_GlcNHglycan	85	88	PF01048	0.712
MOD_GSK3_1	115	122	PF00069	0.417
MOD_GSK3_1	197	204	PF00069	0.452
MOD_GSK3_1	217	224	PF00069	0.421
MOD_GSK3_1	327	334	PF00069	0.568
MOD_GSK3_1	338	345	PF00069	0.577
MOD_GSK3_1	364	371	PF00069	0.488
MOD_GSK3_1	387	394	PF00069	0.542
MOD_GSK3_1	399	406	PF00069	0.542
MOD_GSK3_1	4	11	PF00069	0.409
MOD_GSK3_1	407	414	PF00069	0.573
MOD_GSK3_1	438	445	PF00069	0.532
MOD_GSK3_1	447	454	PF00069	0.544
MOD_GSK3_1	70	77	PF00069	0.520
MOD_GSK3_1	79	86	PF00069	0.499
MOD_N-GLC_1	458	463	PF02516	0.661
MOD_NEK2_1	185	190	PF00069	0.395
MOD_NEK2_1	273	278	PF00069	0.405
MOD_NEK2_1	30	35	PF00069	0.532
MOD_NEK2_1	327	332	PF00069	0.459
MOD_NEK2_1	364	369	PF00069	0.476
MOD_NEK2_1	497	502	PF00069	0.484
MOD_PIKK_1	197	203	PF00454	0.449
MOD_PKA_1	65	71	PF00069	0.511
MOD_PKA_2	188	194	PF00069	0.481
MOD_PKA_2	384	390	PF00069	0.475
MOD_PKA_2	64	70	PF00069	0.491
MOD_Plk_1	178	184	PF00069	0.412
MOD_Plk_1	292	298	PF00069	0.432
MOD_Plk_4	115	121	PF00069	0.411
MOD_Plk_4	22	28	PF00069	0.430
MOD_Plk_4	275	281	PF00069	0.402
MOD_Plk_4	407	413	PF00069	0.443
MOD_Plk_4	48	54	PF00069	0.295
MOD_Plk_4	80	86	PF00069	0.503
MOD_Plk_4	89	95	PF00069	0.387
MOD_ProDKin_1	112	118	PF00069	0.347
MOD_ProDKin_1	239	245	PF00069	0.563
MOD_ProDKin_1	313	319	PF00069	0.384
MOD_ProDKin_1	43	49	PF00069	0.285
MOD_ProDKin_1	447	453	PF00069	0.584
MOD_ProDKin_1	454	460	PF00069	0.540
MOD_ProDKin_1	473	479	PF00069	0.475
MOD_SUMO_rev_2	188	198	PF00179	0.404
TRG_DiLeu_BaEn_1	36	41	PF01217	0.448
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.492
TRG_ENDOCYTIC_2	357	360	PF00928	0.441
TRG_ER_diArg_1	153	156	PF00400	0.534
TRG_ER_diArg_1	256	259	PF00400	0.470
TRG_ER_diArg_1	482	484	PF00400	0.463
TRG_ER_diArg_1	550	552	PF00400	0.639
TRG_ER_diArg_1	64	66	PF00400	0.450
TRG_NLS_MonoExtC_3	425	430	PF00514	0.579
TRG_NLS_MonoExtN_4	424	431	PF00514	0.564
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6X8	Leishmania donovani	85%	100%
A4HLQ0	Leishmania braziliensis	67%	100%
A4I950	Leishmania infantum	84%	100%
Q4Q3Z9	Leishmania major	85%	100%