Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B424_LEIMU

TriTrypDb:

LmxM.32.1880

Length:

272

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B424

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B424

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.556
CLV_C14_Caspase3-7	19	23	PF00656	0.376
CLV_C14_Caspase3-7	77	81	PF00656	0.460
CLV_NRD_NRD_1	203	205	PF00675	0.453
CLV_NRD_NRD_1	62	64	PF00675	0.576
CLV_NRD_NRD_1	72	74	PF00675	0.640
CLV_PCSK_KEX2_1	203	205	PF00082	0.516
CLV_PCSK_KEX2_1	62	64	PF00082	0.576
CLV_PCSK_KEX2_1	72	74	PF00082	0.640
CLV_PCSK_SKI1_1	246	250	PF00082	0.558
CLV_PCSK_SKI1_1	62	66	PF00082	0.516
CLV_PCSK_SKI1_1	72	76	PF00082	0.604
DOC_CDC14_PxL_1	231	239	PF14671	0.520
DOC_MAPK_gen_1	203	213	PF00069	0.503
DOC_MAPK_MEF2A_6	85	92	PF00069	0.317
DOC_PP1_RVXF_1	130	136	PF00149	0.487
DOC_USP7_MATH_1	137	141	PF00917	0.561
DOC_USP7_MATH_1	159	163	PF00917	0.633
DOC_USP7_MATH_1	184	188	PF00917	0.485
DOC_USP7_MATH_1	224	228	PF00917	0.591
LIG_14-3-3_CanoR_1	130	136	PF00244	0.558
LIG_14-3-3_CanoR_1	206	212	PF00244	0.422
LIG_14-3-3_CanoR_1	221	231	PF00244	0.615
LIG_14-3-3_CanoR_1	255	261	PF00244	0.494
LIG_14-3-3_CanoR_1	54	61	PF00244	0.584
LIG_14-3-3_CterR_2	269	272	PF00244	0.512
LIG_BIR_II_1	1	5	PF00653	0.557
LIG_CaM_IQ_9	253	268	PF13499	0.474
LIG_deltaCOP1_diTrp_1	6	14	PF00928	0.533
LIG_FHA_1	117	123	PF00498	0.547
LIG_FHA_1	53	59	PF00498	0.362
LIG_FHA_1	77	83	PF00498	0.372
LIG_FHA_2	17	23	PF00498	0.358
LIG_FHA_2	38	44	PF00498	0.461
LIG_LIR_Gen_1	115	125	PF02991	0.557
LIG_LIR_Gen_1	134	143	PF02991	0.461
LIG_LIR_Gen_1	216	224	PF02991	0.410
LIG_LIR_Gen_1	40	49	PF02991	0.456
LIG_LIR_Nem_3	115	121	PF02991	0.517
LIG_LIR_Nem_3	134	138	PF02991	0.321
LIG_LIR_Nem_3	216	220	PF02991	0.542
LIG_LIR_Nem_3	258	263	PF02991	0.535
LIG_LIR_Nem_3	40	45	PF02991	0.535
LIG_LIR_Nem_3	6	11	PF02991	0.546
LIG_LIR_Nem_3	81	87	PF02991	0.520
LIG_SH2_NCK_1	166	170	PF00017	0.421
LIG_SH2_STAP1	114	118	PF00017	0.588
LIG_SH2_STAP1	94	98	PF00017	0.308
LIG_SH2_STAT5	114	117	PF00017	0.515
LIG_SH2_STAT5	166	169	PF00017	0.681
LIG_SH2_STAT5	38	41	PF00017	0.449
LIG_SUMO_SIM_anti_2	210	216	PF11976	0.407
LIG_SUMO_SIM_par_1	210	216	PF11976	0.563
LIG_SxIP_EBH_1	160	169	PF03271	0.476
LIG_UBA3_1	211	219	PF00899	0.506
LIG_WRC_WIRS_1	220	225	PF05994	0.482
MOD_CK1_1	222	228	PF00069	0.682
MOD_CK2_1	114	120	PF00069	0.566
MOD_CK2_1	37	43	PF00069	0.464
MOD_GlcNHglycan	16	19	PF01048	0.581
MOD_GlcNHglycan	174	177	PF01048	0.666
MOD_GlcNHglycan	224	227	PF01048	0.586
MOD_GlcNHglycan	250	254	PF01048	0.635
MOD_GSK3_1	112	119	PF00069	0.519
MOD_GSK3_1	164	171	PF00069	0.601
MOD_GSK3_1	236	243	PF00069	0.504
MOD_GSK3_1	251	258	PF00069	0.570
MOD_NEK2_1	14	19	PF00069	0.554
MOD_NEK2_1	158	163	PF00069	0.632
MOD_NEK2_1	241	246	PF00069	0.564
MOD_NEK2_1	249	254	PF00069	0.545
MOD_NEK2_1	86	91	PF00069	0.556
MOD_PKA_2	131	137	PF00069	0.559
MOD_PKA_2	159	165	PF00069	0.641
MOD_PKA_2	53	59	PF00069	0.591
MOD_Plk_2-3	37	43	PF00069	0.464
MOD_Plk_4	184	190	PF00069	0.401
MOD_Plk_4	207	213	PF00069	0.406
TRG_DiLeu_BaEn_1	60	65	PF01217	0.628
TRG_DiLeu_BaEn_2	69	75	PF01217	0.585
TRG_DiLeu_LyEn_5	60	65	PF01217	0.450
TRG_ENDOCYTIC_2	11	14	PF00928	0.560
TRG_ENDOCYTIC_2	125	128	PF00928	0.500
TRG_ENDOCYTIC_2	217	220	PF00928	0.502
TRG_ENDOCYTIC_2	42	45	PF00928	0.467
TRG_ER_diArg_1	130	133	PF00400	0.563
TRG_ER_diArg_1	203	206	PF00400	0.464
TRG_ER_diArg_1	263	266	PF00400	0.532
TRG_ER_diArg_1	268	271	PF00400	0.546
TRG_ER_diArg_1	61	63	PF00400	0.602
TRG_ER_diArg_1	72	74	PF00400	0.556
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2B3	Leptomonas seymouri	43%	100%
A0A1X0P3M6	Trypanosomatidae	27%	97%
A0A3R7ME57	Trypanosoma rangeli	29%	96%
A0A3S7X6V8	Leishmania donovani	87%	100%
A4HLP9	Leishmania braziliensis	71%	100%
D0A6C5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	98%
E9AHN7	Leishmania infantum	87%	100%
Q4Q400	Leishmania major	88%	100%
V5BTW6	Trypanosoma cruzi	31%	97%