Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3Y7_LEIMU

TriTrypDb:

LmxM.32.1510

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3Y7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.381
CLV_C14_Caspase3-7	421	425	PF00656	0.443
CLV_C14_Caspase3-7	468	472	PF00656	0.392
CLV_NRD_NRD_1	181	183	PF00675	0.506
CLV_NRD_NRD_1	214	216	PF00675	0.570
CLV_NRD_NRD_1	309	311	PF00675	0.579
CLV_NRD_NRD_1	333	335	PF00675	0.431
CLV_NRD_NRD_1	438	440	PF00675	0.447
CLV_PCSK_KEX2_1	180	182	PF00082	0.507
CLV_PCSK_KEX2_1	213	215	PF00082	0.563
CLV_PCSK_KEX2_1	309	311	PF00082	0.583
CLV_PCSK_KEX2_1	333	335	PF00082	0.431
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.507
CLV_PCSK_PC7_1	176	182	PF00082	0.509
CLV_PCSK_SKI1_1	131	135	PF00082	0.649
CLV_PCSK_SKI1_1	150	154	PF00082	0.485
CLV_PCSK_SKI1_1	181	185	PF00082	0.544
CLV_PCSK_SKI1_1	326	330	PF00082	0.557
CLV_PCSK_SKI1_1	503	507	PF00082	0.419
CLV_Separin_Metazoa	210	214	PF03568	0.545
CLV_Separin_Metazoa	436	440	PF03568	0.450
DEG_Nend_UBRbox_1	1	4	PF02207	0.504
DEG_SPOP_SBC_1	481	485	PF00917	0.648
DOC_CDC14_PxL_1	156	164	PF14671	0.573
DOC_CYCLIN_RxL_1	339	350	PF00134	0.453
DOC_CYCLIN_RxL_1	368	378	PF00134	0.398
DOC_MAPK_gen_1	372	381	PF00069	0.410
DOC_MAPK_MEF2A_6	2	9	PF00069	0.468
DOC_MAPK_MEF2A_6	375	383	PF00069	0.401
DOC_PP2B_LxvP_1	25	28	PF13499	0.581
DOC_USP7_MATH_1	107	111	PF00917	0.622
DOC_USP7_MATH_1	126	130	PF00917	0.492
DOC_USP7_MATH_1	187	191	PF00917	0.574
DOC_USP7_MATH_1	28	32	PF00917	0.717
DOC_USP7_MATH_1	42	46	PF00917	0.485
DOC_USP7_MATH_1	482	486	PF00917	0.652
DOC_USP7_MATH_1	596	600	PF00917	0.543
DOC_USP7_MATH_1	88	92	PF00917	0.471
DOC_USP7_MATH_2	312	318	PF00917	0.439
DOC_WW_Pin1_4	165	170	PF00397	0.563
DOC_WW_Pin1_4	181	186	PF00397	0.577
DOC_WW_Pin1_4	355	360	PF00397	0.641
DOC_WW_Pin1_4	361	366	PF00397	0.509
DOC_WW_Pin1_4	408	413	PF00397	0.388
DOC_WW_Pin1_4	556	561	PF00397	0.610
LIG_14-3-3_CanoR_1	125	133	PF00244	0.643
LIG_14-3-3_CanoR_1	213	221	PF00244	0.613
LIG_14-3-3_CanoR_1	242	251	PF00244	0.557
LIG_14-3-3_CanoR_1	368	376	PF00244	0.510
LIG_14-3-3_CanoR_1	390	400	PF00244	0.442
LIG_14-3-3_CanoR_1	56	62	PF00244	0.518
LIG_14-3-3_CanoR_1	577	586	PF00244	0.596
LIG_14-3-3_CanoR_1	86	94	PF00244	0.457
LIG_Actin_WH2_2	226	244	PF00022	0.460
LIG_Actin_WH2_2	452	467	PF00022	0.370
LIG_Actin_WH2_2	517	533	PF00022	0.403
LIG_APCC_ABBA_1	5	10	PF00400	0.454
LIG_APCC_ABBA_1	506	511	PF00400	0.378
LIG_BRCT_BRCA1_1	51	55	PF00533	0.493
LIG_CtBP_PxDLS_1	560	564	PF00389	0.567
LIG_deltaCOP1_diTrp_1	501	509	PF00928	0.459
LIG_FHA_1	195	201	PF00498	0.502
LIG_FHA_1	216	222	PF00498	0.455
LIG_FHA_1	286	292	PF00498	0.524
LIG_FHA_1	320	326	PF00498	0.385
LIG_FHA_1	341	347	PF00498	0.470
LIG_FHA_1	368	374	PF00498	0.438
LIG_FHA_1	4	10	PF00498	0.459
LIG_FHA_2	166	172	PF00498	0.776
LIG_FHA_2	196	202	PF00498	0.466
LIG_FHA_2	261	267	PF00498	0.607
LIG_FHA_2	419	425	PF00498	0.439
LIG_FHA_2	466	472	PF00498	0.480
LIG_FHA_2	578	584	PF00498	0.690
LIG_IBAR_NPY_1	87	89	PF08397	0.432
LIG_Integrin_isoDGR_2	569	571	PF01839	0.535
LIG_LIR_Apic_2	583	589	PF02991	0.608
LIG_LIR_Gen_1	151	161	PF02991	0.539
LIG_LIR_Gen_1	270	280	PF02991	0.536
LIG_LIR_Gen_1	427	433	PF02991	0.300
LIG_LIR_Nem_3	151	156	PF02991	0.508
LIG_LIR_Nem_3	270	276	PF02991	0.562
LIG_LIR_Nem_3	427	431	PF02991	0.295
LIG_LYPXL_yS_3	447	450	PF13949	0.390
LIG_NRBOX	286	292	PF00104	0.441
LIG_NRBOX	324	330	PF00104	0.460
LIG_PCNA_PIPBox_1	1	10	PF02747	0.535
LIG_Pex14_2	494	498	PF04695	0.442
LIG_RPA_C_Plants	315	326	PF08784	0.307
LIG_SH2_CRK	273	277	PF00017	0.499
LIG_SH2_CRK	428	432	PF00017	0.368
LIG_SH2_NCK_1	273	277	PF00017	0.544
LIG_SH2_NCK_1	89	93	PF00017	0.452
LIG_SH2_SRC	101	104	PF00017	0.480
LIG_SH2_STAP1	273	277	PF00017	0.544
LIG_SH2_STAP1	428	432	PF00017	0.408
LIG_SH2_STAP1	89	93	PF00017	0.452
LIG_SH2_STAT5	458	461	PF00017	0.356
LIG_SH2_STAT5	93	96	PF00017	0.438
LIG_SH3_3	120	126	PF00018	0.569
LIG_SH3_3	261	267	PF00018	0.742
LIG_Sin3_3	70	77	PF02671	0.491
LIG_SUMO_SIM_anti_2	343	348	PF11976	0.445
LIG_SUMO_SIM_par_1	218	224	PF11976	0.443
LIG_TRAF2_1	169	172	PF00917	0.749
LIG_TYR_ITIM	445	450	PF00017	0.462
MOD_CDK_SPxxK_3	361	368	PF00069	0.565
MOD_CK1_1	110	116	PF00069	0.561
MOD_CK1_1	33	39	PF00069	0.655
MOD_CK1_1	350	356	PF00069	0.701
MOD_CK1_1	367	373	PF00069	0.378
MOD_CK1_1	41	47	PF00069	0.632
MOD_CK1_1	556	562	PF00069	0.663
MOD_CK1_1	59	65	PF00069	0.501
MOD_CK2_1	165	171	PF00069	0.778
MOD_CK2_1	186	192	PF00069	0.711
MOD_CK2_1	195	201	PF00069	0.468
MOD_CK2_1	254	260	PF00069	0.585
MOD_CK2_1	577	583	PF00069	0.747
MOD_DYRK1A_RPxSP_1	165	169	PF00069	0.486
MOD_GlcNHglycan	109	112	PF01048	0.491
MOD_GlcNHglycan	128	131	PF01048	0.509
MOD_GlcNHglycan	157	160	PF01048	0.705
MOD_GlcNHglycan	22	25	PF01048	0.551
MOD_GlcNHglycan	316	319	PF01048	0.575
MOD_GlcNHglycan	349	352	PF01048	0.692
MOD_GlcNHglycan	40	43	PF01048	0.711
MOD_GlcNHglycan	412	415	PF01048	0.386
MOD_GlcNHglycan	484	487	PF01048	0.648
MOD_GlcNHglycan	503	506	PF01048	0.453
MOD_GlcNHglycan	594	597	PF01048	0.602
MOD_GlcNHglycan	598	601	PF01048	0.662
MOD_GlcNHglycan	90	93	PF01048	0.450
MOD_GSK3_1	103	110	PF00069	0.473
MOD_GSK3_1	134	141	PF00069	0.621
MOD_GSK3_1	215	222	PF00069	0.627
MOD_GSK3_1	249	256	PF00069	0.639
MOD_GSK3_1	28	35	PF00069	0.726
MOD_GSK3_1	355	362	PF00069	0.599
MOD_GSK3_1	37	44	PF00069	0.605
MOD_GSK3_1	454	461	PF00069	0.392
MOD_GSK3_1	55	62	PF00069	0.503
MOD_GSK3_1	592	599	PF00069	0.532
MOD_LATS_1	452	458	PF00433	0.367
MOD_N-GLC_1	260	265	PF02516	0.766
MOD_N-GLC_1	33	38	PF02516	0.532
MOD_N-GLC_1	465	470	PF02516	0.452
MOD_NEK2_1	155	160	PF00069	0.554
MOD_NEK2_1	340	345	PF00069	0.433
MOD_NEK2_1	418	423	PF00069	0.429
MOD_NEK2_1	464	469	PF00069	0.390
MOD_NEK2_1	55	60	PF00069	0.581
MOD_NEK2_1	553	558	PF00069	0.628
MOD_PIKK_1	28	34	PF00454	0.640
MOD_PIKK_1	602	608	PF00454	0.508
MOD_PK_1	375	381	PF00069	0.448
MOD_PKA_1	213	219	PF00069	0.590
MOD_PKA_2	124	130	PF00069	0.661
MOD_PKA_2	213	219	PF00069	0.609
MOD_PKA_2	28	34	PF00069	0.595
MOD_PKA_2	295	301	PF00069	0.421
MOD_PKA_2	314	320	PF00069	0.553
MOD_PKA_2	367	373	PF00069	0.531
MOD_PKA_2	464	470	PF00069	0.425
MOD_PKA_2	496	502	PF00069	0.523
MOD_PKA_2	55	61	PF00069	0.570
MOD_PKA_2	592	598	PF00069	0.549
MOD_PKB_1	213	221	PF00069	0.593
MOD_PKB_1	575	583	PF00069	0.578
MOD_Plk_1	138	144	PF00069	0.540
MOD_Plk_1	260	266	PF00069	0.588
MOD_Plk_1	9	15	PF00069	0.450
MOD_Plk_2-3	138	144	PF00069	0.576
MOD_Plk_2-3	260	266	PF00069	0.532
MOD_Plk_4	268	274	PF00069	0.512
MOD_Plk_4	3	9	PF00069	0.500
MOD_Plk_4	375	381	PF00069	0.431
MOD_Plk_4	427	433	PF00069	0.378
MOD_Plk_4	454	460	PF00069	0.342
MOD_Plk_4	613	619	PF00069	0.428
MOD_ProDKin_1	165	171	PF00069	0.566
MOD_ProDKin_1	181	187	PF00069	0.574
MOD_ProDKin_1	355	361	PF00069	0.625
MOD_ProDKin_1	408	414	PF00069	0.384
MOD_ProDKin_1	556	562	PF00069	0.615
MOD_SUMO_for_1	14	17	PF00179	0.471
TRG_DiLeu_BaEn_1	336	341	PF01217	0.447
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.270
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.401
TRG_DiLeu_BaLyEn_6	525	530	PF01217	0.376
TRG_ENDOCYTIC_2	101	104	PF00928	0.418
TRG_ENDOCYTIC_2	273	276	PF00928	0.569
TRG_ENDOCYTIC_2	428	431	PF00928	0.405
TRG_ENDOCYTIC_2	447	450	PF00928	0.271
TRG_ER_diArg_1	181	183	PF00400	0.511
TRG_ER_diArg_1	212	215	PF00400	0.578
TRG_ER_diArg_1	308	310	PF00400	0.501
TRG_ER_diArg_1	491	494	PF00400	0.536
TRG_ER_diArg_1	575	578	PF00400	0.577
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	372	377	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	528	532	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P490	Leptomonas seymouri	36%	100%
A0A3Q8IGM0	Leishmania donovani	85%	100%
A4HLL1	Leishmania braziliensis	71%	98%
A4I923	Leishmania infantum	85%	100%
Q4Q437	Leishmania major	85%	100%