LeishMANIAdb
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ANAPC5 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
ANAPC5 domain-containing protein
Gene product:
Tetratricopeptide repeat, putative
Species:
Leishmania mexicana
UniProt:
E9B409_LEIMU
TriTrypDb:
LmxM.32.1720
Length:
408

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B409
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B409

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 381 385 PF00656 0.500
CLV_NRD_NRD_1 117 119 PF00675 0.501
CLV_PCSK_KEX2_1 117 119 PF00082 0.502
CLV_PCSK_KEX2_1 40 42 PF00082 0.696
CLV_PCSK_PC1ET2_1 40 42 PF00082 0.696
CLV_PCSK_PC7_1 36 42 PF00082 0.684
CLV_PCSK_SKI1_1 192 196 PF00082 0.317
CLV_PCSK_SKI1_1 23 27 PF00082 0.697
CLV_PCSK_SKI1_1 41 45 PF00082 0.646
CLV_PCSK_SKI1_1 5 9 PF00082 0.701
DEG_APCC_DBOX_1 27 35 PF00400 0.654
DOC_CYCLIN_RxL_1 192 203 PF00134 0.369
DOC_CYCLIN_RxL_1 2 10 PF00134 0.563
DOC_CYCLIN_yCln2_LP_2 89 95 PF00134 0.586
DOC_MAPK_gen_1 192 200 PF00069 0.424
DOC_MAPK_MEF2A_6 323 332 PF00069 0.336
DOC_MAPK_MEF2A_6 85 93 PF00069 0.523
DOC_PP1_RVXF_1 206 213 PF00149 0.520
DOC_PP2B_LxvP_1 89 92 PF13499 0.570
DOC_PP4_FxxP_1 95 98 PF00568 0.625
DOC_USP7_MATH_1 158 162 PF00917 0.521
DOC_USP7_MATH_1 369 373 PF00917 0.474
DOC_USP7_MATH_2 63 69 PF00917 0.728
DOC_WW_Pin1_4 133 138 PF00397 0.716
LIG_14-3-3_CanoR_1 157 163 PF00244 0.512
LIG_Actin_WH2_2 283 301 PF00022 0.455
LIG_BIR_II_1 1 5 PF00653 0.729
LIG_BRCT_BRCA1_1 176 180 PF00533 0.475
LIG_deltaCOP1_diTrp_1 188 194 PF00928 0.522
LIG_FHA_1 1 7 PF00498 0.453
LIG_FHA_1 134 140 PF00498 0.671
LIG_FHA_1 285 291 PF00498 0.335
LIG_FHA_1 394 400 PF00498 0.641
LIG_FHA_2 142 148 PF00498 0.643
LIG_GBD_Chelix_1 115 123 PF00786 0.542
LIG_LIR_Apic_2 132 138 PF02991 0.681
LIG_LIR_Apic_2 99 104 PF02991 0.609
LIG_LIR_Gen_1 256 265 PF02991 0.441
LIG_LIR_Gen_1 335 342 PF02991 0.328
LIG_LIR_Nem_3 256 260 PF02991 0.430
LIG_LIR_Nem_3 335 340 PF02991 0.328
LIG_NBox_RRM_1 194 204 PF00076 0.577
LIG_NRBOX 327 333 PF00104 0.450
LIG_SH2_CRK 101 105 PF00017 0.678
LIG_SH2_CRK 135 139 PF00017 0.682
LIG_SH2_CRK 15 19 PF00017 0.608
LIG_SH2_CRK 257 261 PF00017 0.425
LIG_SH2_CRK 337 341 PF00017 0.352
LIG_SH2_GRB2like 47 50 PF00017 0.760
LIG_SH2_NCK_1 15 19 PF00017 0.716
LIG_SH2_SRC 47 50 PF00017 0.760
LIG_SH2_STAP1 15 19 PF00017 0.446
LIG_SH2_STAP1 244 248 PF00017 0.443
LIG_SH2_STAT5 135 138 PF00017 0.714
LIG_SH2_STAT5 143 146 PF00017 0.628
LIG_SH3_3 57 63 PF00018 0.633
LIG_SUMO_SIM_anti_2 72 78 PF11976 0.716
LIG_SUMO_SIM_par_1 329 335 PF11976 0.336
LIG_SUMO_SIM_par_1 72 78 PF11976 0.726
LIG_TRAF2_1 97 100 PF00917 0.649
LIG_TYR_ITIM 255 260 PF00017 0.398
MOD_CK1_1 129 135 PF00069 0.676
MOD_CK1_1 324 330 PF00069 0.418
MOD_CK1_1 398 404 PF00069 0.649
MOD_CK2_1 141 147 PF00069 0.619
MOD_CK2_1 196 202 PF00069 0.460
MOD_CK2_1 258 264 PF00069 0.438
MOD_GlcNHglycan 176 179 PF01048 0.458
MOD_GlcNHglycan 322 326 PF01048 0.354
MOD_GlcNHglycan 79 82 PF01048 0.613
MOD_GlcNHglycan 86 89 PF01048 0.525
MOD_GSK3_1 125 132 PF00069 0.620
MOD_GSK3_1 17 24 PF00069 0.647
MOD_GSK3_1 280 287 PF00069 0.458
MOD_N-GLC_1 165 170 PF02516 0.506
MOD_N-GLC_1 21 26 PF02516 0.677
MOD_N-GLC_1 48 53 PF02516 0.732
MOD_NEK2_1 174 179 PF00069 0.403
MOD_NEK2_1 240 245 PF00069 0.515
MOD_NEK2_1 253 258 PF00069 0.323
MOD_NEK2_1 284 289 PF00069 0.463
MOD_NEK2_1 393 398 PF00069 0.611
MOD_NEK2_1 7 12 PF00069 0.677
MOD_NEK2_1 75 80 PF00069 0.701
MOD_NEK2_2 158 163 PF00069 0.568
MOD_NEK2_2 294 299 PF00069 0.450
MOD_PIKK_1 401 407 PF00454 0.656
MOD_PIKK_1 48 54 PF00454 0.729
MOD_PK_1 395 401 PF00069 0.664
MOD_PKA_2 277 283 PF00069 0.549
MOD_PKA_2 369 375 PF00069 0.423
MOD_PKA_2 382 388 PF00069 0.415
MOD_PKA_2 84 90 PF00069 0.578
MOD_Plk_1 141 147 PF00069 0.549
MOD_Plk_1 21 27 PF00069 0.666
MOD_Plk_1 280 286 PF00069 0.465
MOD_Plk_2-3 30 36 PF00069 0.464
MOD_Plk_4 126 132 PF00069 0.654
MOD_Plk_4 21 27 PF00069 0.664
MOD_Plk_4 227 233 PF00069 0.436
MOD_Plk_4 280 286 PF00069 0.438
MOD_Plk_4 335 341 PF00069 0.336
MOD_Plk_4 382 388 PF00069 0.591
MOD_Plk_4 398 404 PF00069 0.573
MOD_Plk_4 70 76 PF00069 0.696
MOD_ProDKin_1 133 139 PF00069 0.717
TRG_DiLeu_BaEn_1 335 340 PF01217 0.352
TRG_ENDOCYTIC_2 15 18 PF00928 0.606
TRG_ENDOCYTIC_2 184 187 PF00928 0.586
TRG_ENDOCYTIC_2 257 260 PF00928 0.401
TRG_ENDOCYTIC_2 337 340 PF00928 0.328
TRG_ER_diArg_1 117 119 PF00400 0.501

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P843 Leptomonas seymouri 79% 100%
A0A0S4JIY4 Bodo saltans 45% 85%
A0A0S4JLP5 Bodo saltans 23% 83%
A0A1X0P137 Trypanosomatidae 53% 94%
A0A3Q8IDU0 Leishmania donovani 97% 100%
A0A422MV93 Trypanosoma rangeli 55% 88%
A4HLN3 Leishmania braziliensis 90% 100%
A4I968 Leishmania infantum 97% 100%
C9ZIW4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 87%
Q4Q415 Leishmania major 95% 100%
V5BLY0 Trypanosoma cruzi 54% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS