MT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B418_LEIMU

TriTrypDb:

LmxM.32.1820

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B418

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B418

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	253	257	PF00656	0.353
CLV_C14_Caspase3-7	9	13	PF00656	0.246
CLV_NRD_NRD_1	237	239	PF00675	0.360
CLV_NRD_NRD_1	296	298	PF00675	0.420
CLV_NRD_NRD_1	71	73	PF00675	0.425
CLV_PCSK_KEX2_1	212	214	PF00082	0.431
CLV_PCSK_KEX2_1	237	239	PF00082	0.361
CLV_PCSK_KEX2_1	296	298	PF00082	0.371
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.431
CLV_PCSK_SKI1_1	132	136	PF00082	0.633
CLV_PCSK_SKI1_1	242	246	PF00082	0.458
CLV_PCSK_SKI1_1	284	288	PF00082	0.440
CLV_PCSK_SKI1_1	5	9	PF00082	0.504
CLV_PCSK_SKI1_1	73	77	PF00082	0.406
DEG_APCC_DBOX_1	131	139	PF00400	0.430
DEG_Kelch_Keap1_1	318	323	PF01344	0.387
DOC_CKS1_1	287	292	PF01111	0.524
DOC_CYCLIN_RxL_1	237	247	PF00134	0.266
DOC_CYCLIN_RxL_1	278	291	PF00134	0.491
DOC_MAPK_gen_1	212	219	PF00069	0.472
DOC_MAPK_MEF2A_6	95	103	PF00069	0.392
DOC_PP2B_LxvP_1	109	112	PF13499	0.337
DOC_PP4_FxxP_1	367	370	PF00568	0.355
DOC_USP7_MATH_1	174	178	PF00917	0.484
DOC_USP7_MATH_1	188	192	PF00917	0.492
DOC_USP7_MATH_1	240	244	PF00917	0.506
DOC_USP7_MATH_1	351	355	PF00917	0.428
DOC_USP7_UBL2_3	212	216	PF12436	0.437
DOC_USP7_UBL2_3	73	77	PF12436	0.379
DOC_WW_Pin1_4	286	291	PF00397	0.384
LIG_14-3-3_CanoR_1	373	382	PF00244	0.396
LIG_Actin_WH2_2	259	274	PF00022	0.486
LIG_Actin_WH2_2	57	74	PF00022	0.453
LIG_APCC_ABBA_1	100	105	PF00400	0.349
LIG_BIR_III_2	256	260	PF00653	0.343
LIG_BIR_III_4	128	132	PF00653	0.360
LIG_BRCT_BRCA1_1	42	46	PF00533	0.470
LIG_deltaCOP1_diTrp_1	405	410	PF00928	0.368
LIG_FHA_1	182	188	PF00498	0.398
LIG_FHA_2	115	121	PF00498	0.601
LIG_FHA_2	287	293	PF00498	0.344
LIG_FHA_2	7	13	PF00498	0.554
LIG_LIR_Apic_2	308	312	PF02991	0.440
LIG_LIR_Apic_2	366	370	PF02991	0.371
LIG_LIR_Gen_1	113	123	PF02991	0.443
LIG_LIR_Gen_1	335	345	PF02991	0.375
LIG_LIR_Gen_1	409	417	PF02991	0.371
LIG_LIR_Gen_1	97	107	PF02991	0.395
LIG_LIR_Nem_3	113	118	PF02991	0.509
LIG_LIR_Nem_3	2	7	PF02991	0.376
LIG_LIR_Nem_3	335	341	PF02991	0.411
LIG_LIR_Nem_3	344	350	PF02991	0.427
LIG_LIR_Nem_3	97	103	PF02991	0.396
LIG_NRBOX	134	140	PF00104	0.450
LIG_NRP_CendR_1	427	430	PF00754	0.593
LIG_Pex14_1	407	411	PF04695	0.359
LIG_SH2_CRK	347	351	PF00017	0.463
LIG_SH2_NCK_1	347	351	PF00017	0.488
LIG_SH2_STAP1	343	347	PF00017	0.350
LIG_SH2_STAP1	388	392	PF00017	0.366
LIG_SH2_STAT5	114	117	PF00017	0.457
LIG_SH2_STAT5	165	168	PF00017	0.506
LIG_SH2_STAT5	343	346	PF00017	0.339
LIG_SH2_STAT5	347	350	PF00017	0.399
LIG_SH3_3	120	126	PF00018	0.500
LIG_SUMO_SIM_anti_2	204	211	PF11976	0.402
LIG_SUMO_SIM_anti_2	354	361	PF11976	0.498
LIG_TYR_ITIM	345	350	PF00017	0.456
LIG_Vh1_VBS_1	330	348	PF01044	0.311
MOD_CK1_1	264	270	PF00069	0.391
MOD_CK1_1	419	425	PF00069	0.390
MOD_CK2_1	114	120	PF00069	0.491
MOD_CK2_1	121	127	PF00069	0.557
MOD_CK2_1	285	291	PF00069	0.398
MOD_CMANNOS	407	410	PF00535	0.360
MOD_GlcNHglycan	150	154	PF01048	0.583
MOD_GlcNHglycan	314	317	PF01048	0.468
MOD_GlcNHglycan	35	38	PF01048	0.664
MOD_GlcNHglycan	375	378	PF01048	0.412
MOD_GSK3_1	240	247	PF00069	0.537
MOD_GSK3_1	341	348	PF00069	0.273
MOD_GSK3_1	416	423	PF00069	0.516
MOD_N-GLC_1	33	38	PF02516	0.646
MOD_N-GLC_1	351	356	PF02516	0.421
MOD_NEK2_1	149	154	PF00069	0.530
MOD_NEK2_1	244	249	PF00069	0.369
MOD_NEK2_1	261	266	PF00069	0.417
MOD_NEK2_1	271	276	PF00069	0.429
MOD_NEK2_1	417	422	PF00069	0.350
MOD_NEK2_1	55	60	PF00069	0.389
MOD_PIKK_1	188	194	PF00454	0.433
MOD_PKA_1	5	11	PF00069	0.489
MOD_PKA_2	217	223	PF00069	0.396
MOD_PKA_2	271	277	PF00069	0.386
MOD_PKA_2	345	351	PF00069	0.521
MOD_PKA_2	78	84	PF00069	0.471
MOD_Plk_1	121	127	PF00069	0.664
MOD_Plk_1	16	22	PF00069	0.379
MOD_Plk_1	240	246	PF00069	0.532
MOD_Plk_1	351	357	PF00069	0.550
MOD_Plk_1	417	423	PF00069	0.360
MOD_Plk_2-3	116	122	PF00069	0.507
MOD_ProDKin_1	286	292	PF00069	0.384
MOD_SUMO_for_1	170	173	PF00179	0.546
MOD_SUMO_for_1	229	232	PF00179	0.324
MOD_SUMO_for_1	94	97	PF00179	0.406
MOD_SUMO_rev_2	204	214	PF00179	0.448
MOD_SUMO_rev_2	356	364	PF00179	0.395
TRG_DiLeu_BaEn_1	105	110	PF01217	0.298
TRG_DiLeu_BaEn_1	51	56	PF01217	0.458
TRG_DiLeu_BaEn_1	97	102	PF01217	0.354
TRG_DiLeu_BaEn_4	150	156	PF01217	0.526
TRG_ENDOCYTIC_2	347	350	PF00928	0.448
TRG_ENDOCYTIC_2	380	383	PF00928	0.474
TRG_ENDOCYTIC_2	411	414	PF00928	0.350
TRG_ER_diArg_1	295	297	PF00400	0.376
TRG_ER_diArg_1	69	72	PF00400	0.409
TRG_NES_CRM1_1	90	105	PF08389	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R4	Leptomonas seymouri	51%	100%
A0A0S4JD21	Bodo saltans	29%	100%
A0A1X0P4D8	Trypanosomatidae	38%	100%
A0A3Q8IGN6	Leishmania donovani	91%	100%
A0A422N3D5	Trypanosoma rangeli	39%	100%
A4HLP2	Leishmania braziliensis	80%	100%
A4I977	Leishmania infantum	91%	100%
D0A6D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q406	Leishmania major	90%	100%
V5DQF0	Trypanosoma cruzi	38%	100%