LeishMANIAdb
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3-ketodihydrosphingosine reductase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
3-ketodihydrosphingosine reductase
Gene product:
3-ketoacyl-CoA reductase, putative
Species:
Leishmania mexicana
UniProt:
E9B3Z6_LEIMU
TriTrypDb:
LmxM.32.1590
Length:
326

Annotations

LeishMANIAdb annotations

These proteins belong to short-chain dehydrogenases / reductases using NAD or NADP as cofactor. All homologs are used for very long fatty acid biosynthesis.. Expanded in multiple organisms, but especially Strigomonas. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

E9B3Z6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3Z6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0016491 oxidoreductase activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 103 105 PF00675 0.231
CLV_NRD_NRD_1 172 174 PF00675 0.237
CLV_NRD_NRD_1 315 317 PF00675 0.598
CLV_PCSK_SKI1_1 206 210 PF00082 0.455
DOC_CYCLIN_RxL_1 287 299 PF00134 0.328
DOC_CYCLIN_yCln2_LP_2 18 24 PF00134 0.150
DOC_MAPK_gen_1 104 110 PF00069 0.365
DOC_MAPK_gen_1 178 186 PF00069 0.422
DOC_MAPK_gen_1 96 103 PF00069 0.463
DOC_MAPK_MEF2A_6 96 103 PF00069 0.473
DOC_PP1_RVXF_1 289 296 PF00149 0.299
DOC_USP7_MATH_1 177 181 PF00917 0.501
DOC_USP7_MATH_1 246 250 PF00917 0.416
DOC_USP7_MATH_1 253 257 PF00917 0.425
DOC_USP7_UBL2_3 251 255 PF12436 0.360
DOC_WW_Pin1_4 200 205 PF00397 0.240
DOC_WW_Pin1_4 230 235 PF00397 0.223
DOC_WW_Pin1_4 256 261 PF00397 0.326
LIG_14-3-3_CanoR_1 273 277 PF00244 0.262
LIG_APCC_ABBA_1 295 300 PF00400 0.347
LIG_BRCT_BRCA1_1 204 208 PF00533 0.248
LIG_BRCT_BRCA1_1 36 40 PF00533 0.408
LIG_Clathr_ClatBox_1 79 83 PF01394 0.423
LIG_CtBP_PxDLS_1 107 113 PF00389 0.523
LIG_DCNL_PONY_1 1 4 PF03556 0.461
LIG_eIF4E_1 139 145 PF01652 0.434
LIG_FHA_1 123 129 PF00498 0.443
LIG_FHA_1 13 19 PF00498 0.272
LIG_FHA_1 297 303 PF00498 0.319
LIG_FHA_2 146 152 PF00498 0.449
LIG_FHA_2 273 279 PF00498 0.259
LIG_FHA_2 88 94 PF00498 0.423
LIG_LIR_Gen_1 114 122 PF02991 0.523
LIG_LIR_Gen_1 294 302 PF02991 0.291
LIG_LIR_Gen_1 303 313 PF02991 0.296
LIG_LIR_Gen_1 89 99 PF02991 0.425
LIG_LIR_Nem_3 294 298 PF02991 0.293
LIG_LIR_Nem_3 303 308 PF02991 0.298
LIG_LIR_Nem_3 50 55 PF02991 0.444
LIG_LIR_Nem_3 89 94 PF02991 0.425
LIG_LYPXL_yS_3 98 101 PF13949 0.523
LIG_Pex14_2 208 212 PF04695 0.223
LIG_PTB_Apo_2 133 140 PF02174 0.423
LIG_PTB_Phospho_1 133 139 PF10480 0.423
LIG_SH2_GRB2like 307 310 PF00017 0.313
LIG_SH2_SRC 193 196 PF00017 0.277
LIG_SH2_SRC 307 310 PF00017 0.217
LIG_SH2_STAT5 139 142 PF00017 0.432
LIG_SH2_STAT5 14 17 PF00017 0.273
LIG_SH2_STAT5 193 196 PF00017 0.262
LIG_SH2_STAT5 27 30 PF00017 0.249
LIG_SH2_STAT5 3 6 PF00017 0.361
LIG_SH2_STAT5 307 310 PF00017 0.217
LIG_SH3_3 226 232 PF00018 0.228
LIG_SUMO_SIM_anti_2 226 231 PF11976 0.248
LIG_SUMO_SIM_par_1 20 26 PF11976 0.255
LIG_SUMO_SIM_par_1 78 84 PF11976 0.423
LIG_UBA3_1 284 291 PF00899 0.285
LIG_WRC_WIRS_1 183 188 PF05994 0.277
LIG_WRC_WIRS_1 209 214 PF05994 0.201
MOD_CDC14_SPxK_1 203 206 PF00782 0.248
MOD_CDK_SPxK_1 200 206 PF00069 0.248
MOD_CK1_1 211 217 PF00069 0.311
MOD_CK1_1 23 29 PF00069 0.277
MOD_CK1_1 249 255 PF00069 0.376
MOD_CK1_1 256 262 PF00069 0.349
MOD_CK2_1 145 151 PF00069 0.449
MOD_CK2_1 87 93 PF00069 0.423
MOD_GlcNHglycan 110 113 PF01048 0.299
MOD_GlcNHglycan 188 191 PF01048 0.269
MOD_GlcNHglycan 255 258 PF01048 0.562
MOD_GlcNHglycan 269 272 PF01048 0.387
MOD_GlcNHglycan 59 62 PF01048 0.223
MOD_GSK3_1 182 189 PF00069 0.305
MOD_GSK3_1 207 214 PF00069 0.276
MOD_GSK3_1 230 237 PF00069 0.244
MOD_GSK3_1 249 256 PF00069 0.367
MOD_GSK3_1 296 303 PF00069 0.359
MOD_GSK3_1 316 323 PF00069 0.291
MOD_GSK3_1 53 60 PF00069 0.444
MOD_N-GLC_1 108 113 PF02516 0.201
MOD_NEK2_1 12 17 PF00069 0.173
MOD_NEK2_1 186 191 PF00069 0.292
MOD_NEK2_1 208 213 PF00069 0.243
MOD_NEK2_1 87 92 PF00069 0.435
MOD_NEK2_2 197 202 PF00069 0.262
MOD_NEK2_2 246 251 PF00069 0.419
MOD_PIKK_1 120 126 PF00454 0.498
MOD_PKA_1 316 322 PF00069 0.423
MOD_PKA_2 177 183 PF00069 0.530
MOD_PKA_2 272 278 PF00069 0.262
MOD_PKB_1 314 322 PF00069 0.348
MOD_Plk_4 197 203 PF00069 0.271
MOD_Plk_4 20 26 PF00069 0.211
MOD_Plk_4 272 278 PF00069 0.282
MOD_Plk_4 3 9 PF00069 0.350
MOD_ProDKin_1 200 206 PF00069 0.240
MOD_ProDKin_1 230 236 PF00069 0.223
MOD_ProDKin_1 256 262 PF00069 0.326
TRG_ENDOCYTIC_2 115 118 PF00928 0.523
TRG_ENDOCYTIC_2 5 8 PF00928 0.347
TRG_ENDOCYTIC_2 98 101 PF00928 0.523
TRG_ER_diArg_1 313 316 PF00400 0.379

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HTS4 Leptomonas seymouri 81% 100%
A0A0N1I6F8 Leptomonas seymouri 31% 100%
A0A0S4IWL0 Bodo saltans 32% 100%
A0A0S4JBE7 Bodo saltans 31% 100%
A0A0S4JNE8 Bodo saltans 62% 100%
A0A0S4JSF1 Bodo saltans 26% 81%
A0A1L5BU05 Sphingobium indicum (strain DSM 16412 / CCM 7286 / MTCC 6364 / B90A) 26% 100%
A0A1X0NKR7 Trypanosomatidae 27% 88%
A0A1X0NWL8 Trypanosomatidae 31% 100%
A0A1X0P1C4 Trypanosomatidae 63% 100%
A0A3Q8IE20 Leishmania donovani 31% 100%
A0A3Q8IHN8 Leishmania donovani 26% 96%
A0A3Q8IIU6 Leishmania donovani 26% 100%
A0A3S7X6T1 Leishmania donovani 92% 100%
A0A422NG64 Trypanosoma rangeli 61% 100%
A0A422NJG3 Trypanosoma rangeli 31% 100%
A1C6J8 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 28% 94%
A1DH66 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 26% 94%
A2QCH3 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 26% 94%
A3LXZ3 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 28% 94%
A4ECA9 Collinsella aerofaciens (strain ATCC 25986 / DSM 3979 / JCM 10188 / KCTC 3647 / NCTC 11838 / VPI 1003) 28% 100%
A4HAC6 Leishmania braziliensis 28% 100%
A4HLM0 Leishmania braziliensis 86% 100%
A4HM71 Leishmania braziliensis 28% 100%
A4HME4 Leishmania braziliensis 26% 100%
A4I931 Leishmania infantum 92% 100%
A4I9G9 Leishmania infantum 28% 100%
A4IAT4 Leishmania infantum 26% 96%
A4IB16 Leishmania infantum 26% 100%
A5DND6 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 28% 96%
A5E0R1 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 27% 93%
A6RBW9 Ajellomyces capsulatus (strain NAm1 / WU24) 29% 96%
A6SG70 Botryotinia fuckeliana (strain B05.10) 30% 98%
A6ZLA1 Saccharomyces cerevisiae (strain YJM789) 25% 94%
A7B4V1 Ruminococcus gnavus (strain ATCC 29149 / VPI C7-9) 26% 100%
A7F8T1 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 29% 98%
A8Q1U2 Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) 23% 100%
B0XSI3 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 26% 94%
B2WMJ3 Pyrenophora tritici-repentis (strain Pt-1C-BFP) 27% 96%
B3LN00 Saccharomyces cerevisiae (strain RM11-1a) 25% 94%
C9ZNQ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
D0A2C4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 94%
D0A534 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 100%
D3U1D9 Klebsiella oxytoca 26% 100%
D4Z260 Sphingobium japonicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S) 26% 100%
E9AEL0 Leishmania major 26% 100%
E9B4G7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B5S1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 96%
E9B601 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
F4JZN6 Arabidopsis thaliana 25% 98%
G4N286 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 25% 100%
G9FRD6 Clostridium sardiniense 24% 100%
M2ZIX7 Pseudocercospora fijiensis (strain CIRAD86) 30% 100%
O17795 Caenorhabditis elegans 24% 100%
O42866 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 100%
O57314 Anas platyrhynchos 29% 100%
O70503 Mus musculus 30% 100%
P0AFP4 Escherichia coli (strain K12) 26% 100%
P0AFP5 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 26% 100%
P38286 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 94%
P54554 Bacillus subtilis (strain 168) 24% 100%
Q06136 Homo sapiens 27% 98%
Q10130 Caenorhabditis elegans 24% 86%
Q17703 Caenorhabditis elegans 23% 100%
Q28IU1 Xenopus tropicalis 31% 100%
Q2KIJ5 Bos taurus 27% 98%
Q2UET3 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 27% 94%
Q3SXM5 Homo sapiens 30% 99%
Q3T0R4 Bos taurus 26% 100%
Q4JK73 Macaca fascicularis 27% 100%
Q4P622 Ustilago maydis (strain 521 / FGSC 9021) 24% 93%
Q4Q3K8 Leishmania major 29% 100%
Q4Q428 Leishmania major 90% 100%
Q4R5G7 Macaca fascicularis 32% 100%
Q4X117 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 26% 94%
Q53GQ0 Homo sapiens 33% 100%
Q556J2 Dictyostelium discoideum 24% 98%
Q566S6 Danio rerio 25% 100%
Q5E9H7 Bos taurus 31% 100%
Q5HLD8 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 25% 100%
Q5R6U1 Pongo abelii 27% 100%
Q5RJY4 Rattus norvegicus 27% 100%
Q5XG41 Xenopus laevis 31% 100%
Q6BIG0 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 29% 94%
Q6BQK1 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 21% 99%
Q6CHP1 Yarrowia lipolytica (strain CLIB 122 / E 150) 25% 84%
Q6CVS4 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 25% 94%
Q6GV12 Mus musculus 26% 98%
Q6IAN0 Homo sapiens 27% 100%
Q6P3L6 Danio rerio 28% 100%
Q6P7R8 Rattus norvegicus 33% 100%
Q6QA32 Danio rerio 26% 100%
Q6QA33 Danio rerio 30% 100%
Q75A60 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 29% 93%
Q7Q732 Anopheles gambiae 25% 100%
Q8AVY8 Xenopus laevis 31% 100%
Q8CN40 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 25% 100%
Q988B7 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) 24% 100%
Q99J47 Mus musculus 26% 100%
Q9FYL6 Arabidopsis thaliana 28% 100%
R9UAM1 Ruminococcus gnavus 26% 100%
V5B376 Trypanosoma cruzi 29% 96%
V5B6S6 Trypanosoma cruzi 31% 100%
V5BCN8 Trypanosoma cruzi 61% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS