Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3Z4_LEIMU

TriTrypDb:

LmxM.32.1575

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3Z4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.504
CLV_NRD_NRD_1	463	465	PF00675	0.648
CLV_NRD_NRD_1	468	470	PF00675	0.647
CLV_NRD_NRD_1	488	490	PF00675	0.530
CLV_NRD_NRD_1	497	499	PF00675	0.473
CLV_PCSK_KEX2_1	15	17	PF00082	0.648
CLV_PCSK_KEX2_1	463	465	PF00082	0.648
CLV_PCSK_KEX2_1	468	470	PF00082	0.647
CLV_PCSK_KEX2_1	497	499	PF00082	0.503
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.598
CLV_PCSK_PC7_1	464	470	PF00082	0.473
CLV_PCSK_SKI1_1	303	307	PF00082	0.483
CLV_PCSK_SKI1_1	42	46	PF00082	0.632
CLV_PCSK_SKI1_1	444	448	PF00082	0.361
CLV_PCSK_SKI1_1	458	462	PF00082	0.455
CLV_PCSK_SKI1_1	85	89	PF00082	0.445
DEG_MDM2_SWIB_1	157	164	PF02201	0.487
DEG_Nend_UBRbox_3	1	3	PF02207	0.540
DEG_SCF_TRCP1_1	278	283	PF00400	0.468
DEG_SPOP_SBC_1	167	171	PF00917	0.622
DEG_SPOP_SBC_1	44	48	PF00917	0.629
DOC_CKS1_1	208	213	PF01111	0.452
DOC_CKS1_1	58	63	PF01111	0.421
DOC_CYCLIN_RxL_1	384	392	PF00134	0.354
DOC_CYCLIN_RxL_1	440	450	PF00134	0.389
DOC_MAPK_DCC_7	425	433	PF00069	0.425
DOC_MAPK_MEF2A_6	425	433	PF00069	0.586
DOC_PP2B_LxvP_1	11	14	PF13499	0.417
DOC_PP2B_LxvP_1	328	331	PF13499	0.503
DOC_PP4_FxxP_1	58	61	PF00568	0.563
DOC_USP7_MATH_1	144	148	PF00917	0.378
DOC_USP7_MATH_1	167	171	PF00917	0.573
DOC_USP7_MATH_1	256	260	PF00917	0.443
DOC_USP7_MATH_1	37	41	PF00917	0.595
DOC_USP7_MATH_1	44	48	PF00917	0.585
DOC_USP7_MATH_1	5	9	PF00917	0.419
DOC_USP7_MATH_1	54	58	PF00917	0.593
DOC_USP7_MATH_1	70	74	PF00917	0.418
DOC_USP7_UBL2_3	126	130	PF12436	0.462
DOC_WW_Pin1_4	207	212	PF00397	0.404
DOC_WW_Pin1_4	339	344	PF00397	0.310
DOC_WW_Pin1_4	381	386	PF00397	0.351
DOC_WW_Pin1_4	432	437	PF00397	0.467
DOC_WW_Pin1_4	468	473	PF00397	0.669
DOC_WW_Pin1_4	57	62	PF00397	0.672
DOC_WW_Pin1_4	79	84	PF00397	0.622
LIG_14-3-3_CanoR_1	232	240	PF00244	0.549
LIG_14-3-3_CanoR_1	387	392	PF00244	0.444
LIG_14-3-3_CanoR_1	42	51	PF00244	0.695
LIG_14-3-3_CanoR_1	489	499	PF00244	0.508
LIG_14-3-3_CanoR_1	507	513	PF00244	0.617
LIG_14-3-3_CanoR_1	74	80	PF00244	0.482
LIG_BRCT_BRCA1_1	153	157	PF00533	0.411
LIG_BRCT_BRCA1_1	47	51	PF00533	0.665
LIG_DLG_GKlike_1	387	394	PF00625	0.431
LIG_FHA_1	213	219	PF00498	0.389
LIG_FHA_1	250	256	PF00498	0.405
LIG_FHA_1	325	331	PF00498	0.593
LIG_FHA_1	370	376	PF00498	0.418
LIG_FHA_1	397	403	PF00498	0.506
LIG_FHA_1	424	430	PF00498	0.550
LIG_FHA_2	294	300	PF00498	0.495
LIG_FHA_2	481	487	PF00498	0.649
LIG_LIR_Apic_2	266	271	PF02991	0.477
LIG_LIR_Apic_2	55	61	PF02991	0.438
LIG_LIR_Gen_1	344	354	PF02991	0.378
LIG_LIR_Nem_3	344	350	PF02991	0.384
LIG_LIR_Nem_3	8	13	PF02991	0.455
LIG_LIR_Nem_3	94	99	PF02991	0.385
LIG_MYND_3	203	207	PF01753	0.297
LIG_NRBOX	442	448	PF00104	0.350
LIG_Pex14_1	95	99	PF04695	0.341
LIG_Pex14_2	157	161	PF04695	0.479
LIG_Pex14_2	257	261	PF04695	0.323
LIG_Pex14_2	71	75	PF04695	0.523
LIG_SH2_STAT5	404	407	PF00017	0.370
LIG_SH2_STAT5	99	102	PF00017	0.400
LIG_SH3_3	337	343	PF00018	0.347
LIG_SH3_3	380	386	PF00018	0.519
LIG_SH3_3	430	436	PF00018	0.485
LIG_SUMO_SIM_par_1	204	210	PF11976	0.378
LIG_TRAF2_1	296	299	PF00917	0.443
LIG_TRAF2_1	343	346	PF00917	0.451
LIG_TRAF2_2	343	348	PF00917	0.391
LIG_WW_3	384	388	PF00397	0.432
MOD_CDC14_SPxK_1	384	387	PF00782	0.316
MOD_CDC14_SPxK_1	82	85	PF00782	0.494
MOD_CDK_SPxK_1	381	387	PF00069	0.341
MOD_CDK_SPxK_1	79	85	PF00069	0.484
MOD_CK1_1	108	114	PF00069	0.473
MOD_CK1_1	170	176	PF00069	0.545
MOD_CK1_1	186	192	PF00069	0.541
MOD_CK1_1	235	241	PF00069	0.578
MOD_CK1_1	368	374	PF00069	0.612
MOD_CK1_1	435	441	PF00069	0.486
MOD_CK1_1	47	53	PF00069	0.628
MOD_CK1_1	473	479	PF00069	0.638
MOD_CK1_1	480	486	PF00069	0.643
MOD_CK1_1	57	63	PF00069	0.462
MOD_CK1_1	73	79	PF00069	0.569
MOD_CK2_1	293	299	PF00069	0.433
MOD_CK2_1	447	453	PF00069	0.635
MOD_CK2_1	480	486	PF00069	0.680
MOD_CK2_1	497	503	PF00069	0.354
MOD_DYRK1A_RPxSP_1	432	436	PF00069	0.461
MOD_GlcNHglycan	118	121	PF01048	0.685
MOD_GlcNHglycan	188	191	PF01048	0.594
MOD_GlcNHglycan	234	237	PF01048	0.521
MOD_GlcNHglycan	24	27	PF01048	0.627
MOD_GlcNHglycan	265	268	PF01048	0.465
MOD_GlcNHglycan	271	274	PF01048	0.570
MOD_GlcNHglycan	278	281	PF01048	0.612
MOD_GlcNHglycan	282	285	PF01048	0.642
MOD_GlcNHglycan	368	371	PF01048	0.542
MOD_GlcNHglycan	39	42	PF01048	0.484
MOD_GlcNHglycan	47	50	PF01048	0.564
MOD_GlcNHglycan	472	475	PF01048	0.745
MOD_GlcNHglycan	479	482	PF01048	0.674
MOD_GlcNHglycan	52	55	PF01048	0.721
MOD_GlcNHglycan	75	78	PF01048	0.560
MOD_GSK3_1	108	115	PF00069	0.539
MOD_GSK3_1	118	125	PF00069	0.660
MOD_GSK3_1	159	166	PF00069	0.495
MOD_GSK3_1	167	174	PF00069	0.623
MOD_GSK3_1	231	238	PF00069	0.501
MOD_GSK3_1	245	252	PF00069	0.590
MOD_GSK3_1	276	283	PF00069	0.670
MOD_GSK3_1	289	296	PF00069	0.604
MOD_GSK3_1	365	372	PF00069	0.673
MOD_GSK3_1	43	50	PF00069	0.629
MOD_GSK3_1	442	449	PF00069	0.525
MOD_GSK3_1	473	480	PF00069	0.629
MOD_GSK3_1	52	59	PF00069	0.462
MOD_N-GLC_1	289	294	PF02516	0.649
MOD_N-GLC_1	324	329	PF02516	0.506
MOD_N-GLC_1	396	401	PF02516	0.390
MOD_NEK2_1	151	156	PF00069	0.367
MOD_NEK2_1	188	193	PF00069	0.446
MOD_NEK2_1	219	224	PF00069	0.446
MOD_NEK2_1	324	329	PF00069	0.468
MOD_NEK2_1	375	380	PF00069	0.417
MOD_NEK2_1	389	394	PF00069	0.385
MOD_NEK2_1	415	420	PF00069	0.530
MOD_NEK2_1	446	451	PF00069	0.606
MOD_PIKK_1	341	347	PF00454	0.451
MOD_PIKK_1	59	65	PF00454	0.482
MOD_PKA_1	497	503	PF00069	0.494
MOD_PKA_2	183	189	PF00069	0.547
MOD_PKA_2	231	237	PF00069	0.557
MOD_PKA_2	269	275	PF00069	0.563
MOD_PKA_2	497	503	PF00069	0.500
MOD_PKA_2	506	512	PF00069	0.604
MOD_PKA_2	73	79	PF00069	0.462
MOD_Plk_1	245	251	PF00069	0.487
MOD_Plk_1	452	458	PF00069	0.630
MOD_Plk_1	85	91	PF00069	0.456
MOD_Plk_4	152	158	PF00069	0.370
MOD_Plk_4	183	189	PF00069	0.591
MOD_Plk_4	256	262	PF00069	0.357
MOD_ProDKin_1	207	213	PF00069	0.401
MOD_ProDKin_1	339	345	PF00069	0.311
MOD_ProDKin_1	381	387	PF00069	0.350
MOD_ProDKin_1	432	438	PF00069	0.468
MOD_ProDKin_1	468	474	PF00069	0.669
MOD_ProDKin_1	57	63	PF00069	0.670
MOD_ProDKin_1	79	85	PF00069	0.624
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.376
TRG_ER_diArg_1	496	498	PF00400	0.485
TRG_NES_CRM1_1	304	319	PF08389	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U7	Leptomonas seymouri	49%	100%
A0A1X0P266	Trypanosomatidae	23%	100%
A0A3Q8IHT9	Leishmania donovani	89%	100%
A0A3R7LW25	Trypanosoma rangeli	29%	100%
A4HLL8	Leishmania braziliensis	76%	100%
A4I929	Leishmania infantum	89%	100%
D0A532	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4Q430	Leishmania major	87%	100%
V5DDH0	Trypanosoma cruzi	27%	100%