A small protein consisting of 2+2 helical bundles, very conserved in Eukaryota. Might have an N-terminal transit signal.. Localization: Mitochondrial (by feature)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 13 |
| NetGPI | no | yes: 0, no: 13 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 14 |
| GO:0110165 | cellular anatomical entity | 1 | 14 |
| GO:0005737 | cytoplasm | 2 | 1 |
| GO:0005794 | Golgi apparatus | 5 | 1 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043227 | membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 1 |
Related structures:
AlphaFold database: E9B3Y8
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 85 | 89 | PF00656 | 0.442 |
| CLV_NRD_NRD_1 | 140 | 142 | PF00675 | 0.267 |
| CLV_NRD_NRD_1 | 186 | 188 | PF00675 | 0.357 |
| CLV_NRD_NRD_1 | 192 | 194 | PF00675 | 0.316 |
| CLV_NRD_NRD_1 | 22 | 24 | PF00675 | 0.237 |
| CLV_NRD_NRD_1 | 95 | 97 | PF00675 | 0.266 |
| CLV_NRD_NRD_1 | 99 | 101 | PF00675 | 0.239 |
| CLV_PCSK_KEX2_1 | 186 | 188 | PF00082 | 0.357 |
| CLV_PCSK_KEX2_1 | 194 | 196 | PF00082 | 0.286 |
| CLV_PCSK_KEX2_1 | 95 | 97 | PF00082 | 0.226 |
| CLV_PCSK_PC1ET2_1 | 194 | 196 | PF00082 | 0.331 |
| CLV_PCSK_SKI1_1 | 23 | 27 | PF00082 | 0.386 |
| CLV_Separin_Metazoa | 20 | 24 | PF03568 | 0.417 |
| DEG_Nend_Nbox_1 | 1 | 3 | PF02207 | 0.570 |
| DOC_CKS1_1 | 58 | 63 | PF01111 | 0.166 |
| DOC_MAPK_gen_1 | 98 | 108 | PF00069 | 0.468 |
| DOC_MAPK_MEF2A_6 | 121 | 128 | PF00069 | 0.328 |
| DOC_PP1_RVXF_1 | 119 | 126 | PF00149 | 0.237 |
| DOC_PP1_RVXF_1 | 24 | 31 | PF00149 | 0.417 |
| DOC_PP2B_LxvP_1 | 34 | 37 | PF13499 | 0.453 |
| DOC_USP7_MATH_1 | 182 | 186 | PF00917 | 0.505 |
| DOC_USP7_UBL2_3 | 153 | 157 | PF12436 | 0.539 |
| DOC_USP7_UBL2_3 | 202 | 206 | PF12436 | 0.494 |
| DOC_WW_Pin1_4 | 57 | 62 | PF00397 | 0.271 |
| LIG_Actin_RPEL_3 | 93 | 112 | PF02755 | 0.417 |
| LIG_APCC_ABBA_1 | 113 | 118 | PF00400 | 0.219 |
| LIG_Clathr_ClatBox_1 | 114 | 118 | PF01394 | 0.171 |
| LIG_EH1_1 | 107 | 115 | PF00400 | 0.242 |
| LIG_FHA_1 | 49 | 55 | PF00498 | 0.309 |
| LIG_FHA_2 | 142 | 148 | PF00498 | 0.539 |
| LIG_LIR_Gen_1 | 11 | 21 | PF02991 | 0.437 |
| LIG_LIR_Gen_1 | 122 | 133 | PF02991 | 0.359 |
| LIG_LIR_Gen_1 | 40 | 50 | PF02991 | 0.501 |
| LIG_LIR_Gen_1 | 66 | 73 | PF02991 | 0.404 |
| LIG_LIR_Nem_3 | 11 | 16 | PF02991 | 0.520 |
| LIG_LIR_Nem_3 | 122 | 128 | PF02991 | 0.355 |
| LIG_LIR_Nem_3 | 40 | 46 | PF02991 | 0.517 |
| LIG_LIR_Nem_3 | 60 | 65 | PF02991 | 0.330 |
| LIG_LIR_Nem_3 | 66 | 70 | PF02991 | 0.357 |
| LIG_NRBOX | 101 | 107 | PF00104 | 0.535 |
| LIG_Pex14_1 | 9 | 13 | PF04695 | 0.448 |
| LIG_Pex14_2 | 63 | 67 | PF04695 | 0.316 |
| LIG_PTB_Apo_2 | 56 | 63 | PF02174 | 0.331 |
| LIG_SH2_CRK | 58 | 62 | PF00017 | 0.298 |
| LIG_SH2_CRK | 99 | 103 | PF00017 | 0.454 |
| LIG_SH2_NCK_1 | 58 | 62 | PF00017 | 0.185 |
| LIG_SH2_PTP2 | 43 | 46 | PF00017 | 0.305 |
| LIG_SH2_SRC | 172 | 175 | PF00017 | 0.596 |
| LIG_SH2_SRC | 43 | 46 | PF00017 | 0.270 |
| LIG_SH2_STAP1 | 161 | 165 | PF00017 | 0.505 |
| LIG_SH2_STAP1 | 39 | 43 | PF00017 | 0.480 |
| LIG_SH2_STAT5 | 145 | 148 | PF00017 | 0.563 |
| LIG_SH2_STAT5 | 172 | 175 | PF00017 | 0.573 |
| LIG_SH2_STAT5 | 43 | 46 | PF00017 | 0.310 |
| LIG_SH2_STAT5 | 48 | 51 | PF00017 | 0.304 |
| LIG_SH3_3 | 47 | 53 | PF00018 | 0.345 |
| LIG_SUMO_SIM_anti_2 | 66 | 72 | PF11976 | 0.379 |
| LIG_SUMO_SIM_par_1 | 69 | 75 | PF11976 | 0.380 |
| LIG_TYR_ITIM | 97 | 102 | PF00017 | 0.453 |
| LIG_UBA3_1 | 72 | 81 | PF00899 | 0.306 |
| LIG_WRC_WIRS_1 | 64 | 69 | PF05994 | 0.254 |
| MOD_Cter_Amidation | 93 | 96 | PF01082 | 0.179 |
| MOD_N-GLC_2 | 130 | 132 | PF02516 | 0.270 |
| MOD_NEK2_1 | 63 | 68 | PF00069 | 0.311 |
| MOD_PKA_1 | 141 | 147 | PF00069 | 0.510 |
| MOD_PKA_1 | 80 | 86 | PF00069 | 0.555 |
| MOD_Plk_4 | 141 | 147 | PF00069 | 0.552 |
| MOD_Plk_4 | 63 | 69 | PF00069 | 0.404 |
| MOD_Plk_4 | 86 | 92 | PF00069 | 0.483 |
| MOD_ProDKin_1 | 57 | 63 | PF00069 | 0.271 |
| MOD_SUMO_for_1 | 201 | 204 | PF00179 | 0.501 |
| MOD_SUMO_rev_2 | 190 | 196 | PF00179 | 0.532 |
| TRG_DiLeu_BaLyEn_6 | 50 | 55 | PF01217 | 0.279 |
| TRG_ENDOCYTIC_2 | 43 | 46 | PF00928 | 0.296 |
| TRG_ENDOCYTIC_2 | 99 | 102 | PF00928 | 0.465 |
| TRG_ER_diArg_1 | 193 | 196 | PF00400 | 0.539 |
| TRG_ER_diArg_1 | 95 | 98 | PF00400 | 0.490 |
| TRG_NLS_MonoExtC_3 | 79 | 85 | PF00514 | 0.417 |
| TRG_NLS_MonoExtN_4 | 77 | 84 | PF00514 | 0.512 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0S4JEM7 | Bodo saltans | 26% | 99% |
| A0A1X0P0Z7 | Trypanosomatidae | 26% | 98% |
| A0A1X0P100 | Trypanosomatidae | 46% | 78% |
| A0A3Q8IK58 | Leishmania donovani | 95% | 100% |
| A0A3R7ML24 | Trypanosoma rangeli | 26% | 100% |
| A0A422NG43 | Trypanosoma rangeli | 46% | 70% |
| A4HLL2 | Leishmania braziliensis | 82% | 100% |
| A4HLL3 | Leishmania braziliensis | 24% | 91% |
| D0A526 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 33% | 91% |
| E9AHN5 | Leishmania infantum | 95% | 100% |
| E9B3Y9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 24% | 100% |
| Q4Q436 | Leishmania major | 89% | 100% |