Dual-specificity kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dual-specificity protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B419_LEIMU

TriTrypDb:

LmxM.32.1830

Length:

957

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B419

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B419

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018107	peptidyl-threonine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0018210	peptidyl-threonine modification	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004712	protein serine/threonine/tyrosine kinase activity	4	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.342
CLV_C14_Caspase3-7	404	408	PF00656	0.523
CLV_C14_Caspase3-7	731	735	PF00656	0.666
CLV_NRD_NRD_1	117	119	PF00675	0.385
CLV_NRD_NRD_1	315	317	PF00675	0.381
CLV_NRD_NRD_1	32	34	PF00675	0.465
CLV_NRD_NRD_1	521	523	PF00675	0.696
CLV_NRD_NRD_1	53	55	PF00675	0.406
CLV_NRD_NRD_1	533	535	PF00675	0.630
CLV_NRD_NRD_1	756	758	PF00675	0.701
CLV_PCSK_FUR_1	313	317	PF00082	0.385
CLV_PCSK_FUR_1	531	535	PF00082	0.717
CLV_PCSK_KEX2_1	313	315	PF00082	0.385
CLV_PCSK_KEX2_1	369	371	PF00082	0.342
CLV_PCSK_KEX2_1	52	54	PF00082	0.369
CLV_PCSK_KEX2_1	521	523	PF00082	0.696
CLV_PCSK_KEX2_1	533	535	PF00082	0.630
CLV_PCSK_KEX2_1	570	572	PF00082	0.513
CLV_PCSK_KEX2_1	756	758	PF00082	0.701
CLV_PCSK_KEX2_1	952	954	PF00082	0.660
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.342
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.369
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.513
CLV_PCSK_PC1ET2_1	952	954	PF00082	0.660
CLV_PCSK_PC7_1	48	54	PF00082	0.359
CLV_PCSK_PC7_1	529	535	PF00082	0.719
CLV_PCSK_SKI1_1	118	122	PF00082	0.385
CLV_PCSK_SKI1_1	316	320	PF00082	0.385
CLV_PCSK_SKI1_1	360	364	PF00082	0.385
CLV_PCSK_SKI1_1	460	464	PF00082	0.541
CLV_PCSK_SKI1_1	869	873	PF00082	0.537
CLV_PCSK_SKI1_1	921	925	PF00082	0.693
DEG_SPOP_SBC_1	842	846	PF00917	0.586
DOC_CKS1_1	851	856	PF01111	0.602
DOC_CYCLIN_yClb5_NLxxxL_5	164	173	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	435	441	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	911	914	PF00134	0.689
DOC_MAPK_FxFP_2	386	389	PF00069	0.526
DOC_MAPK_gen_1	753	763	PF00069	0.707
DOC_MAPK_gen_1	827	835	PF00069	0.664
DOC_MAPK_HePTP_8	244	256	PF00069	0.527
DOC_MAPK_MEF2A_6	192	199	PF00069	0.414
DOC_MAPK_MEF2A_6	247	256	PF00069	0.527
DOC_PP1_RVXF_1	260	267	PF00149	0.342
DOC_PP1_RVXF_1	698	705	PF00149	0.527
DOC_PP2B_LxvP_1	299	302	PF13499	0.385
DOC_PP2B_LxvP_1	911	914	PF13499	0.689
DOC_PP4_FxxP_1	386	389	PF00568	0.526
DOC_PP4_FxxP_1	448	451	PF00568	0.531
DOC_USP7_MATH_1	20	24	PF00917	0.425
DOC_USP7_MATH_1	201	205	PF00917	0.221
DOC_USP7_MATH_1	389	393	PF00917	0.620
DOC_USP7_MATH_1	415	419	PF00917	0.633
DOC_USP7_MATH_1	421	425	PF00917	0.568
DOC_USP7_MATH_1	497	501	PF00917	0.666
DOC_USP7_MATH_1	551	555	PF00917	0.677
DOC_USP7_MATH_1	648	652	PF00917	0.663
DOC_USP7_MATH_1	703	707	PF00917	0.636
DOC_USP7_MATH_1	727	731	PF00917	0.663
DOC_USP7_MATH_1	741	745	PF00917	0.627
DOC_USP7_MATH_1	812	816	PF00917	0.595
DOC_USP7_MATH_1	819	823	PF00917	0.581
DOC_USP7_MATH_1	837	841	PF00917	0.558
DOC_USP7_MATH_1	843	847	PF00917	0.648
DOC_USP7_MATH_1	852	856	PF00917	0.578
DOC_USP7_MATH_1	883	887	PF00917	0.643
DOC_USP7_MATH_1	919	923	PF00917	0.592
DOC_WW_Pin1_4	428	433	PF00397	0.560
DOC_WW_Pin1_4	447	452	PF00397	0.628
DOC_WW_Pin1_4	52	57	PF00397	0.564
DOC_WW_Pin1_4	547	552	PF00397	0.649
DOC_WW_Pin1_4	581	586	PF00397	0.661
DOC_WW_Pin1_4	614	619	PF00397	0.600
DOC_WW_Pin1_4	636	641	PF00397	0.628
DOC_WW_Pin1_4	737	742	PF00397	0.709
DOC_WW_Pin1_4	744	749	PF00397	0.654
DOC_WW_Pin1_4	838	843	PF00397	0.695
DOC_WW_Pin1_4	850	855	PF00397	0.586
DOC_WW_Pin1_4	940	945	PF00397	0.690
LIG_14-3-3_CanoR_1	147	154	PF00244	0.342
LIG_14-3-3_CanoR_1	155	164	PF00244	0.285
LIG_14-3-3_CanoR_1	457	467	PF00244	0.528
LIG_14-3-3_CanoR_1	531	541	PF00244	0.712
LIG_14-3-3_CanoR_1	609	618	PF00244	0.637
LIG_14-3-3_CanoR_1	622	630	PF00244	0.548
LIG_14-3-3_CanoR_1	663	672	PF00244	0.575
LIG_14-3-3_CanoR_1	709	719	PF00244	0.696
LIG_14-3-3_CanoR_1	857	863	PF00244	0.616
LIG_14-3-3_CanoR_1	915	919	PF00244	0.687
LIG_Actin_WH2_2	203	220	PF00022	0.328
LIG_Actin_WH2_2	608	624	PF00022	0.637
LIG_APCC_ABBA_1	794	799	PF00400	0.698
LIG_BRCT_BRCA1_1	175	179	PF00533	0.221
LIG_BRCT_BRCA1_1	231	235	PF00533	0.384
LIG_BRCT_BRCA1_1	90	94	PF00533	0.385
LIG_deltaCOP1_diTrp_1	265	269	PF00928	0.385
LIG_EVH1_1	464	468	PF00568	0.568
LIG_EVH1_2	302	306	PF00568	0.385
LIG_FHA_1	159	165	PF00498	0.264
LIG_FHA_1	180	186	PF00498	0.342
LIG_FHA_1	408	414	PF00498	0.522
LIG_FHA_1	605	611	PF00498	0.543
LIG_FHA_1	851	857	PF00498	0.657
LIG_FHA_2	27	33	PF00498	0.451
LIG_FHA_2	388	394	PF00498	0.547
LIG_FHA_2	470	476	PF00498	0.549
LIG_Integrin_isoDGR_2	58	60	PF01839	0.549
LIG_LIR_Apic_2	246	252	PF02991	0.385
LIG_LIR_Apic_2	297	301	PF02991	0.385
LIG_LIR_Apic_2	385	389	PF02991	0.513
LIG_LIR_Apic_2	447	451	PF02991	0.530
LIG_LIR_Apic_2	787	791	PF02991	0.613
LIG_LIR_Apic_2	898	902	PF02991	0.657
LIG_LIR_Gen_1	161	170	PF02991	0.428
LIG_LIR_Gen_1	352	363	PF02991	0.368
LIG_LIR_Nem_3	161	165	PF02991	0.428
LIG_LIR_Nem_3	265	269	PF02991	0.387
LIG_LIR_Nem_3	352	358	PF02991	0.368
LIG_LIR_Nem_3	701	707	PF02991	0.578
LIG_LIR_Nem_3	91	97	PF02991	0.385
LIG_MLH1_MIPbox_1	175	179	PF16413	0.221
LIG_MYND_1	854	858	PF01753	0.689
LIG_Pex14_2	358	362	PF04695	0.385
LIG_Pex14_2	94	98	PF04695	0.385
LIG_PTAP_UEV_1	450	455	PF05743	0.514
LIG_PTB_Apo_2	277	284	PF02174	0.221
LIG_REV1ctd_RIR_1	316	324	PF16727	0.342
LIG_SH2_CRK	143	147	PF00017	0.385
LIG_SH2_CRK	170	174	PF00017	0.221
LIG_SH2_CRK	788	792	PF00017	0.618
LIG_SH2_SRC	774	777	PF00017	0.650
LIG_SH2_STAP1	260	264	PF00017	0.342
LIG_SH2_STAP1	759	763	PF00017	0.667
LIG_SH2_STAT3	44	47	PF00017	0.443
LIG_SH2_STAT5	172	175	PF00017	0.437
LIG_SH2_STAT5	243	246	PF00017	0.433
LIG_SH2_STAT5	298	301	PF00017	0.527
LIG_SH2_STAT5	44	47	PF00017	0.399
LIG_SH2_STAT5	71	74	PF00017	0.455
LIG_SH2_STAT5	860	863	PF00017	0.600
LIG_SH3_2	910	915	PF14604	0.647
LIG_SH3_3	278	284	PF00018	0.385
LIG_SH3_3	448	454	PF00018	0.545
LIG_SH3_3	462	468	PF00018	0.580
LIG_SH3_3	511	517	PF00018	0.704
LIG_SH3_3	538	544	PF00018	0.707
LIG_SH3_3	612	618	PF00018	0.569
LIG_SH3_3	770	776	PF00018	0.646
LIG_SH3_3	818	824	PF00018	0.566
LIG_SH3_3	848	854	PF00018	0.653
LIG_SH3_3	900	906	PF00018	0.608
LIG_SH3_3	907	913	PF00018	0.653
LIG_SH3_3	934	940	PF00018	0.689
LIG_SUMO_SIM_anti_2	182	188	PF11976	0.348
LIG_SUMO_SIM_par_1	193	198	PF11976	0.385
LIG_SUMO_SIM_par_1	226	232	PF11976	0.342
LIG_SUMO_SIM_par_1	626	632	PF11976	0.599
LIG_TRAF2_1	124	127	PF00917	0.385
LIG_TRAF2_2	903	908	PF00917	0.534
LIG_TYR_ITIM	160	165	PF00017	0.385
LIG_TYR_ITIM	37	42	PF00017	0.478
LIG_WRC_WIRS_1	21	26	PF05994	0.441
LIG_WRC_WIRS_1	355	360	PF05994	0.385
LIG_WW_3	371	375	PF00397	0.342
LIG_WW_3	912	916	PF00397	0.689
MOD_CDK_SPK_2	744	749	PF00069	0.676
MOD_CDK_SPxxK_3	636	643	PF00069	0.598
MOD_CDK_SPxxK_3	850	857	PF00069	0.692
MOD_CK1_1	220	226	PF00069	0.234
MOD_CK1_1	399	405	PF00069	0.685
MOD_CK1_1	424	430	PF00069	0.607
MOD_CK1_1	498	504	PF00069	0.603
MOD_CK1_1	583	589	PF00069	0.665
MOD_CK1_1	7	13	PF00069	0.510
MOD_CK1_1	708	714	PF00069	0.551
MOD_CK1_1	744	750	PF00069	0.709
MOD_CK1_1	828	834	PF00069	0.694
MOD_CK1_1	841	847	PF00069	0.586
MOD_CK2_1	13	19	PF00069	0.503
MOD_CK2_1	26	32	PF00069	0.338
MOD_CK2_1	302	308	PF00069	0.342
MOD_CK2_1	387	393	PF00069	0.489
MOD_CK2_1	469	475	PF00069	0.521
MOD_CK2_1	563	569	PF00069	0.682
MOD_CK2_1	749	755	PF00069	0.612
MOD_GlcNHglycan	15	18	PF01048	0.420
MOD_GlcNHglycan	231	234	PF01048	0.385
MOD_GlcNHglycan	310	313	PF01048	0.385
MOD_GlcNHglycan	4	9	PF01048	0.637
MOD_GlcNHglycan	407	410	PF01048	0.682
MOD_GlcNHglycan	451	454	PF01048	0.617
MOD_GlcNHglycan	460	463	PF01048	0.625
MOD_GlcNHglycan	480	483	PF01048	0.605
MOD_GlcNHglycan	496	500	PF01048	0.532
MOD_GlcNHglycan	523	526	PF01048	0.687
MOD_GlcNHglycan	564	568	PF01048	0.654
MOD_GlcNHglycan	623	626	PF01048	0.568
MOD_GlcNHglycan	666	669	PF01048	0.654
MOD_GlcNHglycan	727	730	PF01048	0.676
MOD_GlcNHglycan	802	805	PF01048	0.527
MOD_GlcNHglycan	845	848	PF01048	0.681
MOD_GlcNHglycan	90	93	PF01048	0.385
MOD_GlcNHglycan	954	957	PF01048	0.649
MOD_GSK3_1	181	188	PF00069	0.361
MOD_GSK3_1	239	246	PF00069	0.484
MOD_GSK3_1	424	431	PF00069	0.578
MOD_GSK3_1	487	494	PF00069	0.576
MOD_GSK3_1	547	554	PF00069	0.646
MOD_GSK3_1	565	572	PF00069	0.515
MOD_GSK3_1	580	587	PF00069	0.649
MOD_GSK3_1	594	601	PF00069	0.571
MOD_GSK3_1	610	617	PF00069	0.646
MOD_GSK3_1	642	649	PF00069	0.702
MOD_GSK3_1	684	691	PF00069	0.708
MOD_GSK3_1	710	717	PF00069	0.645
MOD_GSK3_1	725	732	PF00069	0.596
MOD_GSK3_1	737	744	PF00069	0.614
MOD_GSK3_1	764	771	PF00069	0.641
MOD_GSK3_1	795	802	PF00069	0.537
MOD_GSK3_1	837	844	PF00069	0.649
MOD_GSK3_1	846	853	PF00069	0.596
MOD_GSK3_1	939	946	PF00069	0.667
MOD_N-GLC_1	405	410	PF02516	0.629
MOD_N-GLC_1	551	556	PF02516	0.678
MOD_N-GLC_1	646	651	PF02516	0.659
MOD_N-GLC_1	725	730	PF02516	0.547
MOD_N-GLC_1	812	817	PF02516	0.515
MOD_N-GLC_2	239	241	PF02516	0.221
MOD_NEK2_1	104	109	PF00069	0.385
MOD_NEK2_1	173	178	PF00069	0.415
MOD_NEK2_1	181	186	PF00069	0.371
MOD_NEK2_1	621	626	PF00069	0.678
MOD_NEK2_1	646	651	PF00069	0.535
MOD_NEK2_2	421	426	PF00069	0.581
MOD_NEK2_2	858	863	PF00069	0.528
MOD_PIKK_1	387	393	PF00454	0.528
MOD_PIKK_1	415	421	PF00454	0.615
MOD_PIKK_1	714	720	PF00454	0.656
MOD_PIKK_1	828	834	PF00454	0.664
MOD_PIKK_1	864	870	PF00454	0.652
MOD_PIKK_1	883	889	PF00454	0.508
MOD_PIKK_1	943	949	PF00454	0.531
MOD_PK_1	757	763	PF00069	0.664
MOD_PKA_1	521	527	PF00069	0.701
MOD_PKA_1	533	539	PF00069	0.626
MOD_PKA_2	146	152	PF00069	0.342
MOD_PKA_2	201	207	PF00069	0.278
MOD_PKA_2	217	223	PF00069	0.317
MOD_PKA_2	327	333	PF00069	0.342
MOD_PKA_2	507	513	PF00069	0.665
MOD_PKA_2	521	527	PF00069	0.603
MOD_PKA_2	532	538	PF00069	0.636
MOD_PKA_2	594	600	PF00069	0.659
MOD_PKA_2	604	610	PF00069	0.584
MOD_PKA_2	621	627	PF00069	0.615
MOD_PKA_2	708	714	PF00069	0.545
MOD_PKA_2	837	843	PF00069	0.648
MOD_PKA_2	864	870	PF00069	0.652
MOD_PKA_2	914	920	PF00069	0.653
MOD_PKB_1	531	539	PF00069	0.713
MOD_Plk_1	104	110	PF00069	0.385
MOD_Plk_1	757	763	PF00069	0.664
MOD_Plk_1	812	818	PF00069	0.540
MOD_Plk_1	828	834	PF00069	0.683
MOD_Plk_4	104	110	PF00069	0.385
MOD_Plk_4	181	187	PF00069	0.404
MOD_Plk_4	195	201	PF00069	0.350
MOD_Plk_4	220	226	PF00069	0.393
MOD_Plk_4	239	245	PF00069	0.329
MOD_Plk_4	302	308	PF00069	0.342
MOD_Plk_4	354	360	PF00069	0.385
MOD_Plk_4	812	818	PF00069	0.514
MOD_ProDKin_1	428	434	PF00069	0.559
MOD_ProDKin_1	447	453	PF00069	0.628
MOD_ProDKin_1	52	58	PF00069	0.574
MOD_ProDKin_1	547	553	PF00069	0.648
MOD_ProDKin_1	581	587	PF00069	0.663
MOD_ProDKin_1	614	620	PF00069	0.599
MOD_ProDKin_1	636	642	PF00069	0.627
MOD_ProDKin_1	737	743	PF00069	0.712
MOD_ProDKin_1	744	750	PF00069	0.654
MOD_ProDKin_1	838	844	PF00069	0.695
MOD_ProDKin_1	850	856	PF00069	0.588
MOD_ProDKin_1	940	946	PF00069	0.691
MOD_SUMO_for_1	210	213	PF00179	0.385
MOD_SUMO_for_1	425	428	PF00179	0.651
MOD_SUMO_rev_2	136	142	PF00179	0.385
MOD_SUMO_rev_2	203	212	PF00179	0.385
MOD_SUMO_rev_2	232	240	PF00179	0.385
MOD_SUMO_rev_2	392	397	PF00179	0.658
MOD_SUMO_rev_2	639	645	PF00179	0.651
TRG_DiLeu_BaEn_2	350	356	PF01217	0.385
TRG_DiLeu_BaEn_4	393	399	PF01217	0.629
TRG_ENDOCYTIC_2	143	146	PF00928	0.414
TRG_ENDOCYTIC_2	162	165	PF00928	0.385
TRG_ENDOCYTIC_2	170	173	PF00928	0.311
TRG_ENDOCYTIC_2	39	42	PF00928	0.470
TRG_ENDOCYTIC_2	83	86	PF00928	0.385
TRG_ER_diArg_1	313	316	PF00400	0.385
TRG_ER_diArg_1	325	328	PF00400	0.264
TRG_ER_diArg_1	531	534	PF00400	0.720
TRG_ER_diArg_1	862	865	PF00400	0.656
TRG_NES_CRM1_1	102	117	PF08389	0.342
TRG_Pf-PMV_PEXEL_1	609	614	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	921	926	PF00026	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6S4	Leishmania donovani	89%	100%
A4HLP3	Leishmania braziliensis	67%	100%
A4I978	Leishmania infantum	89%	100%
Q4Q405	Leishmania major	87%	100%