Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B421_LEIMU

TriTrypDb:

LmxM.32.1850

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B421

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B421

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.748
CLV_C14_Caspase3-7	227	231	PF00656	0.454
CLV_NRD_NRD_1	32	34	PF00675	0.497
CLV_PCSK_KEX2_1	32	34	PF00082	0.494
CLV_PCSK_SKI1_1	226	230	PF00082	0.545
CLV_PCSK_SKI1_1	32	36	PF00082	0.504
CLV_PCSK_SKI1_1	9	13	PF00082	0.542
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.512
DOC_MAPK_gen_1	195	202	PF00069	0.639
DOC_PP2B_LxvP_1	138	141	PF13499	0.503
DOC_PP4_FxxP_1	145	148	PF00568	0.519
DOC_USP7_MATH_1	86	90	PF00917	0.704
DOC_USP7_MATH_1	97	101	PF00917	0.795
DOC_WW_Pin1_4	144	149	PF00397	0.505
DOC_WW_Pin1_4	73	78	PF00397	0.789
DOC_WW_Pin1_4	79	84	PF00397	0.699
LIG_14-3-3_CanoR_1	119	126	PF00244	0.512
LIG_APCC_ABBA_1	200	205	PF00400	0.534
LIG_BIR_II_1	1	5	PF00653	0.570
LIG_eIF4E_1	210	216	PF01652	0.541
LIG_FHA_1	180	186	PF00498	0.480
LIG_FHA_2	225	231	PF00498	0.489
LIG_FHA_2	236	242	PF00498	0.458
LIG_LIR_Apic_2	143	148	PF02991	0.516
LIG_LIR_Gen_1	155	165	PF02991	0.561
LIG_LIR_Nem_3	155	161	PF02991	0.531
LIG_PTB_Apo_2	35	42	PF02174	0.483
LIG_PTB_Phospho_1	35	41	PF10480	0.478
LIG_SH2_CRK	52	56	PF00017	0.472
LIG_SH2_STAT5	59	62	PF00017	0.306
LIG_SH3_3	102	108	PF00018	0.824
LIG_SH3_3	123	129	PF00018	0.450
LIG_SUMO_SIM_anti_2	184	189	PF11976	0.613
LIG_SUMO_SIM_par_1	181	186	PF11976	0.621
LIG_TRAF2_1	238	241	PF00917	0.588
LIG_UBA3_1	130	139	PF00899	0.495
LIG_WRC_WIRS_1	248	253	PF05994	0.639
MOD_CDC14_SPxK_1	147	150	PF00782	0.508
MOD_CDK_SPxK_1	144	150	PF00069	0.500
MOD_CDK_SPxK_1	73	79	PF00069	0.566
MOD_CK1_1	100	106	PF00069	0.685
MOD_CK1_1	179	185	PF00069	0.562
MOD_CK1_1	201	207	PF00069	0.655
MOD_CK1_1	217	223	PF00069	0.637
MOD_CK1_1	233	239	PF00069	0.347
MOD_CK1_1	247	253	PF00069	0.557
MOD_CK1_1	89	95	PF00069	0.697
MOD_CK2_1	235	241	PF00069	0.579
MOD_GlcNHglycan	1	4	PF01048	0.569
MOD_GlcNHglycan	100	103	PF01048	0.818
MOD_GlcNHglycan	164	168	PF01048	0.607
MOD_GlcNHglycan	178	181	PF01048	0.512
MOD_GlcNHglycan	232	235	PF01048	0.460
MOD_GlcNHglycan	61	64	PF01048	0.607
MOD_GlcNHglycan	67	70	PF01048	0.665
MOD_GlcNHglycan	88	91	PF01048	0.704
MOD_GlcNHglycan	92	95	PF01048	0.732
MOD_GSK3_1	140	147	PF00069	0.475
MOD_GSK3_1	152	159	PF00069	0.425
MOD_GSK3_1	172	179	PF00069	0.452
MOD_GSK3_1	73	80	PF00069	0.692
MOD_GSK3_1	85	92	PF00069	0.709
MOD_N-GLC_1	172	177	PF02516	0.717
MOD_N-GLC_1	230	235	PF02516	0.484
MOD_N-GLC_1	241	246	PF02516	0.622
MOD_NEK2_1	156	161	PF00069	0.540
MOD_NEK2_1	183	188	PF00069	0.495
MOD_NEK2_2	198	203	PF00069	0.515
MOD_PKA_2	41	47	PF00069	0.522
MOD_Plk_1	217	223	PF00069	0.637
MOD_Plk_2-3	111	117	PF00069	0.748
MOD_Plk_4	152	158	PF00069	0.467
MOD_Plk_4	183	189	PF00069	0.501
MOD_Plk_4	198	204	PF00069	0.520
MOD_Plk_4	217	223	PF00069	0.548
MOD_Plk_4	244	250	PF00069	0.572
MOD_ProDKin_1	144	150	PF00069	0.500
MOD_ProDKin_1	73	79	PF00069	0.789
MOD_SUMO_for_1	24	27	PF00179	0.511
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.530
TRG_ENDOCYTIC_2	157	160	PF00928	0.530
TRG_ENDOCYTIC_2	52	55	PF00928	0.468
TRG_ER_diArg_1	31	33	PF00400	0.504
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P841	Leptomonas seymouri	58%	100%
A0A3S7X6W7	Leishmania donovani	89%	100%
A4HLP6	Leishmania braziliensis	76%	98%
A4I947	Leishmania infantum	89%	100%
Q4Q403	Leishmania major	89%	100%