LeishMANIAdb
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Histone-lysine N-methyltransferase ATXR3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Histone-lysine N-methyltransferase ATXR3
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B417_LEIMU
TriTrypDb:
LmxM.32.1810
Length:
388

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B417
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B417

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0016874 ligase activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 115 117 PF00675 0.382
CLV_NRD_NRD_1 119 121 PF00675 0.391
CLV_NRD_NRD_1 354 356 PF00675 0.395
CLV_PCSK_KEX2_1 115 117 PF00082 0.399
CLV_PCSK_SKI1_1 116 120 PF00082 0.376
CLV_PCSK_SKI1_1 3 7 PF00082 0.445
DOC_CYCLIN_yClb5_NLxxxL_5 162 171 PF00134 0.407
DOC_MAPK_FxFP_2 122 125 PF00069 0.463
DOC_MAPK_gen_1 355 361 PF00069 0.414
DOC_MAPK_gen_1 8 16 PF00069 0.407
DOC_MAPK_MEF2A_6 11 18 PF00069 0.336
DOC_MAPK_MEF2A_6 346 353 PF00069 0.343
DOC_PP4_FxxP_1 122 125 PF00568 0.513
DOC_USP7_MATH_1 232 236 PF00917 0.419
DOC_USP7_MATH_1 78 82 PF00917 0.539
DOC_USP7_UBL2_3 247 251 PF12436 0.289
LIG_14-3-3_CanoR_1 120 125 PF00244 0.446
LIG_14-3-3_CanoR_1 168 172 PF00244 0.347
LIG_14-3-3_CanoR_1 33 39 PF00244 0.289
LIG_Actin_WH2_2 131 146 PF00022 0.479
LIG_Actin_WH2_2 152 170 PF00022 0.351
LIG_APCC_ABBA_1 14 19 PF00400 0.349
LIG_BIR_II_1 1 5 PF00653 0.452
LIG_BRCT_BRCA1_1 215 219 PF00533 0.484
LIG_BRCT_BRCA1_1 317 321 PF00533 0.402
LIG_deltaCOP1_diTrp_1 186 190 PF00928 0.327
LIG_FHA_1 33 39 PF00498 0.579
LIG_FHA_1 45 51 PF00498 0.531
LIG_FHA_2 159 165 PF00498 0.365
LIG_FHA_2 32 38 PF00498 0.435
LIG_LIR_Apic_2 119 125 PF02991 0.518
LIG_LIR_Apic_2 209 214 PF02991 0.489
LIG_LIR_Apic_2 354 360 PF02991 0.461
LIG_LIR_Gen_1 268 278 PF02991 0.357
LIG_LIR_Gen_1 318 329 PF02991 0.443
LIG_LIR_Nem_3 105 111 PF02991 0.442
LIG_LIR_Nem_3 130 135 PF02991 0.463
LIG_LIR_Nem_3 170 176 PF02991 0.407
LIG_LIR_Nem_3 186 190 PF02991 0.513
LIG_LIR_Nem_3 224 230 PF02991 0.342
LIG_LIR_Nem_3 268 273 PF02991 0.366
LIG_LIR_Nem_3 316 322 PF02991 0.421
LIG_LIR_Nem_3 47 51 PF02991 0.453
LIG_LIR_Nem_3 55 61 PF02991 0.381
LIG_LIR_Nem_3 81 85 PF02991 0.358
LIG_MLH1_MIPbox_1 317 321 PF16413 0.402
LIG_PDZ_Class_1 383 388 PF00595 0.499
LIG_Pex14_1 58 62 PF04695 0.468
LIG_Pex14_2 169 173 PF04695 0.295
LIG_REV1ctd_RIR_1 217 225 PF16727 0.431
LIG_SH2_CRK 132 136 PF00017 0.492
LIG_SH2_CRK 357 361 PF00017 0.390
LIG_SH2_PTP2 211 214 PF00017 0.444
LIG_SH2_SRC 211 214 PF00017 0.444
LIG_SH2_STAP1 82 86 PF00017 0.377
LIG_SH2_STAT5 211 214 PF00017 0.384
LIG_SH2_STAT5 227 230 PF00017 0.273
LIG_SH2_STAT5 280 283 PF00017 0.396
LIG_SH2_STAT5 320 323 PF00017 0.295
LIG_SH2_STAT5 357 360 PF00017 0.315
LIG_SH2_STAT5 372 375 PF00017 0.283
LIG_SH2_STAT5 62 65 PF00017 0.442
LIG_SH2_STAT5 85 88 PF00017 0.401
LIG_SH3_3 196 202 PF00018 0.435
LIG_SH3_3 66 72 PF00018 0.612
LIG_SUMO_SIM_par_1 335 341 PF11976 0.345
LIG_SUMO_SIM_par_1 66 73 PF11976 0.358
LIG_WRC_WIRS_1 173 178 PF05994 0.327
MOD_CK1_1 235 241 PF00069 0.470
MOD_CK2_1 158 164 PF00069 0.347
MOD_CK2_1 207 213 PF00069 0.256
MOD_CK2_1 239 245 PF00069 0.549
MOD_GlcNHglycan 199 202 PF01048 0.399
MOD_GlcNHglycan 215 218 PF01048 0.224
MOD_GlcNHglycan 263 266 PF01048 0.491
MOD_GlcNHglycan 75 78 PF01048 0.467
MOD_GSK3_1 116 123 PF00069 0.419
MOD_GSK3_1 175 182 PF00069 0.439
MOD_GSK3_1 235 242 PF00069 0.485
MOD_GSK3_1 261 268 PF00069 0.461
MOD_N-GLC_1 20 25 PF02516 0.361
MOD_NEK2_1 158 163 PF00069 0.338
MOD_NEK2_1 167 172 PF00069 0.331
MOD_NEK2_1 207 212 PF00069 0.510
MOD_NEK2_1 215 220 PF00069 0.452
MOD_NEK2_1 281 286 PF00069 0.402
MOD_PIKK_1 310 316 PF00454 0.539
MOD_PKA_1 120 126 PF00069 0.475
MOD_PKA_2 167 173 PF00069 0.344
MOD_PKA_2 32 38 PF00069 0.546
MOD_PKA_2 7 13 PF00069 0.490
MOD_Plk_1 20 26 PF00069 0.364
MOD_Plk_1 332 338 PF00069 0.364
MOD_Plk_2-3 332 338 PF00069 0.339
MOD_Plk_4 179 185 PF00069 0.404
MOD_Plk_4 20 26 PF00069 0.409
MOD_Plk_4 207 213 PF00069 0.491
MOD_Plk_4 215 221 PF00069 0.416
MOD_Plk_4 315 321 PF00069 0.434
MOD_Plk_4 332 338 PF00069 0.347
MOD_Plk_4 344 350 PF00069 0.357
MOD_SUMO_for_1 100 103 PF00179 0.467
MOD_SUMO_rev_2 200 210 PF00179 0.521
MOD_SUMO_rev_2 242 249 PF00179 0.305
TRG_DiLeu_BaEn_2 185 191 PF01217 0.298
TRG_ENDOCYTIC_2 132 135 PF00928 0.497
TRG_ENDOCYTIC_2 319 322 PF00928 0.333
TRG_ER_diArg_1 114 116 PF00400 0.473
TRG_Pf-PMV_PEXEL_1 3 7 PF00026 0.523
TRG_Pf-PMV_PEXEL_1 365 369 PF00026 0.278

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM57 Leptomonas seymouri 67% 95%
A0A0S4JGX9 Bodo saltans 38% 100%
A0A1X0P3L5 Trypanosomatidae 47% 100%
A0A3Q8IME8 Leishmania donovani 92% 100%
A0A422N3E6 Trypanosoma rangeli 47% 97%
A4HLP1 Leishmania braziliensis 83% 100%
A4I976 Leishmania infantum 92% 100%
D0A6D2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 99%
Q4Q407 Leishmania major 91% 100%
V5BTX0 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS