LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial RNA binding complex 1 subunit
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B410_LEIMU
TriTrypDb:
LmxM.32.1730
Length:
893

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B410
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B410

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009451 RNA modification 5 1
GO:0009892 negative regulation of metabolic process 4 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0009894 regulation of catabolic process 4 1
GO:0009895 negative regulation of catabolic process 5 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0010628 positive regulation of gene expression 6 1
GO:0016070 RNA metabolic process 5 1
GO:0016553 base conversion or substitution editing 6 1
GO:0016554 cytidine to uridine editing 7 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031324 negative regulation of cellular metabolic process 5 1
GO:0031329 regulation of cellular catabolic process 5 1
GO:0031330 negative regulation of cellular catabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043487 regulation of RNA stability 3 1
GO:0043488 regulation of mRNA stability 4 1
GO:0043489 RNA stabilization 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 6 1
GO:0046483 heterocycle metabolic process 3 1
GO:0048255 mRNA stabilization 5 1
GO:0048518 positive regulation of biological process 3 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051172 negative regulation of nitrogen compound metabolic process 5 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0051253 negative regulation of RNA metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0061013 regulation of mRNA catabolic process 6 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1902369 negative regulation of RNA catabolic process 7 1
GO:1902373 negative regulation of mRNA catabolic process 7 1
GO:1903311 regulation of mRNA metabolic process 6 1
GO:1903312 negative regulation of mRNA metabolic process 7 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 641 645 PF00656 0.478
CLV_C14_Caspase3-7 689 693 PF00656 0.238
CLV_C14_Caspase3-7 879 883 PF00656 0.658
CLV_NRD_NRD_1 129 131 PF00675 0.471
CLV_NRD_NRD_1 13 15 PF00675 0.498
CLV_NRD_NRD_1 512 514 PF00675 0.462
CLV_NRD_NRD_1 761 763 PF00675 0.400
CLV_NRD_NRD_1 79 81 PF00675 0.394
CLV_NRD_NRD_1 809 811 PF00675 0.444
CLV_NRD_NRD_1 851 853 PF00675 0.432
CLV_NRD_NRD_1 860 862 PF00675 0.396
CLV_NRD_NRD_1 874 876 PF00675 0.431
CLV_PCSK_KEX2_1 129 131 PF00082 0.484
CLV_PCSK_KEX2_1 395 397 PF00082 0.487
CLV_PCSK_KEX2_1 553 555 PF00082 0.511
CLV_PCSK_KEX2_1 761 763 PF00082 0.400
CLV_PCSK_KEX2_1 79 81 PF00082 0.375
CLV_PCSK_KEX2_1 809 811 PF00082 0.384
CLV_PCSK_KEX2_1 851 853 PF00082 0.418
CLV_PCSK_KEX2_1 860 862 PF00082 0.382
CLV_PCSK_KEX2_1 874 876 PF00082 0.428
CLV_PCSK_PC1ET2_1 395 397 PF00082 0.406
CLV_PCSK_PC1ET2_1 553 555 PF00082 0.511
CLV_PCSK_SKI1_1 15 19 PF00082 0.510
CLV_PCSK_SKI1_1 246 250 PF00082 0.420
CLV_PCSK_SKI1_1 287 291 PF00082 0.426
CLV_PCSK_SKI1_1 306 310 PF00082 0.213
CLV_PCSK_SKI1_1 419 423 PF00082 0.325
CLV_PCSK_SKI1_1 586 590 PF00082 0.476
CLV_PCSK_SKI1_1 666 670 PF00082 0.371
CLV_PCSK_SKI1_1 675 679 PF00082 0.341
CLV_PCSK_SKI1_1 681 685 PF00082 0.338
CLV_PCSK_SKI1_1 772 776 PF00082 0.460
CLV_PCSK_SKI1_1 836 840 PF00082 0.524
CLV_Separin_Metazoa 634 638 PF03568 0.518
DEG_APCC_DBOX_1 305 313 PF00400 0.530
DEG_APCC_DBOX_1 395 403 PF00400 0.399
DEG_APCC_DBOX_1 43 51 PF00400 0.496
DEG_APCC_DBOX_1 585 593 PF00400 0.361
DEG_SCF_FBW7_1 1 7 PF00400 0.474
DEG_SCF_FBW7_1 774 779 PF00400 0.451
DEG_SPOP_SBC_1 103 107 PF00917 0.387
DOC_ANK_TNKS_1 479 486 PF00023 0.593
DOC_CDC14_PxL_1 342 350 PF14671 0.515
DOC_CKS1_1 1 6 PF01111 0.671
DOC_CKS1_1 115 120 PF01111 0.361
DOC_CKS1_1 754 759 PF01111 0.467
DOC_CKS1_1 773 778 PF01111 0.519
DOC_CKS1_1 820 825 PF01111 0.434
DOC_CKS1_1 829 834 PF01111 0.369
DOC_CYCLIN_RxL_1 416 426 PF00134 0.329
DOC_CYCLIN_RxL_1 833 843 PF00134 0.379
DOC_CYCLIN_yCln2_LP_2 754 760 PF00134 0.447
DOC_MAPK_DCC_7 444 454 PF00069 0.378
DOC_MAPK_gen_1 41 50 PF00069 0.538
DOC_MAPK_gen_1 498 507 PF00069 0.504
DOC_PP2B_LxvP_1 387 390 PF13499 0.394
DOC_PP4_FxxP_1 659 662 PF00568 0.402
DOC_PP4_FxxP_1 773 776 PF00568 0.306
DOC_PP4_FxxP_1 820 823 PF00568 0.502
DOC_USP7_MATH_1 151 155 PF00917 0.393
DOC_USP7_MATH_1 160 164 PF00917 0.339
DOC_USP7_MATH_1 25 29 PF00917 0.302
DOC_USP7_MATH_1 617 621 PF00917 0.364
DOC_USP7_MATH_1 64 68 PF00917 0.522
DOC_USP7_MATH_1 82 86 PF00917 0.257
DOC_USP7_MATH_1 883 887 PF00917 0.594
DOC_USP7_MATH_2 558 564 PF00917 0.402
DOC_USP7_UBL2_3 681 685 PF12436 0.403
DOC_WW_Pin1_4 114 119 PF00397 0.373
DOC_WW_Pin1_4 191 196 PF00397 0.476
DOC_WW_Pin1_4 375 380 PF00397 0.515
DOC_WW_Pin1_4 54 59 PF00397 0.561
DOC_WW_Pin1_4 68 73 PF00397 0.360
DOC_WW_Pin1_4 753 758 PF00397 0.453
DOC_WW_Pin1_4 772 777 PF00397 0.248
DOC_WW_Pin1_4 819 824 PF00397 0.429
DOC_WW_Pin1_4 828 833 PF00397 0.369
LIG_14-3-3_CanoR_1 102 111 PF00244 0.487
LIG_14-3-3_CanoR_1 129 138 PF00244 0.465
LIG_14-3-3_CanoR_1 480 484 PF00244 0.598
LIG_14-3-3_CanoR_1 513 522 PF00244 0.513
LIG_14-3-3_CanoR_1 637 646 PF00244 0.435
LIG_14-3-3_CanoR_1 698 704 PF00244 0.469
LIG_14-3-3_CanoR_1 827 832 PF00244 0.476
LIG_14-3-3_CanoR_1 875 885 PF00244 0.603
LIG_14-3-3_CterR_2 889 893 PF00244 0.631
LIG_Actin_WH2_2 108 124 PF00022 0.461
LIG_Actin_WH2_2 745 763 PF00022 0.469
LIG_APCC_ABBA_1 34 39 PF00400 0.413
LIG_BIR_III_2 882 886 PF00653 0.490
LIG_BIR_III_4 180 184 PF00653 0.398
LIG_CSL_BTD_1 115 118 PF09270 0.361
LIG_deltaCOP1_diTrp_1 347 354 PF00928 0.482
LIG_FHA_1 1 7 PF00498 0.552
LIG_FHA_1 106 112 PF00498 0.402
LIG_FHA_1 174 180 PF00498 0.585
LIG_FHA_1 211 217 PF00498 0.513
LIG_FHA_1 33 39 PF00498 0.476
LIG_FHA_1 527 533 PF00498 0.374
LIG_FHA_1 754 760 PF00498 0.460
LIG_FHA_1 820 826 PF00498 0.450
LIG_FHA_1 829 835 PF00498 0.378
LIG_FHA_1 871 877 PF00498 0.416
LIG_FHA_2 115 121 PF00498 0.354
LIG_FHA_2 17 23 PF00498 0.510
LIG_FHA_2 261 267 PF00498 0.516
LIG_FHA_2 342 348 PF00498 0.433
LIG_FHA_2 443 449 PF00498 0.482
LIG_FHA_2 479 485 PF00498 0.540
LIG_FHA_2 636 642 PF00498 0.530
LIG_FHA_2 687 693 PF00498 0.350
LIG_FHA_2 745 751 PF00498 0.371
LIG_FHA_2 773 779 PF00498 0.451
LIG_FHA_2 877 883 PF00498 0.641
LIG_HCF-1_HBM_1 664 667 PF13415 0.464
LIG_LIR_Gen_1 231 241 PF02991 0.320
LIG_LIR_Gen_1 296 305 PF02991 0.367
LIG_LIR_Gen_1 411 420 PF02991 0.453
LIG_LIR_Gen_1 540 551 PF02991 0.462
LIG_LIR_Gen_1 606 614 PF02991 0.524
LIG_LIR_Gen_1 627 636 PF02991 0.384
LIG_LIR_Gen_1 651 660 PF02991 0.343
LIG_LIR_Gen_1 717 726 PF02991 0.447
LIG_LIR_Gen_1 731 742 PF02991 0.249
LIG_LIR_Gen_1 97 104 PF02991 0.498
LIG_LIR_Nem_3 231 236 PF02991 0.330
LIG_LIR_Nem_3 296 300 PF02991 0.463
LIG_LIR_Nem_3 344 348 PF02991 0.449
LIG_LIR_Nem_3 411 415 PF02991 0.433
LIG_LIR_Nem_3 417 423 PF02991 0.343
LIG_LIR_Nem_3 540 546 PF02991 0.466
LIG_LIR_Nem_3 581 585 PF02991 0.364
LIG_LIR_Nem_3 606 611 PF02991 0.522
LIG_LIR_Nem_3 627 632 PF02991 0.379
LIG_LIR_Nem_3 651 656 PF02991 0.344
LIG_LIR_Nem_3 717 722 PF02991 0.482
LIG_LIR_Nem_3 97 103 PF02991 0.503
LIG_LRP6_Inhibitor_1 123 129 PF00058 0.283
LIG_LYPXL_yS_3 345 348 PF13949 0.531
LIG_LYPXL_yS_3 582 585 PF13949 0.377
LIG_Pex14_1 350 354 PF04695 0.453
LIG_SH2_NCK_1 134 138 PF00017 0.339
LIG_SH2_SRC 37 40 PF00017 0.442
LIG_SH2_STAP1 134 138 PF00017 0.485
LIG_SH2_STAT5 330 333 PF00017 0.446
LIG_SH2_STAT5 37 40 PF00017 0.436
LIG_SH2_STAT5 437 440 PF00017 0.483
LIG_SH2_STAT5 549 552 PF00017 0.381
LIG_SH2_STAT5 667 670 PF00017 0.422
LIG_SH2_STAT5 718 721 PF00017 0.480
LIG_SH3_3 112 118 PF00018 0.504
LIG_SH3_3 169 175 PF00018 0.386
LIG_SH3_3 277 283 PF00018 0.476
LIG_SH3_3 831 837 PF00018 0.382
LIG_SUMO_SIM_anti_2 337 342 PF11976 0.374
LIG_SUMO_SIM_par_1 160 167 PF11976 0.395
LIG_SUMO_SIM_par_1 333 339 PF11976 0.447
LIG_TRAF2_1 218 221 PF00917 0.339
LIG_TRAF2_1 263 266 PF00917 0.522
LIG_TRAF2_1 367 370 PF00917 0.503
LIG_UBA3_1 745 751 PF00899 0.451
LIG_WRC_WIRS_1 415 420 PF05994 0.473
MOD_CK1_1 105 111 PF00069 0.466
MOD_CK1_1 163 169 PF00069 0.461
MOD_CK1_1 374 380 PF00069 0.529
MOD_CK1_1 411 417 PF00069 0.491
MOD_CK1_1 563 569 PF00069 0.398
MOD_CK1_1 57 63 PF00069 0.563
MOD_CK1_1 700 706 PF00069 0.361
MOD_CK1_1 727 733 PF00069 0.520
MOD_CK1_1 753 759 PF00069 0.421
MOD_CK1_1 821 827 PF00069 0.520
MOD_CK2_1 16 22 PF00069 0.536
MOD_CK2_1 164 170 PF00069 0.405
MOD_CK2_1 260 266 PF00069 0.526
MOD_CK2_1 478 484 PF00069 0.531
MOD_CK2_1 617 623 PF00069 0.653
MOD_CK2_1 827 833 PF00069 0.533
MOD_Cter_Amidation 77 80 PF01082 0.369
MOD_GlcNHglycan 131 134 PF01048 0.563
MOD_GlcNHglycan 153 156 PF01048 0.364
MOD_GlcNHglycan 250 253 PF01048 0.386
MOD_GlcNHglycan 27 30 PF01048 0.382
MOD_GlcNHglycan 276 279 PF01048 0.434
MOD_GlcNHglycan 319 322 PF01048 0.492
MOD_GlcNHglycan 373 376 PF01048 0.528
MOD_GlcNHglycan 473 476 PF01048 0.733
MOD_GlcNHglycan 562 565 PF01048 0.399
MOD_GlcNHglycan 600 603 PF01048 0.493
MOD_GlcNHglycan 692 695 PF01048 0.399
MOD_GlcNHglycan 699 702 PF01048 0.377
MOD_GlcNHglycan 842 845 PF01048 0.581
MOD_GlcNHglycan 855 858 PF01048 0.323
MOD_GlcNHglycan 861 864 PF01048 0.286
MOD_GlcNHglycan 879 882 PF01048 0.481
MOD_GlcNHglycan 92 95 PF01048 0.541
MOD_GSK3_1 110 117 PF00069 0.233
MOD_GSK3_1 160 167 PF00069 0.383
MOD_GSK3_1 371 378 PF00069 0.480
MOD_GSK3_1 4 11 PF00069 0.434
MOD_GSK3_1 612 619 PF00069 0.582
MOD_GSK3_1 64 71 PF00069 0.557
MOD_GSK3_1 686 693 PF00069 0.305
MOD_GSK3_1 703 710 PF00069 0.394
MOD_GSK3_1 772 779 PF00069 0.311
MOD_GSK3_1 90 97 PF00069 0.543
MOD_GSK3_1 98 105 PF00069 0.476
MOD_LATS_1 127 133 PF00433 0.372
MOD_N-GLC_1 32 37 PF02516 0.347
MOD_N-GLC_2 208 210 PF02516 0.251
MOD_N-GLC_2 274 276 PF02516 0.364
MOD_N-GLC_2 407 409 PF02516 0.440
MOD_NEK2_1 189 194 PF00069 0.527
MOD_NEK2_1 229 234 PF00069 0.306
MOD_NEK2_1 32 37 PF00069 0.391
MOD_NEK2_1 336 341 PF00069 0.439
MOD_NEK2_1 442 447 PF00069 0.382
MOD_NEK2_1 635 640 PF00069 0.400
MOD_NEK2_1 725 730 PF00069 0.428
MOD_NEK2_1 840 845 PF00069 0.509
MOD_NEK2_1 876 881 PF00069 0.554
MOD_NEK2_2 718 723 PF00069 0.361
MOD_PIKK_1 514 520 PF00454 0.392
MOD_PIKK_1 603 609 PF00454 0.500
MOD_PIKK_1 845 851 PF00454 0.412
MOD_PKA_1 129 135 PF00069 0.382
MOD_PKA_2 129 135 PF00069 0.426
MOD_PKA_2 260 266 PF00069 0.502
MOD_PKA_2 4 10 PF00069 0.565
MOD_PKA_2 40 46 PF00069 0.466
MOD_PKA_2 479 485 PF00069 0.594
MOD_PKA_2 537 543 PF00069 0.547
MOD_PKA_2 697 703 PF00069 0.482
MOD_PKA_2 859 865 PF00069 0.390
MOD_PKA_2 883 889 PF00069 0.574
MOD_Plk_1 32 38 PF00069 0.410
MOD_Plk_1 336 342 PF00069 0.409
MOD_Plk_1 812 818 PF00069 0.372
MOD_Plk_2-3 268 274 PF00069 0.470
MOD_Plk_2-3 388 394 PF00069 0.534
MOD_Plk_4 160 166 PF00069 0.522
MOD_Plk_4 32 38 PF00069 0.476
MOD_Plk_4 336 342 PF00069 0.359
MOD_Plk_4 686 692 PF00069 0.529
MOD_Plk_4 703 709 PF00069 0.423
MOD_Plk_4 94 100 PF00069 0.527
MOD_ProDKin_1 114 120 PF00069 0.368
MOD_ProDKin_1 191 197 PF00069 0.470
MOD_ProDKin_1 375 381 PF00069 0.515
MOD_ProDKin_1 54 60 PF00069 0.557
MOD_ProDKin_1 68 74 PF00069 0.359
MOD_ProDKin_1 753 759 PF00069 0.446
MOD_ProDKin_1 772 778 PF00069 0.245
MOD_ProDKin_1 819 825 PF00069 0.427
MOD_ProDKin_1 828 834 PF00069 0.362
MOD_SUMO_rev_2 388 397 PF00179 0.403
MOD_SUMO_rev_2 663 668 PF00179 0.333
TRG_DiLeu_BaEn_1 732 737 PF01217 0.403
TRG_DiLeu_BaEn_2 292 298 PF01217 0.347
TRG_DiLeu_BaEn_2 583 589 PF01217 0.465
TRG_DiLeu_BaEn_2 768 774 PF01217 0.416
TRG_DiLeu_BaLyEn_6 174 179 PF01217 0.433
TRG_DiLeu_BaLyEn_6 382 387 PF01217 0.467
TRG_DiLeu_BaLyEn_6 834 839 PF01217 0.380
TRG_ENDOCYTIC_2 345 348 PF00928 0.503
TRG_ENDOCYTIC_2 582 585 PF00928 0.377
TRG_ENDOCYTIC_2 653 656 PF00928 0.332
TRG_ER_diArg_1 128 130 PF00400 0.472
TRG_ER_diArg_1 636 639 PF00400 0.531
TRG_ER_diArg_1 760 762 PF00400 0.404
TRG_ER_diArg_1 79 81 PF00400 0.425
TRG_ER_diArg_1 809 811 PF00400 0.444
TRG_ER_diArg_1 859 861 PF00400 0.466
TRG_ER_diArg_1 874 876 PF00400 0.447
TRG_ER_diArg_1 889 892 PF00400 0.487
TRG_NES_CRM1_1 292 307 PF08389 0.375
TRG_NES_CRM1_1 499 510 PF08389 0.369
TRG_Pf-PMV_PEXEL_1 306 310 PF00026 0.404
TRG_Pf-PMV_PEXEL_1 436 440 PF00026 0.347
TRG_Pf-PMV_PEXEL_1 836 841 PF00026 0.480
TRG_Pf-PMV_PEXEL_1 866 870 PF00026 0.400

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAS6 Leptomonas seymouri 61% 98%
A0A0S4JFF4 Bodo saltans 34% 85%
A0A1X0P174 Trypanosomatidae 42% 100%
A0A3Q8IHV0 Leishmania donovani 95% 100%
A0A3R7M0F7 Trypanosoma rangeli 40% 100%
A4HLN4 Leishmania braziliensis 90% 100%
A4I969 Leishmania infantum 95% 100%
C9ZIW5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
Q4Q414 Leishmania major 94% 100%
V5AXB1 Trypanosoma cruzi 42% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS