LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B3Z1_LEIMU
TriTrypDb:
LmxM.32.1550
Length:
328

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3Z1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3Z1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 36 40 PF00656 0.341
CLV_NRD_NRD_1 209 211 PF00675 0.415
CLV_NRD_NRD_1 47 49 PF00675 0.462
CLV_PCSK_KEX2_1 46 48 PF00082 0.457
CLV_PCSK_SKI1_1 302 306 PF00082 0.420
CLV_PCSK_SKI1_1 38 42 PF00082 0.490
DEG_Nend_UBRbox_1 1 4 PF02207 0.557
DEG_SCF_FBW7_1 168 175 PF00400 0.543
DEG_SCF_FBW7_1 229 236 PF00400 0.434
DEG_SPOP_SBC_1 167 171 PF00917 0.601
DEG_SPOP_SBC_1 172 176 PF00917 0.538
DEG_SPOP_SBC_1 84 88 PF00917 0.727
DOC_MAPK_gen_1 210 217 PF00069 0.505
DOC_MAPK_gen_1 246 256 PF00069 0.630
DOC_PP4_FxxP_1 52 55 PF00568 0.423
DOC_USP7_MATH_1 166 170 PF00917 0.589
DOC_USP7_MATH_1 172 176 PF00917 0.714
DOC_USP7_MATH_1 179 183 PF00917 0.360
DOC_USP7_MATH_1 258 262 PF00917 0.599
DOC_USP7_MATH_1 79 83 PF00917 0.677
DOC_WW_Pin1_4 168 173 PF00397 0.561
DOC_WW_Pin1_4 229 234 PF00397 0.442
DOC_WW_Pin1_4 272 277 PF00397 0.599
DOC_WW_Pin1_4 69 74 PF00397 0.766
DOC_WW_Pin1_4 85 90 PF00397 0.588
DOC_WW_Pin1_4 99 104 PF00397 0.403
LIG_14-3-3_CanoR_1 126 132 PF00244 0.395
LIG_14-3-3_CanoR_1 148 156 PF00244 0.561
LIG_14-3-3_CanoR_1 214 218 PF00244 0.445
LIG_14-3-3_CanoR_1 249 257 PF00244 0.551
LIG_14-3-3_CanoR_1 308 317 PF00244 0.453
LIG_Actin_WH2_2 181 199 PF00022 0.429
LIG_BIR_III_4 296 300 PF00653 0.522
LIG_BRCT_BRCA1_1 174 178 PF00533 0.505
LIG_BRCT_BRCA1_1 273 277 PF00533 0.641
LIG_FHA_1 85 91 PF00498 0.559
LIG_FHA_2 11 17 PF00498 0.379
LIG_FHA_2 178 184 PF00498 0.487
LIG_FHA_2 230 236 PF00498 0.582
LIG_FHA_2 34 40 PF00498 0.329
LIG_FHA_2 64 70 PF00498 0.657
LIG_LIR_Apic_2 314 319 PF02991 0.464
LIG_LIR_Apic_2 49 55 PF02991 0.405
LIG_LIR_Gen_1 23 31 PF02991 0.462
LIG_LIR_Gen_1 59 65 PF02991 0.637
LIG_LIR_Nem_3 23 28 PF02991 0.460
LIG_LIR_Nem_3 261 267 PF02991 0.582
LIG_MLH1_MIPbox_1 174 178 PF16413 0.566
LIG_PCNA_yPIPBox_3 114 126 PF02747 0.465
LIG_SH2_STAT5 177 180 PF00017 0.664
LIG_SH2_STAT5 25 28 PF00017 0.600
LIG_SH2_STAT5 316 319 PF00017 0.410
LIG_SH3_2 288 293 PF14604 0.599
LIG_SH3_3 153 159 PF00018 0.591
LIG_SH3_3 285 291 PF00018 0.603
LIG_UBA3_1 206 211 PF00899 0.473
LIG_WRC_WIRS_1 11 16 PF05994 0.383
LIG_WRC_WIRS_1 301 306 PF05994 0.461
MOD_CDK_SPxxK_3 272 279 PF00069 0.546
MOD_CK1_1 102 108 PF00069 0.462
MOD_CK1_1 125 131 PF00069 0.398
MOD_CK1_1 182 188 PF00069 0.381
MOD_CK1_1 272 278 PF00069 0.741
MOD_CK2_1 10 16 PF00069 0.382
MOD_CK2_1 177 183 PF00069 0.504
MOD_CK2_1 26 32 PF00069 0.408
MOD_CK2_1 263 269 PF00069 0.614
MOD_CK2_1 300 306 PF00069 0.470
MOD_CK2_1 63 69 PF00069 0.650
MOD_GlcNHglycan 220 223 PF01048 0.506
MOD_GlcNHglycan 224 227 PF01048 0.545
MOD_GlcNHglycan 271 274 PF01048 0.601
MOD_GlcNHglycan 28 31 PF01048 0.380
MOD_GSK3_1 167 174 PF00069 0.677
MOD_GSK3_1 218 225 PF00069 0.502
MOD_GSK3_1 229 236 PF00069 0.581
MOD_GSK3_1 248 255 PF00069 0.468
MOD_GSK3_1 259 266 PF00069 0.512
MOD_GSK3_1 268 275 PF00069 0.537
MOD_GSK3_1 65 72 PF00069 0.713
MOD_GSK3_1 75 82 PF00069 0.649
MOD_GSK3_1 85 92 PF00069 0.521
MOD_NEK2_1 202 207 PF00069 0.483
MOD_NEK2_1 218 223 PF00069 0.453
MOD_NEK2_1 228 233 PF00069 0.574
MOD_NEK2_1 259 264 PF00069 0.599
MOD_NEK2_2 10 15 PF00069 0.378
MOD_PIKK_1 125 131 PF00454 0.432
MOD_PIKK_1 33 39 PF00454 0.404
MOD_PK_1 197 203 PF00069 0.373
MOD_PKA_2 125 131 PF00069 0.398
MOD_PKA_2 147 153 PF00069 0.535
MOD_PKA_2 213 219 PF00069 0.478
MOD_PKA_2 248 254 PF00069 0.584
MOD_Plk_1 182 188 PF00069 0.439
MOD_Plk_2-3 65 71 PF00069 0.616
MOD_Plk_4 173 179 PF00069 0.509
MOD_Plk_4 197 203 PF00069 0.356
MOD_Plk_4 20 26 PF00069 0.465
MOD_Plk_4 213 219 PF00069 0.482
MOD_Plk_4 239 245 PF00069 0.592
MOD_Plk_4 252 258 PF00069 0.659
MOD_Plk_4 300 306 PF00069 0.467
MOD_ProDKin_1 168 174 PF00069 0.562
MOD_ProDKin_1 229 235 PF00069 0.439
MOD_ProDKin_1 272 278 PF00069 0.599
MOD_ProDKin_1 69 75 PF00069 0.769
MOD_ProDKin_1 85 91 PF00069 0.587
MOD_ProDKin_1 99 105 PF00069 0.399
TRG_DiLeu_BaEn_1 16 21 PF01217 0.391
TRG_DiLeu_BaEn_1 320 325 PF01217 0.381
TRG_ENDOCYTIC_2 25 28 PF00928 0.467
TRG_ER_diArg_1 46 48 PF00400 0.460

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2U9 Leptomonas seymouri 46% 99%
A0A3S7X6T2 Leishmania donovani 92% 100%
A4HLL5 Leishmania braziliensis 80% 100%
A4I926 Leishmania infantum 93% 100%
Q4Q433 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS