Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3Z7_LEIMU

TriTrypDb:

LmxM.32.1600

Length:

887

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3Z7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3Z7

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0009982	pseudouridine synthase activity	4	11
GO:0016853	isomerase activity	2	11
GO:0016866	intramolecular transferase activity	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	655	659	PF00656	0.646
CLV_C14_Caspase3-7	881	885	PF00656	0.609
CLV_MEL_PAP_1	863	869	PF00089	0.476
CLV_NRD_NRD_1	217	219	PF00675	0.522
CLV_NRD_NRD_1	277	279	PF00675	0.677
CLV_NRD_NRD_1	375	377	PF00675	0.476
CLV_NRD_NRD_1	606	608	PF00675	0.558
CLV_NRD_NRD_1	635	637	PF00675	0.411
CLV_NRD_NRD_1	723	725	PF00675	0.690
CLV_PCSK_FUR_1	275	279	PF00082	0.675
CLV_PCSK_KEX2_1	217	219	PF00082	0.522
CLV_PCSK_KEX2_1	275	277	PF00082	0.687
CLV_PCSK_KEX2_1	340	342	PF00082	0.760
CLV_PCSK_KEX2_1	375	377	PF00082	0.476
CLV_PCSK_KEX2_1	546	548	PF00082	0.564
CLV_PCSK_KEX2_1	605	607	PF00082	0.531
CLV_PCSK_KEX2_1	635	637	PF00082	0.559
CLV_PCSK_KEX2_1	723	725	PF00082	0.692
CLV_PCSK_KEX2_1	818	820	PF00082	0.723
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.752
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.564
CLV_PCSK_PC1ET2_1	818	820	PF00082	0.749
CLV_PCSK_SKI1_1	282	286	PF00082	0.561
CLV_PCSK_SKI1_1	421	425	PF00082	0.544
CLV_PCSK_SKI1_1	458	462	PF00082	0.536
CLV_PCSK_SKI1_1	636	640	PF00082	0.630
CLV_PCSK_SKI1_1	662	666	PF00082	0.732
CLV_PCSK_SKI1_1	741	745	PF00082	0.406
CLV_PCSK_SKI1_1	774	778	PF00082	0.674
CLV_PCSK_SKI1_1	821	825	PF00082	0.713
CLV_PCSK_SKI1_1	99	103	PF00082	0.620
CLV_Separin_Metazoa	72	76	PF03568	0.735
DEG_APCC_DBOX_1	457	465	PF00400	0.523
DEG_Nend_UBRbox_1	1	4	PF02207	0.720
DEG_SIAH_1	808	816	PF03145	0.700
DEG_SPOP_SBC_1	80	84	PF00917	0.658
DOC_CDC14_PxL_1	70	78	PF14671	0.736
DOC_CYCLIN_RxL_1	738	748	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	671	677	PF00134	0.549
DOC_MAPK_DCC_7	662	671	PF00069	0.567
DOC_MAPK_MEF2A_6	445	452	PF00069	0.407
DOC_MAPK_MEF2A_6	454	463	PF00069	0.382
DOC_PP2B_LxvP_1	671	674	PF13499	0.589
DOC_PP4_FxxP_1	346	349	PF00568	0.679
DOC_PP4_FxxP_1	527	530	PF00568	0.284
DOC_PP4_FxxP_1	761	764	PF00568	0.574
DOC_PP4_FxxP_1	770	773	PF00568	0.722
DOC_USP7_MATH_1	119	123	PF00917	0.701
DOC_USP7_MATH_1	150	154	PF00917	0.488
DOC_USP7_MATH_1	247	251	PF00917	0.601
DOC_USP7_MATH_1	252	256	PF00917	0.463
DOC_USP7_MATH_1	330	334	PF00917	0.748
DOC_USP7_MATH_1	39	43	PF00917	0.700
DOC_USP7_MATH_1	443	447	PF00917	0.357
DOC_USP7_MATH_1	565	569	PF00917	0.663
DOC_USP7_MATH_1	656	660	PF00917	0.742
DOC_USP7_MATH_1	762	766	PF00917	0.562
DOC_USP7_MATH_1	776	780	PF00917	0.593
DOC_USP7_MATH_1	803	807	PF00917	0.600
DOC_USP7_MATH_1	837	841	PF00917	0.643
DOC_USP7_MATH_1	865	869	PF00917	0.497
DOC_USP7_MATH_2	311	317	PF00917	0.603
DOC_WW_Pin1_4	234	239	PF00397	0.719
DOC_WW_Pin1_4	339	344	PF00397	0.680
DOC_WW_Pin1_4	360	365	PF00397	0.514
DOC_WW_Pin1_4	41	46	PF00397	0.676
DOC_WW_Pin1_4	453	458	PF00397	0.546
DOC_WW_Pin1_4	481	486	PF00397	0.649
DOC_WW_Pin1_4	520	525	PF00397	0.419
DOC_WW_Pin1_4	882	887	PF00397	0.432
LIG_14-3-3_CanoR_1	26	30	PF00244	0.690
LIG_14-3-3_CanoR_1	286	293	PF00244	0.412
LIG_14-3-3_CanoR_1	375	381	PF00244	0.455
LIG_14-3-3_CanoR_1	662	667	PF00244	0.590
LIG_14-3-3_CanoR_1	686	690	PF00244	0.516
LIG_14-3-3_CanoR_1	723	733	PF00244	0.672
LIG_14-3-3_CanoR_1	821	828	PF00244	0.587
LIG_14-3-3_CanoR_1	866	870	PF00244	0.532
LIG_Actin_WH2_2	163	179	PF00022	0.455
LIG_Actin_WH2_2	869	885	PF00022	0.559
LIG_BIR_III_4	469	473	PF00653	0.531
LIG_BRCT_BRCA1_1	700	704	PF00533	0.604
LIG_deltaCOP1_diTrp_1	589	596	PF00928	0.488
LIG_DLG_GKlike_1	376	384	PF00625	0.480
LIG_EVH1_1	131	135	PF00568	0.736
LIG_FHA_1	173	179	PF00498	0.486
LIG_FHA_1	286	292	PF00498	0.486
LIG_FHA_1	454	460	PF00498	0.521
LIG_FHA_1	535	541	PF00498	0.477
LIG_FHA_1	8	14	PF00498	0.653
LIG_FHA_1	822	828	PF00498	0.661
LIG_FHA_2	307	313	PF00498	0.521
LIG_FHA_2	707	713	PF00498	0.413
LIG_FHA_2	786	792	PF00498	0.406
LIG_FHA_2	98	104	PF00498	0.675
LIG_HP1_1	457	461	PF01393	0.531
LIG_LIR_Apic_2	44	50	PF02991	0.715
LIG_LIR_Apic_2	760	764	PF02991	0.569
LIG_LIR_Gen_1	614	625	PF02991	0.403
LIG_LIR_LC3C_4	627	630	PF02991	0.260
LIG_LIR_Nem_3	614	620	PF02991	0.404
LIG_LIR_Nem_3	737	743	PF02991	0.511
LIG_PDZ_Class_1	882	887	PF00595	0.671
LIG_Pex14_1	757	761	PF04695	0.549
LIG_REV1ctd_RIR_1	532	540	PF16727	0.488
LIG_RPA_C_Fungi	175	187	PF08784	0.469
LIG_RPA_C_Fungi	371	383	PF08784	0.347
LIG_RPA_C_Fungi	681	693	PF08784	0.495
LIG_SH2_CRK	490	494	PF00017	0.382
LIG_SH2_NCK_1	549	553	PF00017	0.480
LIG_SH2_NCK_1	679	683	PF00017	0.529
LIG_SH2_PTP2	47	50	PF00017	0.447
LIG_SH2_SRC	47	50	PF00017	0.736
LIG_SH2_SRC	549	552	PF00017	0.466
LIG_SH2_STAP1	264	268	PF00017	0.405
LIG_SH2_STAP1	287	291	PF00017	0.486
LIG_SH2_STAP1	490	494	PF00017	0.382
LIG_SH2_STAP1	549	553	PF00017	0.463
LIG_SH2_STAT5	185	188	PF00017	0.538
LIG_SH2_STAT5	227	230	PF00017	0.663
LIG_SH2_STAT5	287	290	PF00017	0.463
LIG_SH2_STAT5	47	50	PF00017	0.725
LIG_SH2_STAT5	521	524	PF00017	0.513
LIG_SH2_STAT5	679	682	PF00017	0.344
LIG_SH3_1	129	135	PF00018	0.740
LIG_SH3_3	112	118	PF00018	0.457
LIG_SH3_3	129	135	PF00018	0.740
LIG_SH3_3	237	243	PF00018	0.706
LIG_SH3_3	419	425	PF00018	0.498
LIG_SH3_3	527	533	PF00018	0.313
LIG_SH3_3	727	733	PF00018	0.520
LIG_SH3_3	736	742	PF00018	0.554
LIG_Sin3_3	212	219	PF02671	0.446
LIG_SUMO_SIM_par_1	667	672	PF11976	0.642
LIG_SUMO_SIM_par_1	694	699	PF11976	0.580
LIG_SUMO_SIM_par_1	741	746	PF11976	0.494
LIG_TYR_ITIM	488	493	PF00017	0.492
LIG_WRC_WIRS_1	106	111	PF05994	0.637
LIG_WRC_WIRS_1	302	307	PF05994	0.472
MOD_CDC14_SPxK_1	484	487	PF00782	0.599
MOD_CDK_SPK_2	239	244	PF00069	0.594
MOD_CDK_SPK_2	41	46	PF00069	0.724
MOD_CDK_SPK_2	453	458	PF00069	0.546
MOD_CDK_SPxK_1	481	487	PF00069	0.631
MOD_CK1_1	105	111	PF00069	0.646
MOD_CK1_1	355	361	PF00069	0.555
MOD_CK1_1	362	368	PF00069	0.564
MOD_CK1_1	779	785	PF00069	0.563
MOD_CK1_1	82	88	PF00069	0.723
MOD_CK1_1	847	853	PF00069	0.487
MOD_CK2_1	119	125	PF00069	0.491
MOD_CK2_1	306	312	PF00069	0.608
MOD_CK2_1	348	354	PF00069	0.636
MOD_CK2_1	66	72	PF00069	0.795
MOD_CK2_1	699	705	PF00069	0.597
MOD_CK2_1	757	763	PF00069	0.520
MOD_CK2_1	97	103	PF00069	0.650
MOD_CMANNOS	592	595	PF00535	0.512
MOD_Cter_Amidation	633	636	PF01082	0.392
MOD_GlcNHglycan	121	124	PF01048	0.765
MOD_GlcNHglycan	188	191	PF01048	0.585
MOD_GlcNHglycan	230	233	PF01048	0.663
MOD_GlcNHglycan	249	252	PF01048	0.261
MOD_GlcNHglycan	254	257	PF01048	0.495
MOD_GlcNHglycan	266	269	PF01048	0.635
MOD_GlcNHglycan	331	335	PF01048	0.769
MOD_GlcNHglycan	346	349	PF01048	0.540
MOD_GlcNHglycan	364	367	PF01048	0.285
MOD_GlcNHglycan	395	398	PF01048	0.528
MOD_GlcNHglycan	662	665	PF01048	0.736
MOD_GlcNHglycan	671	674	PF01048	0.651
MOD_GlcNHglycan	835	838	PF01048	0.608
MOD_GSK3_1	150	157	PF00069	0.446
MOD_GSK3_1	262	269	PF00069	0.572
MOD_GSK3_1	344	351	PF00069	0.698
MOD_GSK3_1	355	362	PF00069	0.542
MOD_GSK3_1	534	541	PF00069	0.423
MOD_GSK3_1	656	663	PF00069	0.757
MOD_GSK3_1	669	676	PF00069	0.642
MOD_GSK3_1	833	840	PF00069	0.543
MOD_GSK3_1	847	854	PF00069	0.526
MOD_GSK3_1	97	104	PF00069	0.642
MOD_N-GLC_1	142	147	PF02516	0.503
MOD_N-GLC_1	735	740	PF02516	0.649
MOD_N-GLC_1	779	784	PF02516	0.635
MOD_NEK2_1	1	6	PF00069	0.748
MOD_NEK2_1	102	107	PF00069	0.598
MOD_NEK2_1	113	118	PF00069	0.588
MOD_NEK2_1	186	191	PF00069	0.582
MOD_NEK2_1	262	267	PF00069	0.590
MOD_NEK2_1	534	539	PF00069	0.393
MOD_NEK2_1	81	86	PF00069	0.620
MOD_NEK2_1	94	99	PF00069	0.662
MOD_NEK2_2	685	690	PF00069	0.480
MOD_NEK2_2	735	740	PF00069	0.360
MOD_PIKK_1	113	119	PF00454	0.753
MOD_PIKK_1	306	312	PF00454	0.393
MOD_PIKK_1	425	431	PF00454	0.595
MOD_PIKK_1	475	481	PF00454	0.650
MOD_PIKK_1	677	683	PF00454	0.467
MOD_PIKK_1	791	797	PF00454	0.496
MOD_PKA_2	25	31	PF00069	0.638
MOD_PKA_2	252	258	PF00069	0.466
MOD_PKA_2	285	291	PF00069	0.511
MOD_PKA_2	352	358	PF00069	0.548
MOD_PKA_2	685	691	PF00069	0.519
MOD_PKA_2	865	871	PF00069	0.530
MOD_PKB_1	819	827	PF00069	0.678
MOD_Plk_1	102	108	PF00069	0.655
MOD_Plk_1	398	404	PF00069	0.469
MOD_Plk_1	735	741	PF00069	0.636
MOD_Plk_1	779	785	PF00069	0.626
MOD_Plk_2-3	654	660	PF00069	0.458
MOD_Plk_2-3	699	705	PF00069	0.602
MOD_Plk_4	735	741	PF00069	0.574
MOD_Plk_4	779	785	PF00069	0.588
MOD_Plk_4	838	844	PF00069	0.630
MOD_Plk_4	847	853	PF00069	0.551
MOD_ProDKin_1	234	240	PF00069	0.713
MOD_ProDKin_1	339	345	PF00069	0.680
MOD_ProDKin_1	360	366	PF00069	0.552
MOD_ProDKin_1	41	47	PF00069	0.667
MOD_ProDKin_1	453	459	PF00069	0.532
MOD_ProDKin_1	481	487	PF00069	0.637
MOD_ProDKin_1	520	526	PF00069	0.426
MOD_SUMO_rev_2	316	326	PF00179	0.717
TRG_DiLeu_BaLyEn_6	739	744	PF01217	0.527
TRG_ENDOCYTIC_2	490	493	PF00928	0.382
TRG_ER_diArg_1	216	218	PF00400	0.521
TRG_ER_diArg_1	275	278	PF00400	0.678
TRG_ER_diArg_1	374	376	PF00400	0.460
TRG_ER_diArg_1	604	607	PF00400	0.527
TRG_ER_diArg_1	819	822	PF00400	0.580
TRG_NES_CRM1_1	614	627	PF08389	0.405
TRG_NLS_MonoExtN_4	815	822	PF00514	0.698
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.744
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	741	746	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	821	825	PF00026	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E0	Leptomonas seymouri	46%	97%
A0A1X0P134	Trypanosomatidae	26%	100%
A0A3Q8IEW6	Leishmania donovani	87%	99%
A0A3R7KAP3	Trypanosoma rangeli	29%	100%
A4HLM1	Leishmania braziliensis	76%	100%
A4I932	Leishmania infantum	87%	99%
D0A535	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q427	Leishmania major	87%	100%
V5BLS1	Trypanosoma cruzi	29%	100%